Sequence analysis of the lactococcal plasmid pNP40: a mobile replicon for coping with environmental hazards

Typeset version

 

TY  - JOUR
  - O'Driscoll, J,Glynn, F,Fitzgerald, GF,van Sinderen, D
  - 2006
  - June
  - Journal of Bacteriology
  - Sequence analysis of the lactococcal plasmid pNP40: a mobile replicon for coping with environmental hazards
  - Validated
  - ()
  - COLD-SHOCK PROTEINS PHAGE RESISTANCE MECHANISMS SUBSP DIACETYLACTIS DRC3 GRAM-POSITIVE BACTERIA LACTIC-ACID BACTERIA IV SECRETION SYSTEM ESCHERICHIA-COLI MOLECULAR CHARACTERIZATION ABORTIVE INFECTION CADMIUM RESISTANCE
  - 188
  - 6629
  - 6639
  - The conjugative lactococcall plasmid pNP40, identified in Lactococcus lactis subsp. diacetylactis DRC3, possesses a potent complement of bacteriophage resistance systems, which has stimulated its application as a fitness-improving, food-grade genetic element for industrial starter cultures. The complete sequence of this plasmid allowed the mapping of previously known functions including replication, conjugation, bacteriocin resistance, heavy metal tolerance, and bacteriophage resistance. In addition, functions for cold shock adaptation and DNA damage repair were identified, further confirming pNP40's contribution to environmental stress protection. A plasmid cointegration event appears to have been part of the evolution of pNP40, resulting in a "stockpiling" of bacteriophage resistance systems.
  - DOI 10.1128/JB.00672-06
DA  - 2006/06
ER  - 
@article{V70046837,
   = {O'Driscoll,  J and Glynn,  F and Fitzgerald,  GF and van Sinderen,  D },
   = {2006},
   = {June},
   = {Journal of Bacteriology},
   = {Sequence analysis of the lactococcal plasmid pNP40: a mobile replicon for coping with environmental hazards},
   = {Validated},
   = {()},
   = {COLD-SHOCK PROTEINS PHAGE RESISTANCE MECHANISMS SUBSP DIACETYLACTIS DRC3 GRAM-POSITIVE BACTERIA LACTIC-ACID BACTERIA IV SECRETION SYSTEM ESCHERICHIA-COLI MOLECULAR CHARACTERIZATION ABORTIVE INFECTION CADMIUM RESISTANCE},
   = {188},
  pages = {6629--6639},
   = {{The conjugative lactococcall plasmid pNP40, identified in Lactococcus lactis subsp. diacetylactis DRC3, possesses a potent complement of bacteriophage resistance systems, which has stimulated its application as a fitness-improving, food-grade genetic element for industrial starter cultures. The complete sequence of this plasmid allowed the mapping of previously known functions including replication, conjugation, bacteriocin resistance, heavy metal tolerance, and bacteriophage resistance. In addition, functions for cold shock adaptation and DNA damage repair were identified, further confirming pNP40's contribution to environmental stress protection. A plasmid cointegration event appears to have been part of the evolution of pNP40, resulting in a "stockpiling" of bacteriophage resistance systems.}},
   = {DOI 10.1128/JB.00672-06},
  source = {IRIS}
}
AUTHORSO'Driscoll, J,Glynn, F,Fitzgerald, GF,van Sinderen, D
YEAR2006
MONTHJune
JOURNAL_CODEJournal of Bacteriology
TITLESequence analysis of the lactococcal plasmid pNP40: a mobile replicon for coping with environmental hazards
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORDCOLD-SHOCK PROTEINS PHAGE RESISTANCE MECHANISMS SUBSP DIACETYLACTIS DRC3 GRAM-POSITIVE BACTERIA LACTIC-ACID BACTERIA IV SECRETION SYSTEM ESCHERICHIA-COLI MOLECULAR CHARACTERIZATION ABORTIVE INFECTION CADMIUM RESISTANCE
VOLUME188
ISSUE
START_PAGE6629
END_PAGE6639
ABSTRACTThe conjugative lactococcall plasmid pNP40, identified in Lactococcus lactis subsp. diacetylactis DRC3, possesses a potent complement of bacteriophage resistance systems, which has stimulated its application as a fitness-improving, food-grade genetic element for industrial starter cultures. The complete sequence of this plasmid allowed the mapping of previously known functions including replication, conjugation, bacteriocin resistance, heavy metal tolerance, and bacteriophage resistance. In addition, functions for cold shock adaptation and DNA damage repair were identified, further confirming pNP40's contribution to environmental stress protection. A plasmid cointegration event appears to have been part of the evolution of pNP40, resulting in a "stockpiling" of bacteriophage resistance systems.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINKDOI 10.1128/JB.00672-06
FUNDING_BODY
GRANT_DETAILS