TY  - JOUR
  - Kilemade, M,Hartl, MGJ,O'Halloran, J,O'Brien, NM,Sheehan, D,Mothersill, C,van Pelt, FNAM
  - 2009
  - March
  - Ecotoxicology and Environmental Safety
  - Effects of contaminated sediment from Cork Harbour, Ireland on the cytochrome P450 system of turbot
  - Validated
  - ()
  - Turbot Cork Harbour Inter-tidal sediment PAH Cytochrome P450-dependent monooxygenases FLOUNDER PLATICHTHYS-FLESUS POLYCYCLIC AROMATIC-HYDROCARBONS SCOPHTHALMUS-MAXIMUS L GADUS-MORHUA L PLAICE PLEURONECTES-PLATESSA TROUT ONCORHYNCHUS-MYKISS O-DEETHYLASE INDUCTION RAINBOW-TROUT COMET ASSAY IMMUNOHISTOCHEMICAL LOCALIZATION
  - 72
  - 747
  - 755
  - Hatchery-reared juvenile turbot (Scophthalmus maximus L.) were exposed for 3 weeks, under laboratory conditions, to inter-tidal sediments collected from polluted sites in Cork Harbour (Whitegate and Agahda) and a reference site at Ballymacoda Co., Cork, Ireland. The potential of the sediment exposure to induce cytochrome P450 activities and CYP1A1 in the fish was assessed. Chemical analysis revealed that the sediments originating from the reference and harbour sites were contaminated principally with PAHs-the harbour sites having double the levels of those at the reference site. Following 3 weeks exposure to the sediments western blotting demonstrated a strong immunogenic response for CYP1A1 in the liver, but not for gill or intestine. P450 activities were generally significantly higher than those exposed to reference site sediment. Liver was the most responsive tissue with significantly greater P450 activities compared with gill and intestinal tissues. (c) 2008 Elsevier Inc. All rights reserved.
  - DOI 10.1016/j.ecoenv.2008.09.026
DA  - 2009/03
ER  - 

@article{V43335032,
   = {Kilemade,  M and Hartl,  MGJ and O'Halloran,  J and O'Brien,  NM and Sheehan,  D and Mothersill,  C and van Pelt,  FNAM },
   = {2009},
   = {March},
   = {Ecotoxicology and Environmental Safety},
   = {Effects of contaminated sediment from Cork Harbour, Ireland on the cytochrome P450 system of turbot},
   = {Validated},
   = {()},
   = {Turbot Cork Harbour Inter-tidal sediment PAH Cytochrome P450-dependent monooxygenases FLOUNDER PLATICHTHYS-FLESUS POLYCYCLIC AROMATIC-HYDROCARBONS SCOPHTHALMUS-MAXIMUS L GADUS-MORHUA L PLAICE PLEURONECTES-PLATESSA TROUT ONCORHYNCHUS-MYKISS O-DEETHYLASE INDUCTION RAINBOW-TROUT COMET ASSAY IMMUNOHISTOCHEMICAL LOCALIZATION},
   = {72},
  pages = {747--755},
   = {{Hatchery-reared juvenile turbot (Scophthalmus maximus L.) were exposed for 3 weeks, under laboratory conditions, to inter-tidal sediments collected from polluted sites in Cork Harbour (Whitegate and Agahda) and a reference site at Ballymacoda Co., Cork, Ireland. The potential of the sediment exposure to induce cytochrome P450 activities and CYP1A1 in the fish was assessed. Chemical analysis revealed that the sediments originating from the reference and harbour sites were contaminated principally with PAHs-the harbour sites having double the levels of those at the reference site. Following 3 weeks exposure to the sediments western blotting demonstrated a strong immunogenic response for CYP1A1 in the liver, but not for gill or intestine. P450 activities were generally significantly higher than those exposed to reference site sediment. Liver was the most responsive tissue with significantly greater P450 activities compared with gill and intestinal tissues. (c) 2008 Elsevier Inc. All rights reserved.}},
   = {DOI 10.1016/j.ecoenv.2008.09.026},
  source = {IRIS}
}