TY  - JOUR
  - Fendt, M,Schmid, S,Thakker, DR,Jacobson, LH,Yamamoto, R,Mitsukawa, K,Maier, R,Natt, F,Husken, D,Kelly, PH,McAllister, KH,Hoyer, D,van der Putten, H,Cryan, JF,Flor, PJ
  - 2008
  - August
  - Molecular Psychiatry
  - mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity
  - Validated
  - ()
  - anxiety fear learning glutamate metabotropic glutamate receptors METABOTROPIC GLUTAMATE-RECEPTOR CONDITIONED TASTE-AVERSION FEAR-POTENTIATED STARTLE LONG-TERM POTENTIATION ADULT-MOUSE BRAIN INSULAR CORTEX D-CYCLOSERINE PREFRONTAL CORTEX MOLECULAR-CLONING RNA INTERFERENCE
  - 13
  - 970
  - 979
  - Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates.
  - DOI 10.1038/sj.mp.4002073
DA  - 2008/08
ER  - 

@article{V43335289,
   = {Fendt,  M and Schmid,  S and Thakker,  DR and Jacobson,  LH and Yamamoto,  R and Mitsukawa,  K and Maier,  R and Natt,  F and Husken,  D and Kelly,  PH and McAllister,  KH and Hoyer,  D and van der Putten,  H and Cryan,  JF and Flor,  PJ },
   = {2008},
   = {August},
   = {Molecular Psychiatry},
   = {mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity},
   = {Validated},
   = {()},
   = {anxiety fear learning glutamate metabotropic glutamate receptors METABOTROPIC GLUTAMATE-RECEPTOR CONDITIONED TASTE-AVERSION FEAR-POTENTIATED STARTLE LONG-TERM POTENTIATION ADULT-MOUSE BRAIN INSULAR CORTEX D-CYCLOSERINE PREFRONTAL CORTEX MOLECULAR-CLONING RNA INTERFERENCE},
   = {13},
  pages = {970--979},
   = {{Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates.}},
   = {DOI 10.1038/sj.mp.4002073},
  source = {IRIS}
}