IRIS publication 116535747
Dissecting the immune response to the entomopathogen Photorhabdus.
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TY - JOUR - Eleftherianos I, ffrench-Constant RH, Clarke DJ, Dowling AJ, Reynolds SE - 2010 - December - Trends In Microbiology - Dissecting the immune response to the entomopathogen Photorhabdus. - Validated - () - 18 - 12 - 552 - 560 - Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival. Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity. During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host. Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila. Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens. - 10.1016/j.tim.2010.09.006 DA - 2010/12 ER -
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@article{V116535747, = {Eleftherianos I, ffrench-Constant RH and Clarke DJ, Dowling AJ and Reynolds SE }, = {2010}, = {December}, = {Trends In Microbiology}, = {Dissecting the immune response to the entomopathogen Photorhabdus.}, = {Validated}, = {()}, = {18}, = {12}, pages = {552--560}, = {{Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival. Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity. During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host. Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila. Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens.}}, = {10.1016/j.tim.2010.09.006}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Eleftherianos I, ffrench-Constant RH, Clarke DJ, Dowling AJ, Reynolds SE | ||
YEAR | 2010 | ||
MONTH | December | ||
JOURNAL_CODE | Trends In Microbiology | ||
TITLE | Dissecting the immune response to the entomopathogen Photorhabdus. | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
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VOLUME | 18 | ||
ISSUE | 12 | ||
START_PAGE | 552 | ||
END_PAGE | 560 | ||
ABSTRACT | Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival. Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity. During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host. Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila. Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens. | ||
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DOI_LINK | 10.1016/j.tim.2010.09.006 | ||
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