IRIS publication 160752610
Gut osmolarity: A key environmental cue initiating the gastrointestinal phase of Listeria monocytogenes infection?
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TY - JOUR - Sleator, RD,Clifford, T,Hill, C - 2007 - July - Medical Hypotheses - Gut osmolarity: A key environmental cue initiating the gastrointestinal phase of Listeria monocytogenes infection? - Validated - () - BACTERIAL STRESS VIRULENCE GASTROENTERITIS TOLERANCE SYSTEM BILE - 69 - 1090 - 1092 - In addition to the severe invasive systemic disease of listeriosis, recent evidence suggests that the Gram-positive intracellular bacterial. pathogen Listeria monocytogenes is also a causative agent of febrile gastroenteritis. We examined the listerial response to stresses normally encountered in the upper small intestine and demonstrate that osmotic stress appears to be at the top of the hierarchy of stress responses during gastrointestinal residence. Furthermore, we suggest that the increased osmolarity of the gastrointestinal lumen may be interpreted as an environmental cue signalling gut entry and that the underlying genetic element governing this response is the alternative stress sigma factor sigma(B). (c) 2007 Elsevier Ltd. All rights reserved. - DOI 10.1016/j.mehy.2007.02.028 DA - 2007/07 ER -
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@article{V160752610, = {Sleator, RD and Clifford, T and Hill, C }, = {2007}, = {July}, = {Medical Hypotheses}, = {Gut osmolarity: A key environmental cue initiating the gastrointestinal phase of Listeria monocytogenes infection?}, = {Validated}, = {()}, = {BACTERIAL STRESS VIRULENCE GASTROENTERITIS TOLERANCE SYSTEM BILE}, = {69}, pages = {1090--1092}, = {{In addition to the severe invasive systemic disease of listeriosis, recent evidence suggests that the Gram-positive intracellular bacterial. pathogen Listeria monocytogenes is also a causative agent of febrile gastroenteritis. We examined the listerial response to stresses normally encountered in the upper small intestine and demonstrate that osmotic stress appears to be at the top of the hierarchy of stress responses during gastrointestinal residence. Furthermore, we suggest that the increased osmolarity of the gastrointestinal lumen may be interpreted as an environmental cue signalling gut entry and that the underlying genetic element governing this response is the alternative stress sigma factor sigma(B). (c) 2007 Elsevier Ltd. All rights reserved.}}, = {DOI 10.1016/j.mehy.2007.02.028}, source = {IRIS} }
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AUTHORS | Sleator, RD,Clifford, T,Hill, C | ||
YEAR | 2007 | ||
MONTH | July | ||
JOURNAL_CODE | Medical Hypotheses | ||
TITLE | Gut osmolarity: A key environmental cue initiating the gastrointestinal phase of Listeria monocytogenes infection? | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | BACTERIAL STRESS VIRULENCE GASTROENTERITIS TOLERANCE SYSTEM BILE | ||
VOLUME | 69 | ||
ISSUE | |||
START_PAGE | 1090 | ||
END_PAGE | 1092 | ||
ABSTRACT | In addition to the severe invasive systemic disease of listeriosis, recent evidence suggests that the Gram-positive intracellular bacterial. pathogen Listeria monocytogenes is also a causative agent of febrile gastroenteritis. We examined the listerial response to stresses normally encountered in the upper small intestine and demonstrate that osmotic stress appears to be at the top of the hierarchy of stress responses during gastrointestinal residence. Furthermore, we suggest that the increased osmolarity of the gastrointestinal lumen may be interpreted as an environmental cue signalling gut entry and that the underlying genetic element governing this response is the alternative stress sigma factor sigma(B). (c) 2007 Elsevier Ltd. All rights reserved. | ||
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DOI_LINK | DOI 10.1016/j.mehy.2007.02.028 | ||
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