TY  - JOUR
  - Dennison U, McKernan D, Cryan J, Dinan T
  - 2012
  - February
  - Psychological medicine
  - Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype.
  - Validated
  - Altmetric: 3 ()
  - 1
  - 7
  - BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls.MethodWe recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor (TNF)-α. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. RESULTS: Patients with childhood trauma had higher levels of IL-6 and TNF-α than patients without trauma and healthy controls, and TNF-α levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. CONCLUSIONS: Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.
  - 10.1017/S0033291712000074
DA  - 2012/02
ER  - 

@article{V143996767,
   = {Dennison U,  McKernan D and  Cryan J,  Dinan T },
   = {2012},
   = {February},
   = {Psychological medicine},
   = {Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype.},
   = {Validated},
   = {Altmetric: 3 ()},
  pages = {1--7},
   = {{BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls.MethodWe recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor (TNF)-α. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. RESULTS: Patients with childhood trauma had higher levels of IL-6 and TNF-α than patients without trauma and healthy controls, and TNF-α levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. CONCLUSIONS: Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.}},
   = {10.1017/S0033291712000074},
  source = {IRIS}
}