Recent advances in Phytosterol Oxidation Products

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TY  - JOUR
  - Yvonne O’Callaghan, Florence O. McCarthy, Nora M. O’Brien
  - 2014
  - January
  - Biochemical Biophysical Research Communications
  - Recent advances in Phytosterol Oxidation Products
  - Published
  - ()
  - Phytosterols; b-Sitosterol; Stigmasterol; Campesterol; Dihydrobrassicasterol; Phytosterol Oxidation Products; Atherosclerosis; Inflammation; Toxicity; Metabolism; Oxidative stress; Caspase; Cholesterol Absorption
  - 446
  - 3
  - 786
  - 791
  - Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity.
  - 10.1016/j.bbrc.2014.01.148
DA  - 2014/01
ER  - 
@article{V242536431,
   = {Yvonne O’Callaghan,  Florence O. McCarthy and  Nora M. O’Brien },
   = {2014},
   = {January},
   = {Biochemical Biophysical Research Communications},
   = {Recent advances in Phytosterol Oxidation Products},
   = {Published},
   = {()},
   = {Phytosterols; b-Sitosterol; Stigmasterol; Campesterol; Dihydrobrassicasterol; Phytosterol Oxidation Products; Atherosclerosis; Inflammation; Toxicity; Metabolism; Oxidative stress; Caspase; Cholesterol Absorption},
   = {446},
   = {3},
  pages = {786--791},
   = {{Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity.}},
   = {10.1016/j.bbrc.2014.01.148},
  source = {IRIS}
}
AUTHORSYvonne O’Callaghan, Florence O. McCarthy, Nora M. O’Brien
YEAR2014
MONTHJanuary
JOURNAL_CODEBiochemical Biophysical Research Communications
TITLERecent advances in Phytosterol Oxidation Products
STATUSPublished
TIMES_CITED()
SEARCH_KEYWORDPhytosterols; b-Sitosterol; Stigmasterol; Campesterol; Dihydrobrassicasterol; Phytosterol Oxidation Products; Atherosclerosis; Inflammation; Toxicity; Metabolism; Oxidative stress; Caspase; Cholesterol Absorption
VOLUME446
ISSUE3
START_PAGE786
END_PAGE791
ABSTRACTPhytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1016/j.bbrc.2014.01.148
FUNDING_BODY
GRANT_DETAILS