Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis

Typeset version

 

TY  - JOUR
  - Curran EA, O’Neill SM, Cryan JF, Kenny LC, Dinan TG, Khashan AS, et al
  - 2014
  - October
  - Journal of Child Psychology ; Psychiatry
  - Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis
  - Published
  - Altmetric: 100 ()
  - Background Given the growing prevalence of birth by Caesarean section (CS) worldwide, it is important to understand any long-term effects CS delivery may have on a child's development. We assessed the impact of mode of delivery on autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). Methods We conducted a systematic review of the literature in PubMed, Embase, CINAHL, PsycINFO and Web of Science up to 28 February 2014. No publication date, language, location or age restrictions were employed. Results Thirteen studies reported an adjusted estimate for CS-ASD, producing a pooled odds ratio (OR) of 1.23 (95% CI: 1.07, 1.40). Two studies reported an adjusted estimate for CS-ADHD, producing a pooled OR of 1.07 (95% CI: 0.86, 1.33). Conclusions Delivery by CS is associated with a modest increased odds of ASD, and possibly ADHD, when compared to vaginal delivery. Although the effect may be due to residual confounding, the current and accelerating rate of CS implies that even a small increase in the odds of disorders, such as ASD or ADHD, may have a large impact on the society as a whole. This warrants further investigation
  - http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12351/full
  - doi:10.1111/jcpp.12351
  - Science Foundation Ireland
  - 12|RC|2272
DA  - 2014/10
ER  - 
@article{V279140971,
   = {Curran EA,  O’Neill SM and  Cryan JF,  Kenny LC and  Dinan TG,  Khashan AS and  et al },
   = {2014},
   = {October},
   = {Journal of Child Psychology ; Psychiatry},
   = {Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis},
   = {Published},
   = {Altmetric: 100 ()},
   = {{Background Given the growing prevalence of birth by Caesarean section (CS) worldwide, it is important to understand any long-term effects CS delivery may have on a child's development. We assessed the impact of mode of delivery on autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). Methods We conducted a systematic review of the literature in PubMed, Embase, CINAHL, PsycINFO and Web of Science up to 28 February 2014. No publication date, language, location or age restrictions were employed. Results Thirteen studies reported an adjusted estimate for CS-ASD, producing a pooled odds ratio (OR) of 1.23 (95% CI: 1.07, 1.40). Two studies reported an adjusted estimate for CS-ADHD, producing a pooled OR of 1.07 (95% CI: 0.86, 1.33). Conclusions Delivery by CS is associated with a modest increased odds of ASD, and possibly ADHD, when compared to vaginal delivery. Although the effect may be due to residual confounding, the current and accelerating rate of CS implies that even a small increase in the odds of disorders, such as ASD or ADHD, may have a large impact on the society as a whole. This warrants further investigation}},
   = {http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12351/full},
   = {doi:10.1111/jcpp.12351},
   = {Science Foundation Ireland},
   = {12|RC|2272},
  source = {IRIS}
}
AUTHORSCurran EA, O’Neill SM, Cryan JF, Kenny LC, Dinan TG, Khashan AS, et al
YEAR2014
MONTHOctober
JOURNAL_CODEJournal of Child Psychology ; Psychiatry
TITLEBirth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis
STATUSPublished
TIMES_CITEDAltmetric: 100 ()
SEARCH_KEYWORD
VOLUME
ISSUE
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END_PAGE
ABSTRACTBackground Given the growing prevalence of birth by Caesarean section (CS) worldwide, it is important to understand any long-term effects CS delivery may have on a child's development. We assessed the impact of mode of delivery on autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). Methods We conducted a systematic review of the literature in PubMed, Embase, CINAHL, PsycINFO and Web of Science up to 28 February 2014. No publication date, language, location or age restrictions were employed. Results Thirteen studies reported an adjusted estimate for CS-ASD, producing a pooled odds ratio (OR) of 1.23 (95% CI: 1.07, 1.40). Two studies reported an adjusted estimate for CS-ADHD, producing a pooled OR of 1.07 (95% CI: 0.86, 1.33). Conclusions Delivery by CS is associated with a modest increased odds of ASD, and possibly ADHD, when compared to vaginal delivery. Although the effect may be due to residual confounding, the current and accelerating rate of CS implies that even a small increase in the odds of disorders, such as ASD or ADHD, may have a large impact on the society as a whole. This warrants further investigation
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URLhttp://onlinelibrary.wiley.com/doi/10.1111/jcpp.12351/full
DOI_LINKdoi:10.1111/jcpp.12351
FUNDING_BODYScience Foundation Ireland
GRANT_DETAILS12|RC|2272