IRIS publication 235379422
Vitamin K status in patients with Crohn's disease and relationship to bone turnover
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TY - JOUR - Duggan, P.,O'Brien, M.,Kiely, M.,McCarthy, J.,Shanahan, F.,Cashman, K. D. - 2004 - November - American Journal of Gastroenterology - Vitamin K status in patients with Crohn's disease and relationship to bone turnover - Validated - () - 99 - 11 - 2178 - 2185 - BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia. - 0002-92700002-9270 - ://WOS:000224767900019://WOS:000224767900019 DA - 2004/11 ER -
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@article{V235379422, = {Duggan, P. and O'Brien, M. and Kiely, M. and McCarthy, J. and Shanahan, F. and Cashman, K. D. }, = {2004}, = {November}, = {American Journal of Gastroenterology}, = {Vitamin K status in patients with Crohn's disease and relationship to bone turnover}, = {Validated}, = {()}, = {99}, = {11}, pages = {2178--2185}, = {{BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.}}, issn = {0002-92700002-9270}, = {://WOS:000224767900019://WOS:000224767900019}, source = {IRIS} }
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AUTHORS | Duggan, P.,O'Brien, M.,Kiely, M.,McCarthy, J.,Shanahan, F.,Cashman, K. D. | ||
YEAR | 2004 | ||
MONTH | November | ||
JOURNAL_CODE | American Journal of Gastroenterology | ||
TITLE | Vitamin K status in patients with Crohn's disease and relationship to bone turnover | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | |||
VOLUME | 99 | ||
ISSUE | 11 | ||
START_PAGE | 2178 | ||
END_PAGE | 2185 | ||
ABSTRACT | BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia. | ||
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ISBN_ISSN | 0002-92700002-9270 | ||
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URL | ://WOS:000224767900019://WOS:000224767900019 | ||
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