Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters.

Typeset version

 

TY  - JOUR
  - Davey KJ, O'Mahony SM, Schellekens H, O'Sullivan O, Bienenstock J, Cotter PD, Dinan TG, Cryan JF
  - 2012
  - May
  - Pharmacology
  - Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters.
  - Validated
  - Altmetric: 7 ()
  - 221
  - 1
  - 155
  - 169
  - Atypical antipsychotic drugs (AAPDs) such as olanzapine have a serious side effect profile including weight gain and metabolic dysfunction, and a number of studies have suggested a role for gender in the susceptibility to these effects. In recent times, the gut microbiota has been recognised as a major contributor to the regulation of body weight and metabolism. Thus, we investigated the effects of olanzapine on body weight, behaviour, gut microbiota and inflammatory and metabolic markers in both male and female rats.
  - 10.1007/s00213-011-2555-2
DA  - 2012/05
ER  - 
@article{V143996774,
   = {Davey KJ,  O'Mahony SM and  Schellekens H,  O'Sullivan O and  Bienenstock J,  Cotter PD and  Dinan TG,  Cryan JF },
   = {2012},
   = {May},
   = {Pharmacology},
   = {Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters.},
   = {Validated},
   = {Altmetric: 7 ()},
   = {221},
   = {1},
  pages = {155--169},
   = {{Atypical antipsychotic drugs (AAPDs) such as olanzapine have a serious side effect profile including weight gain and metabolic dysfunction, and a number of studies have suggested a role for gender in the susceptibility to these effects. In recent times, the gut microbiota has been recognised as a major contributor to the regulation of body weight and metabolism. Thus, we investigated the effects of olanzapine on body weight, behaviour, gut microbiota and inflammatory and metabolic markers in both male and female rats.}},
   = {10.1007/s00213-011-2555-2},
  source = {IRIS}
}
AUTHORSDavey KJ, O'Mahony SM, Schellekens H, O'Sullivan O, Bienenstock J, Cotter PD, Dinan TG, Cryan JF
YEAR2012
MONTHMay
JOURNAL_CODEPharmacology
TITLEGender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters.
STATUSValidated
TIMES_CITEDAltmetric: 7 ()
SEARCH_KEYWORD
VOLUME221
ISSUE1
START_PAGE155
END_PAGE169
ABSTRACTAtypical antipsychotic drugs (AAPDs) such as olanzapine have a serious side effect profile including weight gain and metabolic dysfunction, and a number of studies have suggested a role for gender in the susceptibility to these effects. In recent times, the gut microbiota has been recognised as a major contributor to the regulation of body weight and metabolism. Thus, we investigated the effects of olanzapine on body weight, behaviour, gut microbiota and inflammatory and metabolic markers in both male and female rats.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1007/s00213-011-2555-2
FUNDING_BODY
GRANT_DETAILS