TY  - JOUR
  - O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF
  - 2012
  - January
  - British Journal of Pharmacology
  - Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat.
  - Validated
  - ()
  - Recent studies indicate that efflux of antidepressants by the multidrug resistance transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) may contribute to treatment-resistant depression (TRD) by limiting intracerebral antidepressant concentrations. In addition, clinical experience shows that adjunctive treatment with the P-gp inhibitor verapamil may improve the clinical outcome in TRD. Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB.
  - 10.1111/j.1476-5381.2012.01858.x
DA  - 2012/01
ER  - 

@article{V121848794,
   = {O'Brien FE,  Clarke G and  Fitzgerald P,  Dinan TG and  Griffin BT,  Cryan JF },
   = {2012},
   = {January},
   = {British Journal of Pharmacology},
   = {Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat.},
   = {Validated},
   = {()},
   = {{Recent studies indicate that efflux of antidepressants by the multidrug resistance transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) may contribute to treatment-resistant depression (TRD) by limiting intracerebral antidepressant concentrations. In addition, clinical experience shows that adjunctive treatment with the P-gp inhibitor verapamil may improve the clinical outcome in TRD. Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB.}},
   = {10.1111/j.1476-5381.2012.01858.x},
  source = {IRIS}
}