TY  - JOUR
  - McCarthy D, Duggan P, O'Brien M, Kiely M, McCarthy J, Shanahan F, Cashman KD.
  - 2005
  - May
  - Alimentary Pharmacology ; Therapeutics
  - Seasonality of vitamin D status and bone turnover in patients with Crohn's disease
  - Validated
  - Altmetric: 1 ()
  - INFLAMMATORY-BOWEL-DISEASE PLACEBO-CONTROLLED TRIAL MINERAL DENSITY D DEFICIENCY BIOCHEMICAL MARKERS PARATHYROID-HORMONE D SUPPLEMENTATION CALCIUM SUPPLEMENTATION CALCIOTROPIC HORMONES POSTMENOPAUSAL WOMEN
  - 21
  - 1073
  - 1083
  - Background: While wintertime vitamin D deficiency has been well-documented in Crohn's disease patients, less is known about vitamin D status during summertime and whether a seasonal variation exists in bone turnover.Aims: To compare vitamin D status and bone turnover markers in Crohn's disease patients with age- and sex-matched controls during late-summer and late-winter.Subjects: Crohn's disease patients (n = 44; mean age 36.9 years, currently in remission) and matched controls (n = 44) were recruited from Cork University Hospital and Cork City area, respectively.Methods: Bloods were analysed for 25-hydroxyvitamin D, parathyroid hormone, bone-specific alkaline phosphatase, osteocalcin and urine analysed for N-telopeptides of type 1 collagen.Results: Serum 25-hydroxyvitamin D concentrations were significantly (P < 0.003) lower in Crohn's disease patients than in control subjects during both seasons. In Crohn's disease patients, serum 25-hydroxyvitamin D concentrations were lower (P < 0.0001) whereas serum parathyroid hormone, osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptides of type 1 collagen levels were higher (P < 0.001) during late-winter than late-summer.Conclusion: There were notable seasonal variations in vitamin D status and bone turnover markers in Crohn's disease patients. The impact of winter decline in vitamin D status and increase in bone turnover on long-term risk of osteopenia/osteoporosis in Crohn's disease patients is unclear.
  - 10.1111/j.1365-2036.2005.02446.x
DA  - 2005/05
ER  - 

@article{V243944837,
   = {McCarthy D,  Duggan P and  O'Brien M,  Kiely M and  McCarthy J,  Shanahan F and  Cashman KD. },
   = {2005},
   = {May},
   = {Alimentary Pharmacology ; Therapeutics},
   = {Seasonality of vitamin D status and bone turnover in patients with Crohn's disease},
   = {Validated},
   = {Altmetric: 1 ()},
   = {INFLAMMATORY-BOWEL-DISEASE PLACEBO-CONTROLLED TRIAL MINERAL DENSITY D DEFICIENCY BIOCHEMICAL MARKERS PARATHYROID-HORMONE D SUPPLEMENTATION CALCIUM SUPPLEMENTATION CALCIOTROPIC HORMONES POSTMENOPAUSAL WOMEN},
   = {21},
  pages = {1073--1083},
   = {{Background: While wintertime vitamin D deficiency has been well-documented in Crohn's disease patients, less is known about vitamin D status during summertime and whether a seasonal variation exists in bone turnover.Aims: To compare vitamin D status and bone turnover markers in Crohn's disease patients with age- and sex-matched controls during late-summer and late-winter.Subjects: Crohn's disease patients (n = 44; mean age 36.9 years, currently in remission) and matched controls (n = 44) were recruited from Cork University Hospital and Cork City area, respectively.Methods: Bloods were analysed for 25-hydroxyvitamin D, parathyroid hormone, bone-specific alkaline phosphatase, osteocalcin and urine analysed for N-telopeptides of type 1 collagen.Results: Serum 25-hydroxyvitamin D concentrations were significantly (P < 0.003) lower in Crohn's disease patients than in control subjects during both seasons. In Crohn's disease patients, serum 25-hydroxyvitamin D concentrations were lower (P < 0.0001) whereas serum parathyroid hormone, osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptides of type 1 collagen levels were higher (P < 0.001) during late-winter than late-summer.Conclusion: There were notable seasonal variations in vitamin D status and bone turnover markers in Crohn's disease patients. The impact of winter decline in vitamin D status and increase in bone turnover on long-term risk of osteopenia/osteoporosis in Crohn's disease patients is unclear.}},
   = {10.1111/j.1365-2036.2005.02446.x},
  source = {IRIS}
}