Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives

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TY  - JOUR
  - McCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R.
  - 2005
  - Organic ; Biomolecular Chemistry
  - Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives
  - Validated
  - ()
  - 3
  - 16
  - 3059
  - 3065
  - beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
DA  - 2005/NaN
ER  - 
@article{V113214869,
   = {McCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R.},
   = {2005},
   = {Organic ; Biomolecular Chemistry},
   = {Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives},
   = {Validated},
   = {()},
   = {3},
   = {16},
  pages = {3059--3065},
   = {{beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.}},
  source = {IRIS}
}
AUTHORSMcCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R.
YEAR2005
MONTH
JOURNAL_CODEOrganic ; Biomolecular Chemistry
TITLESynthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORD
VOLUME3
ISSUE16
START_PAGE3059
END_PAGE3065
ABSTRACTbeta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
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