TY  - JOUR
  - Moore, A. C., Crean, A. M., O¿Mahony
  - 2010
  - December
  - European Pharmaceutical Review
  - Development of stabilized vaccines with needle-free devices for targeted skin immunization
  - Published
  - ()
  - 15
  - 6
  - 56
  - 60
  - Vaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.
  - Kent, United Kingdom
  - 1759-1279
  - http://www.europeanpharmaceuticalreview.com
DA  - 2010/12
ER  - 

@article{V69323984,
   = {Moore,  A. C. and  Crean,  A. M. and  O¿Mahony },
   = {2010},
   = {December},
   = {European Pharmaceutical Review},
   = {Development of stabilized vaccines with needle-free devices for targeted skin immunization},
   = {Published},
   = {()},
   = {15},
   = {6},
  pages = {56--60},
   = {{Vaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.}},
   = {Kent, United Kingdom},
  issn = {1759-1279},
   = {http://www.europeanpharmaceuticalreview.com},
  source = {IRIS}
}