TY  - JOUR
  - Turroni, F,Bottacini, F,Foroni, E,Mulder, I,Kim, JH,Zomer, A,Sanchez, B,Bidossi, A,Ferrarini, A,Giubellini, V,Delledonne, M,Henrissat, B,Coutinho, P,Oggioni, M,Fitzgerald, GF,Mills, D,Margolles, A,Kelly, D,van Sinderen, D,Ventura, M
  - 2010
  - November
  - Proceedings of The National Academy of Sciences of The United States of America
  - Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging
  - Validated
  - WOS: 269 ()
  - coevolution genomics host-glycans metabolism human gut intestinal bacteria mucin ALPHA-N-ACETYLGALACTOSAMINIDASE HUMAN-MILK OLIGOSACCHARIDES GLYCOSIDE HYDROLASE FAMILY HUMAN INTESTINAL-TRACT HUMAN DISTAL GUT AKKERMANSIA-MUCINIPHILA MUCIN GLYCOPROTEINS MOLECULAR-CLONING LONGUM BACTERIAL
  - 107
  - 19514
  - 19519
  - The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.
  - 10.1073/pnas.1011100107
DA  - 2010/11
ER  - 

@article{V243942080,
   = {Turroni,  F and Bottacini,  F and Foroni,  E and Mulder,  I and Kim,  JH and Zomer,  A and Sanchez,  B and Bidossi,  A and Ferrarini,  A and Giubellini,  V and Delledonne,  M and Henrissat,  B and Coutinho,  P and Oggioni,  M and Fitzgerald,  GF and Mills,  D and Margolles,  A and Kelly,  D and van Sinderen,  D and Ventura,  M },
   = {2010},
   = {November},
   = {Proceedings of The National Academy of Sciences of The United States of America},
   = {Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging},
   = {Validated},
   = {WOS: 269 ()},
   = {coevolution genomics host-glycans metabolism human gut intestinal bacteria mucin ALPHA-N-ACETYLGALACTOSAMINIDASE HUMAN-MILK OLIGOSACCHARIDES GLYCOSIDE HYDROLASE FAMILY HUMAN INTESTINAL-TRACT HUMAN DISTAL GUT AKKERMANSIA-MUCINIPHILA MUCIN GLYCOPROTEINS MOLECULAR-CLONING LONGUM BACTERIAL},
   = {107},
  pages = {19514--19519},
   = {{The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.}},
   = {10.1073/pnas.1011100107},
  source = {IRIS}
}