IRIS publication 243945282
Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate
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TY - JOUR - Slattery, CN,Deasy, RE,Maguire, AR,Kopach, ME,Singh, UK,Argentine, MD,Trankle, WG,Scherer, RB,Moynihan, H - 2013 - June - The Journal of Organic Chemistry - Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate - Validated - WOS: 10 () - GRIGNARD-REAGENTS FORMYLATION EXCHANGE - 78 - 5955 - 5963 - An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup. - 10.1021/jo400647t DA - 2013/06 ER -
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@article{V243945282, = {Slattery, CN and Deasy, RE and Maguire, AR and Kopach, ME and Singh, UK and Argentine, MD and Trankle, WG and Scherer, RB and Moynihan, H }, = {2013}, = {June}, = {The Journal of Organic Chemistry}, = {Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate}, = {Validated}, = {WOS: 10 ()}, = {GRIGNARD-REAGENTS FORMYLATION EXCHANGE}, = {78}, pages = {5955--5963}, = {{An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.}}, = {10.1021/jo400647t}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Slattery, CN,Deasy, RE,Maguire, AR,Kopach, ME,Singh, UK,Argentine, MD,Trankle, WG,Scherer, RB,Moynihan, H | ||
YEAR | 2013 | ||
MONTH | June | ||
JOURNAL_CODE | The Journal of Organic Chemistry | ||
TITLE | Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate | ||
STATUS | Validated | ||
TIMES_CITED | WOS: 10 () | ||
SEARCH_KEYWORD | GRIGNARD-REAGENTS FORMYLATION EXCHANGE | ||
VOLUME | 78 | ||
ISSUE | |||
START_PAGE | 5955 | ||
END_PAGE | 5963 | ||
ABSTRACT | An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup. | ||
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DOI_LINK | 10.1021/jo400647t | ||
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