IRIS publication 235379802
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest
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TY - JOUR - Shanahan, F.,Seghezzi, W.,Parry, D.,Mahony, D.,Lees, E. - 1999 - February - Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest - Validated - () - 19 - 22 - 1460 - 14691460 - SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G(1)/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state.SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G(1)/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state. - 0270-73060270-7306 - ://WOS:000078140900048://WOS:000078140900048 DA - 1999/02 ER -
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@article{V235379802, = {Shanahan, F. and Seghezzi, W. and Parry, D. and Mahony, D. and Lees, E. }, = {1999}, = {February}, = {Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest}, = {Validated}, = {()}, = {19}, = {22}, pages = {1460--14691460}, = {{SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G(1)/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state.SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G(1)/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state.}}, issn = {0270-73060270-7306}, = {://WOS:000078140900048://WOS:000078140900048}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Shanahan, F.,Seghezzi, W.,Parry, D.,Mahony, D.,Lees, E. | ||
YEAR | 1999 | ||
MONTH | February | ||
JOURNAL_CODE | |||
TITLE | Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | |||
VOLUME | 19 | ||
ISSUE | 22 | ||
START_PAGE | 1460 | ||
END_PAGE | 14691460 | ||
ABSTRACT | SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G(1)/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state.SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G(1)/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state. | ||
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ISBN_ISSN | 0270-73060270-7306 | ||
EDITION | |||
URL | ://WOS:000078140900048://WOS:000078140900048 | ||
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