TY  - JOUR
  - Collins L.M., Downer E.J., Toulouse A., Nolan Y.M.
  - 2015
  - June
  - Molecular Neurobiology
  - Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.
  - Published
  - ()
  - 51
  - June
  - 1158
  - 1167
  - Mitogen-activated protein kinase phosphatase (MKP)-1 provides a negative feedback mechanism for regulating mitogen-activated protein kinase (MAPK) activity and thus a variety of cellular processes such as proliferation, differentiation, growth and apoptosis. MKP-1 is established as a central regulator of a variety of functions in the immune, metabolic and cardiovascular systems and it is now increasingly acknowledged as having a role to play in the nervous system. It has been implicated in regulating processes of neuronal cell development and death as well as in glial cell function. Reduced MKP-1 levels have been observed in models of neurological conditions including Huntington’s disease, Multiple Sclerosis, ischemia and cerebral hypoxia. It has also been suggested to have a role to play in psychiatric disorders such as major depressive disorder, chronic social stress and in post-traumatic stress disorder. Here we discuss the role of MKP-1 in nervous system development and disease and examine current evidence providing insight into MKP-1 as a potential therapeutic target for various diseases of the central nervous system.
  - http://link.springer.com/article/10.1007%2Fs12035-014-8786-6
  - 10.1007/s12035-014-8786-6
DA  - 2015/06
ER  - 

@article{V260919249,
   = {Collins L.M.,  Downer E.J. and  Toulouse A.,  Nolan Y.M. },
   = {2015},
   = {June},
   = {Molecular Neurobiology},
   = {Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.},
   = {Published},
   = {()},
   = {51},
   = {June},
  pages = {1158--1167},
   = {{Mitogen-activated protein kinase phosphatase (MKP)-1 provides a negative feedback mechanism for regulating mitogen-activated protein kinase (MAPK) activity and thus a variety of cellular processes such as proliferation, differentiation, growth and apoptosis. MKP-1 is established as a central regulator of a variety of functions in the immune, metabolic and cardiovascular systems and it is now increasingly acknowledged as having a role to play in the nervous system. It has been implicated in regulating processes of neuronal cell development and death as well as in glial cell function. Reduced MKP-1 levels have been observed in models of neurological conditions including Huntington’s disease, Multiple Sclerosis, ischemia and cerebral hypoxia. It has also been suggested to have a role to play in psychiatric disorders such as major depressive disorder, chronic social stress and in post-traumatic stress disorder. Here we discuss the role of MKP-1 in nervous system development and disease and examine current evidence providing insight into MKP-1 as a potential therapeutic target for various diseases of the central nervous system.}},
   = {http://link.springer.com/article/10.1007%2Fs12035-014-8786-6},
   = {10.1007/s12035-014-8786-6},
  source = {IRIS}
}