TY  - JOUR
  - Dwyer, M. P.,Paruch, K.,Alvarez, C.,Doll, R. J.,Keertikar, K.,Duca, J.,Fischmann, T. O.,Hruza, A.,Madison, V.,Lees, E.,Parry, D.,Seghezzi, W.,Sgambellone, N.,Shanahan, F.,Wiswell, D.,Guzi, T. J.
  - 2007
  - November
  - Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
  - Validated
  - ()
  - 17
  - 2222
  - 6216
  - 62196216
  - A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.
  - 0960-894X0960-894X
  - ://WOS:000250906200035://WOS:000250906200035
DA  - 2007/11
ER  - 

@article{V235379241,
   = {Dwyer,  M. P. and Paruch,  K. and Alvarez,  C. and Doll,  R. J. and Keertikar,  K. and Duca,  J. and Fischmann,  T. O. and Hruza,  A. and Madison,  V. and Lees,  E. and Parry,  D. and Seghezzi,  W. and Sgambellone,  N. and Shanahan,  F. and Wiswell,  D. and Guzi,  T. J. },
   = {2007},
   = {November},
   = {Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors},
   = {Validated},
   = {()},
   = {17},
   = {2222},
  pages = {6216--62196216},
   = {{A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.}},
  issn = {0960-894X0960-894X},
   = {://WOS:000250906200035://WOS:000250906200035},
  source = {IRIS}
}