IRIS publication 271355276
Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages
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TY - JOUR - Kenny, OM,McCarthy, CM,Brunton, NP,Hossain, MB,Rai, DK,Collins, SG,Jones, PW,Maguire, AR,O'Brien, NM - 2013 - April - Life sciences - Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages - Validated - Altmetric: 2 () - Inflammation Glycoalkaloids Interleukin 2 production Interleukin-8 production Nitric oxide production Jurkat cells Raw 264.7 mouse macrophages NITRIC-OXIDE SYNTHASE INFLAMMATORY-BOWEL-DISEASE NF-KAPPA-B CYTOKINE PRODUCTION ALKALOID GLYCOSIDE CELLS INHIBITION EXPRESSION ADJUVANT TOMATINE - 92 - 775 - 782 - Aims: The potato glycoalkaloids, alpha-chaconine, alpha-solanine and solanidine, along with potato peel extracts were investigated for potential anti-inflammatory effects in vitro. Their potential to reduce two biomarkers of inflammation, cytokine and nitric oxide (NO) productions, were assessed in the stimulated Jurkat and macrophage models, respectively.Main methods: Cytokine and nitric oxide productions were stimulated in Jurkat and Raw 264.7 macrophages with Concanavalin A (Con A; 25 mu g/ml) and lipopolysaccaride (LPS; 1 mu g/ml), respectively. Selective concentrations of glycoalkaloids and potato peel extracts were added simultaneously with Con A or LPS for 24 h to investigate their potential to reduce inflammatory activity.Key findings: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells. The potato peel extracts did not influence cytokine production. In LPS-stimulated Raw macrophages, alpha-solanine, solanidine and two potato peel extracts significantly reduced induced NO production.Significance: Our findings suggest that sub-cytotoxic concentrations of potato glycoalkaloids and potato peel extracts possess anti-inflammatory effects in vitro and with further investigation may be useful in the prevention of anti-inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved. - 10.1016/j.lfs.2013.02.006 DA - 2013/04 ER -
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@article{V271355276, = {Kenny, OM and McCarthy, CM and Brunton, NP and Hossain, MB and Rai, DK and Collins, SG and Jones, PW and Maguire, AR and O'Brien, NM }, = {2013}, = {April}, = {Life sciences}, = {Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages}, = {Validated}, = {Altmetric: 2 ()}, = {Inflammation Glycoalkaloids Interleukin 2 production Interleukin-8 production Nitric oxide production Jurkat cells Raw 264.7 mouse macrophages NITRIC-OXIDE SYNTHASE INFLAMMATORY-BOWEL-DISEASE NF-KAPPA-B CYTOKINE PRODUCTION ALKALOID GLYCOSIDE CELLS INHIBITION EXPRESSION ADJUVANT TOMATINE}, = {92}, pages = {775--782}, = {{Aims: The potato glycoalkaloids, alpha-chaconine, alpha-solanine and solanidine, along with potato peel extracts were investigated for potential anti-inflammatory effects in vitro. Their potential to reduce two biomarkers of inflammation, cytokine and nitric oxide (NO) productions, were assessed in the stimulated Jurkat and macrophage models, respectively.Main methods: Cytokine and nitric oxide productions were stimulated in Jurkat and Raw 264.7 macrophages with Concanavalin A (Con A; 25 mu g/ml) and lipopolysaccaride (LPS; 1 mu g/ml), respectively. Selective concentrations of glycoalkaloids and potato peel extracts were added simultaneously with Con A or LPS for 24 h to investigate their potential to reduce inflammatory activity.Key findings: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells. The potato peel extracts did not influence cytokine production. In LPS-stimulated Raw macrophages, alpha-solanine, solanidine and two potato peel extracts significantly reduced induced NO production.Significance: Our findings suggest that sub-cytotoxic concentrations of potato glycoalkaloids and potato peel extracts possess anti-inflammatory effects in vitro and with further investigation may be useful in the prevention of anti-inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved.}}, = {10.1016/j.lfs.2013.02.006}, source = {IRIS} }
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AUTHORS | Kenny, OM,McCarthy, CM,Brunton, NP,Hossain, MB,Rai, DK,Collins, SG,Jones, PW,Maguire, AR,O'Brien, NM | ||
YEAR | 2013 | ||
MONTH | April | ||
JOURNAL_CODE | Life sciences | ||
TITLE | Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages | ||
STATUS | Validated | ||
TIMES_CITED | Altmetric: 2 () | ||
SEARCH_KEYWORD | Inflammation Glycoalkaloids Interleukin 2 production Interleukin-8 production Nitric oxide production Jurkat cells Raw 264.7 mouse macrophages NITRIC-OXIDE SYNTHASE INFLAMMATORY-BOWEL-DISEASE NF-KAPPA-B CYTOKINE PRODUCTION ALKALOID GLYCOSIDE CELLS INHIBITION EXPRESSION ADJUVANT TOMATINE | ||
VOLUME | 92 | ||
ISSUE | |||
START_PAGE | 775 | ||
END_PAGE | 782 | ||
ABSTRACT | Aims: The potato glycoalkaloids, alpha-chaconine, alpha-solanine and solanidine, along with potato peel extracts were investigated for potential anti-inflammatory effects in vitro. Their potential to reduce two biomarkers of inflammation, cytokine and nitric oxide (NO) productions, were assessed in the stimulated Jurkat and macrophage models, respectively.Main methods: Cytokine and nitric oxide productions were stimulated in Jurkat and Raw 264.7 macrophages with Concanavalin A (Con A; 25 mu g/ml) and lipopolysaccaride (LPS; 1 mu g/ml), respectively. Selective concentrations of glycoalkaloids and potato peel extracts were added simultaneously with Con A or LPS for 24 h to investigate their potential to reduce inflammatory activity.Key findings: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells. The potato peel extracts did not influence cytokine production. In LPS-stimulated Raw macrophages, alpha-solanine, solanidine and two potato peel extracts significantly reduced induced NO production.Significance: Our findings suggest that sub-cytotoxic concentrations of potato glycoalkaloids and potato peel extracts possess anti-inflammatory effects in vitro and with further investigation may be useful in the prevention of anti-inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved. | ||
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DOI_LINK | 10.1016/j.lfs.2013.02.006 | ||
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