Bacteriocins - a viable alternative to antibiotics?

Typeset version

 

TY  - JOUR
  - Cotter, PD,Ross, RP,Hill, C
  - 2013
  - January
  - Nature Reviews. Microbiology
  - Bacteriocins - a viable alternative to antibiotics?
  - Validated
  - ()
  - RESISTANT STAPHYLOCOCCUS-AUREUS CLASS IIA BACTERIOCINS ANTIMICROBIAL PEPTIDE SUBTILOSIN GRAM-POSITIVE BACTERIA INHIBITOR MICROCIN-C LACTIC-ACID BACTERIA IN-VITRO CLOSTRIDIUM-DIFFICILE ESCHERICHIA-COLI ANTIBACTERIAL ACTIVITY
  - 11
  - 95
  - 105
  - Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem.
  - DOI 10.1038/nrmicro2937
DA  - 2013/01
ER  - 
@article{V206307630,
   = {Cotter,  PD and Ross,  RP and Hill,  C },
   = {2013},
   = {January},
   = {Nature Reviews. Microbiology},
   = {Bacteriocins - a viable alternative to antibiotics?},
   = {Validated},
   = {()},
   = {RESISTANT STAPHYLOCOCCUS-AUREUS CLASS IIA BACTERIOCINS ANTIMICROBIAL PEPTIDE SUBTILOSIN GRAM-POSITIVE BACTERIA INHIBITOR MICROCIN-C LACTIC-ACID BACTERIA IN-VITRO CLOSTRIDIUM-DIFFICILE ESCHERICHIA-COLI ANTIBACTERIAL ACTIVITY},
   = {11},
  pages = {95--105},
   = {{Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem.}},
   = {DOI 10.1038/nrmicro2937},
  source = {IRIS}
}
AUTHORSCotter, PD,Ross, RP,Hill, C
YEAR2013
MONTHJanuary
JOURNAL_CODENature Reviews. Microbiology
TITLEBacteriocins - a viable alternative to antibiotics?
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORDRESISTANT STAPHYLOCOCCUS-AUREUS CLASS IIA BACTERIOCINS ANTIMICROBIAL PEPTIDE SUBTILOSIN GRAM-POSITIVE BACTERIA INHIBITOR MICROCIN-C LACTIC-ACID BACTERIA IN-VITRO CLOSTRIDIUM-DIFFICILE ESCHERICHIA-COLI ANTIBACTERIAL ACTIVITY
VOLUME11
ISSUE
START_PAGE95
END_PAGE105
ABSTRACTSolutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem.
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ISBN_ISSN
EDITION
URL
DOI_LINKDOI 10.1038/nrmicro2937
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