TY  - JOUR
  - Draper S.J, Moore A.C., Goodman A.L., Long C.A., Holder A.A., Gilbert S.C., Hill F., Hill A.V.S.
  - 2008
  - January
  - Nature Medicine
  - Multi-Stage Protection against Malaria using Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1.
  - Published
  - Altmetric: 1 ()
  - 14
  - 819
  - 821
  - Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro. 
  - http://www.nature.com/nm/journal/v14/n8/abs/nm.1850.html
  - 10.1038/nm.1850
DA  - 2008/01
ER  - 

@article{V12012129,
   = {Draper S.J,  Moore A.C. and  Goodman A.L.,  Long C.A. and  Holder A.A.,  Gilbert S.C. and  Hill F.,  Hill A.V.S. },
   = {2008},
   = {January},
   = {Nature Medicine},
   = {Multi-Stage Protection against Malaria using Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1.},
   = {Published},
   = {Altmetric: 1 ()},
   = {14},
  pages = {819--821},
   = {{Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro. }},
   = {http://www.nature.com/nm/journal/v14/n8/abs/nm.1850.html},
   = {10.1038/nm.1850},
  source = {IRIS}
}