IRIS publication 118300092
Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction.
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TY - JOUR - O'Malley D, Dinan TG, Cryan JF - 2011 - June - Journal of Neuroimmunology - Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction. - Validated - WOS: 25 () - 235 - 1-2 - 48 - 55 - Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than control Sprague Dawley (SD) colons (5.55 pg/ml) and WKY secretions stimulated calcium responses in naïve submucosal neurons of greater amplitude. Recombinant IL-6 activated more submucosal neurons in WKY tissue preparations (p<0.05). These data demonstrate that WKY colonic supernatants activate submucosal neurons using an IL-6-dependent mechanism, thereby providing a link between gastrointestinal dysfunction and alterations in IL-6 levels. - 10.1016/j.jneuroim.2011.04.003 DA - 2011/06 ER -
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@article{V118300092, = {O'Malley D, Dinan TG and Cryan JF }, = {2011}, = {June}, = {Journal of Neuroimmunology}, = {Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction.}, = {Validated}, = {WOS: 25 ()}, = {235}, = {1-2}, pages = {48--55}, = {{Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than control Sprague Dawley (SD) colons (5.55 pg/ml) and WKY secretions stimulated calcium responses in naïve submucosal neurons of greater amplitude. Recombinant IL-6 activated more submucosal neurons in WKY tissue preparations (p<0.05). These data demonstrate that WKY colonic supernatants activate submucosal neurons using an IL-6-dependent mechanism, thereby providing a link between gastrointestinal dysfunction and alterations in IL-6 levels.}}, = {10.1016/j.jneuroim.2011.04.003}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | O'Malley D, Dinan TG, Cryan JF | ||
YEAR | 2011 | ||
MONTH | June | ||
JOURNAL_CODE | Journal of Neuroimmunology | ||
TITLE | Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction. | ||
STATUS | Validated | ||
TIMES_CITED | WOS: 25 () | ||
SEARCH_KEYWORD | |||
VOLUME | 235 | ||
ISSUE | 1-2 | ||
START_PAGE | 48 | ||
END_PAGE | 55 | ||
ABSTRACT | Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than control Sprague Dawley (SD) colons (5.55 pg/ml) and WKY secretions stimulated calcium responses in naïve submucosal neurons of greater amplitude. Recombinant IL-6 activated more submucosal neurons in WKY tissue preparations (p<0.05). These data demonstrate that WKY colonic supernatants activate submucosal neurons using an IL-6-dependent mechanism, thereby providing a link between gastrointestinal dysfunction and alterations in IL-6 levels. | ||
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DOI_LINK | 10.1016/j.jneuroim.2011.04.003 | ||
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