TY  - JOUR
  - Goodman AL, Forbes EK, Williams AR, Douglas AD, de Cassan SC, Bauza K, Biswas S, Dicks MD, Llewellyn D, Moore AC, Janse CJ, Franke-Fayard BM, Gilbert SC, Hill AV, Pleass RJ, Draper SJ.
  - 2013
  - Scientific Reports
  - The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment.
  - Published
  - Altmetric: 2 ()
  - 3
  - 1706
  - Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malaria may be able to circumvent vaccine-induced anti-merozoite responses. Here we confirm a failure to protect against P. berghei, despite successful antibody induction against leading merozoite antigens using protein-in-adjuvant or viral vectored vaccine delivery. No subunit vaccine approach showed efficacy in mice following immunization and challenge with the wild-type P. berghei strains ANKA or NK65, or against a chimeric parasite line encoding a merozoite antigen from P. falciparum. Protection was not improved in knockout mice lacking the inhibitory Fc receptor CD32b, nor against a Δsmac P. berghei parasite line with a non-sequestering phenotype. An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum.
  - Nature Publishing Group
  - http://www.nature.com/srep/2013/130423/srep01706/full/srep01706.html
  - 10.1038/srep01706
DA  - 2013/NaN
ER  - 

@article{V215228136,
   = {Goodman AL,  Forbes EK and  Williams AR,  Douglas AD and  de Cassan SC,  Bauza K and  Biswas S,  Dicks MD and  Llewellyn D,  Moore AC and  Janse CJ,  Franke-Fayard BM and  Gilbert SC,  Hill AV and  Pleass RJ,  Draper SJ. },
   = {2013},
   = {Scientific Reports},
   = {The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment.},
   = {Published},
   = {Altmetric: 2 ()},
   = {3},
  pages = {1706},
   = {{Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malaria may be able to circumvent vaccine-induced anti-merozoite responses. Here we confirm a failure to protect against P. berghei, despite successful antibody induction against leading merozoite antigens using protein-in-adjuvant or viral vectored vaccine delivery. No subunit vaccine approach showed efficacy in mice following immunization and challenge with the wild-type P. berghei strains ANKA or NK65, or against a chimeric parasite line encoding a merozoite antigen from P. falciparum. Protection was not improved in knockout mice lacking the inhibitory Fc receptor CD32b, nor against a Δsmac P. berghei parasite line with a non-sequestering phenotype. An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum.}},
   = {Nature Publishing Group},
   = {http://www.nature.com/srep/2013/130423/srep01706/full/srep01706.html},
   = {10.1038/srep01706},
  source = {IRIS}
}