IRIS publication 108083260
Modifications to the Vilsmeier-Haack Formylation of 1,4-Dimethylcarbazole and Its Application to the Synthesis of Ellipticines
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TY - JOUR - Deane, FM,Miller, CM,Maguire, AR,McCarthy, FO - 2011 - January - Rna-A Publication of The Rna Society - Modifications to the Vilsmeier-Haack Formylation of 1,4-Dimethylcarbazole and Its Application to the Synthesis of Ellipticines - Validated - () - DERIVATIVES DNA ALKALOIDS BINDING TUMOUR - 48 - 814 - 823 - An improved method for the preparation of 3-formyl-1,4-dimethylcarbazole, a key intermediate in the synthesis of ellipticine, is presented. Conditions of the Vilsmeier-Haack reaction have been modified to facilitate the production of 3-formyl-1,4-dimethylcarbazole as a major product leading to an overall improvement in yield of ellipticine from 3% to 14%. This approach was also applied to the synthesis of 6-methylellipticine and 9-methoxyellipticine. - DOI 10.1002/jhet.598 DA - 2011/01 ER -
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@article{V108083260, = {Deane, FM and Miller, CM and Maguire, AR and McCarthy, FO }, = {2011}, = {January}, = {Rna-A Publication of The Rna Society}, = {Modifications to the Vilsmeier-Haack Formylation of 1,4-Dimethylcarbazole and Its Application to the Synthesis of Ellipticines}, = {Validated}, = {()}, = {DERIVATIVES DNA ALKALOIDS BINDING TUMOUR}, = {48}, pages = {814--823}, = {{An improved method for the preparation of 3-formyl-1,4-dimethylcarbazole, a key intermediate in the synthesis of ellipticine, is presented. Conditions of the Vilsmeier-Haack reaction have been modified to facilitate the production of 3-formyl-1,4-dimethylcarbazole as a major product leading to an overall improvement in yield of ellipticine from 3% to 14%. This approach was also applied to the synthesis of 6-methylellipticine and 9-methoxyellipticine.}}, = {DOI 10.1002/jhet.598}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Deane, FM,Miller, CM,Maguire, AR,McCarthy, FO | ||
YEAR | 2011 | ||
MONTH | January | ||
JOURNAL_CODE | Rna-A Publication of The Rna Society | ||
TITLE | Modifications to the Vilsmeier-Haack Formylation of 1,4-Dimethylcarbazole and Its Application to the Synthesis of Ellipticines | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | DERIVATIVES DNA ALKALOIDS BINDING TUMOUR | ||
VOLUME | 48 | ||
ISSUE | |||
START_PAGE | 814 | ||
END_PAGE | 823 | ||
ABSTRACT | An improved method for the preparation of 3-formyl-1,4-dimethylcarbazole, a key intermediate in the synthesis of ellipticine, is presented. Conditions of the Vilsmeier-Haack reaction have been modified to facilitate the production of 3-formyl-1,4-dimethylcarbazole as a major product leading to an overall improvement in yield of ellipticine from 3% to 14%. This approach was also applied to the synthesis of 6-methylellipticine and 9-methoxyellipticine. | ||
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DOI_LINK | DOI 10.1002/jhet.598 | ||
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