TY  - JOUR
  - Fendt, M, Schmid, S, Thakker, DR, Jacobson, LH, Yamamoto, R, Mitsukawa, K, Maier, R, Natt, F, Husken, D, Kelly, PH, McAllister, KH, Hoyer, D, van der Putten, H, Cryan, JF, Flor, PJ
  - 2008
  - August
  - Molecular Psychiatry
  - Mglur7 Facilitates Extinction of Aversive Memories and Controls Amygdala Plasticity
  - Validated
  - ()
  - 13
  - 10
  - 970
  - 979
  - Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates..
  - DOI 10.1038/sj.mp.4002073
DA  - 2008/08
ER  - 

@article{V722873,
   = {Fendt,  M and  Schmid,  S and  Thakker,  DR and  Jacobson,  LH and  Yamamoto,  R and  Mitsukawa,  K and  Maier,  R and  Natt,  F and  Husken,  D and  Kelly,  PH and  McAllister,  KH and  Hoyer,  D and  van der Putten,  H and  Cryan,  JF and  Flor,  PJ },
   = {2008},
   = {August},
   = {Molecular Psychiatry},
   = {Mglur7 Facilitates Extinction of Aversive Memories and Controls Amygdala Plasticity},
   = {Validated},
   = {()},
   = {13},
   = {10},
  pages = {970--979},
   = {{Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates..}},
   = {DOI 10.1038/sj.mp.4002073},
  source = {IRIS}
}