IRIS publication 190495908
Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain
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TY - JOUR - Browne, CA,Clarke, G,Hanke, J,Dinan, TG,Schwegler, H,Yilmazer-Hanke, DM,Cryan, JF - 2013 - January - Behavioural Brain Research - Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain - Validated - () - Depression Medial prefrontal cortex Serotonin DBA/2J C3H/HeJHd FST Fear-sensitized acoustic startle reflex (FSS) ANTERIOR CINGULATE CORTEX DEPRESSION-RELATED BEHAVIOR ANXIETY-RELATED BEHAVIOR DEEP BRAIN-STIMULATION TAIL SUSPENSION TEST MAJOR DEPRESSION FEAR EXTINCTION BASOLATERAL AMYGDALA COGNITIVE-BEHAVIOR GLUCOSE-METABOLISM - 236 - 283 - 288 - In the present study, two genetically related inbred mouse strains selectively bred for high and low fear-sensitized acoustic startle reflex (FSS) were assessed in the forced swim test model of anti-depressant action and central monoamine concentrations in several brain regions were investigated. These mice were generated through backcrossing C3H/HeJ mice on DBA/2J mice, followed by inbreeding for several generations. The high-FSS and low-FSS strains are known to differ in their acquisition and extinction of fear following auditory fear conditioning. Significantly increased concentrations of 5-HT and its metabolite 5-HIAA were observed in the medial prefrontal cortex (mPFC) but not in the hypothalamus, striatum, hippocampus, amygdala, or midbrain of high-FSS mice compared to low-FSS mice. In addition the concentration of DOPAC, the major metabolite of dopamine was also significantly increased in the mPFC. Furthermore, the high-FSS mice displayed significantly higher levels of immobility in the forced swim test but not the tail suspension test in comparison to the low-FSS group. The mPFC is not only important in the regulation of fear extinction, but also a key region of interest in the study of depression and maintenance of depressive-like behaviors. These data implicate serotonergic modulation in the mPFC in the maintenance of antidepressant-like behavior in a highly fearful mouse strain. (C) 2012 Elsevier B.V. All rights reserved. - DOI 10.1016/j.bbr.2012.08.012 DA - 2013/01 ER -
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@article{V190495908, = {Browne, CA and Clarke, G and Hanke, J and Dinan, TG and Schwegler, H and Yilmazer-Hanke, DM and Cryan, JF }, = {2013}, = {January}, = {Behavioural Brain Research}, = {Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain}, = {Validated}, = {()}, = {Depression Medial prefrontal cortex Serotonin DBA/2J C3H/HeJHd FST Fear-sensitized acoustic startle reflex (FSS) ANTERIOR CINGULATE CORTEX DEPRESSION-RELATED BEHAVIOR ANXIETY-RELATED BEHAVIOR DEEP BRAIN-STIMULATION TAIL SUSPENSION TEST MAJOR DEPRESSION FEAR EXTINCTION BASOLATERAL AMYGDALA COGNITIVE-BEHAVIOR GLUCOSE-METABOLISM}, = {236}, pages = {283--288}, = {{In the present study, two genetically related inbred mouse strains selectively bred for high and low fear-sensitized acoustic startle reflex (FSS) were assessed in the forced swim test model of anti-depressant action and central monoamine concentrations in several brain regions were investigated. These mice were generated through backcrossing C3H/HeJ mice on DBA/2J mice, followed by inbreeding for several generations. The high-FSS and low-FSS strains are known to differ in their acquisition and extinction of fear following auditory fear conditioning. Significantly increased concentrations of 5-HT and its metabolite 5-HIAA were observed in the medial prefrontal cortex (mPFC) but not in the hypothalamus, striatum, hippocampus, amygdala, or midbrain of high-FSS mice compared to low-FSS mice. In addition the concentration of DOPAC, the major metabolite of dopamine was also significantly increased in the mPFC. Furthermore, the high-FSS mice displayed significantly higher levels of immobility in the forced swim test but not the tail suspension test in comparison to the low-FSS group. The mPFC is not only important in the regulation of fear extinction, but also a key region of interest in the study of depression and maintenance of depressive-like behaviors. These data implicate serotonergic modulation in the mPFC in the maintenance of antidepressant-like behavior in a highly fearful mouse strain. (C) 2012 Elsevier B.V. All rights reserved.}}, = {DOI 10.1016/j.bbr.2012.08.012}, source = {IRIS} }
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AUTHORS | Browne, CA,Clarke, G,Hanke, J,Dinan, TG,Schwegler, H,Yilmazer-Hanke, DM,Cryan, JF | ||
YEAR | 2013 | ||
MONTH | January | ||
JOURNAL_CODE | Behavioural Brain Research | ||
TITLE | Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | Depression Medial prefrontal cortex Serotonin DBA/2J C3H/HeJHd FST Fear-sensitized acoustic startle reflex (FSS) ANTERIOR CINGULATE CORTEX DEPRESSION-RELATED BEHAVIOR ANXIETY-RELATED BEHAVIOR DEEP BRAIN-STIMULATION TAIL SUSPENSION TEST MAJOR DEPRESSION FEAR EXTINCTION BASOLATERAL AMYGDALA COGNITIVE-BEHAVIOR GLUCOSE-METABOLISM | ||
VOLUME | 236 | ||
ISSUE | |||
START_PAGE | 283 | ||
END_PAGE | 288 | ||
ABSTRACT | In the present study, two genetically related inbred mouse strains selectively bred for high and low fear-sensitized acoustic startle reflex (FSS) were assessed in the forced swim test model of anti-depressant action and central monoamine concentrations in several brain regions were investigated. These mice were generated through backcrossing C3H/HeJ mice on DBA/2J mice, followed by inbreeding for several generations. The high-FSS and low-FSS strains are known to differ in their acquisition and extinction of fear following auditory fear conditioning. Significantly increased concentrations of 5-HT and its metabolite 5-HIAA were observed in the medial prefrontal cortex (mPFC) but not in the hypothalamus, striatum, hippocampus, amygdala, or midbrain of high-FSS mice compared to low-FSS mice. In addition the concentration of DOPAC, the major metabolite of dopamine was also significantly increased in the mPFC. Furthermore, the high-FSS mice displayed significantly higher levels of immobility in the forced swim test but not the tail suspension test in comparison to the low-FSS group. The mPFC is not only important in the regulation of fear extinction, but also a key region of interest in the study of depression and maintenance of depressive-like behaviors. These data implicate serotonergic modulation in the mPFC in the maintenance of antidepressant-like behavior in a highly fearful mouse strain. (C) 2012 Elsevier B.V. All rights reserved. | ||
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DOI_LINK | DOI 10.1016/j.bbr.2012.08.012 | ||
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