Cocrystals of Fenamic Acids with Nicotinamide

Typeset version

 

TY  - JOUR
  - Fabian, L,Hamill, N,Eccles, KS,Moynihan, HA,Maguire, AR,McCausland, L,Lawrence, SE
  - 2011
  - January
  - Crystal Growth ; Design
  - Cocrystals of Fenamic Acids with Nicotinamide
  - Published
  - ()
  - SWISS LIGHT-SOURCE TOLFENAMIC ACID MEFENAMIC-ACID POWDER DIFFRACTION CO-CRYSTALS SOLUBILITY COMPLEXES CHALLENGE 1-OCTANOL ETHANOL
  - 11
  - 3522
  - 3528
  - Cocrystal formation between nicotinamide and five fenamic acid derivative drugs (flufenamic acid, niflumic tolfenamic acid, mefenamic acid and meclofenamic acid) was investigated using solution-based and solid-state preparation methods. It was anticipated that the well-known acid-aromatic nitrogen heterosynthon would provide a sufficient driving force for cocrystallization. The experiments yielded cocrystals with four of the five acids. Although the structures of these molecules are similar, they showed marked differences in both the stability and the stoichiometry of the cocrystals. A detailed analysis of the structures and properties of both the starting materials and the cocrystals allows a tentative explanation of these differences, but it also shows that even though all four cocrystals utilize one of the most predictable supramolecular synthons (COOH center dot center dot center dot N), their structures and properties remain elusive to design.
  - DOI 10.1021/cg200429j
DA  - 2011/01
ER  - 
@article{V102259568,
   = {Fabian,  L and Hamill,  N and Eccles,  KS and Moynihan,  HA and Maguire,  AR and McCausland,  L and Lawrence,  SE },
   = {2011},
   = {January},
   = {Crystal Growth ; Design},
   = {Cocrystals of Fenamic Acids with Nicotinamide},
   = {Published},
   = {()},
   = {SWISS LIGHT-SOURCE TOLFENAMIC ACID MEFENAMIC-ACID POWDER DIFFRACTION CO-CRYSTALS SOLUBILITY COMPLEXES CHALLENGE 1-OCTANOL ETHANOL},
   = {11},
  pages = {3522--3528},
   = {{Cocrystal formation between nicotinamide and five fenamic acid derivative drugs (flufenamic acid, niflumic tolfenamic acid, mefenamic acid and meclofenamic acid) was investigated using solution-based and solid-state preparation methods. It was anticipated that the well-known acid-aromatic nitrogen heterosynthon would provide a sufficient driving force for cocrystallization. The experiments yielded cocrystals with four of the five acids. Although the structures of these molecules are similar, they showed marked differences in both the stability and the stoichiometry of the cocrystals. A detailed analysis of the structures and properties of both the starting materials and the cocrystals allows a tentative explanation of these differences, but it also shows that even though all four cocrystals utilize one of the most predictable supramolecular synthons (COOH center dot center dot center dot N), their structures and properties remain elusive to design.}},
   = {DOI 10.1021/cg200429j},
  source = {IRIS}
}
AUTHORSFabian, L,Hamill, N,Eccles, KS,Moynihan, HA,Maguire, AR,McCausland, L,Lawrence, SE
YEAR2011
MONTHJanuary
JOURNAL_CODECrystal Growth ; Design
TITLECocrystals of Fenamic Acids with Nicotinamide
STATUSPublished
TIMES_CITED()
SEARCH_KEYWORDSWISS LIGHT-SOURCE TOLFENAMIC ACID MEFENAMIC-ACID POWDER DIFFRACTION CO-CRYSTALS SOLUBILITY COMPLEXES CHALLENGE 1-OCTANOL ETHANOL
VOLUME11
ISSUE
START_PAGE3522
END_PAGE3528
ABSTRACTCocrystal formation between nicotinamide and five fenamic acid derivative drugs (flufenamic acid, niflumic tolfenamic acid, mefenamic acid and meclofenamic acid) was investigated using solution-based and solid-state preparation methods. It was anticipated that the well-known acid-aromatic nitrogen heterosynthon would provide a sufficient driving force for cocrystallization. The experiments yielded cocrystals with four of the five acids. Although the structures of these molecules are similar, they showed marked differences in both the stability and the stoichiometry of the cocrystals. A detailed analysis of the structures and properties of both the starting materials and the cocrystals allows a tentative explanation of these differences, but it also shows that even though all four cocrystals utilize one of the most predictable supramolecular synthons (COOH center dot center dot center dot N), their structures and properties remain elusive to design.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINKDOI 10.1021/cg200429j
FUNDING_BODY
GRANT_DETAILS