IRIS publication 206307630
Bacteriocins - a viable alternative to antibiotics?
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TY - JOUR - Cotter, PD,Ross, RP,Hill, C - 2013 - January - Nature Reviews. Microbiology - Bacteriocins - a viable alternative to antibiotics? - Validated - () - RESISTANT STAPHYLOCOCCUS-AUREUS CLASS IIA BACTERIOCINS ANTIMICROBIAL PEPTIDE SUBTILOSIN GRAM-POSITIVE BACTERIA INHIBITOR MICROCIN-C LACTIC-ACID BACTERIA IN-VITRO CLOSTRIDIUM-DIFFICILE ESCHERICHIA-COLI ANTIBACTERIAL ACTIVITY - 11 - 95 - 105 - Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem. - DOI 10.1038/nrmicro2937 DA - 2013/01 ER -
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@article{V206307630, = {Cotter, PD and Ross, RP and Hill, C }, = {2013}, = {January}, = {Nature Reviews. Microbiology}, = {Bacteriocins - a viable alternative to antibiotics?}, = {Validated}, = {()}, = {RESISTANT STAPHYLOCOCCUS-AUREUS CLASS IIA BACTERIOCINS ANTIMICROBIAL PEPTIDE SUBTILOSIN GRAM-POSITIVE BACTERIA INHIBITOR MICROCIN-C LACTIC-ACID BACTERIA IN-VITRO CLOSTRIDIUM-DIFFICILE ESCHERICHIA-COLI ANTIBACTERIAL ACTIVITY}, = {11}, pages = {95--105}, = {{Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem.}}, = {DOI 10.1038/nrmicro2937}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Cotter, PD,Ross, RP,Hill, C | ||
YEAR | 2013 | ||
MONTH | January | ||
JOURNAL_CODE | Nature Reviews. Microbiology | ||
TITLE | Bacteriocins - a viable alternative to antibiotics? | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | RESISTANT STAPHYLOCOCCUS-AUREUS CLASS IIA BACTERIOCINS ANTIMICROBIAL PEPTIDE SUBTILOSIN GRAM-POSITIVE BACTERIA INHIBITOR MICROCIN-C LACTIC-ACID BACTERIA IN-VITRO CLOSTRIDIUM-DIFFICILE ESCHERICHIA-COLI ANTIBACTERIAL ACTIVITY | ||
VOLUME | 11 | ||
ISSUE | |||
START_PAGE | 95 | ||
END_PAGE | 105 | ||
ABSTRACT | Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem. | ||
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DOI_LINK | DOI 10.1038/nrmicro2937 | ||
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