IRIS publication 350688
Structure of the human retinoic acid receptor beta 1 gene
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TY - JOUR - Toulouse A., Morin J., Pelletier M., Bradley W. E. C. - 1996 - November - Biochem Biophys Acta - Structure of the human retinoic acid receptor beta 1 gene - Published - () - 1309 - 1 - 4 - We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers. Primer extension analysis revealed a principal transcription start site with a secondary site 23 bp further upstream in both SCLC and fetal tissues. The sequences isolated were CpG-rich between -60 and the 3' end of the first exon but there were no features like a TATA-box or an Inr element. In several important aspects, the human RAR beta 1 differs from its mouse counterpart. The 5'-UTR is 823 bp long and is encoded by four exons (vs two in the mouse giving a 477 bp UTR). The 5' end of the mouse cDNA has been mapped to a 67 bp CT repeat which is absent in our sequences. We were also unable to find evidence for a human isoform RAR beta 3 which is widely expressed in mouse tissues. DA - 1996/11 ER -
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@article{V350688, = {Toulouse A., Morin J. and Pelletier M., Bradley W. E. C. }, = {1996}, = {November}, = {Biochem Biophys Acta}, = {Structure of the human retinoic acid receptor beta 1 gene}, = {Published}, = {()}, = {1309}, pages = {1--4}, = {{We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers. Primer extension analysis revealed a principal transcription start site with a secondary site 23 bp further upstream in both SCLC and fetal tissues. The sequences isolated were CpG-rich between -60 and the 3' end of the first exon but there were no features like a TATA-box or an Inr element. In several important aspects, the human RAR beta 1 differs from its mouse counterpart. The 5'-UTR is 823 bp long and is encoded by four exons (vs two in the mouse giving a 477 bp UTR). The 5' end of the mouse cDNA has been mapped to a 67 bp CT repeat which is absent in our sequences. We were also unable to find evidence for a human isoform RAR beta 3 which is widely expressed in mouse tissues.}}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Toulouse A., Morin J., Pelletier M., Bradley W. E. C. | ||
YEAR | 1996 | ||
MONTH | November | ||
JOURNAL_CODE | Biochem Biophys Acta | ||
TITLE | Structure of the human retinoic acid receptor beta 1 gene | ||
STATUS | Published | ||
TIMES_CITED | () | ||
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VOLUME | 1309 | ||
ISSUE | |||
START_PAGE | 1 | ||
END_PAGE | 4 | ||
ABSTRACT | We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers. Primer extension analysis revealed a principal transcription start site with a secondary site 23 bp further upstream in both SCLC and fetal tissues. The sequences isolated were CpG-rich between -60 and the 3' end of the first exon but there were no features like a TATA-box or an Inr element. In several important aspects, the human RAR beta 1 differs from its mouse counterpart. The 5'-UTR is 823 bp long and is encoded by four exons (vs two in the mouse giving a 477 bp UTR). The 5' end of the mouse cDNA has been mapped to a 67 bp CT repeat which is absent in our sequences. We were also unable to find evidence for a human isoform RAR beta 3 which is widely expressed in mouse tissues. | ||
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