IRIS publication 271356249
Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane
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TY - JOUR - Deasy, RE,O'Riordan, N,Maguire, AR - 2014 - June - Catalysts - Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane - Validated - WOS: 4 () - baker's yeast (Saccharomyces cerevisiae) biocatalysis asymmetric reduction chiral alcohol sulfolane HIV-1 PROTEASE INHIBITORS ASYMMETRIC REDUCTION STEREOCHEMICAL CONTROL CYCLIC SULFONES 3-OXO ESTERS - 4 - 186 - 195 - The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (<= 25%) and diastereocontrol. - 10.3390/catal4020186 DA - 2014/06 ER -
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@article{V271356249, = {Deasy, RE and O'Riordan, N and Maguire, AR }, = {2014}, = {June}, = {Catalysts}, = {Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane}, = {Validated}, = {WOS: 4 ()}, = {baker's yeast (Saccharomyces cerevisiae) biocatalysis asymmetric reduction chiral alcohol sulfolane HIV-1 PROTEASE INHIBITORS ASYMMETRIC REDUCTION STEREOCHEMICAL CONTROL CYCLIC SULFONES 3-OXO ESTERS}, = {4}, pages = {186--195}, = {{The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (<= 25%) and diastereocontrol.}}, = {10.3390/catal4020186}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Deasy, RE,O'Riordan, N,Maguire, AR | ||
YEAR | 2014 | ||
MONTH | June | ||
JOURNAL_CODE | Catalysts | ||
TITLE | Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane | ||
STATUS | Validated | ||
TIMES_CITED | WOS: 4 () | ||
SEARCH_KEYWORD | baker's yeast (Saccharomyces cerevisiae) biocatalysis asymmetric reduction chiral alcohol sulfolane HIV-1 PROTEASE INHIBITORS ASYMMETRIC REDUCTION STEREOCHEMICAL CONTROL CYCLIC SULFONES 3-OXO ESTERS | ||
VOLUME | 4 | ||
ISSUE | |||
START_PAGE | 186 | ||
END_PAGE | 195 | ||
ABSTRACT | The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (<= 25%) and diastereocontrol. | ||
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DOI_LINK | 10.3390/catal4020186 | ||
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