Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model.

Typeset version

 

TY  - JOUR
  - Monk IR, Casey PG, Hill C, Gahan CG
  - 2010
  - December
  - BMC Microbiology
  - Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model.
  - Validated
  - ()
  - 10
  - Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts. The interaction of InlA with the host cell ligand E-cadherin efficiently stimulates L. monocytogenes entry into human enterocytes, but has only a limited interaction with murine cells.
  - 10.1186/1471-2180-10-318
DA  - 2010/12
ER  - 
@article{V69454824,
   = {Monk IR,  Casey PG and  Hill C,  Gahan CG },
   = {2010},
   = {December},
   = {BMC Microbiology},
   = {Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model.},
   = {Validated},
   = {()},
   = {10},
   = {{Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts. The interaction of InlA with the host cell ligand E-cadherin efficiently stimulates L. monocytogenes entry into human enterocytes, but has only a limited interaction with murine cells.}},
   = {10.1186/1471-2180-10-318},
  source = {IRIS}
}
AUTHORSMonk IR, Casey PG, Hill C, Gahan CG
YEAR2010
MONTHDecember
JOURNAL_CODEBMC Microbiology
TITLEDirected evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model.
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORD
VOLUME10
ISSUE
START_PAGE
END_PAGE
ABSTRACTInternalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts. The interaction of InlA with the host cell ligand E-cadherin efficiently stimulates L. monocytogenes entry into human enterocytes, but has only a limited interaction with murine cells.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1186/1471-2180-10-318
FUNDING_BODY
GRANT_DETAILS