IRIS publication 160956996
The dawning of a 'Golden era' in lantibiotic bioengineering
RIS format for Endnote and similar
TY - JOUR - Book Reviews - Field, D,Hill, C,Cotter, PD,Ross, RP - 2010 - January - The dawning of a 'Golden era' in lantibiotic bioengineering - Validated - 1 - () - RESISTANT STAPHYLOCOCCUS-AUREUS NONPROTEINOGENIC AMINO-ACIDS ANTIMICROBIAL PEPTIDE NISIN GENE REPLACEMENT STRATEGY SITE-DIRECTED MUTAGENESIS IN-VITRO RECONSTITUTION PRECURSOR LIPID-II LACTOCOCCUS-LACTIS POSTTRANSLATIONAL MODIFICATION EXPRESSION SYSTEM - P>There are many examples of highly modified antimicrobial peptides in nature, many of which are non-ribosomally synthesized. However, the bacterial lantibiotics are produced as gene-encoded pre-peptides that are subsequently modified by dedicated enzyme systems to form extraordinarily potent inhibitors. Consequently, they are much more amenable to bioengineering which could lead to the generation of a new arsenal of potent antimicrobials. However, although bioengineering of these compounds has been underway for at least two decades, significant progress has only been reported in recent years. This review charts these recent developments which suggest that we are entering a 'Golden era' of lantibiotic bioengineering. - 1077 - 1087 - DOI 10.1111/j.1365-2958.2010.07406.x DA - 2010/01 ER -
BIBTeX format for JabRef and similar
@review{V160956996, = {Book Reviews}, = {Field, D and Hill, C and Cotter, PD and Ross, RP }, = {2010}, = {January}, = {The dawning of a 'Golden era' in lantibiotic bioengineering}, = {Validated}, = {1}, = {()}, = {RESISTANT STAPHYLOCOCCUS-AUREUS NONPROTEINOGENIC AMINO-ACIDS ANTIMICROBIAL PEPTIDE NISIN GENE REPLACEMENT STRATEGY SITE-DIRECTED MUTAGENESIS IN-VITRO RECONSTITUTION PRECURSOR LIPID-II LACTOCOCCUS-LACTIS POSTTRANSLATIONAL MODIFICATION EXPRESSION SYSTEM}, = {{P>There are many examples of highly modified antimicrobial peptides in nature, many of which are non-ribosomally synthesized. However, the bacterial lantibiotics are produced as gene-encoded pre-peptides that are subsequently modified by dedicated enzyme systems to form extraordinarily potent inhibitors. Consequently, they are much more amenable to bioengineering which could lead to the generation of a new arsenal of potent antimicrobials. However, although bioengineering of these compounds has been underway for at least two decades, significant progress has only been reported in recent years. This review charts these recent developments which suggest that we are entering a 'Golden era' of lantibiotic bioengineering.}}, pages = {1077--1087}, = {DOI 10.1111/j.1365-2958.2010.07406.x}, source = {IRIS} }
Data as stored in IRIS
OTHER_PUB_TYPE | Book Reviews | ||
AUTHORS | Field, D,Hill, C,Cotter, PD,Ross, RP | ||
YEAR | 2010 | ||
MONTH | January | ||
TITLE | The dawning of a 'Golden era' in lantibiotic bioengineering | ||
RESEARCHER_ROLE | |||
STATUS | Validated | ||
PEER_REVIEW | 1 | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | RESISTANT STAPHYLOCOCCUS-AUREUS NONPROTEINOGENIC AMINO-ACIDS ANTIMICROBIAL PEPTIDE NISIN GENE REPLACEMENT STRATEGY SITE-DIRECTED MUTAGENESIS IN-VITRO RECONSTITUTION PRECURSOR LIPID-II LACTOCOCCUS-LACTIS POSTTRANSLATIONAL MODIFICATION EXPRESSION SYSTEM | ||
REFERENCE | |||
ABSTRACT | P>There are many examples of highly modified antimicrobial peptides in nature, many of which are non-ribosomally synthesized. However, the bacterial lantibiotics are produced as gene-encoded pre-peptides that are subsequently modified by dedicated enzyme systems to form extraordinarily potent inhibitors. Consequently, they are much more amenable to bioengineering which could lead to the generation of a new arsenal of potent antimicrobials. However, although bioengineering of these compounds has been underway for at least two decades, significant progress has only been reported in recent years. This review charts these recent developments which suggest that we are entering a 'Golden era' of lantibiotic bioengineering. | ||
PUBLISHER_LOCATION | |||
PUBLISHER | |||
EDITORS | |||
ISBN_ISSN | |||
EDITION | |||
URL | |||
START_PAGE | 1077 | ||
END_PAGE | 1087 | ||
DOI_LINK | DOI 10.1111/j.1365-2958.2010.07406.x | ||
FUNDING_BODY | |||
GRANT_DETAILS |