TY  - JOUR
  - A. Crean, C. O’Mahony and A. C. Moore
  - 2010
  - June
  - European Pharmaceutical Review
  - Development of Stabilised Vaccines with Needle-Free Devices for Targeted Skin Immunization
  - Published
  - 0
  - microneedles, transdermal delivery, vaccine
  - 15
  - 6
  - 56
  - 60
  - Vaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.
DA  - 2010/06
ER  - 

@article{V179169603,
   = {A. Crean, C. O’Mahony and A. C. Moore},
   = {2010},
   = {June},
   = {European Pharmaceutical Review},
   = {Development of Stabilised Vaccines with Needle-Free Devices for Targeted Skin Immunization},
   = {Published},
   = {0},
   = {microneedles, transdermal delivery, vaccine},
   = {15},
   = {6},
  pages = {56--60},
   = {{Vaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.}},
  source = {IRIS}
}