TY  - JOUR
  - Schellekens, H,Nongonierma, AB,Clarke, G,van Oeffelen, WEPA,FitzGerald, RJ,Dinan, TG,Cryan, JF
  - 2014
  - September
  - International Dairy Journal
  - Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo
  - Validated
  - WOS: 14 ()
  - 5-HT2C SEROTONIN RECEPTORS AMINO-ACID PROFILES FOOD-INTAKE ALPHA-LACTALBUMIN ENERGY-INTAKE TRANSEPITHELIAL TRANSPORT ANTIOXIDANT ACTIVITY APPETITE EXPRESSION BIOACTIVE PEPTIDES LENTIVIRAL-VECTORS
  - 38
  - 55
  - 64
  - This study investigates the ability of milk protein-derived peptides to specifically activate the serotonin 2C (5-HT2C) receptor, a key receptor in central regulation of food intake. A dose dependent 5-HT2C receptor activation by the 1 kDa ultrafiltration permeates of a sodium caseinate (NaCNH-1 kDa permeate) and a whey protein hydrolysate (WPH-1 kDa permeate) was demonstrated using an intracellular calcium mobilisation assay in human embryonic kidney (Hek) cells expressing the 5-HT2C receptor. Both samples activated the 5-HT2C but not the 5-HT2A and 5-HT2B receptors. NaCNH-1 kDa permeate significantly (p < 0.01) reduced cumulative food intake when administered to male mice (C57Bl/6) by intraperitoneal injection at 500 mg kg(-1) body weight. In contrast, no effect of WPH-1 kDa permeate could be seen on food intake in vivo. These results demonstrate the promising appetite-suppressing potential of NaCN-derived peptides, targeting the 5-HT2C receptor. (C) 2014 Elsevier Ltd. All rights reserved.
  - 10.1016/j.idairyj.2014.04.004
DA  - 2014/09
ER  - 

@article{V271355842,
   = {Schellekens,  H and Nongonierma,  AB and Clarke,  G and van Oeffelen,  WEPA and FitzGerald,  RJ and Dinan,  TG and Cryan,  JF },
   = {2014},
   = {September},
   = {International Dairy Journal},
   = {Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo},
   = {Validated},
   = {WOS: 14 ()},
   = {5-HT2C SEROTONIN RECEPTORS AMINO-ACID PROFILES FOOD-INTAKE ALPHA-LACTALBUMIN ENERGY-INTAKE TRANSEPITHELIAL TRANSPORT ANTIOXIDANT ACTIVITY APPETITE EXPRESSION BIOACTIVE PEPTIDES LENTIVIRAL-VECTORS},
   = {38},
  pages = {55--64},
   = {{This study investigates the ability of milk protein-derived peptides to specifically activate the serotonin 2C (5-HT2C) receptor, a key receptor in central regulation of food intake. A dose dependent 5-HT2C receptor activation by the 1 kDa ultrafiltration permeates of a sodium caseinate (NaCNH-1 kDa permeate) and a whey protein hydrolysate (WPH-1 kDa permeate) was demonstrated using an intracellular calcium mobilisation assay in human embryonic kidney (Hek) cells expressing the 5-HT2C receptor. Both samples activated the 5-HT2C but not the 5-HT2A and 5-HT2B receptors. NaCNH-1 kDa permeate significantly (p < 0.01) reduced cumulative food intake when administered to male mice (C57Bl/6) by intraperitoneal injection at 500 mg kg(-1) body weight. In contrast, no effect of WPH-1 kDa permeate could be seen on food intake in vivo. These results demonstrate the promising appetite-suppressing potential of NaCN-derived peptides, targeting the 5-HT2C receptor. (C) 2014 Elsevier Ltd. All rights reserved.}},
   = {10.1016/j.idairyj.2014.04.004},
  source = {IRIS}
}