TY  - JOUR
  - Dennison, U,McKernan, D,Cryan, J,Dinan, T
  - 2012
  - January
  - Psychological medicine
  - Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype
  - Validated
  - ()
  - Childhood trauma inflammation schizophrenia EARLY-LIFE STRESS MAJOR DEPRESSION PLASMA INTERLEUKIN-6 CYTOKINE RESPONSES PSYCHOSIS VALIDITY ADULTS BRAIN SCALE RATS
  - 42
  - 1865
  - 1871
  - Background. Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls.Method. We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1 beta, IL-6, IL-8 and tumour necrosis factor (TNF)-alpha. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls.Results. Patients with childhood trauma had higher levels of IL-6 and TNF-alpha than patients without trauma and healthy controls, and TNF-alpha levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls.Conclusions. Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.
  - DOI 10.1017/S0033291712000074
DA  - 2012/01
ER  - 

@article{V190496296,
   = {Dennison,  U and McKernan,  D and Cryan,  J and Dinan,  T },
   = {2012},
   = {January},
   = {Psychological medicine},
   = {Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype},
   = {Validated},
   = {()},
   = {Childhood trauma inflammation schizophrenia EARLY-LIFE STRESS MAJOR DEPRESSION PLASMA INTERLEUKIN-6 CYTOKINE RESPONSES PSYCHOSIS VALIDITY ADULTS BRAIN SCALE RATS},
   = {42},
  pages = {1865--1871},
   = {{Background. Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls.Method. We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1 beta, IL-6, IL-8 and tumour necrosis factor (TNF)-alpha. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls.Results. Patients with childhood trauma had higher levels of IL-6 and TNF-alpha than patients without trauma and healthy controls, and TNF-alpha levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls.Conclusions. Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.}},
   = {DOI 10.1017/S0033291712000074},
  source = {IRIS}
}