IRIS publication 271355402
Recent advances in Phytosterol Oxidation Products
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TY - - Reviews - O'Callaghan, Y,McCarthy, FO,O'Brien, NM - 2014 - April - Recent advances in Phytosterol Oxidation Products - Author - Validated - 0 - () - Phytosterols beta-Sitosterol Stigmasterol Campesterol Dihydrobrassicasterol Phytosterol Oxidation Products Atherosclerosis Toxicity Oxidative stress Cholesterol absorption BETA-SITOSTEROL OXIDIZED DERIVATIVES PLANT STEROLS COLON-CANCER CHOLESTEROL OXIDES CELLS OXYPHYTOSTEROL CAMPESTEROL APOPTOSIS - Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity. (C) 2014 Elsevier Inc. All rights reserved. - 786 - 791 - 10.1016/j.bbrc.2014.01.148 DA - 2014/04 ER -
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@review{V271355402, = {Reviews}, = {O'Callaghan, Y and McCarthy, FO and O'Brien, NM }, = {2014}, = {April}, = {Recent advances in Phytosterol Oxidation Products}, = {Author}, = {Validated}, = {0}, = {()}, = {Phytosterols beta-Sitosterol Stigmasterol Campesterol Dihydrobrassicasterol Phytosterol Oxidation Products Atherosclerosis Toxicity Oxidative stress Cholesterol absorption BETA-SITOSTEROL OXIDIZED DERIVATIVES PLANT STEROLS COLON-CANCER CHOLESTEROL OXIDES CELLS OXYPHYTOSTEROL CAMPESTEROL APOPTOSIS}, = {{Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity. (C) 2014 Elsevier Inc. All rights reserved.}}, pages = {786--791}, = {10.1016/j.bbrc.2014.01.148}, source = {IRIS} }
Data as stored in IRIS
OTHER_PUB_TYPE | Reviews | ||
AUTHORS | O'Callaghan, Y,McCarthy, FO,O'Brien, NM | ||
YEAR | 2014 | ||
MONTH | April | ||
TITLE | Recent advances in Phytosterol Oxidation Products | ||
RESEARCHER_ROLE | Author | ||
STATUS | Validated | ||
PEER_REVIEW | 0 | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | Phytosterols beta-Sitosterol Stigmasterol Campesterol Dihydrobrassicasterol Phytosterol Oxidation Products Atherosclerosis Toxicity Oxidative stress Cholesterol absorption BETA-SITOSTEROL OXIDIZED DERIVATIVES PLANT STEROLS COLON-CANCER CHOLESTEROL OXIDES CELLS OXYPHYTOSTEROL CAMPESTEROL APOPTOSIS | ||
REFERENCE | |||
ABSTRACT | Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity. (C) 2014 Elsevier Inc. All rights reserved. | ||
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START_PAGE | 786 | ||
END_PAGE | 791 | ||
DOI_LINK | 10.1016/j.bbrc.2014.01.148 | ||
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