TY  - JOUR
  - Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O'Sullivan O, Fitzgerald GF, Deane J, O'Connor M, Harnedy N, O'Connor K, O'Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O'Toole PW
  - 2012
  - August
  - Nature
  - Gut microbiota composition correlates with diet and health in the elderly.
  - Validated
  - Altmetric: 291 ()
  - 488
  - 7410
  - 178
  - 184
  - Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
  - 10.1038/nature11319
DA  - 2012/08
ER  - 

@article{V249695996,
   = {Claesson MJ,  Jeffery IB and  Conde S,  Power SE and  O'Connor EM,  Cusack S and  Harris HM,  Coakley M and  Lakshminarayanan B,  O'Sullivan O and  Fitzgerald GF,  Deane J and  O'Connor M,  Harnedy N and  O'Connor K,  O'Mahony D and  van Sinderen D,  Wallace M and  Brennan L,  Stanton C and  Marchesi JR,  Fitzgerald AP and  Shanahan F,  Hill C and  Ross RP,  O'Toole PW },
   = {2012},
   = {August},
   = {Nature},
   = {Gut microbiota composition correlates with diet and health in the elderly.},
   = {Validated},
   = {Altmetric: 291 ()},
   = {488},
   = {7410},
  pages = {178--184},
   = {{Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.}},
   = {10.1038/nature11319},
  source = {IRIS}
}