IRIS publication 113214869
Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives
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TY - JOUR - McCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R. - 2005 - Organic ; Biomolecular Chemistry - Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives - Validated - () - 3 - 16 - 3059 - 3065 - beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides. DA - 2005/NaN ER -
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@article{V113214869, = {McCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R.}, = {2005}, = {Organic ; Biomolecular Chemistry}, = {Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives}, = {Validated}, = {()}, = {3}, = {16}, pages = {3059--3065}, = {{beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.}}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | McCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R. | ||
YEAR | 2005 | ||
MONTH | |||
JOURNAL_CODE | Organic ; Biomolecular Chemistry | ||
TITLE | Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
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VOLUME | 3 | ||
ISSUE | 16 | ||
START_PAGE | 3059 | ||
END_PAGE | 3065 | ||
ABSTRACT | beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides. | ||
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