TY  - JOUR
  - Tramullas, M,Dinan, TG,Cryan, JF
  - 2012
  - January
  - Stress (Amsterdam, Netherlands)
  - Chronic psychosocial stress induces visceral hyperalgesia in mice
  - Validated
  - ()
  - Brain-gut axis chronic stress colorectal distension social avoidance somatic analgesia visceral hypersensitivity IRRITABLE-BOWEL-SYNDROME SOCIAL DEFEAT STRESS PSEUDO-AFFECTIVE RESPONSES FUNCTIONAL GI-DISORDERS DSS-INDUCED COLITIS BRAIN-GUT AXIS COLORECTAL DISTENSION MANOMETRIC RECORDINGS COLONIC INFLAMMATION MATERNAL SEPARATION
  - 15
  - 281
  - 292
  - Experimental and clinical evidence has shown that chronic stress plays an important role in the onset and/or exacerbation of symptoms of functional gastrointestinal disorders. Here, we aimed to investigate whether exposure to a chronic and temporally unpredictable psychosocial stressor alters visceral and somatic nociception as well as anxiety-related behaviour. In male C57BL/6J mice, chronic stress was induced by repeated exposure to social defeat (SD, 2 h) and overcrowding (OC, 24 h) during 19 consecutive days. Visceral and somatic nociception was evaluated by colorectal distension and a hot plate, respectively. The social interaction test was used to assess social anxiety. Mice exposed to psychosocial stress developed visceral hyperalgesia and somatic hypoalgesia 24 h following the last stress session. SD/OC mice also exhibited social anxiety-like behaviour. All these changes were also associated with physiological alterations, measured as a decreased faecal pellet output and hypothalamic-pituitary-adrenal (HPA) axis disruption. Taken together, these data confirm that this mouse model of chronic psychosocial stress may be useful for studies on the pathophysiological mechanisms underlying such stress-associated disorders and to further test potential therapies.
  - DOI 10.3109/10253890.2011.622816
DA  - 2012/01
ER  - 

@article{V146554633,
   = {Tramullas,  M and Dinan,  TG and Cryan,  JF },
   = {2012},
   = {January},
   = {Stress (Amsterdam, Netherlands)},
   = {Chronic psychosocial stress induces visceral hyperalgesia in mice},
   = {Validated},
   = {()},
   = {Brain-gut axis chronic stress colorectal distension social avoidance somatic analgesia visceral hypersensitivity IRRITABLE-BOWEL-SYNDROME SOCIAL DEFEAT STRESS PSEUDO-AFFECTIVE RESPONSES FUNCTIONAL GI-DISORDERS DSS-INDUCED COLITIS BRAIN-GUT AXIS COLORECTAL DISTENSION MANOMETRIC RECORDINGS COLONIC INFLAMMATION MATERNAL SEPARATION},
   = {15},
  pages = {281--292},
   = {{Experimental and clinical evidence has shown that chronic stress plays an important role in the onset and/or exacerbation of symptoms of functional gastrointestinal disorders. Here, we aimed to investigate whether exposure to a chronic and temporally unpredictable psychosocial stressor alters visceral and somatic nociception as well as anxiety-related behaviour. In male C57BL/6J mice, chronic stress was induced by repeated exposure to social defeat (SD, 2 h) and overcrowding (OC, 24 h) during 19 consecutive days. Visceral and somatic nociception was evaluated by colorectal distension and a hot plate, respectively. The social interaction test was used to assess social anxiety. Mice exposed to psychosocial stress developed visceral hyperalgesia and somatic hypoalgesia 24 h following the last stress session. SD/OC mice also exhibited social anxiety-like behaviour. All these changes were also associated with physiological alterations, measured as a decreased faecal pellet output and hypothalamic-pituitary-adrenal (HPA) axis disruption. Taken together, these data confirm that this mouse model of chronic psychosocial stress may be useful for studies on the pathophysiological mechanisms underlying such stress-associated disorders and to further test potential therapies.}},
   = {DOI 10.3109/10253890.2011.622816},
  source = {IRIS}
}