IRIS publication 271355911
Metabolism of Sialic Acid by Bifidobacterium breve UCC2003
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TY - JOUR - Egan, M,Motherway, MO,Ventura, M,van Sinderen, D - 2014 - July - Applied and Environmental Microbiology - Metabolism of Sialic Acid by Bifidobacterium breve UCC2003 - Validated - Altmetric: 2 () - N-ACETYLNEURAMINATE LYASE HUMAN-MILK OLIGOSACCHARIDES DNA-MICROARRAY DATA ESCHERICHIA-COLI LACTOCOCCUS-LACTIS GENE-EXPRESSION HAEMOPHILUS-INFLUENZAE CLOSTRIDIUM-PERFRINGENS GENOME SEQUENCE INFANT FORMULAS - 80 - 4414 - 4426 - Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin-and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010. - 10.1128/AEM.01114-14 DA - 2014/07 ER -
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@article{V271355911, = {Egan, M and Motherway, MO and Ventura, M and van Sinderen, D }, = {2014}, = {July}, = {Applied and Environmental Microbiology}, = {Metabolism of Sialic Acid by Bifidobacterium breve UCC2003}, = {Validated}, = {Altmetric: 2 ()}, = {N-ACETYLNEURAMINATE LYASE HUMAN-MILK OLIGOSACCHARIDES DNA-MICROARRAY DATA ESCHERICHIA-COLI LACTOCOCCUS-LACTIS GENE-EXPRESSION HAEMOPHILUS-INFLUENZAE CLOSTRIDIUM-PERFRINGENS GENOME SEQUENCE INFANT FORMULAS}, = {80}, pages = {4414--4426}, = {{Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin-and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010.}}, = {10.1128/AEM.01114-14}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Egan, M,Motherway, MO,Ventura, M,van Sinderen, D | ||
YEAR | 2014 | ||
MONTH | July | ||
JOURNAL_CODE | Applied and Environmental Microbiology | ||
TITLE | Metabolism of Sialic Acid by Bifidobacterium breve UCC2003 | ||
STATUS | Validated | ||
TIMES_CITED | Altmetric: 2 () | ||
SEARCH_KEYWORD | N-ACETYLNEURAMINATE LYASE HUMAN-MILK OLIGOSACCHARIDES DNA-MICROARRAY DATA ESCHERICHIA-COLI LACTOCOCCUS-LACTIS GENE-EXPRESSION HAEMOPHILUS-INFLUENZAE CLOSTRIDIUM-PERFRINGENS GENOME SEQUENCE INFANT FORMULAS | ||
VOLUME | 80 | ||
ISSUE | |||
START_PAGE | 4414 | ||
END_PAGE | 4426 | ||
ABSTRACT | Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin-and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010. | ||
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DOI_LINK | 10.1128/AEM.01114-14 | ||
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