IRIS publication 121848794
Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat.
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TY - JOUR - O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF - 2012 - January - British Journal of Pharmacology - Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat. - Validated - () - Recent studies indicate that efflux of antidepressants by the multidrug resistance transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) may contribute to treatment-resistant depression (TRD) by limiting intracerebral antidepressant concentrations. In addition, clinical experience shows that adjunctive treatment with the P-gp inhibitor verapamil may improve the clinical outcome in TRD. Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB. - 10.1111/j.1476-5381.2012.01858.x DA - 2012/01 ER -
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@article{V121848794, = {O'Brien FE, Clarke G and Fitzgerald P, Dinan TG and Griffin BT, Cryan JF }, = {2012}, = {January}, = {British Journal of Pharmacology}, = {Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat.}, = {Validated}, = {()}, = {{Recent studies indicate that efflux of antidepressants by the multidrug resistance transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) may contribute to treatment-resistant depression (TRD) by limiting intracerebral antidepressant concentrations. In addition, clinical experience shows that adjunctive treatment with the P-gp inhibitor verapamil may improve the clinical outcome in TRD. Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB.}}, = {10.1111/j.1476-5381.2012.01858.x}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF | ||
YEAR | 2012 | ||
MONTH | January | ||
JOURNAL_CODE | British Journal of Pharmacology | ||
TITLE | Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat. | ||
STATUS | Validated | ||
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ABSTRACT | Recent studies indicate that efflux of antidepressants by the multidrug resistance transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) may contribute to treatment-resistant depression (TRD) by limiting intracerebral antidepressant concentrations. In addition, clinical experience shows that adjunctive treatment with the P-gp inhibitor verapamil may improve the clinical outcome in TRD. Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB. | ||
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DOI_LINK | 10.1111/j.1476-5381.2012.01858.x | ||
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