IRIS publication 242536431
Recent advances in Phytosterol Oxidation Products
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TY - JOUR - Yvonne O’Callaghan, Florence O. McCarthy, Nora M. O’Brien - 2014 - January - Biochemical Biophysical Research Communications - Recent advances in Phytosterol Oxidation Products - Published - () - Phytosterols; b-Sitosterol; Stigmasterol; Campesterol; Dihydrobrassicasterol; Phytosterol Oxidation Products; Atherosclerosis; Inflammation; Toxicity; Metabolism; Oxidative stress; Caspase; Cholesterol Absorption - 446 - 3 - 786 - 791 - Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity. - 10.1016/j.bbrc.2014.01.148 DA - 2014/01 ER -
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@article{V242536431, = {Yvonne O’Callaghan, Florence O. McCarthy and Nora M. O’Brien }, = {2014}, = {January}, = {Biochemical Biophysical Research Communications}, = {Recent advances in Phytosterol Oxidation Products}, = {Published}, = {()}, = {Phytosterols; b-Sitosterol; Stigmasterol; Campesterol; Dihydrobrassicasterol; Phytosterol Oxidation Products; Atherosclerosis; Inflammation; Toxicity; Metabolism; Oxidative stress; Caspase; Cholesterol Absorption}, = {446}, = {3}, pages = {786--791}, = {{Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity.}}, = {10.1016/j.bbrc.2014.01.148}, source = {IRIS} }
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AUTHORS | Yvonne O’Callaghan, Florence O. McCarthy, Nora M. O’Brien | ||
YEAR | 2014 | ||
MONTH | January | ||
JOURNAL_CODE | Biochemical Biophysical Research Communications | ||
TITLE | Recent advances in Phytosterol Oxidation Products | ||
STATUS | Published | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | Phytosterols; b-Sitosterol; Stigmasterol; Campesterol; Dihydrobrassicasterol; Phytosterol Oxidation Products; Atherosclerosis; Inflammation; Toxicity; Metabolism; Oxidative stress; Caspase; Cholesterol Absorption | ||
VOLUME | 446 | ||
ISSUE | 3 | ||
START_PAGE | 786 | ||
END_PAGE | 791 | ||
ABSTRACT | Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity. | ||
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DOI_LINK | 10.1016/j.bbrc.2014.01.148 | ||
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