TY  - JOUR
  - O'Sullivan, A.,Gibney, M. J.,Connor, A. O.,Mion, B.,Kaluskar, S.,Cashman, K. D.,Flynn, A.,Shanahan, F.,Brennan, L.
  - 2011
  - May
  - Molecular Nutrition ; Food Research
  - Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome
  - Validated
  - ()
  - 55
  - 55
  - 679
  - 690
  - Scope: Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome. Methods and results: In a double-blind, randomised placebo-controlled dietary intervention subjects were assigned to receive 15 mu g vitamin D(3) or placebo daily. Serum 25-hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4-wk intervention. k-means clustering and (1)H-NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH) D to an endpoint concentration of 78.1 +/- 20.0 nmol/L (p < 0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. k-means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH) D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic model assessment scores (19% decrease) and c-reactive protein (54% decrease). Metabolomic analysis revealed further changes and the extent of change in serum vitamin D correlated negatively with changes in glucose. Conclusion: Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation.Scope: Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome. Methods and results: In a double-blind, randomised placebo-controlled dietary intervention subjects were assigned to receive 15 mu g vitamin D(3) or placebo daily. Serum 25-hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4-wk intervention. k-means clustering and (1)H-NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH) D to an endpoint concentration of 78.1 +/- 20.0 nmol/L (p < 0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. k-means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH) D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic model assessment scores (19% decrease) and c-reactive protein (54% decrease). Metabolomic analysis revealed further changes and the extent of change in serum vitamin D correlated negatively with changes in glucose. Conclusion: Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation.
  - 1613-41251613-4125
  - ://WOS:000290472800002://WOS:000290472800002
DA  - 2011/05
ER  - 

@article{V235379001,
   = {O'Sullivan,  A. and Gibney,  M. J. and Connor,  A. O. and Mion,  B. and Kaluskar,  S. and Cashman,  K. D. and Flynn,  A. and Shanahan,  F. and Brennan,  L. },
   = {2011},
   = {May},
   = {Molecular Nutrition ; Food Research},
   = {Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome},
   = {Validated},
   = {()},
   = {55},
   = {55},
  pages = {679--690},
   = {{Scope: Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome. Methods and results: In a double-blind, randomised placebo-controlled dietary intervention subjects were assigned to receive 15 mu g vitamin D(3) or placebo daily. Serum 25-hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4-wk intervention. k-means clustering and (1)H-NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH) D to an endpoint concentration of 78.1 +/- 20.0 nmol/L (p < 0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. k-means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH) D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic model assessment scores (19% decrease) and c-reactive protein (54% decrease). Metabolomic analysis revealed further changes and the extent of change in serum vitamin D correlated negatively with changes in glucose. Conclusion: Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation.Scope: Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome. Methods and results: In a double-blind, randomised placebo-controlled dietary intervention subjects were assigned to receive 15 mu g vitamin D(3) or placebo daily. Serum 25-hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4-wk intervention. k-means clustering and (1)H-NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH) D to an endpoint concentration of 78.1 +/- 20.0 nmol/L (p < 0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. k-means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH) D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic model assessment scores (19% decrease) and c-reactive protein (54% decrease). Metabolomic analysis revealed further changes and the extent of change in serum vitamin D correlated negatively with changes in glucose. Conclusion: Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation.}},
  issn = {1613-41251613-4125},
   = {://WOS:000290472800002://WOS:000290472800002},
  source = {IRIS}
}