IRIS publication 280546227
Neurotransmitters and cytokines in CNS pathology
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TY - JOUR - Mitrovic, B.,Martin, F. C.,Charles, A. C.,Ignarro, L. J.,Anton, P. A.,Shanahan, F.,Merrill, J. E. - 1994 - Prog Brain Resprog Brain Res - Neurotransmitters and cytokines in CNS pathology - Validated - () - 103 - 319 - 30 - In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied. - 0079-6123 (Print) 0079-61 DA - 1994/NaN ER -
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@article{V280546227, = {Mitrovic, B. and Martin, F. C. and Charles, A. C. and Ignarro, L. J. and Anton, P. A. and Shanahan, F. and Merrill, J. E. }, = {1994}, = {Prog Brain Resprog Brain Res}, = {Neurotransmitters and cytokines in CNS pathology}, = {Validated}, = {()}, = {103}, pages = {319--30}, = {{In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.}}, issn = {0079-6123 (Print) 0079-61}, source = {IRIS} }
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AUTHORS | Mitrovic, B.,Martin, F. C.,Charles, A. C.,Ignarro, L. J.,Anton, P. A.,Shanahan, F.,Merrill, J. E. | ||
YEAR | 1994 | ||
MONTH | |||
JOURNAL_CODE | Prog Brain Resprog Brain Res | ||
TITLE | Neurotransmitters and cytokines in CNS pathology | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | |||
VOLUME | 103 | ||
ISSUE | |||
START_PAGE | 319 | ||
END_PAGE | 30 | ||
ABSTRACT | In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied. | ||
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ISBN_ISSN | 0079-6123 (Print) 0079-61 | ||
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