Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes.

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TY  - JOUR
  - Phillips C, Owens D, Collins P, Tomkin GH
  - 2005
  - July
  - Atherosclerosis
  - Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes.
  - Validated
  - ()
  - 181
  - 1
  - 109
  - 114
  - Fatty acid metabolism is disturbed in poorly controlled diabetes. Low density lipoprotein (LDL) oxidation, thought to be an atherogenic modification, is partly dependent on LDL fatty acid content whether it be in the form of cholesteryl ester, phospholipids, triglyceride or non-esterified fatty acid (NEFA). Lipoprotein lipase (LPL) is deficient in diabetic patients. Lipoprotein lipase bound to LDL may facilitate cholesterol accumulation in the artery wall through the attachment of LDL to the proteoglycans expressed on endothelial cells and collagen. The purpose of this study was to examine the degree of binding of fatty acids and lipoprotein lipase to LDL in type 2 diabetic patients and to examine the relationship between non-esterified fatty acids attached to LDL and LDL oxidisability.
  - 10.1016/j.atherosclerosis.2004.12.033
DA  - 2005/07
ER  - 
@article{V70177622,
   = {Phillips C,  Owens D and  Collins P,  Tomkin GH },
   = {2005},
   = {July},
   = {Atherosclerosis},
   = {Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes.},
   = {Validated},
   = {()},
   = {181},
   = {1},
  pages = {109--114},
   = {{Fatty acid metabolism is disturbed in poorly controlled diabetes. Low density lipoprotein (LDL) oxidation, thought to be an atherogenic modification, is partly dependent on LDL fatty acid content whether it be in the form of cholesteryl ester, phospholipids, triglyceride or non-esterified fatty acid (NEFA). Lipoprotein lipase (LPL) is deficient in diabetic patients. Lipoprotein lipase bound to LDL may facilitate cholesterol accumulation in the artery wall through the attachment of LDL to the proteoglycans expressed on endothelial cells and collagen. The purpose of this study was to examine the degree of binding of fatty acids and lipoprotein lipase to LDL in type 2 diabetic patients and to examine the relationship between non-esterified fatty acids attached to LDL and LDL oxidisability.}},
   = {10.1016/j.atherosclerosis.2004.12.033},
  source = {IRIS}
}
AUTHORSPhillips C, Owens D, Collins P, Tomkin GH
YEAR2005
MONTHJuly
JOURNAL_CODEAtherosclerosis
TITLELow density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes.
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORD
VOLUME181
ISSUE1
START_PAGE109
END_PAGE114
ABSTRACTFatty acid metabolism is disturbed in poorly controlled diabetes. Low density lipoprotein (LDL) oxidation, thought to be an atherogenic modification, is partly dependent on LDL fatty acid content whether it be in the form of cholesteryl ester, phospholipids, triglyceride or non-esterified fatty acid (NEFA). Lipoprotein lipase (LPL) is deficient in diabetic patients. Lipoprotein lipase bound to LDL may facilitate cholesterol accumulation in the artery wall through the attachment of LDL to the proteoglycans expressed on endothelial cells and collagen. The purpose of this study was to examine the degree of binding of fatty acids and lipoprotein lipase to LDL in type 2 diabetic patients and to examine the relationship between non-esterified fatty acids attached to LDL and LDL oxidisability.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1016/j.atherosclerosis.2004.12.033
FUNDING_BODY
GRANT_DETAILS