Professor & Chair
Anatomy & Neuroscience
386
Western Gateway Building
University College Cork
Cork
Ireland

T: +353-21-420-5426
E: J.Cryan@ucc.ie

John F. Cryan is Professor & Chair, Dept. of Anatomy & Neuroscience, University College Cork.  He received a B.Sc. (Hons) and PhD from the National University of Ireland, Galway, Ireland. He was a visiting fellow at the Dept Psychiatry, University of Melbourne, Australia (1997-1998), which was followed by postdoctoral fellowships  at the University of Pennsylvania, Philadelphia, USA and The Scripps Research Institute, La Jolla, California. He spent four years at the Novartis Institutes for BioMedical Research in Basel Switzerland, as a LabHead, Behavioural Pharmacology prior to joining UCC in 2005 where he was  a Senior Lecturer in Pharmacology in the School of Pharmacy and in the Dept. Pharmacology & Therapeutics UCC. Currently he is also a Principal Investigator in the Alimentary Pharmabiotic Centre (http://www.ucc.ie/research/apc/content).

Prof. Cryan has an H-Index of 57 (Google Scholar) having published over 250 peer-reviewed articles and book chapters including articles in high-impact journals such as PNAS, Neuron, Nature Reviews Neurosci. Molecular Psychiatry, Biological Psychiatry, Progress in Neurobiology, Nature Reviews Drug Discovery, Gastroenterology, Gut and Journal of Neuroscience. He  has edited books  on "Behavioural Neurogenetics" (Springer Press, 2012) on "Depression: From Psychopathology to Pharmacotherapy" (Karger Press, 2010)

and “Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease” (Springer Press, 2014).


Prof. Cryan was recently selected as a Highly Cited Researcher by Thomson Reuters.  Those researchers who, within an ESI-defined field, published Highly Cited Papers were judged to be influential, so the production of multiple top 1% papers was interpreted as a mark of exceptional impact.  Professor Cryan, as a member of the Highly Cited Researcher List is also included in the 2014 The World's most Influential Scientific Minds

Prof. Cryan is a Senior Editor of Neuropharmacology and Nutritional Neuroscience and an Editor of British Journal of Pharmacology. He is Advisory Editor of Psychopharmacology; on the Board of Reviewing Editors of Brain Research; an Associate Editor of Frontiers in Behavioural Neuroscience; an Associate Editor of Frontiers in Psychopharmacology and Frontiers in Gastrointestinal Pharmacology; an Editorial Board Member of Behavioural Pharmacology; Neuroscience and Biobehavioral Reviews, Genes, Brain & Behavior and International Journal of Neuropsychopharmacology. Prof Cryan received the inaugural University College Cork Researcher of the Year Award in 2012. Cryan has also been honoured with the European College of Neuropsychopharmacology (ECNP) Fellowship Award, the Wyeth Psychopharmacology Award from British Association of Psychopharmacology and the Young Scientist Award from the European Behavioural Pharmacology Society. He has received commercialisation awards from UCC in 2012 and 2013. Further, in 2013 he received the University of Utrecht Award for Excellence in Pharmaceutical Research and delivered the Royal Academy of Medicine in Ireland Conway Review Lecture and the De Pazzi Lecture at University College Cork. He gave the Wingate Lecture at Barts & The London School of Medicine and Dentistry in 2014. Prof Cryan was also a TEDMED Invited Speaker in 2014.



Research Interests

Prof. Cryan's current research interests include the neurobiological basis of stress-related neuropsychiatric disorders including depression, anxiety and drug dependence. Moreover, his group is also focused on understanding the interaction between brain, gut & microbiome and how it applies to stress and immune-related disorders, including irritable bowel syndrome and obesity and neurodevelopmental disorders such as autism. He is also interested in applying novel approaches to facilitate drug/siRNA delivery to the brain in vivo.

Prof. Cryan's research group consists of 12 Postdoctoral Fellows, 14 PhD students, 2 MD students, 2 MSc Students, 3 research scientists and various visiting students from Ireland, Spain, The Netherlands, USA & Canada. It is funded by Science Foundation Ireland, the Health Research Board, Enterprise Ireland and the Irish Research Council. Moreover, Prof. Cryan receives funding as a PI on the two different EU Framework 7 Programme grants.

Books

YearPublication
(2012)Behavioural Neurogenetics.
John F. Cryan Andreas Reif (2012) Behavioural Neurogenetics. Heidelberg: Springer. [Details]
(2010)Depression: From Psychopathology to Pharmacotherapy.
Cryan, JF and Leonard, BE; (2010) Depression: From Psychopathology to Pharmacotherapy. Basel: Karger. [Details]
(2014)Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease.
Mark Lyte John F. Cryan (2014) Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. Heidelberg: Springer. [Details]

Book Chapters

YearPublication
(2009)'The tail suspension test: A model for characterizing antidepressant activity in mice'
O'Leary OF, Cryan JF; (2009) 'The tail suspension test: A model for characterizing antidepressant activity in mice' In: Mood & Anxiety Related Phenotypes in Mice; Neuromethods. USA: Springer. [Details]
(2010)'The behavioural Genetics of serotonin: relevance to anxiety and depression'
O'Leary OF, Cryan JF ; (2010) 'The behavioural Genetics of serotonin: relevance to anxiety and depression' In: Handbook of the Behavioral Neurobiology of Serotonin. USA: Academic Press. [Details]
(2008)'GABA receptors and depression: Focus on GABAB'
Cryan JF, Slattery DA; (2008) 'GABA receptors and depression: Focus on GABAB' In: Recent Developments on Depression Research. to follow: to follow. [Details]
(2008)'Developing more efficacious antidepressant medications: Improving and aligning preclinical and clinical assessment tools'
Cryan JF, Sanchez C, Dinan TG, Borsini F; (2008) 'Developing more efficacious antidepressant medications: Improving and aligning preclinical and clinical assessment tools' In: Animal and Translational Models for Drug Discovery: Psychiatric Disorders. NY: Elsevier. [Details]
(2007)'Role of glutamate in anxiety'
Cryan JF, Dev KK; (2007) 'Role of glutamate in anxiety' In: Handbook of fear and anxiety. to follow: to follow. [Details]
(2006)'Modelling human anxiety and depression in mutant mice'
Holmes A, Cryan JF; (2006) 'Modelling human anxiety and depression in mutant mice' In: Transgenic and Knockout Models of Neuropsychiatric Disorders. to follow: Humana Press. [Details]
(2013)'Ghrelin at the interface of obesity and reward'
Schellekens, H.,Dinan, T. G.,Cryan, J. F. (2013) 'Ghrelin at the interface of obesity and reward' In: Obesity, Vitamins & Hormones. USA: elsevier. [Details]
(2014)'Characterising the Gut Microbiome: Role in Brain–Gut Function'
Clarke G, O'Toole P, Cryan JF, Dinan TG (2014) 'Characterising the Gut Microbiome: Role in Brain–Gut Function' In: The Omics:Applications in Neuroscience. New York: Oxford University Press. [Details]
(2014)'The Ghrelin Receptor: A Novel Therapeutic Target for Obesity'
Schellekens, H., Dinan, T.G., Cryan, J.F (2014) 'The Ghrelin Receptor: A Novel Therapeutic Target for Obesity' In: J. Portelli and I. Smolders (eds). Central Functions of the Ghrelin Receptor. New York: Springer. [Details]
(2014)'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential'
Borre YE, Moloney RD, Clarke G, Dinan TG, Cryan JF. (2014) 'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential' In: Microbial Endocrinology. New York: Springer. [Details]

Peer Reviewed Journals

YearPublication
(2012)'Interleukin-6 modulates transepithelial ion transport in Wistar Kyoto rat distal colon'
O’Malley D, Dinan TG & Cryan JF (2012) 'Interleukin-6 modulates transepithelial ion transport in Wistar Kyoto rat distal colon'. Frontiers In Pharmacology, [Details]
(2012)'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'
O'Mahony AM, Doyle D, Darcy R, Cryan JF, O'Driscoll CM. (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 (5):896-903 [DOI] [CORA Link] [Details]
(2012)'Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery'
O'Mahony, AM, Godinho, BMDC, Ogier, J, Devocelle, M, Darcy, R, Cryan, JF, O'Driscoll, CM (2012) 'Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery'. ACS Chemical Neuroscience, 10 (3):744-752 [DOI] [CORA Link] [Details]
(2012)'DIFFERENTIAL LIPOPOLYSACCHARIDE-INDUCED IMMUNE ALTERATIONS IN THE HIPPOCAMPUS OF TWO MOUSE STRAINS: EFFECTS OF STRESS'
Browne, CA,O'Brien, FE,Connor, TJ,Dinan, TG,Cryan, JF (2012) 'DIFFERENTIAL LIPOPOLYSACCHARIDE-INDUCED IMMUNE ALTERATIONS IN THE HIPPOCAMPUS OF TWO MOUSE STRAINS: EFFECTS OF STRESS'. Neuroscience, 225 :237-248 [DOI] [Details]
(2012)'Bifidobacterium breve with alpha-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome'
Barrett, E,Fitzgerald, P,Dinan, TG,Cryan, JF,Ross, RP,Quigley, EM,Shanahan, F,Kiely, B,Fitzgerald, GF,O'Toole, PW,Stanton, C (2012) 'Bifidobacterium breve with alpha-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome'. Plos One, 7 [DOI] [Details]
(2012)'Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action'
Felice, D,O'Leary, OF,Pizzo, RC,Cryan, JF (2012) 'Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action'. Neuropharmacology, 63 :1380-1388 [DOI] [Details]
(2012)'Click-Modified Cyclodextrins as Nonviral Vectors for Neuronal siRNA Delivery'
O'Mahony, AM,Godinho, BMDC,Ogier, J,Devocelle, M,Darcy, R,Cryan, JF,O'Driscoll, CM (2012) 'Click-Modified Cyclodextrins as Nonviral Vectors for Neuronal siRNA Delivery'. ACS Chemical Neuroscience, 3 :744-752 [DOI] [Details]
(2012)'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'
O'Tuathaigh, CMP,Clarke, G,Walsh, J,Desbonnet, L,Petit, E,O'Leary, C,Tighe, O,Clarke, N,Karayiorgou, M,Gogos, JA,Dinan, TG,Cryan, JF,Waddington, JL (2012) 'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'. International Journal of Neuropsychopharmacology, 15 :1331-1342 [DOI] [Details]
(2012)'Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype'
Dennison, U,McKernan, D,Cryan, J,Dinan, T (2012) 'Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype'. Psychological medicine, 42 :1865-1871 [DOI] [Details]
(2013)'In vitro investigations of the efficacy of Cyclodextrin-siRNA complexes modified with Lipid-PEG-Octaarginine: Towards A Formulation Strategy for Effective Neuronal siRNA Delivery'
O'Mahony, AM., Desgranges S., Ogier JR., Quinlan A., Devocelle M., Darcy, R., Cryan, JF and O'Driscoll, CM. (2013) 'In vitro investigations of the efficacy of Cyclodextrin-siRNA complexes modified with Lipid-PEG-Octaarginine: Towards A Formulation Strategy for Effective Neuronal siRNA Delivery'. Pharmaceutical Research, 30 (4):1086-1098 [DOI] [CORA Link] [Details]
(2013)'Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'
Godinho BM, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF. (2013) 'Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'. Molecular Pharmaceutics, 10 :640-649 [DOI] [Details]
(2013)'Cyclodextrins for Non-Viral Gene and siRNA Delivery'
O'Mahony AM., O’Neill MJ., Godinho BMDC., Darcy, R., Cryan, JF and; O'Driscoll, CM. (2013) 'Cyclodextrins for Non-Viral Gene and siRNA Delivery'. Pharmaceutical Nanotechnology, 1 :6-14 [CORA Link] [Details]
(2013)'Towards translational rodent models of depression'
O'Leary OF, Cryan JF (2013) 'Towards translational rodent models of depression'. Cell Tissue Research, 354 (1):141-145 [Details]
(2010)'A Gut Feeling about GABA: Focus on GABA(B) Receptors'
Hyland NP and Cryan JF (2010) 'A Gut Feeling about GABA: Focus on GABA(B) Receptors'. Frontiers In Pharmacology, [DOI] [Details]
(2011)'Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype'
McKernan, DP,Dennison, U,Gaszner, G,Cryan, JF,Dinan, TG (2011) 'Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype'. Translational Psychiatry, 1 [DOI] [Details]
(2011)'BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?'
O'Sullivan, E,Barrett, E,Grenham, S,Fitzgerald, P,Stanton, C,Ross, RP,Quigley, EMM,Cryan, JF,Dinan, TG (2011) 'BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?'. Beneficial microbes, 2 :199-207 [DOI] [Details]
(2012)'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery'
O'Mahony, AM,Ogier, J,Desgranges, S,Cryan, JF,Darcy, R,O'Driscoll, CM (2012) 'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery'. Organic & Biomolecular Chemistry, 10 :4954-4960 [DOI] [CORA Link] [Details]
(2012)'Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats'
O'Brien, FE,Clarke, G,Fitzgerald, P,Dinan, TG,Griffin, BT,Cryan, JF (2012) 'Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats'. British Journal of Pharmacology, 166 :1333-1343 [DOI] [Details]
(2012)'Using the rat forced swim test to assess antidepressant-like activity in rodents'
Slattery, DA,Cryan, JF (2012) 'Using the rat forced swim test to assess antidepressant-like activity in rodents'. Nature Protocols, 7 :1009-1014 [DOI] [Details]
(2012)'Rodent models of colorectal distension'
O'Mahony SM, Tramullas M, Fitzgerald P, Cryan JF (2012) 'Rodent models of colorectal distension'. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.], Chapter 9 [DOI] [Details]
(2012)'Dynamic 5-HT2C Receptor Editing in a Mouse Model of Obesity'
Schellekens, H,Clarke, G,Jeffery, IB,Dinan, TG,Cryan, JF (2012) 'Dynamic 5-HT2C Receptor Editing in a Mouse Model of Obesity'. Plos One, 7 [DOI] [Details]
(2012)'The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight'
Finger, BC,Dinan, TG,Cryan, JF (2012) 'The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight'. Psychoneuroendocrinology, 37 :729-741 [DOI] [Details]
(2012)'Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent'
Julio-Pieper, M,O'Mahony, CM,Clarke, G,Bravo, JA,Dinan, TG,Cryan, JF (2012) 'Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent'. Stress (Amsterdam, Netherlands), 15 :218-226 [DOI] [Details]
(2012)'Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice'
O'Leary, OF,O'Connor, RM,Cryan, JF (2012) 'Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice'. Neuropharmacology, 62 :247-255 [DOI] [Details]
(2012)'Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task'
Finger, BC,Dinan, TG,Cryan, JF (2012) 'Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task'. Psychopharmacology, 220 :173-181 [DOI] [Details]
(2012)'Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action'
Felice D, O'Leary OF, Pizzo RC, Cryan JF. (2012) 'Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action'. Neuropharmacology, 63 (8):1380-1388 [DOI] [Details]
(2013)'Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action'
O'Connor RM, Pusceddu M, O'Leary OF, Savignac HM, Bravo JF, El Yacoubi M, Vaugeois JM, Dinan TG, Cryan JF. (2013) 'Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action'. Pharmacology Biochemistry and Behavior, 103 (3):561-567 [DOI] [Details]
(2013)'Lithium Augmentation of the effects of Desipramine in a Mouse Model of Treatment-Resistant Depression: A Role for Hippocampal Cell Proliferation'
O'Leary OF, Zandy S, Dinan TG, Cryan JF (2013) 'Lithium Augmentation of the effects of Desipramine in a Mouse Model of Treatment-Resistant Depression: A Role for Hippocampal Cell Proliferation'. Neuroscience, 228 :36-46 [DOI] [Details]
(2013)'Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain'
Browne, CA,Clarke, G,Hanke, J,Dinan, TG,Schwegler, H,Yilmazer-Hanke, DM,Cryan, JF (2013) 'Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain'. Behavioural Brain Research, 236 :283-288 [DOI] [Details]
(2004)'Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors'
Cryan JF, O'Leary OF, Jin SH, Friedland JC, Ouyang M, Hirsch BR, Page ME, Dalvi A, Thomas SA, Lucki I; (2004) 'Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors'. Proceedings of The National Academy of Sciences of The United States of America, 101 (21):8186-8191 [DOI] [Details]
(2010)'A Gut Feeling about GABA: Focus on GABA(B) Receptors'
Hyland NP, Cryan JF (2010) 'A Gut Feeling about GABA: Focus on GABA(B) Receptors'. Frontiers In Pharmacology, 1 [DOI] [Details]
(2011)'Altered expression and secretion of colonic Interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction'
O'Malley, D,Dinan, TG,Cryan, JF; (2011) 'Altered expression and secretion of colonic Interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction'. The Journal of Immunology, 235 :48-55 [DOI] [Details]
(2012)'Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice'
O'Leary OF, O'Connor RM, Cryan JF; (2012) 'Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice'. Neuropharmacology, 62 (1):247-255 [DOI] [Details]
(2011)'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'
O'Tuathaigh CM, Clarke G, Walsh J, Desbonnet L, Petit E, O'Leary C, Tighe O, Clarke N, Karayiorgou M, Gogos JA, Dinan TG, Cryan JF, Waddington JL (2011) 'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'. International Journal of Neuropsychopharmacology, :1-12 [DOI] [Details]
(2011)'BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?'
O'Sullivan E, Barrett E, Grenham S, Fitzgerald P, Stanton C, Ross RP, Quigley EM, Cryan JF, Dinan TG (2011) 'BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?'. Beneficial microbes, 2 (3):199-207 [DOI] [Details]
(2011)'Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?'
O'Malley D, Quigley EM, Dinan TG, Cryan JF (2011) 'Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?'. Brain Behav Immun, 25 (7):1333-1341 [DOI] [Details]
(2011)'Behavioral satiety sequence in a genetic mouse model of obesity: effects of ghrelin receptor ligands'
Finger, BC,Dinan, TG,Cryan, JF; (2011) 'Behavioral satiety sequence in a genetic mouse model of obesity: effects of ghrelin receptor ligands'. Behavioural Pharmacology, 22 :624-632 [DOI] [Details]
(2011)'Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve'
Bravo, JA,Forsythe, P,Chew, MV,Escaravage, E,Savignac, HM,Dinan, TG,Bienenstock, J,Cryan, JF; (2011) 'Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve'. Proceedings of The National Academy of Science Usa, 108 :16050-16055 [DOI] [Details]
(2011)'The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity'
O'Mahony, SM,Coelho, AM,Fitzgerald, P,Lee, K,Winchester, W,Dinan, TG,Cryan, JF; (2011) 'The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity'. European Journal of Pharmacology, 667 :169-174 [DOI] [Details]
(2011)'The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity'
O'Mahony, SM,Coelho, AM,Fitzgerald, P,Lee, K,Winchester, W,Dinan, TG,Cryan, JF; (2011) 'The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity'. European Journal of Pharmacology, 667 :169-174 [DOI] [Details]
(2011)'HIGH-FAT DIET SELECTIVELY PROTECTS AGAINST THE EFFECTS OF CHRONIC SOCIAL STRESS IN THE MOUSE'
Finger, BC,Dinan, TG,Cryan, JF (2011) 'HIGH-FAT DIET SELECTIVELY PROTECTS AGAINST THE EFFECTS OF CHRONIC SOCIAL STRESS IN THE MOUSE'. Neuroscience, 192 :351-360 [DOI] [Details]
(2011)'Brain-gut-microbe communication in health and disease'
Grenham S, Clarke G, Cryan JF, Dinan TG (2011) 'Brain-gut-microbe communication in health and disease'. Frontiers in Physiology, 2 [DOI] [Details]
(2011)'Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve'
Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) 'Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve'. Proceedings of The National Academy of Sciences of The United States of America, 108 (38):16050-16055 [DOI] [Details]
(2011)'High-fat diet selectively protects against the effects of chronic social stress in the mouse'
Finger BC, Dinan TG, Cryan JF (2011) 'High-fat diet selectively protects against the effects of chronic social stress in the mouse'. Science (New York, N.Y.), 192 :351-360 [DOI] [Details]
(2011)'The age of anxiety: role of animal models of anxiolytic action in drug discovery'
Cryan JF, Sweeney FF (2011) 'The age of anxiety: role of animal models of anxiolytic action in drug discovery'. British Journal of Pharmacology, 164 (4):1129-1161 [DOI] [Details]
(2011)'Resistance to early-life stress in mice: effects of genetic background and stress duration'
Savignac HM, Dinan TG, Cryan JF (2011) 'Resistance to early-life stress in mice: effects of genetic background and stress duration'. Behavioral Neuroscience, 5 [DOI] [Details]
(2011)'Altered peripheral toll-like receptor responses in the irritable bowel syndrome'
McKernan DP, Gaszner G, Quigley EM, Cryan JF, Dinan TG (2011) 'Altered peripheral toll-like receptor responses in the irritable bowel syndrome'. Pharmacology & Therapeutics, 33 (9):1045-1052 [DOI] [Details]
(2011)'Gut Memories: Towards a Cognitive Neurobiology of Irritable Bowel Syndrome'
Kennedy, P.J., G. Clarke, G., Quigley, E.M.M., Groeger., J.A., Dinan., T.G., Cryan. J.F. ; (2011) 'Gut Memories: Towards a Cognitive Neurobiology of Irritable Bowel Syndrome'. Neuroscience and Biobehavioral Reviews, [Details]
(2011)'Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction'
O'Malley D, Dinan TG, Cryan JF (2011) 'Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction'. Journal of Neuroimmunology, 235 (1-2):48-55 [DOI] [Details]
(2011)'Chronic psychosocial stress induces visceral hyperalgesia in mice'
Tramullas M, Dinan TG, Cryan JF (2011) 'Chronic psychosocial stress induces visceral hyperalgesia in mice'. Stress (Amsterdam, Netherlands), [DOI] [Details]
(2011)'Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain'
Savignac HM, Finger BC, Pizzo RC, O'Leary OF, Dinan TG, Cryan JF; (2011) 'Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain'. Neuroscience, 192 :524-536 [DOI] [Details]
(2012)'Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent'
Julio-Pieper M, O'Mahony CM, Clarke G, Bravo JA, Dinan TG, Cryan JF (2012) 'Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent'. Stress (Amsterdam, Netherlands), [DOI] [Details]
(2012)'Gut memories: towards a cognitive neurobiology of irritable bowel syndrome'
Kennedy PJ, Clarke G, Quigley EM, Groeger JA, Dinan TG, Cryan JF (2012) 'Gut memories: towards a cognitive neurobiology of irritable bowel syndrome'. Neuroscience and Biobehavioral Reviews, 36 (1):310-340 [DOI] [Details]
(2012)'Dynamic 5-HT(2C) Receptor Editing in a Mouse Model of Obesity'
Schellekens H, Clarke G, Jeffery IB, Dinan TG, Cryan JF (2012) 'Dynamic 5-HT(2C) Receptor Editing in a Mouse Model of Obesity'. Plos One, 7 (3) [DOI] [CORA Link] [Details]
(2012)'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene×environment interaction'
Desbonnet L, O'Tuathaigh C, Clarke G, O'Leary C, Petit E, Clarke N, Tighe O, Lai D, Harvey R, Cryan JF, Dinan TG, Waddington JL (2012) 'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene×environment interaction'. Brain Behav Immun, [Details]
(2012)'Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype'
Dennison U, McKernan D, Cryan J, Dinan T (2012) 'Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype'. Psychological medicine, :1-7 [DOI] [Details]
(2012)'Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters'
Davey KJ, O'Mahony SM, Schellekens H, O'Sullivan O, Bienenstock J, Cotter PD, Dinan TG, Cryan JF (2012) 'Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters'. Pharmacology, 221 (1):155-169 [DOI] [Details]
(2012)'Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters'
Davey KJ, O'Mahony SM, Schellekens H, O'Sullivan O, Bienenstock J, Cotter PD, Dinan TG, Cryan JF (2012) 'Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters'. Pharmacology, 221 (1):155-169 [DOI] [Details]
(2012)'Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task'
Finger BC, Dinan TG, Cryan JF (2012) 'Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task'. Pharmacology, 220 (1):173-181 [DOI] [Details]
(2012)'A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome'
Clarke, G; McKernan, D; Gaszner, G; Quigley, E; Cryan, J; Dinan, T (2012) 'A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome'. Frontiers In Pharmacology, 3:90 [DOI] [Details]
(2013)'The Microbiome-Gut-Brain Axis During Early-Life Regulates the Hippocampal Serotonergic System in a Sex-Dependent Manner'
Clarke, G; Grenham, S; Scully, P; Fitzgerald, P; Moloney, R; Shanahan, F; Dinan, T; Cryan, J (2013) 'The Microbiome-Gut-Brain Axis During Early-Life Regulates the Hippocampal Serotonergic System in a Sex-Dependent Manner'. Molecular Psychiatry, 18 (6):666-673 [Details]
(2012)'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene x environment interaction'
Desbonnet, L,O'Tuathaigh, C,Clarke, G,O'Leary, C,Petit, E,Clarke, N,Tighe, O,Lai, D,Harvey, R,Cryan, JF,Dinan, TG,Waddington, JL (2012) 'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene x environment interaction'. Brain Behav Immun, 26 :660-671 [DOI] [Details]
(2012)'Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic, and Amygdala Dendritic Phenotypes'
Camp, MC,MacPherson, KP,Lederle, L,Graybeal, C,Gaburro, S,DeBrouse, LM,Ihne, JL,Bravo, JA,O'Connor, RM,Ciocchi, S,Wellman, CL,Luthi, A,Cryan, JF,Singewald, N,Holmes, A (2012) 'Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic, and Amygdala Dendritic Phenotypes'. Neuropsychopharmacology, 37 :1534-1547 [DOI] [Details]
(2012)'Chronic psychosocial stress induces visceral hyperalgesia in mice'
Tramullas, M,Dinan, TG,Cryan, JF (2012) 'Chronic psychosocial stress induces visceral hyperalgesia in mice'. Stress (Amsterdam, Netherlands), 15 :281-292 [DOI] [Details]
(2012)'Early-life stress induces visceral hypersensitivity in mice'
Moloney, RD,O'Leary, OF,Felice, D,Bettler, B,Dinan, TG,Cryan, JF (2012) 'Early-life stress induces visceral hypersensitivity in mice'. Neuroscience Letters, 512 :99-102 [DOI] [Details]
(2012)'An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour'
Browne, CA,Clarke, G,Dinan, TG,Cryan, JF (2012) 'An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour'. Neuropharmacology, 62 :1903-1915 [DOI] [Details]
(2012)'Menstrual Cycle Influences Toll-Like Receptor Responses'
Dennison, U,McKernan, DP,Scully, P,Clarke, G,Cryan, J,Dinan, T (2012) 'Menstrual Cycle Influences Toll-Like Receptor Responses'. Neuroimmunomodulation, 19 :171-179 [DOI] [Details]
(2012)'The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight'
Finger BC, Dinan TG, Cryan JF (2012) 'The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight'. Psychoneuroendocrinology, 37 (6):729-741 [DOI] [Details]
(2012)'Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression'
O'Connor RM, Dinan TG, Cryan JF (2012) 'Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression'. Molecular Psychiatry, 17 (4):359-376 [DOI] [Details]
(2012)'Early-life stress induces visceral hypersensitivity in mice'
Moloney RD, O'Leary OF, Felice D, Bettler B, Dinan TG, Cryan JF (2012) 'Early-life stress induces visceral hypersensitivity in mice'. Neuroscience Letters, 512 (2):99-102 [DOI] [Details]
(2012)'Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology'
Dinan TG, Cryan JF (2012) 'Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology'. Psychoneuroendocrinology, [DOI] [Details]
(2012)'Early-life stress induces visceral hypersensitivity in mice'
Moloney RD, O'Leary OF, Felice D, Bettler B, Dinan TG, Cryan JF. (2012) 'Early-life stress induces visceral hypersensitivity in mice'. Neuroscience Letters, 512 (2):99-102 [Details]
(2012)'An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour'
Browne CA, Clarke G, Dinan TG, Cryan JF (2012) 'An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour'. Neuropharmacology, [DOI] [Details]
(2012)'Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria'
Clarke G, Cryan JF, Dinan TG, Quigley EM (2012) 'Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria'. Alimentary Pharmacology And Therapeutics, 35 (4):403-413 [DOI] [Details]
(2012)'Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat'
O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF (2012) 'Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat'. British Journal of Pharmacology, [DOI] [Details]
(2012)'Menstrual Cycle Influences Toll-Like Receptor Responses'
Dennison U, McKernan DP, Scully P, Clarke G, Cryan J, Dinan T (2012) 'Menstrual Cycle Influences Toll-Like Receptor Responses'. Neuroimmunomodulation, 19 (3):171-179 [DOI] [Details]
(2011)'Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: Clinical significance of in vitro and in vivo findings'
O'Brien FE, Dinan TG, Griffin BT, Cryan JF; (2011) 'Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: Clinical significance of in vitro and in vivo findings'. British Journal of Pharmacology, [DOI] [Details]
(2011)'Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues'
Julio-Pieper M, Flor PJ, Dinan TG, Cryan JF; (2011) 'Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues'. Pharmacological reviews, [DOI] [Details]
(2011)'The microbiome-gut-brain axis: from bowel to behavior'
Cryan JF, O'Mahony SM; (2011) 'The microbiome-gut-brain axis: from bowel to behavior'. Neurogastroenterology and Motility, 23 (3):187-192 [DOI] [Details]
(2011)'Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains'
Browne CA, Clarke G, Dinan TG, Cryan JF; (2011) 'Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains'. Neuropharmacology, 60 (4):683-691 [DOI] [Details]
(2011)'Altered peripheral toll-like receptor responses in the irritable bowel syndrome'
McKernan, DP,Gaszner, G,Quigley, EM,Cryan, JF,Dinan, TG; (2011) 'Altered peripheral toll-like receptor responses in the irritable bowel syndrome'. Alimentary Pharmacology & Therapeutics, 33 :1045-1052 [DOI] [Details]
(2011)'Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders'
Bravo, JA,Dinan, TG,Cryan, JF; (2011) 'Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders'. International Journal of Neuropsychopharmacology, 14 :666-683 [DOI] [Details]
(2011)'Is there altered sensitivity to ghrelin-receptor ligands in leptin-deficient mice?: importance of satiety state and time of day'
Finger BC, Schellekens H, Dinan TG, Cryan JF; (2011) 'Is there altered sensitivity to ghrelin-receptor ligands in leptin-deficient mice?: importance of satiety state and time of day'. Psychopharmacology, [DOI] [Details]
(2010)'Riluzole Normalizes Early-Life Stress-induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms'
Gosselin, RD; O'Connor, RM; Tramullas, M; Julio-Pieper, M; Dinan, TG; Cryan, JF; (2010) 'Riluzole Normalizes Early-Life Stress-induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms'. Gastroenterology, [DOI] [Details]
(2010)'Lean mean fat reducing ghrelin machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity'
Schellekens, H; Dinan, TG; Cryan, JF; (2010) 'Lean mean fat reducing ghrelin machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity'. Neuropharmacology, 58 (1):2-16 [DOI] [Details]
(2010)'Colorectal distension-induced prefrontal cortex activation in the Wistar-Kyoto rat: implications for irritable bowel syndrome'
Gibney, SM; Gosselin, RD; Dinan, TG; Cryan, JF; (2010) 'Colorectal distension-induced prefrontal cortex activation in the Wistar-Kyoto rat: implications for irritable bowel syndrome'. Neuroscience, 165 (3):675-683 [DOI] [Details]
(2010)'Metabotropic glutamate receptor 7: At the interface of cognition and emotion'
O'Connor, RM; Finger, BC; Flor, PJ; Cryan, JF; (2010) 'Metabotropic glutamate receptor 7: At the interface of cognition and emotion'. European Journal of Pharmacology, [DOI] [Details]
(2010)'Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat'
Slattery, DA; Neumann, I; Cryan, JF; (2010) 'Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat'. Journal of Psychopharmacology, [DOI] [Details]
(2010)'Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood'
O'Malley, D; Dinan, TG; Cryan, JF; (2010) 'Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood'. Psychopharmacology, [DOI] [Details]
(2010)'Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour'
O'Mahony, CM; Sweeney, FF; Daly, E; Dinan, TG; Cryan, JF; (2010) 'Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour'. Behavioural Brain Research, 213 :148-154 [DOI] [Details]
(2010)'5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction'
O'Mahony, SM; Bulmer, DC; Coelho, AM; Fitzgerald, P; Bongiovanni, C; Lee, K; Winchester, W; Dinan, TG; Cryan, JF; (2010) '5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction'. Neurogastroenterology and Motility, 22 [DOI] [Details]
(2010)'A Sensitive Period of Mice Inhibitory System to Neonatal GABA Enhancement by Vigabatrin is Brain Region Dependent'
Levav-Rabkin, T; Melamed, O; Clarke, G; Farber, M; Cryan, JF; Dinan, TG; Grossman, Y; Golan, HM; (2010) 'A Sensitive Period of Mice Inhibitory System to Neonatal GABA Enhancement by Vigabatrin is Brain Region Dependent'. Neuropsychopharmacology, 35 :1138-1154 [DOI] [Details]
(2010)'GABAB receptors and depression. Current status'
Cryan JF, Slattery DA; (2010) 'GABAB receptors and depression. Current status'. Advances In Pharmacology, 58 :427-451 [DOI] [Details]
(2010)'IBs: an epigenetic perspective'
Dinan, Timothy G; Cryan, John; Shanahan, Fergus; Keeling, PW Napoleon; Quigley, Eamonn MM; (2010) 'IBs: an epigenetic perspective'. Nature Reviews Gastroenterology & Hepatology, 7 (8):465-471 [DOI] [Details]
(2010)'Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression'
O'Mahony CM, Clarke G, Gibney S, Dinan TG, Cryan JF; (2010) 'Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression'. Pharmacology Biochemistry and Behavior, [DOI] [Details]
(2010)'A Gut Feeling about GABA: Focus on GABAB receptors'
Hyland, NP; Cryan, JF; (2010) 'A Gut Feeling about GABA: Focus on GABAB receptors'. Frontiers in Pharmacology, [DOI] [Details]
(2011)'Maternal separation as a model of brain-gut axis dysfunction'
O'Mahony, SM; Hyland, NP; Dinan, TG; Cryan, JF; (2011) 'Maternal separation as a model of brain-gut axis dysfunction'. Psychopharmacology, [DOI] [Details]
(2010)'Colonic Soluble Mediators from the Maternal Separation Model of Irritable Bowel Syndrome Activate Submucosal Neurons via an Interleukin-6-dependent Mechanism'
O'Malley D, Liston M, Hyland NP, Dinan TG, Cryan JF; (2010) 'Colonic Soluble Mediators from the Maternal Separation Model of Irritable Bowel Syndrome Activate Submucosal Neurons via an Interleukin-6-dependent Mechanism'. American Journal of Physiology - Gastrointestinal and Liver Physiology, [DOI] [Details]
(2010)'Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome'
Clarke, G; Fitzgerald, P; Hennessy, AA; Cassidy, EM; Quigley, EMM; Ross, P; Stanton, C; Cryan, JF; Dinan, TG; (2010) 'Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome'. Journal of Lipid Research, 51 :1186-1192 [DOI] [Details]
(2010)'Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour'
O'Malley, D; Julio-Pieper, M; Gibney, SM; Dinan, TG; Cryan, JF; (2010) 'Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour'. Stress (Amsterdam, Netherlands), 13 :114-122 [DOI] [Details]
(2010)'Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat'
O'Malley, D; Julio-Pieper, M; Gibney, SM; Gosselin, RD; Dinan, TG; Cryan, JF; (2010) 'Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat'. Neurogastroenterology and Motility, 22 :301-311 [DOI] [Details]
(2010)'Neuroscience. A glutamate pathway to faster-acting antidepressants?'
Cryan JF, O'Leary OF; (2010) 'Neuroscience. A glutamate pathway to faster-acting antidepressants?'. Science, 329 (5994):913-914 [DOI] [Details]
(2010)'Progressive ratio responding in an obese mouse model: Effects of fenfluramine'
Finger BC, Dinan TG, Cryan JF; (2010) 'Progressive ratio responding in an obese mouse model: Effects of fenfluramine'. Neuropharmacology, 59 (7-8):619-626 [DOI] [Details]
(2010)'A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse'
Pieper-Julio, M; Hyland, NP; Bravo, JA; Dinan, TG; Cryan, JF; (2010) 'A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse'. British Journal of Pharmacology, 160 :367-375 [DOI] [Details]
(2010)'Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: Differential effects of acute psychological and physical stressors'
O'Malley, D; Dinan, TG; Cryan, JF; (2010) 'Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: Differential effects of acute psychological and physical stressors'. Peptides, 31 :662-670 [DOI] [Details]
(2010)'The effects of repeated social interaction stress on behavioural and physiological parameters in a stress-sensitive mouse strain'
Savignac, HM; Hyland, NP; Dinan, TG; Cryan, JF; (2010) 'The effects of repeated social interaction stress on behavioural and physiological parameters in a stress-sensitive mouse strain'. Behavioural Brain Research, [DOI] [Details]
(2010)'The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat'
McKernan, DP; Fitzgerald, P; Dinan, TG; Cryan, JF; (2010) 'The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat'. Neurogastroenterology and Motility, [DOI] [Details]
(2010)'Comparison of Hippocampal Metabotropic Glutamate Receptor 7 (mGlu(7)) mRNA Levels in Two Animal Models of Depression'
O'Mahony, CM; Bravo, J; Dinan, TG; Cryan, JF; (2010) 'Comparison of Hippocampal Metabotropic Glutamate Receptor 7 (mGlu(7)) mRNA Levels in Two Animal Models of Depression'. Neuroscience Letters, [DOI] [Details]
(2010)'Therapeutic targeting in the silent era: advances in non-viral siRNA delivery'
Guo, J; Fisher, KA; Darcy, R; Cryan, JF; O'Driscoll, C; (2010) 'Therapeutic targeting in the silent era: advances in non-viral siRNA delivery'. Molecular Biosystems, 6 (7):1143-1161 [DOI] [CORA Link] [Details]
(2010)'Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours'
Finger, BC; Dinan, TG; Cryan JF; (2010) 'Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours'. Psychopharmacology, [DOI] [Details]
(2009)'Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression'
Gosselin RD, Gibney S, O'Malley D, Dinan TG, Cryan JF; (2009) 'Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression'. Neuroscience, 159 (2):915-925 [DOI] [Details]
(2009)'Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome'
McKernan, DP,Nolan, A,Brint, EK,O'Mahony, SM,Hyland, NP,Cryan, JF,Dinan, TG; (2009) 'Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome'. Plos One, 4 [DOI] [Details]
(2009)'Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood'
Clarke, G,O'Mahony, SM,Hennessy, AA,Ross, P,Stanton, C,Cryan, JF,Dinan, TG; (2009) 'Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood'. Behavioural Brain Research, 205 :319-321 [DOI] [Details]
(2009)'REGION SPECIFIC DECREASE IN GLIAL FIBRILLARY ACIDIC PROTEIN IMMUNOREACTIVITY IN THE BRAIN OF A RAT MODEL OF DEPRESSION'
Gosselin, RD,Gibney, S,O'Malley, D,Dinan, TG,Cryan, JF; (2009) 'REGION SPECIFIC DECREASE IN GLIAL FIBRILLARY ACIDIC PROTEIN IMMUNOREACTIVITY IN THE BRAIN OF A RAT MODEL OF DEPRESSION'. Neuroscience, 159 :915-925 [DOI] [Details]
(2009)'Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol'
Clarke, G.,Fitzgerald, P.,Cryan, J. F.,Cassidy, E. M.,Quigley, E. M.,Dinan, T. G.; (2009) 'Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol'. BMC Gastroenterol, 9 [Details]
(2009)'A mouse model for visualization of GABA(B) receptors'
Casanova E, Guetg N, Vigot R, Seddik R, Julio-Pieper M, Hyland NP, Cryan JF, Gassmann M, Bettler B; (2009) 'A mouse model for visualization of GABA(B) receptors'. Genesis, 47 (9):595-602 [DOI] [Details]
(2009)'Killing the Blues: a role for cellular suicide (apoptosis) in depression and the antidepressant response?'
McKernan DP, Dinan TG, Cryan JF; (2009) 'Killing the Blues: a role for cellular suicide (apoptosis) in depression and the antidepressant response?'. Progress In Neurobiology, 88 (4):246-263 [DOI] [Details]
(2009)'Update on smoking cessation therapies'
Glynn DA, Cryan JF, Kent P, Flynn RA, Kennedy MP; (2009) 'Update on smoking cessation therapies'. Advances In Therapy, 26 (4):369-382 [DOI] [Details]
(2009)'Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?'
Clarke G, O'Mahony SM, Cryan JF, Dinan TG; (2009) 'Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?'. Human Psychopharmacology, 24 (3):217-223 [DOI] [Details]
(2009)'Irritable bowel syndrome: towards biomarker identification'
Clarke, G; Quigley, EM; Cryan, JF; Dinan, TG; (2009) 'Irritable bowel syndrome: towards biomarker identification'. Trends In Molecular Medicine, 15 (10):478-489 [DOI] [Details]
(2009)'A Distinct Subset of Submucosal Mast Cells Undergoes Hyperplasia Following Neonatal Maternal Separation: A Role In Visceral Hypersensitivity?'
Hyland, NP, Julio-Pieper, M, O'Mahony, SM, Bulmer, DC, Lee, K, Quigley, EM, Dinan, TG, Cryan, JF; (2009) 'A Distinct Subset of Submucosal Mast Cells Undergoes Hyperplasia Following Neonatal Maternal Separation: A Role In Visceral Hypersensitivity?'. Gut, (7):1029-1030 [DOI] [Details]
(2008)'The Rostral Anterior Cingulate Cortex Modulates The Efficiency of Amygdala-Dependent Fear Learning'
Bissiere, S, Plachta, N, Hoyer, D, McAllister, KH, Olpe, HR, Grace, AA, Cryan, JF; (2008) 'The Rostral Anterior Cingulate Cortex Modulates The Efficiency of Amygdala-Dependent Fear Learning'. Biological Psychiatry, 63 (9):821-831 [DOI] [Details]
(2008)'Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors'
Dinan TG, Clarke G, Quigley EM, Scott LV, Shanahan F, Cryan J, Cooney J, Keeling PW; (2008) 'Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors'. The American Journal of Gastroenterology, 103 (10):2570-2576 [DOI] [Details]
(2008)'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'
Fitzgerald, P,Eugene, MC,Clarke, G,Scully, P,Barry, S,Eamonn, MMQ,Shanahan, F,Cryan, J,Timothy, GD; (2008) 'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'. Neurogastroenterology and Motility, 20 :1291-1297 [DOI] [Details]
(2008)'Evaluation of the anxiolytic-like profile of the GABA(B) receptor positive modulator CGP7930 in rodents'
Jacobson, LH,Cryan, JF; (2008) 'Evaluation of the anxiolytic-like profile of the GABA(B) receptor positive modulator CGP7930 in rodents'. Neuropharmacology, 54 :854-862 [DOI] [Details]
(2008)'mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity'
Fendt, M,Schmid, S,Thakker, DR,Jacobson, LH,Yamamoto, R,Mitsukawa, K,Maier, R,Natt, F,Husken, D,Kelly, PH,McAllister, KH,Hoyer, D,van der Putten, H,Cryan, JF,Flor, PJ; (2008) 'mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity'. Molecular Psychiatry, 13 :970-979 [DOI] [Details]
(2008)'Specific roles of GABAB(1) receptor isoforms in cognition'
Jacobson LH, Kelly PH, Bettler B, Kaupmann K and Cryan JF ; (2008) 'Specific roles of GABAB(1) receptor isoforms in cognition'. Behavioural brain research, (181):158-162 [Details]
(2008)'Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission'
Stachowicz K, Brañski P, Kłak K, van der Putten H, Cryan JF, Flor PJ, Andrzej P; (2008) 'Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission'. Behavioural Pharmacology, [Details]
(2008)'Activation of mGluR7 alters amygdala plasticity and facilitates extinction of fear memories'
5. Fendt, M., Schmid, S., Thakker, D.R., Jacobson, L.H., Yamamota, R. Mitsukawa, K. Maier, R, McAllister, K.H., Hoyer, D. van der Putten, H. Cryan JF and Flor, P.J; (2008) 'Activation of mGluR7 alters amygdala plasticity and facilitates extinction of fear memories'. Molecular Psychiatry, [Details]
(2008)'Early life stress alters behaviour, immunity and microbiota: implications for irritable bowel syndrome and psychiatric illnesses'
2. O' Mahony SM, Marchesi J, Scully P, Codling C, Ceolho A-M, Quigley EMM, Cryan JF, and Dinan TG; (2008) 'Early life stress alters behaviour, immunity and microbiota: implications for irritable bowel syndrome and psychiatric illnesses'. Biological Psychiatry, [Details]
(2008)'Mglur7 Facilitates Extinction of Aversive Memories and Controls Amygdala Plasticity'
Fendt, M, Schmid, S, Thakker, DR, Jacobson, LH, Yamamoto, R, Mitsukawa, K, Maier, R, Natt, F, Husken, D, Kelly, PH, McAllister, KH, Hoyer, D, van der Putten, H, Cryan, JF, Flor, PJ; (2008) 'Mglur7 Facilitates Extinction of Aversive Memories and Controls Amygdala Plasticity'. Molecular Psychiatry, 13 (10):970-979 [DOI] [Details]
(2007)'Amyloid Precursor Protein Knockdown By Sirna Impairs Spontaneous Alternation In Adult Mice'
Senechal, Y, Kelly, PH, Cryan, JF, Natt, F, Dev, KK; (2007) 'Amyloid Precursor Protein Knockdown By Sirna Impairs Spontaneous Alternation In Adult Mice'. Journal of Neurochemistry, 102 (6):1928-1940 [DOI] [Details]
(2007)'Evaluation of Reward Processes In An Animal Model of Depression'
Slattery, DA, Markou, A, Cryan, JF; (2007) 'Evaluation of Reward Processes In An Animal Model of Depression'. Psychopharmacology, 190 (4):555-568 [DOI] [Details]
(2007)'GABAB Receptor positive modulation decreases selective molecular and behavioral effects of cocaine'
Lhuillier L., Mombereau C., *Cryan JF and *Kaupmann, K. ; (2007) 'GABAB Receptor positive modulation decreases selective molecular and behavioral effects of cocaine'. Neuropsychopharmacology, (32):388-398 [Details]
(2007)'Animal models of mood disorders: recent developments'
Cryan, JF,Slattery, DA; (2007) 'Animal models of mood disorders: recent developments'. Current Opinion In Psychiatry, 20 :1-7 [Details]
(2007)'GABA(B) receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens Delta FosB accumulation'
Mombereau, C,Lhuillier, L,Kaupmann, K,Cryan, JF; (2007) 'GABA(B) receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens Delta FosB accumulation'. Journal of Pharmacology and Experimental Therapeutics, 321 :172-177 [DOI] [Details]
(2007)'Feeling strained? Influence of genetic background on depression-related behavior in mice: A review'
Jacobson LH and Cryan JF; (2007) 'Feeling strained? Influence of genetic background on depression-related behavior in mice: A review'. Behavior Genetics, (37):171-213 [Details]
(2007)'Behavioural evaluation of mice deficient in GABAB(1) receptor isoforms in tests of unconditioned anxiety'
Jacobson LH, Kaupmann, K., Bettler., Cryan JF ; (2007) 'Behavioural evaluation of mice deficient in GABAB(1) receptor isoforms in tests of unconditioned anxiety'. Psychopharmacology, (190):541-553 [Details]
(2007)'Antidepressant-like effects of the novel, slelective, 5-HT2C receptor agonist WAY-163909 in rodents'
Rosenzweig-Lipson S, Sabb A, Stack G, Mitchell PJ, Lucki I, Malberg J, Grauer S, Brennan J, Cryan JF, Dunlop J, Barrett J, Marquis KL; (2007) 'Antidepressant-like effects of the novel, slelective, 5-HT2C receptor agonist WAY-163909 in rodents'. Psychopharmacology, :159-170 [Details]
(2007)'Neurogenetics and Behaviour: From Basic Processes to Neuropsychiatric Disorders'
Cryan, JF, Driscoll, P, Waddington, JL; (2007) 'Neurogenetics and Behaviour: From Basic Processes to Neuropsychiatric Disorders'. Neuroscience & Biobehavioral Reviews, (1):1-2 [DOI] [Details]
(2007)'Concise Clinical Pharmacology'
Sahm L., and Cryan J.F.; (2007) 'Concise Clinical Pharmacology'. Irish Pharmacy Journal, [Details]
(2007)'Emerging use of non-viral RNA interference in the brain'
Cryan JF, Thakker DR, Hoyer D; (2007) 'Emerging use of non-viral RNA interference in the brain'. Biochemical Society Transactions, 35 (Pt 2):411-415 [DOI] [Details]
(2006)'The Rostral Anterior Cingulate Cortex Modulates Depression But Not Anxiety-Related Behaviour In The Rat'
Bissiere, S, McAllister, KH, Olpe, HR, Cryan, JF; (2006) 'The Rostral Anterior Cingulate Cortex Modulates Depression But Not Anxiety-Related Behaviour In The Rat'. Behavioural Brain Research, 175 (1):195-199 [DOI] [Details]
(2006)'Gaba(B(1)) Receptor Subunit Isoforms Exert A Differential Influence On Baseline But Not Gaba(B) Receptor Agonist-Induced Changes In Mice'
Jacobson, LH, Bettler, B, Kaupmann, K, Cryan, JF; (2006) 'Gaba(B(1)) Receptor Subunit Isoforms Exert A Differential Influence On Baseline But Not Gaba(B) Receptor Agonist-Induced Changes In Mice'. Journal of Pharmacology and Experimental Therapeutics, 319 (3):1317-1326 [DOI] [Details]
(2006)'The role of GABAB receptors in depression and the antidepressant response'
Slattery DA, Cryan JF; (2006) 'The role of GABAB receptors in depression and the antidepressant response'. Drug Development Research, :477-494 [Details]
(2006)'GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories'
Jacobson, LH,Kelly, PH,Bettler, B,Kaupmann, K,Cryan, JF; (2006) 'GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories'. The Journal of Neuroscience, 26 :8800-8803 [DOI] [Details]
(2006)'GABA(B(1)) receptor subunit isoforms exert a differential influence on baseline but not GABA(B) receptor agonist-induced changes in mice'
Jacobson, LH,Bettler, B,Kaupmann, K,Cryan, JF; (2006) 'GABA(B(1)) receptor subunit isoforms exert a differential influence on baseline but not GABA(B) receptor agonist-induced changes in mice'. Journal of Pharmacology and Experimental Therapeutics, 319 :1317-1326 [DOI] [Details]
(2006)'Differential compartmentalization and distinct functions of GABAB receptor variants'
Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG and Bettler B; (2006) 'Differential compartmentalization and distinct functions of GABAB receptor variants'. Neuron, (50):589-601 [Details]
(2006)'Interfering with the brain: The utility of siRNA to unravel the pathophysiology of psychiatric and neurological disorders'
Thakker DR, Hoyer D, Cryan JF; (2006) 'Interfering with the brain: The utility of siRNA to unravel the pathophysiology of psychiatric and neurological disorders'. Pharmacology &Amp; Therapeutics, (109):413-438 [Details]
(2006)'Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders'
Hoyer D, Thakker DR, Natt F, Maier R, Huesken D, Müller M, Flor PJ, van der Putten H, Schmutz M, Bilbe, G. and Cryan JF; (2006) 'Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders'. Journal of Receptors and Signal Transduction, (26):527-547 [Details]
(2006)'GABAB(1) receptor isoforms differentially mediate the acquisition and the extinction of aversive taste learning'
Jacobson LH, Kelly PH, Bettler B, Kaupmann K and Cryan JF; (2006) 'GABAB(1) receptor isoforms differentially mediate the acquisition and the extinction of aversive taste learning'. Journal of Neuroscience, (26):8800-8803 [Details]
(2006)'Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels; implications for stress-related psychiatric disorders'
Mitsukawa K, Mombereau C, Loetscher E, Uzunov D, van der Putten H, Flor PJ, Cryan JF; (2006) 'Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels; implications for stress-related psychiatric disorders'. Neuropsychopharmacology, :1112-1122 [Details]
(2006)'Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in mGluR7-deficient mice'
Callaerts-Vegh Z, Beckers T, Baeyens F, Callaerts PF, Cryan JF, Molnar E, D'Hooge R; (2006) 'Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in mGluR7-deficient mice'. Journal of Neuroscience, :6573-6582 [CORA Link] [Details]
(2005)'The GABAB receptor positive modulator GS39783 and the GABAB receptor agonist decrease the rewarding effects of cocaine: Intracranial self-stimulation studies in the rat'
Slattery DA, Markou A. and Cryan JF; (2005) 'The GABAB receptor positive modulator GS39783 and the GABAB receptor agonist decrease the rewarding effects of cocaine: Intracranial self-stimulation studies in the rat'. Neuropsychopharmacology, 30 (11):2065-2072 [Details]
(2005)'siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. '
Thakker DR, Natt F, Husken D, van der Putten H, Maier R, Hoyer D, Cryan JF; (2005) 'siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. '. Molecular Psychiatry, 10 (8):782-789 [Details]
(2005)'Short and long-term administration of reboxetine, fluoxetine and moclobemide differentially alter behaviour in a modified rat forced swim test'
Cryan JF, Page M.E. and Lucki I.; (2005) 'Short and long-term administration of reboxetine, fluoxetine and moclobemide differentially alter behaviour in a modified rat forced swim test'. Psychopharmacology, 6 (*):1-10 [Details]
(2005)'Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. '
Cryan JF, Kaupmann K. ; (2005) 'Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. '. Trends In Pharmacological Sciences, 26 (1):36-43 [Details]
(2005)'Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. '
Jacobson LH, Cryan JF; (2005) 'Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. '. Psychopharmacology, 179 (3):688-699 [Details]
(2005)'The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. '
Cryan JF, Mombereau C, Vassout A. ; (2005) 'The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. '. Neuroscience & Biobehavioral Reviews, 29 (4-5):571-625 [Details]
(2005)'Blockade of the Group I metabotropic glutamate receptor mGluR5 decreases basal and stress induced increases in cortical norepinephrine in the rat'
Page, M.E., Szeliga, P.J., Gasparini, F. and Cryan, JF ; (2005) 'Blockade of the Group I metabotropic glutamate receptor mGluR5 decreases basal and stress induced increases in cortical norepinephrine in the rat'. Psychopharmacology, (179):240-246 [Details]
(2005)'GABAB receptor-mediated antidepressant-like effects are serotonin dependent'
Slattery, D., Desrayaud, S. and Cryan JF ; (2005) 'GABAB receptor-mediated antidepressant-like effects are serotonin dependent'. Journal of Pharmacology and Experimental Therapeutics, (312):290-296 [Details]
(2005)'The modified rat forced swim test: Assessing serotonergic influences on depression-related behavior'
Cryan JF, Valentino RJ, Lucki I; (2005) 'The modified rat forced swim test: Assessing serotonergic influences on depression-related behavior'. Neuroscience & Biobehavioral Reviews, 29 (4-5):547-569 [Details]
(2005)'Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. '
Mombereau C, Kaupmann K, Gassmann M, Bettler B, van der Putten H, Cryan JF. ; (2005) 'Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. '. Neuroreport, 28 (16):307-310 [Details]
(2005)'Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents. '
Page ME, Szeliga P, Gasparini F, Cryan JF; (2005) 'Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents. '. Psychopharmacology, 179 (1):240-246 [Details]
(2005)'The first selective mGluR7 agonist, AMN082 activates receptor signaling via a novel allosteric site and modulates stress parameters in vivo'
Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, Stoehr N, Mombereau C, Kuhn R, McAllister KH, van der Putten H, Cryan JF, Flor PJ; (2005) 'The first selective mGluR7 agonist, AMN082 activates receptor signaling via a novel allosteric site and modulates stress parameters in vivo'. Proceedings of The National Academy of Sciences of The United States of America, :18712-18717 [Details]
(2005)'The ascent of mouse: Using mice to model human depression and anxiety'
Cryan JF, Holmes A; (2005) 'The ascent of mouse: Using mice to model human depression and anxiety'. Nature Reviews Drug Discovery, :775-790 [Details]
(2004)'Genetic and pharmacological evidence of a key role for GABAB receptors in the modulation of anxiety and antidepressant-like behaviour'
Mombereau C., Kaupmann K., Froestl, W. Sansig, G. van der Putten H. and Cryan, JF; (2004) 'Genetic and pharmacological evidence of a key role for GABAB receptors in the modulation of anxiety and antidepressant-like behaviour'. Neuropsychopharmacology, 29 (6):1050-1062 [Details]
(2004)'Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. '
Gassmann M., Shaban H., Vigot R., Sansig G., Haller C., Barbieri S., Humeau Y., Schuler V., Muller M., Kinzel B., Klebs K., Schmutz M., Froestl W., Heid J., Kelly P.H., Gentry C., Jaton A.L., Van der Putten H., Mombereau C., Lecourtier L., Mosbacher J., Cryan JF, Fritschy J.M., Luthi A., Kaupmann K., Bettler B. ; (2004) 'Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. '. Journal of Neuroscience, 24 (27):6086-6097 [Details]
(2004)'In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice'
Cryan JF, Mombereau C.; (2004) 'In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice'. Molecular Psychiatry, 9 (4):326-357 [Details]
(2004)'Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors'
Cryan, JF, O’Leary O., Hirsch, B.R., Jin S-H, Page M.E., Dalvi A., Thomas S.A. and Lucki I.; (2004) 'Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors'. Proceedings of The National Acadamy of Sciences, 101 (*):8186-8191 [Details]
(2004)'Altered response to benzodiazepine anxiolytics in mice lacking GABAB(1) receptors'
Mombereau C., Kaupmann K., van der Putten H., and Cryan JF; (2004) 'Altered response to benzodiazepine anxiolytics in mice lacking GABAB(1) receptors'. European Journal of Pharmacology, 497 (1):119-120 [Details]
(2004)'Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines'
Cryan JF, Kelly PH, Chaperon F, Gentsch C, Froestl W, Mombereau C, Lingenhoehl K, Bettler B, Kaupmann K, Spooren WPJM; (2004) 'Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines'. Journal of Pharmacology and Experimental Therapeutics, :952-963 [Details]
(2003)'The antidepressant bupropion enhances brain reward function and reverses affective and somatic aspects of nicotine withdrawal'
Cryan J.F, Bruijnzeel A.W., Skjei K.S. and Markou A.; (2003) 'The antidepressant bupropion enhances brain reward function and reverses affective and somatic aspects of nicotine withdrawal'. Psychopharmacology, 168 (*):347-358 [Details]
(2003)'Withdrawal from chronic amphetamine induces depression-like behavioural effects in rodents'
Cryan J.F., Hoyer D. and Markou A.; (2003) 'Withdrawal from chronic amphetamine induces depression-like behavioural effects in rodents'. Biological Psychiatry, 54 (*):49-58 [Details]
(2003)'Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7'
Cryan J.F., Kelly P.H., Sansig G., Flor P.J. and van Der Putten H.; (2003) 'Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7'. European Journal of Neuroscience, 17 (11):2409-2417 [Details]
(2003)'Non-nicotinic neuropharmacological strategies for Smoking Cessation'
Cryan J.F., Gasparini F., van Heeke G. and Markou A.; (2003) 'Non-nicotinic neuropharmacological strategies for Smoking Cessation'. Drug Discovery Today, 8 (22):1025-1034 [Details]
(2003)'Specific ã-Hydroxybutyrate (GHB) binding sites but loss of pharmacological effects of GHB in GABA-B(1) receptor deficient mice'
Kaupmann K., Cryan J.F., Wellendorph P., Mombereau C., Sansig G., Klebs K., Schmutz, M., Froestl, W. van der Putten, H., Mosbacher, J., Bräuner-Osborne, H., Waldmeier, P., and Bettler, B.; (2003) 'Specific ã-Hydroxybutyrate (GHB) binding sites but loss of pharmacological effects of GHB in GABA-B(1) receptor deficient mice'. European Journal of Neuroscience, 18 (10):2722-2730 [Details]
(2002)'Neurochemical and behavioral characterization of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor EMD 68843'
Page M.E., Cryan J.F., Sulivan A., Dalvi A. and Lucki I.; (2002) 'Neurochemical and behavioral characterization of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor EMD 68843'. The Journal of Pharmacology and Experimental Therapeuti, 302 (3):1220-1227 [Details]
(2002)'Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine'
Cryan, J.F. Page M.E., and Lucki. I.; (2002) 'Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine'. European Journal of Pharmacology, 436 (3):197-205 [Details]
(2002)'CREB is essential for upregulation of brain derived neurotrophic factor transcription, but not behavioral or endocrine responses to antidepressant drugs'
Conti A.C., Cryan J.F., Dalvi A., Lucki I. and Blendy J.A.; (2002) 'CREB is essential for upregulation of brain derived neurotrophic factor transcription, but not behavioral or endocrine responses to antidepressant drugs'. Journal of Neuroscience, 15 (22):3262-3268 [Details]
(2002)'Assessing antidepressant activity in rodents: recent developments and future needs. '
Cryan J.F., Markou A., Lucki I. ; (2002) 'Assessing antidepressant activity in rodents: recent developments and future needs. '. Trends In Pharmacological Sciences, 23 (5):238-245 [Details]
(2001)'Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs. '
Cryan J.F., Dalvi A., Hirsch B.R., Jin, S-H, Lucki , I. and Thomas, S.A.; (2001) 'Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs. '. The Journal of Pharmacology and Experimental Therapeuti, 298 (2):651-657 [Details]
(2000)'Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors'
Cryan J.F. and Lucki I.; (2000) 'Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors'. The Journal of Pharmacology and Experimental Therapeuti, 295 (3):1120-1126 [Details]
(2000)'Pindolol augmentation of antidepressants: a review and rationale. '
Olver J.S., Cryan J.F., Burrows G.D. and Norman T.R.; (2000) 'Pindolol augmentation of antidepressants: a review and rationale. '. Australian and New Zealand Journal of Psychiatry, 34 (1):71-79 [Details]
(2000)'5-HT1A and Beyond- The role of serotonin and its receptors in depression and the antidepressant response'
Cryan J.F. and Leonard B.E.; (2000) '5-HT1A and Beyond- The role of serotonin and its receptors in depression and the antidepressant response'. Human Psychopharmacology, 15 (2):113-135 [Details]
(2000)'Characterization of d-fenfluramine-induced hypothermia- Evidence for multiple sites of action'
Cryan J.F., Harkin A., Kelly J.P. and Leonard B.E.; (2000) 'Characterization of d-fenfluramine-induced hypothermia- Evidence for multiple sites of action'. European Journal of Pharmacology, 390 (3):275-285 [Details]
(1999)'Metyrapone displays antidepressant-like properties in preclinical paradigms'
Healy D.G., Harkin A. Cryan J.F., Kelly J.P. and Leonard B.E.; (1999) 'Metyrapone displays antidepressant-like properties in preclinical paradigms'. Psychopharmacology, 145 (3):303-308 [Details]
(1999)'Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. '
Cryan J.F., McGrath C., Leonard B.E. and Norman T.R.; (1999) 'Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. '. Pharmacology Biochemistry and Behavior, 63 (2):333-338 [Details]
(1999)'Comparative effects of serotonergic agonists with varying efficacy at the 5-HT1A receptor on core body temperature: Modification by the selective 5-HT1A receptor antagonist WAY-100635'
Cryan J.F., Kelliher P., Kelly J.P. and Leonard B.E.; (1999) 'Comparative effects of serotonergic agonists with varying efficacy at the 5-HT1A receptor on core body temperature: Modification by the selective 5-HT1A receptor antagonist WAY-100635'. Journal of Psychopharmacology, 13 (3):278-283 [Details]
(1998)'Combining pindolol and paroxetine in an animal model of chronic antidepressant action - Can early onset of action be detected?'
Cryan J.F., McGrath C., Leonard B.E. and Norman T.R.; (1998) 'Combining pindolol and paroxetine in an animal model of chronic antidepressant action - Can early onset of action be detected?'. European Journal of Pharmacology, 352 (1):23-28 [Details]
(1997)'The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat. '
Cryan J.F., Redmond A.M., Kelly J.P. and Leonard B.E.; (1997) 'The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat. '. European Neuropsychopharmacology, 7 (2):109-114 [Details]
(2014)'Strain differences in stress-induced changes in central CRF1 receptor expression'
O’Malley D, Julio-Pieper M, Dinan TG & Cryan JF (2014) 'Strain differences in stress-induced changes in central CRF1 receptor expression'. Neuroscience Letters, 21 (561):192-197 [Details]
(1996)'Does the serenic eltoprazine have antidepressant potential? -An investigation in three rodent paradigms'
Cryan J.F., Redmond A.M., Kelly J.P. and Leonard B.E.; (1996) 'Does the serenic eltoprazine have antidepressant potential? -An investigation in three rodent paradigms'. Medical Science Research, 24 (*):719-720 [Details]
(2014)'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'
O’Malley D, Julio-Pieper M, O’Mahony, SM, Dinan TG & Cryan JF (2014) 'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'. Experimental Physiology, 99 (2):359-367 [Details]
(2013)'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'
O'Brien, FE,O'Connor, RM,Clarke, G,Dinan, TG,Griffin, BT,Cryan, JF (2013) 'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. Neuropsychopharmacology, 38 :2209-2219 [DOI] [Details]
(2007)'Specific roles of GABA(B(l)) receptor isoforms in cognition'
Jacobson, LH,Kelly, PH,Bettler, B,Kaupmann, K,Cryan, JF (2007) 'Specific roles of GABA(B(l)) receptor isoforms in cognition'. Behavioural Brain Research, 181 :158-162 [DOI] [Details]
(2013)'Milk protein hydrolysates activate 5-HT2C serotonin receptors: influence of the starting substrate and isolation of bioactive fractions'
Nongonierma, AB,Schellekens, H,Dinan, TG,Cryan, JF,FitzGerald, RJ (2013) 'Milk protein hydrolysates activate 5-HT2C serotonin receptors: influence of the starting substrate and isolation of bioactive fractions'. Food & Function, 4 :728-737 [DOI] [Details]
(2013)'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'
O'Mahony, AM,Ogier, J,Darcy, R,Cryan, JF,O'Driscoll, CM (2013) 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'. Plos One, 8 [DOI] [Details]
(2013)'Disodium Cromoglycate Reverses Colonic Visceral Hypersensitivity and Influences Colonic Ion Transport in a Stress-Sensitive Rat Strain'
Carroll, SY,O'Mahony, SM,Grenham, S,Cryan, JF,Hyland, NP (2013) 'Disodium Cromoglycate Reverses Colonic Visceral Hypersensitivity and Influences Colonic Ion Transport in a Stress-Sensitive Rat Strain'. Plos One, 8 [DOI] [Details]
(2013)'Effects of the Intestinal Microbiota on Behavior and Brain Biochemistry'
Barrett, E,Dinan, TG,Cryan, JF,Quigley, EMM,Shanahan, F,O'Toole, PW,Fitzgerald, GF,Stanton, C,Ross, RP,Guarino, A,Quigley, EMM,Walker, WA (2013) 'Effects of the Intestinal Microbiota on Behavior and Brain Biochemistry'. Probiotic Bacteria And Their Effect On Human Health And Well-Being, 107 :56-63 [DOI] [Details]
(2013)'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'
Mahony, SMO,Clarke, G,McKernan, DP,Bravo, JA,Dinan, TG,Cryan, JF (2013) 'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'. Behavioural Brain Research, 253 :310-317 [DOI] [Details]
(2011)'Resistance to early-life stress in mice: effects of genetic background and stress duration'
Savignac, HM,Dinan, TG,Cryan, JF (2011) 'Resistance to early-life stress in mice: effects of genetic background and stress duration'. Frontiers In Behavioral Neuroscience, 5 [DOI] [Details]
(2013)'The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner'
Clarke, G,Grenham, S,Scully, P,Fitzgerald, P,Moloney, RD,Shanahan, F,Dinan, TG,Cryan, JF (2013) 'The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner'. Molecular Psychiatry, 18 :666-673 [DOI] [Details]
(2013)'GABA(B) receptor ligands do not modify conditioned fear responses in BALB/c mice'
Sweeney, FF,O'Leary, OF,Cryan, JF (2013) 'GABA(B) receptor ligands do not modify conditioned fear responses in BALB/c mice'. Behavioural Brain Research, 256 :151-156 [DOI] [Details]
(2013)'The orthosteric GABA(A) receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors'
Hoestgaard-Jensen, K,O'Connor, RM,Dalby, NO,Simonsen, C,Finger, BC,Golubeva, A,Hammer, H,Bergmann, ML,Kristiansen, U,Krogsgaard-Larsen, P,Brauner-Osborne, H,Ebert, B,Frolund, B,Cryan, JF,Jensen, AA (2013) 'The orthosteric GABA(A) receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors'. British Journal of Pharmacology, 170 :919-932 [DOI] [Details]
(2013)'Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion'
O'Malley D, Cryan JF, Dinan TG (2013) 'Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion'. Brain Behav Immun, doi:pii: S0889-1591(13)00081-0. 10.1016/j.bbi.2013.01.078. [Epub ahead of print] [Details]
(2013)'In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery'
O'Mahony, AM,Desgranges, S,Ogier, J,Quinlan, A,Devocelle, M,Darcy, R,Cryan, JF,O'Driscoll, CM (2013) 'In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery'. Pharmaceutical Research, 30 :1086-1098 [DOI] [Details]
(2013)'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'
Schellekens, H,McNamara, O,Dinan, TG,McCarthy, JV,McGlacken, GP,Cryan, JF (2013) 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. Journal of Pharmacy and Pharmacology, 65 :528-538 [DOI] [Details]
(2013)'Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment'
O'Connor, RM,Pusceddu, MM,Dinan, TG,Cryan, JF (2013) 'Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment'. Neuropharmacology, 66 :236-241 [DOI] [Details]
(2013)'The effects of mGlu(7) receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains'
O'Connor, RM,Cryan, JF (2013) 'The effects of mGlu(7) receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains'. Behavioural Pharmacology, 24 :105-113 [DOI] [Details]
(2013)'Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action'
O'Connor, RM,Pusceddu, MM,O'Leary, OF,Savignac, HM,Bravo, JA,El Yacoubi, M,Vaugeois, JM,Dinan, TG,Cryan, JF (2013) 'Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action'. Pharmacology Biochemistry and Behavior, 103 :561-567 [DOI] [Details]
(2013)'Self-assembling Modified beta-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'
Godinho, BMDC,Ogier, JR,Darcy, R,Driscoll, CM,Cryan, JF (2013) 'Self-assembling Modified beta-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'. Molecular Pharmaceutics, 10 :640-649 [DOI] [Details]
(2013)'LITHIUM AUGMENTATION OF THE EFFECTS OF DESIPRAMINE IN A MOUSE MODEL OF TREATMENT-RESISTANT DEPRESSION: A ROLE FOR HIPPOCAMPAL CELL PROLIFERATION'
O'Leary, OF,Zandy, S,Dinan, TG,Cryan, JF (2013) 'LITHIUM AUGMENTATION OF THE EFFECTS OF DESIPRAMINE IN A MOUSE MODEL OF TREATMENT-RESISTANT DEPRESSION: A ROLE FOR HIPPOCAMPAL CELL PROLIFERATION'. Neuroscience, 228 :36-46 [DOI] [Details]
(2013)'Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling'
Schellekens, H,van Oeffelen, WEPA,Dinan, TG,Cryan, JF (2013) 'Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling'. The Journal of Biological Chemistry, 288 :181-191 [DOI] [Details]
(2012)'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'
O'Mahony, AM,Doyle, D,Darcy, R,Cryan, JF,O'Driscoll, CM (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 :896-903 [DOI] [Details]
(2012)'Communication between gastrointestinal bacteria and the nervous system'
Bravo, JA,Julio-Pieper, M,Forsythe, P,Kunze, W,Dinan, TG,Bienenstock, J,Cryan, JF (2012) 'Communication between gastrointestinal bacteria and the nervous system'. Current Opinion In Pharmacology, 12 :667-672 [DOI] [Details]
(2013)'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'
O'Brien FE, O'Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (2013) 'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. Neuropsychopharmacology, [DOI] [Details]
(2014)'Microbiota is essential for social development in the mouse'
Desbonnet, L; Clarke, G; Shanahan, F; Dinan, TG; Cryan, JF (2014) 'Microbiota is essential for social development in the mouse'. Molecular Psychiatry, [DOI] [Details]
(2014)'Microbiota is essential for social development in the mouse'
Desbonnet, L; Clarke, G; Shanahan, F; Dinan, TG; Cryan, JF (2014) 'Microbiota is essential for social development in the mouse'. Molecular Psychiatry, [DOI] [Details]
(2013)'Human P-glycoprotein Differentially Affects Antidepressant Drug Transport: Relevance to Blood-Brain Barrier Permeability'
O'Brien FE; Clarke G; Dinan TG; Griffin BT; Cryan JF (2013) 'Human P-glycoprotein Differentially Affects Antidepressant Drug Transport: Relevance to Blood-Brain Barrier Permeability'. International Journal of Neurosychopharmacology, [Details]
(2013)'Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain'
Browne CA; Clarke G; Hanke J; Dinan TG; Schwegler H; Yilmazer-Hanke DM; Cryan JF (2013) 'Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain'. Behavioral Brain Research, [Details]
(2013)'Self-assembling Modified Beta-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease. Molecular Pharmaceutics'
Godinho BMDC, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF (2013) 'Self-assembling Modified Beta-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease. Molecular Pharmaceutics'. Molecular Pharmaceutics, 10 :640-649 [DOI] [Details]
(2014)'A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'
Naughton M, Clarke G, O'Leary OF, Cryan JF, Dinan TG (2014) 'A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'. Journal of Affective Disorders, 156 :24-35 [Details]
(2013)'Effects of the Intestinal Microbiota on Behavior and Brain Biochemistry'
Barrett, E.,Dinan, T. G.,Cryan, J. F.,Quigley, E. M. M.,Shanahan, F.,O'Toole, P. W.,Fitzgerald, G. F.,Stanton, C.,Ross, R. P. (2013) 'Effects of the Intestinal Microbiota on Behavior and Brain Biochemistry'. Probiotic Bacteria and Their Effect on Human Health and Well-Being, 107 :56-6356 [Details]
(2014)'Activation but not Blockade of GABAB Receptors During Early-life Alters Anxiety in Adulthood in BALB/c mice'
Sweeney F., O'Leary O.F., Cryan J.F. (2014) 'Activation but not Blockade of GABAB Receptors During Early-life Alters Anxiety in Adulthood in BALB/c mice'. Neuropharmacology, 81 :303-310 [Details]
(2013)'GABAB receptor ligands do not modify conditioned fear responses in BALB/c mice'
Sweeney F.F., O'Leary O.F., Cryan J.F. (2013) 'GABAB receptor ligands do not modify conditioned fear responses in BALB/c mice'. Behavioural Brain Research, 256 :151-156 [DOI] [Details]
(2013)'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'
O'Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2013) 'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'. International Journal of Neuropsychopharmacology, :1-14 [DOI] [Details]
(2013)'Cationic and PEGylated amphiphilic Cyclodextrins: Co-formulation opportunities for neuronal siRNA delivery. PLoS ONE'
O'Mahony AM, Ogier J, Darcy R, Cryan JF, O'Driscoll CM (2013) 'Cationic and PEGylated amphiphilic Cyclodextrins: Co-formulation opportunities for neuronal siRNA delivery. PLoS ONE'. Plos One, 8 (6) [DOI] [Details]
(2013)'The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner'
Clarke, G.,Grenham, S.,Scully, P.,Fitzgerald, P.,Moloney, R. D.,Shanahan, F.,Dinan, T. G.,Cryan, J. F. (2013) 'The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner'. Molecular Psychiatry, 18 (66):666-673 [Details]
(2013)'A Prospective Assessment of Cognitive Performance in Irritable Bowel Syndrome Reveals Persistent Visuospatial Memory Deficits'
Kennedy, P. J.,Clarke, G.,Allen, A. P.,O'Neill, A.,Groeger, J. A.,Quigley, E. M.,Shanahan, F.,Cryan, J. F.,Dinan, T. G. (2013) 'A Prospective Assessment of Cognitive Performance in Irritable Bowel Syndrome Reveals Persistent Visuospatial Memory Deficits'. Gastroenterology, 144 (55) [Details]
(2013)'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'
Godinho BMDC., McCarthy DJ., Torres-Fuentes C., Beltrán CJ., McCarthy J., Quinlan A., Ogier JR., Darcy R., O’Driscoll CM.., Cryan JF. (2013) 'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'. Biomaterials, [Details]
(2013)'Drugs, Genes and the Blues: Pharmacogenetics of the Antidepressant Response from Mouse to Man'
O’Leary O.F., O’Brien F.E., O’Connor R.M., Cryan J.F. (2013) 'Drugs, Genes and the Blues: Pharmacogenetics of the Antidepressant Response from Mouse to Man'. Pharmacology Biochemistry and Behavior, (123):55-76 [Details]
(2013)'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'
O' Mahony SM, Clarke G, McKernan DP, Bravo JA, Dinan TG, Cryan JF. (2013) 'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'. European Journal of Pharmacology, 15 (253):310-317 [DOI] [Details]
(2012)'Bifidobacterium breve with alpha-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome'
Barrett, E.,Fitzgerald, P.,Dinan, T. G.,Cryan, J. F.,Ross, R. P.,Quigley, E. M.,Shanahan, F.,Kiely, B.,Fitzgerald, G. F.,O'Toole, P. W.,Stanton, C. (2012) 'Bifidobacterium breve with alpha-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome'. PLoS One, 7 (1111) [Details]
(2012)'The microbiome-gut-brain axis as a regulator of serotonergic neurotransmission and behaviour'
Clarke, G.,Grenham, S.,Scully, P.,Fitzgerald, P.,Moloney, R.,Shanahan, F.,Dinan, T.,Cryan, J. (2012) 'The microbiome-gut-brain axis as a regulator of serotonergic neurotransmission and behaviour'. Neurogastroenterology and Motility, 24 :149-149149 [Details]
(2012)'An Assessment of Cognitive Function in Irritable Bowel Syndrome (IBS): Are Deficits in Visuo-Spatial Memory Stress-Related and Mediated by Tryptophan Metabolism Along the Kynurenine Pathway?'
Kennedy, P. J.,Clarke, G.,O'Neill, A.,Groeger, J. A.,Quigley, E. M.,Shanahan, F.,Cryan, J. F.,Dinan, T. G. (2012) 'An Assessment of Cognitive Function in Irritable Bowel Syndrome (IBS): Are Deficits in Visuo-Spatial Memory Stress-Related and Mediated by Tryptophan Metabolism Along the Kynurenine Pathway?'. Gastroenterology, 142 (55) [Details]
(2012)'An evaluation of neuropsychological performance in Irritable Bowel Syndrome (IBS): Relationship between altered visuo-spatial memory function, salivary cortisol levels and tryptophan metabolism along the kynurenine pathway'
Kennedy, P.,Clarke, G.,O'Neill, A.,O'Mahony, C.,Groeger, J. A.,Quigley, E. M.,Shanahan, F.,Cryan, J. F.,Dinan, T. G. (2012) 'An evaluation of neuropsychological performance in Irritable Bowel Syndrome (IBS): Relationship between altered visuo-spatial memory function, salivary cortisol levels and tryptophan metabolism along the kynurenine pathway'. Neurogastroenterology and Motility, 24 :175-175175 [Details]
(2012)'Regulation of Serotonergic Neurotransmission and Behaviour by the Brain-Gut-Microbiome Axis'
Clarke, G.,Grenham, S.,Fitzgerald, P.,Moloney, R. D.,Shanahan, F.,Dinan, T. G.,Cryan, J. F. (2012) 'Regulation of Serotonergic Neurotransmission and Behaviour by the Brain-Gut-Microbiome Axis'. Gastroenterology, 142 (55) [Details]
(2008)'Tryptophan catabolism in irritable bowel syndrome: Relationship to cytokines, severity and psychiatric co-morbidity'
Fitzgerald, P.,Clarke, G.,Scully, P.,Cryan, J. F.,Shanahan, F.,Quigley, E. M.,Cassidy, E.,Dinan, T. G. (2008) 'Tryptophan catabolism in irritable bowel syndrome: Relationship to cytokines, severity and psychiatric co-morbidity'. Gastroenterology, 134 (44) [Details]
(2008)'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'
Fitzgerald, P.,Eugene, M. C.,Clarke, G.,Scully, P.,Barry, S.,Eamonn, M. M. Q.,Shanahan, F.,Cryan, J.,Timothy, G. D. (2008) 'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'. Neurogastroenterology and Motility, 20 (1212):1291-12971291 [Details]
(2008)'Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors'
Dinan, T. G.,Clarke, G.,Quigley, E. M. M.,Scott, L. V.,Shanahan, F.,Cryan, J.,Cooney, J.,Keeling, P. W. N. (2008) 'Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors'. 103 (1010):2570-25762570 [Details]
(2013)'Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion'
O'Malley, D,Cryan, JF,Dinan, TG (2013) 'Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion'. Brain Behav Immun, 30 :115-124 [DOI] [Details]
(2013)'microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus'
O'Connor, RM,Grenham, S,Dinan, TG,Cryan, JF (2013) 'microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus'. International Journal of Neuropsychopharmacology, 16 :1885-1892 [DOI] [Details]
(2013)'Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat'
Davey, KJ,Cotter, PD,O'Sullivan, O,Crispie, F,Dinan, TG,Cryan, JF,O'Mahony, SM (2013) 'Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat'. Translational Psychiatry, 3 [DOI] [Details]
(2014)'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'
Godinho, BMDC,McCarthy, DJ,Torres-Fuentes, C,Beltran, CJ,McCarthy, J,Quinlan, A,Ogier, JR,Darcy, R,O'Driscoll, CM,Cryan, JF (2014) 'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'. Biomaterials, 35 :489-499 [DOI] [Details]
(2011)'Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat'
Slattery, DA,Neumann, ID,Cryan, JF (2011) 'Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat'. Journal of psychopharmacology (Oxford, England), 25 :1295-1303 [DOI] [Details]
(2013)'Adult siRNA-induced knockdown of mGlu(7) receptors reduces anxiety in the mouse'
O'Connor, RM,Thakker, DR,Schmutz, M,van der Putten, H,Hoyer, D,Flor, PJ,Cryan, JF (2013) 'Adult siRNA-induced knockdown of mGlu(7) receptors reduces anxiety in the mouse'. Neuropharmacology, 72 :66-73 [DOI] [Details]
(2013)'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'
O'Brien, FE,Clarke, G,Dinan, TG,Cryan, JF,Griffin, BT (2013) 'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'. International Journal of Neuropsychopharmacology, 16 :2259-2272 [DOI] [Details]
(2014)'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'
O'Brien, F.E., O'Connor, R.M., Clarke, G., Donovan, M.D., Dinan, T.G., Griffin, B.T., Cryan, J.F. (2014) 'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'. Behavioral Brain Research, 15 (261):17-25 [DOI] [Details]
(2014)'The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat'
Donovan MD, O'Brien FE, Boylan GB, Cryan JF, Griffin BT (2014) 'The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat'. The Journal of pharmacy and pharmacology, [DOI] [Details]
(2014)'Microbiota and neurodevelopmental windows: implications for brain disorders'
Borre YE, O'Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF. (2014) 'Microbiota and neurodevelopmental windows: implications for brain disorders'. Trends In Molecular Medicine, 20 (9):509-518 [Details]
(2014)'Delivering a Disease-Modifying Treatment for Huntington's Disease'
Godinho BMDC, Malhotra M, O’Driscoll CM, Cryan JF. (2014) 'Delivering a Disease-Modifying Treatment for Huntington's Disease'. Drug Discovery Today, [Details]
(2013)'Non-Viral Nanosystems for Gene and siRNA delivery to the Central Nervous System: Formulating the Solution'
O’Mahony AM,. Godinho BMDC, Cryan JF and O’Driscoll CM. (2013) 'Non-Viral Nanosystems for Gene and siRNA delivery to the Central Nervous System: Formulating the Solution'. Journal of Pharmaceutical Sciences, 102 :4369-4384 [Details]
(2014)'Bacterial neuroactive compounds produced by psychobiotics'
Wall, R.,Cryan, J. F.,Ross, R. P.,Fitzgerald, G. F.,Dinan, T. G.,Stanton, C. (2014) 'Bacterial neuroactive compounds produced by psychobiotics'. Adv Exp Med Biol, 817 :221-39 [Details]
(2014)'Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test'
Allen, A.P., Kennedy, P.J., Cryan, J.F., Dinan, T.G. & Clarke G. (2014) 'Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test'. Neuroscience & Biobehavioral Reviews, 38 :94-124 [Details]
(2014)'Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour'
Clarke, G.,O'Mahony, S. M.,Dinan, T. G.,Cryan, J. F. (2014) 'Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour'. Acta Paediatracta Paediatr, 103 (88):812-9 [Details]
(2014)'Immune modulation of the brain-gut-microbe axis'
El Aidy, S.,Dinan, T. G.,Cryan, J. F. (2014) 'Immune modulation of the brain-gut-microbe axis'. Front Microbiol, 5 [Details]
(2014)'Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon'
Lomasney KW, Houston A, Shanahan F, Dinan TG, Cryan JF and Hyland NP. (2014) 'Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon'. Neurogastroenterol & Motility, 26 (6):887-890 [Details]
(2014)'Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon'
Lomasney KW, Houston A, Shanahan F, Dinan TG, Cryan JF and Hyland NP. (2014) 'Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon'. Neurogastroenterol & Motility, 26 (6):887-890 [Details]
(2014)'DIFFERENTIAL ACTIVATION OF THE PREFRONTAL CORTEX AND AMYGDALA FOLLOWING PSYCHOLOGICAL STRESS AND COLORECTAL DISTENSION IN THE MATERNALLY SEPARATED RAT'
Felice, VD,Gibney, SM,Gosselin, RD,Dinan, TG,O'Mahony, SM,Cryan, JF (2014) 'DIFFERENTIAL ACTIVATION OF THE PREFRONTAL CORTEX AND AMYGDALA FOLLOWING PSYCHOLOGICAL STRESS AND COLORECTAL DISTENSION IN THE MATERNALLY SEPARATED RAT'. Neuroscience, 267 :252-262 [DOI] [Details]
(2014)'Medical Student Perceptions of Radiology use in Anatomy Teaching'
Murphy KP, Crush L, O'Malley E, Daly FE, O'Tuathaigh CMP, Maher MM, Cryan JF, O'Connor OJ (2014) 'Medical Student Perceptions of Radiology use in Anatomy Teaching'. Anatomical Sciences Education, [Details]
(2014)'A Ventral View on Antidepressant Action: Roles for Adult Hippocampal Neurogenesis along the Dorso-ventral Axis'
O'Leary OF, Cryan JF (2014) 'A Ventral View on Antidepressant Action: Roles for Adult Hippocampal Neurogenesis along the Dorso-ventral Axis'. Trends In Pharmacological Sciences, 35 :675-687 [DOI] [Details]
(2014)'A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review'
Torres-Fuentes, C.,Schellekens, H.,Dinan, T. G.,Cryan, J. F. (2014) 'A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review'. Nutr Neurosci, [Details]
(2014)'Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain'
Bravo, J. A.,Dinan, T. G.,Cryan, J. F. (2014) 'Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain'. Front Mol Neurosci, 7 [Details]
(2014)'Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat'
Felice, V. D.,Gibney, S. M.,Gosselin, R. D.,Dinan, T. G.,O'Mahony, S. M.,Cryan, J. F. (2014) 'Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat'. Neuroscienceneuroscience, 267 :252-62 [Details]
(2014)'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'
O'Malley, D.,Julio-Pieper, M.,O'Mahony, S. M.,Dinan, T. G.,Cryan, J. F. (2014) 'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'. Exp Physiol, 99 (22):359-67 [Details]
(2014)'Disturbance of the Gut Microbiota in Early-Life Selectively Affects Visceral Pain in Adulthood without Impacting Cognitive or Anxiety-Related Behaviors in Male Rats'
O'mahony, S. M.,Felice, V. D.,Nally, K.,Savignac, H. M.,Claesson, M. J.,Scully, P.,Woznicki, J.,Hyland, N. P.,Shanahan, F.,Quigley, E. M.,Marchesi, J. R.,O'Toole, P. W.,Dinan, T. G.,Cryan, J. F. (2014) 'Disturbance of the Gut Microbiota in Early-Life Selectively Affects Visceral Pain in Adulthood without Impacting Cognitive or Anxiety-Related Behaviors in Male Rats'. Neuroscience, 277 :885-901 [Details]
(2014)'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential'
Borre, Y. E.,Moloney, R. D.,Clarke, G.,Dinan, T. G.,Cryan, J. F. (2014) 'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential'. Adv Exp Med Biol, 817 :373-403 [Details]
(2014)'The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors'
Golubeva, A. V.,Zhdanov, A. V.,Mallel, G.,Dinan, T. G.,Cryan, J. F. (2014) 'The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors'. Physiol Rep, 2 (33) [Details]
(2014)'Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test'
Allen, A. P.,Kennedy, P. J.,Cryan, J. F.,Dinan, T. G.,Clarke, G. (2014) 'Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test'. Neurosci Biobehav Rev, 38 :94-124 [Details]
(2014)'Acute tryptophan depletion reduces kynurenine levels: Implications for treatment of visuospatial memory performance in irritable bowel syndrome'
Kennedy, P.J., Allen, A.P., O’Neill, A., Quigley, E.M.M., Cryan, J.F., Dinan, T.G., Clarke G. (2014) 'Acute tryptophan depletion reduces kynurenine levels: Implications for treatment of visuospatial memory performance in irritable bowel syndrome'. Psychopharmacology, [DOI] [Details]
(2014)'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'
O'Malley D, Buckley MM, McKernan DP, Quigley EM, Cryan JF, Dinan TG (2014) 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'. Brain Behav Immun, [DOI] [Details]
(2014)'Faster, better, stronger: Towards new antidepressant therapeutic strategies'
O'Leary OF, Dinan TG, Cryan JF (2014) 'Faster, better, stronger: Towards new antidepressant therapeutic strategies'. European journal of pharmacology, [DOI] [Details]
(2014)'Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon'
Lomasney, KW,Houston, A,Shanahan, F,Dinan, TG,Cryan, JF,Hyland, NP (2014) 'Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon'. Neurogastroenterology and Motility, 26 :887-890 [DOI] [Details]
(2014)'Strain differences in stress-induced changes in central CRF1 receptor expression'
O'Malley, D,Julio-Pieper, M,Dinan, TG,Cryan, JF (2014) 'Strain differences in stress-induced changes in central CRF1 receptor expression'. Neuroscience letters, 561 :192-197 [DOI] [Details]
(2014)'The Ups and Downs of Modelling Mood Disorders in Rodents'
Slattery, DA,Cryan, JF (2014) 'The Ups and Downs of Modelling Mood Disorders in Rodents'. Ilar Journal, 55 :297-309 [DOI] [Details]
(2014)'Gut microbiota, the pharmabiotics they produce and host health'
Patterson, E,Cryan, JF,Fitzgerald, GF,Ross, RP,Dinan, TG,Stanton, C (2014) 'Gut microbiota, the pharmabiotics they produce and host health'. Proceedings of The Nutrition Society, 73 :477-489 [DOI] [Details]
(2015)'Role of adult hippocampal neurogenesis in stress resilience'
Levone BR, Cryan JF, O'Leary OF (2015) 'Role of adult hippocampal neurogenesis in stress resilience'. Neurobiology of Stress, 1 :147-155 [DOI] [Details]
(2014)'Faster, better, stronger: Towards new antidepressant therapeutic strategies'
O'Leary, O. F.,Dinan, T. G.,Cryan, J. F. (2014) 'Faster, better, stronger: Towards new antidepressant therapeutic strategies'. Eur J Pharmacol, [Details]
(2014)'Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice'
Melamed, O.,Levav-Rabkin, T.,Zukerman, C.,Clarke, G.,Cryan, J. F.,Dinan, T. G.,Grossman, Y.,Golan, H. M. (2014) 'Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice'. Neuropharmacology, 79 :616-25 [Details]
(2014)'Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis'
Stilling, R. M.,Dinan, T. G.,Cryan, J. F. (2014) 'Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis'. Genes Brain Behav, 13 (11):69-86 [Details]
(2014)'The microbiome: stress, health and disease'
Moloney, R. D.,Desbonnet, L.,Clarke, G.,Dinan, T. G.,Cryan, J. F. (2014) 'The microbiome: stress, health and disease'. Mamm Genome, 25 (1-21-2):49-74 [Details]
(2014)'Gut microbiota, the pharmabiotics they produce and host health'
Patterson, E.,Cryan, J. F.,Fitzgerald, G. F.,Ross, R. P.,Dinan, T. G.,Stanton, C. (2014) 'Gut microbiota, the pharmabiotics they produce and host health'. Proc Nutr Soc, :1-13 [Details]
(2014)'Serotonin, tryptophan metabolism and the brain-gut-microbiome axis'
O'Mahony, S. M.,Clarke, G.,Borre, Y. E.,Dinan, T. G.,Cryan, J. F. (2014) 'Serotonin, tryptophan metabolism and the brain-gut-microbiome axis'. Behav Brain Resbehav Brain Res, [Details]
(2014)'Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract'
Torres-Fuentes, C.,Theeuwes, W. F.,McMullen, M. K.,McMullen, A. K.,Dinan, T. G.,Cryan, J. F.,Schellekens, H. (2014) 'Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract'. PLoS One, 9 (77) [Details]
(2014)'Activation but not blockade of GABA(B) receptors during early-life alters anxiety in adulthood in BALB/c mice'
Sweeney, FE,O'Leary, OF,Cryan, JF (2014) 'Activation but not blockade of GABA(B) receptors during early-life alters anxiety in adulthood in BALB/c mice'. Neuropharmacology, 81 :303-310 [DOI] [Details]
(2014)'Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology'
Lomasney, KW,Cryan, JF,Hyland, NP (2014) 'Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 307 :241-247 [DOI] [Details]
(2014)'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'
O'Brien, FE,O'Connor, RM,Clarke, G,Donovan, MD,Dinan, TG,Griffin, BT,Cryan, JF (2014) 'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'. Behavioural Brain Research, 261 :17-25 [DOI] [Details]
(2014)'GABA(B(1)) receptor subunit isoforms differentially regulate stress resilience'
O'Leary, OF,Felice, D,Galimberti, S,Savignac, HM,Bravo, JA,Crowley, T,Yacoubi, M,Vaugeois, JM,Gassmann, M,Bettler, B,Dinan, TG,Cryan, JF (2014) 'GABA(B(1)) receptor subunit isoforms differentially regulate stress resilience'. Proceedings of The National Academy of Sciences of The United States of America, 111 :15232-15237 [DOI] [Details]
(2014)'A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome'
Kennedy, P. J.,Cryan, J. F.,Quigley, E. M.,Dinan, T. G.,Clarke, G. (2014) 'A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome'. Psychol Med, 44 (1414):3123-34 [Details]
(2014)'Microbiota and neurodevelopmental windows: implications for brain disorders'
Borre, Y. E.,O'Keeffe, G. W.,Clarke, G.,Stanton, C.,Dinan, T. G.,Cryan, J. F. (2014) 'Microbiota and neurodevelopmental windows: implications for brain disorders'. Trends Mol Med, 20 (99):509-518 [Details]
(2014)'Minireview: gut microbiota: the neglected endocrine organ'
Clarke, G.,Stilling, R. M.,Kennedy, P. J.,Stanton, C.,Cryan, J. F.,Dinan, T. G. (2014) 'Minireview: gut microbiota: the neglected endocrine organ'. Mol Endocrinol, 28 (88):1221-38 [Details]
(2014)'Strain differences in stress-induced changes in central CRF1 receptor expression'
O'Malley, D.,Julio-Piepera, M.,Dinan, T. G.,Cryan, J. F. (2014) 'Strain differences in stress-induced changes in central CRF1 receptor expression'. Neurosci Lett, 561 :192-7 [Details]
(2014)'Faster, Better, Stronger: Towards New Antidepressant Therapeutic Strategies'
O'leary O.F, Dinan T.G, Cryan J.F. (2014) 'Faster, Better, Stronger: Towards New Antidepressant Therapeutic Strategies'. European Journal of Pharmacology, 123 :55-76 [DOI] [Details]
(2014)'A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X'
Dollard, J.,Kearney, P.,Clarke, G.,Moloney, G.,Cryan, J. F.,Dinan, T. G. (2014) 'A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X'. Brain Behav Immun, [Details]
(2014)'Toll-like receptor 4 regulates chronic stress-induced visceral pain in mice'
Tramullas, M.,Finger, B. C.,Moloney, R. D.,Golubeva, A. V.,Moloney, G.,Dinan, T. G.,Cryan, J. F. (2014) 'Toll-like receptor 4 regulates chronic stress-induced visceral pain in mice'. Biol Psychiatry, 76 (44):340-8 [Details]
(2014)'Gut microbiota, the pharmabiotics they produce and host health'
Patterson E, Cryan JF, Fitzgerald GF, Ross RP, Dinan TG, Stanton C (2014) 'Gut microbiota, the pharmabiotics they produce and host health'. The Proceedings of The Nutrition Society, :1-13 [DOI] [Details]
(2014)'Gut microbiota, the pharmabiotics they produce and host health'
Patterson E, Cryan JF, Fitzgerald GF, Ross RP, Dinan TG, Stanton C (2014) 'Gut microbiota, the pharmabiotics they produce and host health'. The Proceedings of The Nutrition Society, :1-13 [DOI] [Details]
(2014)'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'
O'Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O'Toole PW, Dinan TG, Cryan JF (2014) 'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'. Neuroscience, 277C :885-901 [DOI] [Details]
(2014)'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'
O'Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O'Toole PW, Dinan TG, Cryan JF (2014) 'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'. Neuroscience, 277C :885-901 [DOI] [Details]
(2014)'Gut microbiota modulation and implications for host health: Dietary strategies to influence the gut-brain axis'
Marques, TM,Cryan, JF,Shanahan, F,Fitzgerald, GF,Ross, RP,Dinan, TG,Stanton, C (2014) 'Gut microbiota modulation and implications for host health: Dietary strategies to influence the gut-brain axis'. Innovative Food Science & Emerging Technologies, 22 :239-247 [DOI] [Details]
(2014)'PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'
Godinho BMDC, Ogier JR, Quinlan A, Darcy R, Griffin BT, Cryan JF, O’Driscoll CM. (2014) 'PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 :105-112 [Details]
(2014)'A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome'
Kennedy, PJ,Cryan, JF,Quigley, EMM,Dinan, TG,Clarke, G (2014) 'A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome'. Psychological medicine, 44 :3123-3134 [DOI] [Details]
(2014)'Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory'
Kennedy, P. J.,Clarke, G.,O'Neill, A.,Groeger, J. A.,Quigley, E. M.,Shanahan, F.,Cryan, J. F.,Dinan, T. G. (2014) 'Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory'. Psychol Med, 44 (77):1553-66 [Details]
(2014)'Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice'
Melamed, O,Levav-Rabkin, T,Zukerman, C,Clarke, G,Cryan, JF,Dinan, TG,Grossman, Y,Golan, HM (2014) 'Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice'. Neuropharmacology, 79 :616-625 [DOI] [Details]
(2014)'Blocking Metabotropic Glutamate Receptor Subtype 7 ( mGlu7) via the Venus Flytrap Domain ( VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior'
Gee, CE,Peterlik, D,Neuhauser, C,Bouhelal, R,Kaupmann, K,Laue, G,Uschold-Schmidt, N,Feuerbach, D,Zimmermann, K,Ofner, S,Cryan, JF,van der Putten, H,Fendt, M,Vranesic, I,Glatthar, R,Flor, PJ (2014) 'Blocking Metabotropic Glutamate Receptor Subtype 7 ( mGlu7) via the Venus Flytrap Domain ( VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior'. The Journal of Biological Chemistry, 289 :10975-10987 [DOI] [Details]
(2014)'Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction'
5. Browne CA, Hanke J, Rose C, Walsh I, Foley T, Clarke G, Schwegler H, Cryan JF, Yilmazer-Hanke D. (2014) 'Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction'. Stress (Amsterdam, Netherlands), [Details]
(2014)'PEGylated cyclodextrins as novel siRNA nanosystems: Correlations between polyethylene glycol length and nanoparticle stability'
Godinho, BMDC,Ogier, JR,Quinlan, A,Darcy, R,Griffin, BT,Cryan, JF,Driscoll, CM (2014) 'PEGylated cyclodextrins as novel siRNA nanosystems: Correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 :105-112 [DOI] [Details]
(2014)'Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract'
Torres-Fuentes C, Theeuwes WF, McMullen MK, McMullen AK, Dinan TG, Cryan JF, Schellekens H (2014) 'Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract'. Plos One, 9 (7) [DOI] [Details]
(2014)'A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'
Naughton, M.,Clarke, G.,O'Leary, O. F.,Cryan, J. F.,Dinan, T. G. (2014) 'A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'. J Affect Disord, 156 :24-35 [Details]
(2014)'Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice'
McAllan, L,Skuse, P,Cotter, PD,O' Connor, P,Cryan, JF,Ross, RP,Fitzgerald, G,Roche, HM,Nilaweera, KN (2014) 'Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice'. Plos One, 9 [DOI] [Details]
(2014)'Toll-Like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice'
Tramullas, M,Finger, BC,Moloney, RD,Golubeva, AV,Moloney, G,Dinan, TG,Cryan, JF (2014) 'Toll-Like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice'. Biological Psychiatry, 76 :340-348 [DOI] [Details]
(2014)'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'
O'Malley, D.,Buckley, M. M.,McKernan, D. P.,Quigley, E. M.,Cryan, J. F.,Dinan, T. G. (2014) 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'. Brain Behav Immun, [Details]
(2014)'Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo'
Schellekens, H,Nongonierma, AB,Clarke, G,van Oeffelen, WEPA,FitzGerald, RJ,Dinan, TG,Cryan, JF (2014) 'Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo'. International Dairy Journal, 38 :55-64 [DOI] [Details]
(2014)'Medical student knowledge regarding radiology before and after a radiological anatomy module: implications for vertical integration and self-directed learning'
Murphy KP, Crush L, O'Malley E, Daly FE, O'Tuathaigh CM, O'Connor OJ, Cryan JF, Maher MM (2014) 'Medical student knowledge regarding radiology before and after a radiological anatomy module: implications for vertical integration and self-directed learning'. Insights into Imaging, [Details]
(2014)'GABAB(1) receptor subunit isoforms differentially regulate stress resilience'
O'Leary OF, Felice D, Galimberti S, Savignac HM, Bravo JA, Crowley T, El Yacoubi M, Vaugeois JM, Gassmann M, Bettler B, Dinan TG, Cryan JF. (2014) 'GABAB(1) receptor subunit isoforms differentially regulate stress resilience'. Proceedings of The National Academy of Science Usa, 111 (42):15232-15237 [Details]
(2014)'Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis'
Curran EA, O’Neill SM, Cryan JF, Kenny LC, Dinan TG, Khashan AS, et al (2014) 'Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis'. Journal of Child Psychology & Psychiatry, [DOI] [Details]
(2014)'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'
O'Malley, D,Julio-Pieper, M,O'Mahony, SM,Dinan, TG,Cryan, JF (2014) 'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'. Experimental physiology, 99 :359-367 [DOI] [Details]
(2014)'DISTURBANCE OF THE GUT MICROBIOTA IN EARLY-LIFE SELECTIVELY AFFECTS VISCERAL PAIN IN ADULTHOOD WITHOUT IMPACTING COGNITIVE OR ANXIETY-RELATED BEHAVIORS IN MALE RATS'
O'Mahony, SM,Felice, VD,Nally, K,Savignac, HM,Claesson, MJ,Scully, P,Woznicki, J,Hyland, NP,Shanahan, F,Quigley, EM,Marchesi, JR,O'Toole, PW,Dinan, TG,Cryan, JF (2014) 'DISTURBANCE OF THE GUT MICROBIOTA IN EARLY-LIFE SELECTIVELY AFFECTS VISCERAL PAIN IN ADULTHOOD WITHOUT IMPACTING COGNITIVE OR ANXIETY-RELATED BEHAVIORS IN MALE RATS'. Neuroscience, 277 :885-901 [DOI] [Details]
(2014)'Devil's Claw to Suppress Appetite-Ghrelin Receptor Modulation Potential of a Harpagophytum procumbens Root Extract'
Torres-Fuentes, C,Theeuwes, WF,McMullen, MK,McMullen, AK,Dinan, TG,Cryan, JF,Schellekens, H (2014) 'Devil's Claw to Suppress Appetite-Ghrelin Receptor Modulation Potential of a Harpagophytum procumbens Root Extract'. Plos One, 9 [DOI] [Details]
(2014)'A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review'
Torres-Fuentes C, Schellekens H, Dinan TG, Cryan JF (2014) 'A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review'. Nutritional Neuroscience, [DOI] [Details]
(2013)'Milk protein hydrolysates activate 5-HT2C serotonin receptors: influence of the starting substrate and isolation of bioactive fractions'
Nongonierma, A. B.,Schellekens, H.,Dinan, T. G.,Cryan, J. F.,Fitzgerald, R. J. (2013) 'Milk protein hydrolysates activate 5-HT2C serotonin receptors: influence of the starting substrate and isolation of bioactive fractions'. Food & Function, 4 (55):728-37728 [Details]
(2013)'Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes'
McAllan L, Keane D, Schellekens H, Roche HM, Korpela R, Cryan JF, Nilaweera KN (2013) 'Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes'. The British journal of nutrition, 110 (11):2114-2126 [DOI] [Details]
(2013)'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'
Schellekens, H.,McNamara, O.,Dinan, T. G.,McCarthy, J. V.,McGlacken, G. P.,Cryan, J. F. (2013) 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. J Pharm Pharmacol, 65 (44):528-38528 [Details]
(2013)'Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling'
Schellekens, H.,van Oeffelen, W. E.,Dinan, T. G.,Cryan, J. F. (2013) 'Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling'. Journal of Biological Chemistry, 288 (11):181-91181 [Details]
(2013)'Milk protein hydrolysates activate 5-HT(2C) serotonin receptors: influence of the starting substrate and isolation of bioactive fractions'
Nongonierma AB, Schellekens H, Dinan TG, Cryan JF, FitzGerald RJ (2013) 'Milk protein hydrolysates activate 5-HT(2C) serotonin receptors: influence of the starting substrate and isolation of bioactive fractions'. Food & Function, 4 (5):728-737 [DOI] [Details]
(2013)'Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes'
McAllan, L,Keane, D,Schellekens, H,Roche, HM,Korpela, R,Cryan, JF,Nilaweera, KN (2013) 'Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes'. British Journal of Nutrition, 110 :2114-2126 [DOI] [Details]
(2013)'Ghrelin at the interface of obesity and reward'
Schellekens H, Dinan TG, Cryan JF (2013) 'Ghrelin at the interface of obesity and reward'. Vitamins and hormones, 91 :285-323 [DOI] [Details]
(2013)'Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling'
Schellekens H, van Oeffelen WE, Dinan TG, Cryan JF (2013) 'Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling'. The Journal of Biological Chemistry, 288 (1):181-191 [DOI] [Details]
(2013)'Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes'
McAllan, L.,Keane, D.,Schellekens, H.,Roche, H. M.,Korpela, R.,Cryan, J. F.,Nilaweera, K. N. (2013) 'Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes'. Br J Nutr, 110 (1111):2114-262114 [Details]
(2013)'Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward'
Schellekens H, Dinan TG, Cryan JF (2013) 'Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward'. Frontiers in neuroscience, 7 [DOI] [Details]
(2013)'Semagacestat, a ¿-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'
Schellekens H, McNamara O, Dinan TG, McCarthy JV, McGlacken GP, Cryan JF (2013) 'Semagacestat, a ¿-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. The Journal of pharmacy and pharmacology, 65 (4):528-538 [DOI] [Details]
(2012)'Ghrelin signalling and obesity: at the interface of stress, mood and food reward'
Schellekens, H.,Finger, B. C.,Dinan, T. G.,Cryan, J. F. (2012) 'Ghrelin signalling and obesity: at the interface of stress, mood and food reward'. Pharmacol Ther, 135 (33):316-26316 [Details]
(2012)'Dynamic 5-HT2C receptor editing in a mouse model of obesity'
Schellekens, H.,Clarke, G.,Jeffery, I. B.,Dinan, T. G.,Cryan, J. F. (2012) 'Dynamic 5-HT2C receptor editing in a mouse model of obesity'. PLoS One, 7 (33) [Details]
(2012)'Ghrelin signalling and obesity: at the interface of stress, mood and food reward'
Schellekens H, Finger BC, Dinan TG, Cryan JF (2012) 'Ghrelin signalling and obesity: at the interface of stress, mood and food reward'. Pharmacology & therapeutics, 135 (3):316-326 [DOI] [Details]
(2012)'Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters'
Davey, K. J.,O'Mahony, S. M.,Schellekens, H.,O'Sullivan, O.,Bienenstock, J.,Cotter, P. D.,Dinan, T. G.,Cryan, J. F. (2012) 'Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters'. Psychopharmacology (Berl), 221 (11):155-69155 [Details]
(2012)'Bifidobacterium breve with alpha-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome'
Barrett, E.,Fitzgerald, P.,Dinan, T. G.,Cryan, J. F.,Ross, R. P.,Quigley, E. M.,Shanahan, F.,Kiely, B.,Fitzgerald, G. F.,O'Toole, P. W.,Stanton, C. (2012) 'Bifidobacterium breve with alpha-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome'. Plos One, 7 (11) [Details]
(2011)'Is there altered sensitivity to ghrelin-receptor ligands in leptin-deficient mice?: importance of satiety state and time of day'
Finger, B. C.,Schellekens, H.,Dinan, T. G.,Cryan, J. F. (2011) 'Is there altered sensitivity to ghrelin-receptor ligands in leptin-deficient mice?: importance of satiety state and time of day'. Psychopharmacology (Berl), 216 (33):421-9421 [Details]
(2010)'IBS: An epigenetic perspective'
Dinan, T. G.,Cryan, J.,Shanahan, F.,Keeling, P. W.,Quigley, E. M. (2010) 'IBS: An epigenetic perspective'. Nat Rev Gastroenterol Hepatol, 7 (88):465-71 [Details]
(2008)'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'
Fitzgerald, P.,Cassidy Eugene, M.,Clarke, G.,Scully, P.,Barry, S.,Quigley Eamonn, M. M.,Shanahan, F.,Cryan, J.,Dinan Timothy, G. (2008) 'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'. Neurogastroenterol & Motility, 20 (12):1291-1297 [Details]
(2008)'Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors'
Dinan, T. G.,Clarke, G.,Quigley, E. M.,Scott, L. V.,Shanahan, F.,Cryan, J.,Cooney, J.,Keeling, P. W. (2008) 'Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors'. American Journal of Gastroenterology, 103 (10):2570-2576 [Details]
(2014)'Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction'
Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF. (2014) 'Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction'. Neurogastroenterology and Motility, [Details]
(2014)'Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models towards Therapeutic Significance'
Mc Carthy DJ, Malhotra M, O’Mahony AM, Cryan JF and O’Driscoll CM. (2014) 'Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models towards Therapeutic Significance'. Pharmaceutical Research, [DOI] [Details]
(2015)'Adult hippocampal neurogenesis is regulated by the microbiome'
Ogbonnaya ES, Clarke G, Shanahan F, Dinan TG, Cryan JF, O'Leary OF (2015) 'Adult hippocampal neurogenesis is regulated by the microbiome'. Biological Psychiatry, [Details]
(2014)'Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction'
Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF. (2014) 'Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction'. Neurogastroenterol Motilneurogastroenterol Motil, [Details]

Other Journals

YearPublication
(2007)'Emerging Use of Non-Viral Rna Interference In The Brain'
Cryan, JF, Thakker, DR, Hoyer, D; (2007) 'Emerging Use of Non-Viral Rna Interference In The Brain' (NA) :411-415. [Details]
(2014)'DISTURBANCE OF THE GUT MICROBIOTA IN EARLY-LIFE SELECTIVELY AFFECTS VISCERAL PAIN IN ADULTHOOD WITHOUT IMPACTING COGNITIVE OR ANXIETY-RELATED BEHAVIORS IN MALE RATS'
O'Mahony, S. M. and Felice, V. D. and Nally, K. and Savignac, H. M. and Claesson, M. J. and Scully, P. and Woznicki, J. and Hyland, N. P. and Shanahan, F. and Quigley, E. M. and Marchesi, J. R. and O'Toole, P. W. and Dinan, T. G. and Cryan, J. F. (2014) 'DISTURBANCE OF THE GUT MICROBIOTA IN EARLY-LIFE SELECTIVELY AFFECTS VISCERAL PAIN IN ADULTHOOD WITHOUT IMPACTING COGNITIVE OR ANXIETY-RELATED BEHAVIORS IN MALE RATS' Neuroscience, 277 :885-901. [DOI] [Details]
(2012)'Inhibition of P-glycoprotein enhances transport of imipramine across the blood--brain barrier: microdialysis studies in conscious freely moving rats'
O'Brien, FE and Clarke, G and Fitzgerald, P and Dinan, TG and Griffin, BT and Cryan, JF (2012) 'Inhibition of P-glycoprotein enhances transport of imipramine across the blood--brain barrier: microdialysis studies in conscious freely moving rats' British journal of pharmacology, 166 (4) :1333-1343. [Details]
(2014)'P. 1.009 A combined in vitro, in vivo and in silico approach to develop and optimise a novel antiepileptic strategy in neonatal seizures'
Donovan, M and O'Brien, FE and Boylan, GB and Griffin, BT and Cryan, JF (2014) 'P. 1.009 A combined in vitro, in vivo and in silico approach to develop and optimise a novel antiepileptic strategy in neonatal seizures' European Neuropsychopharmacology, 24 (Supplement 1) . [Details]

Conference Publications

YearPublication
(2008)Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008
Clarke G, Mahony SM, Hyland NP, Fitzgerald P, Cryan JF, Dinan TG (2008) Visceral pain and beta3 adrenoceptor modulation a role for the kynurenine pathway? Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008 [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008
Clarke G, Mahony SM, Hyland NP, Fitzgerald P, Cryan JF, Dinan TG (2008) Visceral pain and beta3 adrenoceptor modulation a role for the kynurenine pathway? Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008 [Details]

Other

YearPublication
(2006)Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: Implications for target characterization in psychiatric and neurological disorders.
Hoyer, D,Thakker, DR,Natt, F,Maier, R,Huesken, D,Muller, M,Flor, P,van der Putten, H,Schmutz, M,Bilbe, G,Cryan, JF (2006) Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: Implications for target characterization in psychiatric and neurological disorders. Other [DOI] [Details]
(2007)Emerging use of non-viral RNA interference in the brain.
Cryan, JF,Thakker, DR,Hoyer, D (2007) Emerging use of non-viral RNA interference in the brain. Other [Details]
(2012)Reply to McLean et al. and Burnet: The microbiome-gut-brain axis as a pathway toward next generation psychotropics.
Cryan, JF,Bravo, JA,Dinan, TG,Forsythe, P,Bienenstock, J (2012) Reply to McLean et al. and Burnet: The microbiome-gut-brain axis as a pathway toward next generation psychotropics. Other [DOI] [Details]
(1997)The effects of paroxetine and pindolol in combination, on 8-OH-DPAT-induced hypothermia in the rat.
Cryan J.F., McGrath C., Leonard B.E. and Norman T.R.; (1997) The effects of paroxetine and pindolol in combination, on 8-OH-DPAT-induced hypothermia in the rat. Other [Details]
(1998)Combining pindolol and paroxetine in an animal model of chronic antidepressant action - Can early onset of action be detected?.
Cryan J.F., McGrath C., Leonard B.E., Burrows G.D. and Norman T.R.; (1998) Combining pindolol and paroxetine in an animal model of chronic antidepressant action - Can early onset of action be detected?. Other [Details]
(1998)Does the 5-HT1A receptor agonist flesinoxan and the serenic eltoprazine have antidepressant potential? An investigation in three rodent paradigms.
Cryan J.F., Redmond A.M., Kelly J.P. and Leonard B.E.; (1998) Does the 5-HT1A receptor agonist flesinoxan and the serenic eltoprazine have antidepressant potential? An investigation in three rodent paradigms. Other [Details]
(1998)The effects of melatonin and melatonin receptor ligands in the rat forced swim test.
Cryan J.F., McGrath C., Leonard B.E., Burrows G.D. and Norman T.R.; (1998) The effects of melatonin and melatonin receptor ligands in the rat forced swim test. Other [Details]
(1999)Reboxetine, a selective norepinephrine reuptake inhibitor, alters active behaviors in a modified rat forced swim test.
Cryan J.F. and Lucki I.; (1999) Reboxetine, a selective norepinephrine reuptake inhibitor, alters active behaviors in a modified rat forced swim test. Other [Details]
(1999)Differential modification of d-fenfluramine-induced serotonergic responses by acute sertraline and fluoxetine administration to rats.
Harkin A., Naughton M., Cryan J.F., Kelly J.P., and Leonard B.E.; (1999) Differential modification of d-fenfluramine-induced serotonergic responses by acute sertraline and fluoxetine administration to rats. Other [Details]
(2000)Postsynaptic Serotonin Receptors Involved in the Antidepressant-Like effects of fluoxetine: Evidence for a Role of 5-HT2C but not 5-HT4 receptors.
Cryan J.F. and Lucki I.; (2000) Postsynaptic Serotonin Receptors Involved in the Antidepressant-Like effects of fluoxetine: Evidence for a Role of 5-HT2C but not 5-HT4 receptors. Other [Details]
(2000)Noradrenergic lesions differentially alter the antidepressant -like effects of reboxetine.
Lucki I., Page M.E. and Cryan J.F.; (2000) Noradrenergic lesions differentially alter the antidepressant -like effects of reboxetine. Other [Details]
(2000)Localization of corticotropin-releasing factor binding sites on serotonergic processes in the raphe nucleus: effects of 5,7 dihydroxytryptamine.
Kirby L.G., Cryan J.F., Bello N., Lucki I. and Valentino R.J.; (2000) Localization of corticotropin-releasing factor binding sites on serotonergic processes in the raphe nucleus: effects of 5,7 dihydroxytryptamine. Other [Details]
(2000)The impact of noradrenergic lesions on the antidepressant-like effects of reboxetine.
Cryan J.F., Page M.E and Lucki I.; (2000) The impact of noradrenergic lesions on the antidepressant-like effects of reboxetine. Other [Details]
(2000)Antidepressant-like behavioral effects mediated by the 5-HT2C receptor.
Cryan J.F. and Lucki I.; (2000) Antidepressant-like behavioral effects mediated by the 5-HT2C receptor. Other [Details]
(2001)The antidepressant bupropion increases brain reward function: reversal of reward deficits associated with nicotine withdrawal.
Cryan J.F., Skjei K.S. and Markou A.; (2001) The antidepressant bupropion increases brain reward function: reversal of reward deficits associated with nicotine withdrawal. Other [Details]
(2001)Role of serotonin in the antidepressant-like effects of SSRIs in the tail suspension test.
O'Leary O.F., Page M.E., Hirsch B.R., Cryan J.F., Thomas S.A. and Lucki I.; (2001) Role of serotonin in the antidepressant-like effects of SSRIs in the tail suspension test. Other [Details]
(2001)Substantial reduction in corticotropin-releasing factor (CRF) binding sites in the dorsal raphe nucleus (drn) of rats administered 5,7-dihydroxytryptamine (5,7-DHT).
Kirby L.G. Cryan J.F., Page M.E., Bello N.T., Kung M-P., Kung H.F., Lucki I and Valentino R.J.; (2001) Substantial reduction in corticotropin-releasing factor (CRF) binding sites in the dorsal raphe nucleus (drn) of rats administered 5,7-dihydroxytryptamine (5,7-DHT). Other [Details]
(2001)Dopamine-B-hydroxylase deficient mice as a tool to assess the role of norepinephrine in the mechanism of action of antidepressant drugs.
Cryan J.F., Dalvi A., Lucki I. and Thomas S.A.; (2001) Dopamine-B-hydroxylase deficient mice as a tool to assess the role of norepinephrine in the mechanism of action of antidepressant drugs. Other [Details]
(2001)Reduced sensitivity to the antidepressant-like effects of SSRIs in dopamine-ƒÒ-hydroxylase deficient mice.
Cryan J.F., Hirsch B.R., Jin S-H, Lucki I. and Thomas S.A.; (2001) Reduced sensitivity to the antidepressant-like effects of SSRIs in dopamine-ƒÒ-hydroxylase deficient mice. Other [Details]
(2002)The antidepressant bupropion enhances brain reward function and reverses nicotine withdrawal in the rat.
Cryan J.F, Bruijnzeel A.W, Skjei K.S and Markou A; (2002) The antidepressant bupropion enhances brain reward function and reverses nicotine withdrawal in the rat. Other [Details]
(2002)Neurochemical and behavioral assays support an anxiolytic-like profile for 2-methyl-6-(phenylethynyl)pyridine (MPEP), a metabotropic glutamate receptor 5 (mGluR5) antagonist.
Page M.E., Szeliga P.J., Gasparini F. and Cryan J.F.; (2002) Neurochemical and behavioral assays support an anxiolytic-like profile for 2-methyl-6-(phenylethynyl)pyridine (MPEP), a metabotropic glutamate receptor 5 (mGluR5) antagonist. Other [Details]
(2002)Reduced sensitivity to the behavioral and neurochemical effects of SSRIs in norepinephrine-deficient mice.
O'Leary O.L. Cryan J.F., Page M.E., Thomas S.A. and Lucki I.; (2002) Reduced sensitivity to the behavioral and neurochemical effects of SSRIs in norepinephrine-deficient mice. Other [Details]
(2003)Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7.
Cryan J.F., Kelly P.H., Sansig G., Flor P.J. and van Der Putten H.; (2003) Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Other [Details]
(2003)GABAB receptors play a key role in the modulation of anxiety and depression-related behaviours: Evidence from GABAB(1) receptor deficient mice.
Cryan J.F. Mombereau C., Sansig G., van der Putten H. and Kaupmann K.; (2003) GABAB receptors play a key role in the modulation of anxiety and depression-related behaviours: Evidence from GABAB(1) receptor deficient mice. Other [Details]
(2003)Potential anxiolytic-like actions of metabotropic glutamate receptor 5 (mGluR5) antagonists revealed by neurochemical and behavioral studies.
Cryan J.F., Szeliga P.J., Gasparini F., Page M.E.; (2003) Potential anxiolytic-like actions of metabotropic glutamate receptor 5 (mGluR5) antagonists revealed by neurochemical and behavioral studies. Other [Details]
(2003)mGluR5 receptor antagonists, future anxiolytics?.
Gentsch C., Cryan J.F., Gasparini F., Vassout A., Spooren W.; (2003) mGluR5 receptor antagonists, future anxiolytics?. Other [Details]
(2003)GABAB receptors play a key role in the modulation of anxiety and depression-related behaviours.
Mombereau C., Kaupmann K., Sansig G., van der Putten H. And Cryan J.F.; (2003) GABAB receptors play a key role in the modulation of anxiety and depression-related behaviours. Other [Details]
(2003)Effects of yƒ{hydroxybutyrate in GABA-B receptor deficient mice.
Kaupmann, K., Cryan, J.F., Wellendorph, P. Mombereau, C. Sansig, G. Klebs, K., Schmutz, M., Froestl, W. van der Putten, H., Mosbacher, J., Bräuner-Osborne, H., Waldmeier, P., and Bettler, B.; (2003) Effects of yƒ{hydroxybutyrate in GABA-B receptor deficient mice. Other [Details]
(2004)Chronic antidepressants and GABAB receptor ligands counteract Handling-Stress induced downregulation of 5-HT1A Receptor mRNA In the hippocampus Of Balb/C Mice.
Mombereau C., Kuntzelmann G., Loetscher E., Cryan J.F.; (2004) Chronic antidepressants and GABAB receptor ligands counteract Handling-Stress induced downregulation of 5-HT1A Receptor mRNA In the hippocampus Of Balb/C Mice. Other [Details]
(2004)Novel pharmacological agents modulating GABAB receptor function: Potential therapeutics for nicotine dependence.
Kaupmann K., Lhuillier L., Mombereau C., Slattery D.A., Dupuis D.S., and Cryan J.F.; (2004) Novel pharmacological agents modulating GABAB receptor function: Potential therapeutics for nicotine dependence. Other [Details]
(2004)GABAB Receptors Play a Key Role in the Modulation of Anxiety and Antidepressant-Related Behaviour: Genetic And Pharmacological Evidence.
Mombereau C., Kaupmann K., Froestl W., Van Der Putten H. and Cryan, J.F.; (2004) GABAB Receptors Play a Key Role in the Modulation of Anxiety and Antidepressant-Related Behaviour: Genetic And Pharmacological Evidence. Other [Details]
(2004)Genetic dissection of GABAB receptor function in mice.
Gassmann M., Vigot R., Shaban H., Barbieri S., Brauner-Osborne H., Thi A.L., Cryan J.F., Kaupmann K. and Bettler B.; (2004) Genetic dissection of GABAB receptor function in mice. Other [Details]
(2004)Mapping of the binding Site of the GABAB positive modulator GS39783 by use of interspecies Rat/Drosophila Subunit Combinations.
Dupuis D.S., Relkovic D., Cryan J.F., Kaupmann K.; (2004) Mapping of the binding Site of the GABAB positive modulator GS39783 by use of interspecies Rat/Drosophila Subunit Combinations. Other [Details]
(2004)Global Down-Regulation Of Gene Expression In The Brain Using RNA Interference: Implications For Target Characterization In Psychiatric And Neurological Disorders.
Thakker D.R., Natt F., Maier R., Muller M., Van Der Putten H., Hoyer D., Cryan, J.F.; (2004) Global Down-Regulation Of Gene Expression In The Brain Using RNA Interference: Implications For Target Characterization In Psychiatric And Neurological Disorders. Other [Details]
(2004)Early deprivation leads to reduced motivation for reward that can be restored with fluoxetine in adult wistar rats.
Russig H., Ruedi-Bettschen D., Feldon J., Wrynn A., Cryan J.F., Pryce C.R.; (2004) Early deprivation leads to reduced motivation for reward that can be restored with fluoxetine in adult wistar rats. Other [Details]
(2004)GABAB Receptor-Mediated Antidepressant-Like Behaviour Is Serotonin Dependent.
Slattery D.A., Desrayaud S., Cryan J.F.; (2004) GABAB Receptor-Mediated Antidepressant-Like Behaviour Is Serotonin Dependent. Other [Details]
(2004)Altered sensitivity to the pharmacological effects of the GABAB receptor agonist baclofen in different mouse strains.
L.H. Jacobson, Cryan, J.F.; (2004) Altered sensitivity to the pharmacological effects of the GABAB receptor agonist baclofen in different mouse strains. Other [Details]
(2004)Positive Allosteric Modulation of ƒ×-Aminobutyric AcidB Receptors.
Urwyler S., Cryan J.F., Dupuis D.S., Gjoni T., Lingenhoehl K., Mombereau C., Mosbacher J., Pozza M.F. and Kaupmann K.; (2004) Positive Allosteric Modulation of ƒ×-Aminobutyric AcidB Receptors. Other [Details]
(2005)Lentiviral vector-mediated transgene expression in vitro and in vivo neuronal models.
Pun S., Osinde M., Stoehr N., Senechal Y., Schade A., Cryan J.F., Dev K.K.; (2005) Lentiviral vector-mediated transgene expression in vitro and in vivo neuronal models. Other [Details]
(2005)Behavioural and neurochemical consequences of siRNA-induced knockdown of serotonin and dopamine transporters in the adult mouse brain: Implications for validation of novel therapeutic targets for psychiatric illnesses.
Thakker D.R., Natt F., Hüsken D., Muller M., Maier R., van der Putten H., Hoyer D., Cryan, J.F.; (2005) Behavioural and neurochemical consequences of siRNA-induced knockdown of serotonin and dopamine transporters in the adult mouse brain: Implications for validation of novel therapeutic targets for psychiatric illnesses. Other [Details]
(2005)A role for the anterior cingulate cortex in amygdala-dependent fear processes: behavioral studies in the rat.
Bissiere, S. Neijt H.C., Lecourtier L., Olpe H.R., Cryan J.F.; (2005) A role for the anterior cingulate cortex in amygdala-dependent fear processes: behavioral studies in the rat. Other [Details]
(2005)Investigation of the molecular markers underlying the anti-addictive effects of GABAB receptor agonists and positive modulators.
Lhuillier L., Mombereau C., Cryan J.F., Kaupmann K.; (2005) Investigation of the molecular markers underlying the anti-addictive effects of GABAB receptor agonists and positive modulators. Other [Details]
(2005)Behavioural and neurochemical consequences of siRNA-induced knockdown of serotonin and dopamine transporters in the adult mouse brain: Implications for validation of novel antidepressant targets.
Thakker D.R., Natt F., Hüsken D., Maier R., van der Putten H., Hoyer D., Cryan J.F.; (2005) Behavioural and neurochemical consequences of siRNA-induced knockdown of serotonin and dopamine transporters in the adult mouse brain: Implications for validation of novel antidepressant targets. Other [Details]
(2005)GABAB receptor positive modulation as a novel therapeutic approach to drug dependence: Blockade of the rewarding and psychostimulant effects of cocaine.
Slattery D.A., Mombereau C., Froestl W., Markou A., Kaupmann K. and Cryan, J.F.; (2005) GABAB receptor positive modulation as a novel therapeutic approach to drug dependence: Blockade of the rewarding and psychostimulant effects of cocaine. Other [Details]
(2006)Evaluation of Reward Processes In An Animal Model of Depression.
Slattery, DA, Markou, A, Cryan, JF; (2006) Evaluation of Reward Processes In An Animal Model of Depression. Other [Details]
(2006)Evaluation of Reward Processes In An Animal Model of Depression.
Slattery, DA, Cryan, JF, Markou, A; (2006) Evaluation of Reward Processes In An Animal Model of Depression. Other [Details]
(2006)Emerging Use of Rna Interference to Understand The Role of Genes In Anxiety.
Cryan, JF, Thakker, DR, van der Putten, H, Flor, PJ, Hoyer, D; (2006) Emerging Use of Rna Interference to Understand The Role of Genes In Anxiety. Other [Details]
(2006)Molecular Dissection of The Role of Gaba1 Receptor Isoforms 1a and 1b In Anxiety-Related Behaviour.
Jacobson, LH, Neijt, HC, Bettler, B, Kaupmann, K, Cryan, JF; (2006) Molecular Dissection of The Role of Gaba1 Receptor Isoforms 1a and 1b In Anxiety-Related Behaviour. Other [Details]
(2006)The Infralimbic Cortex Modulates Stress-Induced Coping Behaviour - Implications For Depression.
Slattery, DA, Cryan, JF; (2006) The Infralimbic Cortex Modulates Stress-Induced Coping Behaviour - Implications For Depression. Other [Details]
(2006)Global Down-Regulation of Gene Expression In The Brain Using Rna Interference, With Emphasis On Monoamine Transporters and Gpcrs: Implications For Target Characterization In Psychiatric and Neurological Disorders.
Hoyer, D, Thakker, DR, Natt, F, Maier, R, Huesken, D, Muller, M, Flor, P, van der Putten, H, Schmutz, M, Bilbe, G, Cryan, JF; (2006) Global Down-Regulation of Gene Expression In The Brain Using Rna Interference, With Emphasis On Monoamine Transporters and Gpcrs: Implications For Target Characterization In Psychiatric and Neurological Disorders. Other [DOI] [Details]
(2007)Assessing The Genetic Influence On Anxiety Behaviour and Stress-Induced Brain Activation In The Mouse.
Mahony, CMO, Sweeney, F, Daly, E, Dinan, TG, Cryan, JF; (2007) Assessing The Genetic Influence On Anxiety Behaviour and Stress-Induced Brain Activation In The Mouse. Other [Details]
(2007)Depressive Behaviours and Alterations In The Immune and Stress Response Systems Following Neonatal Maternal Separation.
Mahony, SO, Clarke, G, Mahony, LO, Quigley, E, Cryan, J, Dinan, T; (2007) Depressive Behaviours and Alterations In The Immune and Stress Response Systems Following Neonatal Maternal Separation. Other [Details]
(2008)Differential Expression of Mglur7 In Two Animal Models of Depression.
O'Mahony, CM, Bravo, J, Dinan, TG, Cryan, JF; (2008) Differential Expression of Mglur7 In Two Animal Models of Depression. Other [Details]
(2008)Aberrant Lps-Induced Cytokine Responses In Mice Following Stress: Relevance to Major Depression.
Browne, CA, O'Brien, F, Connor, TJ, Dinan, TG, Cryan, JF; (2008) Aberrant Lps-Induced Cytokine Responses In Mice Following Stress: Relevance to Major Depression. Other [Details]
(2008)Genetic Influences On Hippocampal Susceptibility to Cell Death Following Immune Activation.
O'Connor, RM, McKernan, DR, Browne, C, Dinan, TG, Cryan, JF; (2008) Genetic Influences On Hippocampal Susceptibility to Cell Death Following Immune Activation. Other [Details]
(2008)The Effects of Acetylcholinesterase Inhibitor Pyridostigmine On Inflammatory Responses In An Animal Model of Irritable Bowel Syndrome.
Bravo, JA, Dinan, TG, Cryan, JF; (2008) The Effects of Acetylcholinesterase Inhibitor Pyridostigmine On Inflammatory Responses In An Animal Model of Irritable Bowel Syndrome. Other [Details]
(2008)Gobal Down-Regulation of Gene Expression In The Brain Using Rna Interference, With Emphasis On Neuropeptides, Gpcrs and Monoamine Transporters.
Hoyer, D, Thakker, DR, Natt, F, Maier, R, Huesken, D, Mueller, M, Flor, PJ, van der Putten, H, Schmutz, M, Cryan, JF; (2008) Gobal Down-Regulation of Gene Expression In The Brain Using Rna Interference, With Emphasis On Neuropeptides, Gpcrs and Monoamine Transporters. Other [Details]
(2008)Aberrant Cytokine Response to Stress In Balb/C Mice After Lipopolysaccharide (Lps) Challenge: Relevance of Tryptophan Hydroxylase 2.
Browne, CA, O'Brien, F, Connor, TJ, Cryan, JF; (2008) Aberrant Cytokine Response to Stress In Balb/C Mice After Lipopolysaccharide (Lps) Challenge: Relevance of Tryptophan Hydroxylase 2. Other [Details]
(2008)The Effects of Acute and Chronic Stress On Mglur7 and Bdnf Gene Expression In Two Inbred Strains of Mice Which Differ In Emotionality.
O'Mahony, CM, Dinan, TG, Cryan, JF; (2008) The Effects of Acute and Chronic Stress On Mglur7 and Bdnf Gene Expression In Two Inbred Strains of Mice Which Differ In Emotionality. Other [Details]
(2008)Altered Stress-Related Gene Expression In The Hippocampus of A Gentetic Model of Anxiety & Depression.
Bravo, JA, Dinan, TG, Cryan, JF; (2008) Altered Stress-Related Gene Expression In The Hippocampus of A Gentetic Model of Anxiety & Depression. Other [Details]
(2008)Balb/C Mice As A Model of Aberrant Stress-Induced Cytokine Expression: Relevence to Major Depression.
Browne, CA, O'Brien, F, Connor, TJ, Dinan, TG, Cryan, JF; (2008) Balb/C Mice As A Model of Aberrant Stress-Induced Cytokine Expression: Relevence to Major Depression. Other [Details]
(2008)Differential Activation of The Prefrontal Cortex In Response to Stress and Colonic Rectal Distension In A Genetically Susceptible Model of Depression & Irritable Bowel Syndrome (Ibs).
Gibney, SM, Gosselin, RD, Dinan, TG, Cryan, JF; (2008) Differential Activation of The Prefrontal Cortex In Response to Stress and Colonic Rectal Distension In A Genetically Susceptible Model of Depression & Irritable Bowel Syndrome (Ibs). Other [Details]
(2008)Region Specific Decrease In Glial Fibrillary Acidic Protein (Gfap) Immunoreactivity In The Brain of A Genetic Rat Model of Depression.
Gosselin, RD, Gibney, S, O'Malley, D, Dinan, TG, Cryan, JF; (2008) Region Specific Decrease In Glial Fibrillary Acidic Protein (Gfap) Immunoreactivity In The Brain of A Genetic Rat Model of Depression. Other [Details]
(2008)Tryptophan Degradation and Irritable Bowel Syndrome (Ibs) - Evidence of An Immune Mediated Indoleamine-2,3-Dioxygenase (Ido) Activation In A Male Cohort.
Clarkc, G, Fitzgerald, P, Cryan, JF, Dinan, TG; (2008) Tryptophan Degradation and Irritable Bowel Syndrome (Ibs) - Evidence of An Immune Mediated Indoleamine-2,3-Dioxygenase (Ido) Activation In A Male Cohort. Other [Details]
(2009)A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity?.
Hyland, NP,Julio-Pieper, M,O'Mahony, SM,Bulmer, DC,Lee, K,Quigley, EM,Dinan, TG,Cryan, JF (2009) A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity?. Other [DOI] [Details]
(2009)Altered Expression of Hippocampal Mglur7 Mrna In A Model of Depression.
O'Mahony, C, Dinan, TG, Cryan, JF; (2009) Altered Expression of Hippocampal Mglur7 Mrna In A Model of Depression. Other [Details]
(2009)Mice Are Resistant to Early-Life Stress-Induced Alterations In Adult Behaviour.
Savignac, HM, Dinan, TG, Cryan, JF; (2009) Mice Are Resistant to Early-Life Stress-Induced Alterations In Adult Behaviour. Other [Details]

Newspaper Articles

YearPublication
(2010)Banning mephedrone won't stop next wave.
Keating J.J., Cryan J.F.; (2010) Banning mephedrone won't stop next wave. Irish Examiner: Newspaper Articles [Details]

Review Articles

YearPublication
(2009)Irritable bowel syndrome: towards biomarker identification.
Clarke G, Quigley EMM, Cryan JF, Dinan TG (2009) Irritable bowel syndrome: towards biomarker identification. Review Articles [Details]
(2011)Brain-Gut-Microbe communication in health and disease.
Grenham S, Clarke G, Cryan JF, Dinan TG (2011) Brain-Gut-Microbe communication in health and disease. Review Articles [Details]
(2012)Gut Memories: Towards a Cognitive Neurobiology of Irritable Bowel Syndrome.
Kennedy P, Clarke G, Groeger J, Quigley EMM, Cryan J, Dinan T (2012) Gut Memories: Towards a Cognitive Neurobiology of Irritable Bowel Syndrome. Review Articles [Details]
(2012)Probiotics for the Treatment of Irritable Bowel Syndrome: Focus on Lactic Acid Bacteria.
Clarke G, Cryan JF, Dinan TG, Quigley EM (2012) Probiotics for the Treatment of Irritable Bowel Syndrome: Focus on Lactic Acid Bacteria. Review Articles [Details]
(2005)New medications for smoking cessation: beyond NRT and bupropion.
Cryan J.F.; (2005) New medications for smoking cessation: beyond NRT and bupropion. Review Articles [Details]
(2005)mGluR7 Plays a Key Role in the Modulation of Anxiety Behavior: Evidence from mGluR7 Knockout Mice and siRNA-induced Knockdown in the Adult Mouse Brain.
Cryan J.F.; (2005) mGluR7 Plays a Key Role in the Modulation of Anxiety Behavior: Evidence from mGluR7 Knockout Mice and siRNA-induced Knockdown in the Adult Mouse Brain. Review Articles [Details]
(2005)Use of RNAi in Target Validation for Neuropsychiatric Disorders.
Cryan J.F.; (2005) Use of RNAi in Target Validation for Neuropsychiatric Disorders. Review Articles [Details]
(2005)The use of genetically modified mice to understand the role of metabotropic glutamate 7 Receptors in Anxiety.
Cryan J.F.; (2005) The use of genetically modified mice to understand the role of metabotropic glutamate 7 Receptors in Anxiety. Review Articles [Details]
(2004)The Modified Rat Forced Swim Test:A tool to assess the role of monoamines in antidepressant action.
Cryan J.F.; (2004) The Modified Rat Forced Swim Test:A tool to assess the role of monoamines in antidepressant action. Review Articles [Details]
(2004)Targeting the GABAB receptor for the development of anxiolytic and antidepressants: Recent advances with novel pharmacological and genetic tools.
Cryan J.F.; (2004) Targeting the GABAB receptor for the development of anxiolytic and antidepressants: Recent advances with novel pharmacological and genetic tools. Review Articles [Details]
(2004)In search of a depressed mouse: models for studying depression-related behaviour in genetically modified mice.
Cryan J.F.; (2004) In search of a depressed mouse: models for studying depression-related behaviour in genetically modified mice. Review Articles [Details]
(2003)Murine models of depression: Utility for knockout and transgenic behavioral studies.
Cryan, J.F.; (2003) Murine models of depression: Utility for knockout and transgenic behavioral studies. Review Articles [Details]
(2000)Antidepressants associated with norepinephrine and serotonin pathways elicit distinct behaviors in a modified forced swim test.
Cryan, J.F., Page, M.E. and Lucki, I.; (2000) Antidepressants associated with norepinephrine and serotonin pathways elicit distinct behaviors in a modified forced swim test. Review Articles [Details]
(1997)Combining pindolol and paroxetine in an animal model of chronic antidepressant action - Can early onset of action be detected?.
Cryan J.F., McGrath, C., Leonard B.E. and Norman T.R; (1997) Combining pindolol and paroxetine in an animal model of chronic antidepressant action - Can early onset of action be detected?. Review Articles [Details]
(1996)The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat.
Cryan J.F., Redmond A.M., Kelly J.P. and Leonard B.E.; (1996) The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat. Review Articles [Details]

Reviews

YearPublication
(2013)Psychobiotics: A Novel Class of Psychotropic.
Dinan, TG,Stanton, C,Cryan, JF (2013) Psychobiotics: A Novel Class of Psychotropic. Reviews [DOI] [Details]
(2013)Towards translational rodent models of depression.
O'Leary, OF,Cryan, JF (2013) Towards translational rodent models of depression. Reviews [DOI] [Details]
(2014)Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis.
Stilling, RM,Dinan, TG,Cryan, JF (2014) Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis. Reviews [DOI] [Details]
(2013)Non-Viral Nanosystems for Gene and Small Interfering RNA Delivery to the Central Nervous System: Formulating the Solution.
O'Mahony, AM,Godinho, BMDC,Cryan, JF,O'Driscoll, CM (2013) Non-Viral Nanosystems for Gene and Small Interfering RNA Delivery to the Central Nervous System: Formulating the Solution. Reviews [DOI] [Details]
(2014)Microbiota and neurodevelopmental windows: implications for brain disorders.
Borre, YE,O'Keeffe, GW,Clarke, G,Stanton, C,Dinan, TG,Cryan, JF (2014) Microbiota and neurodevelopmental windows: implications for brain disorders. Reviews [DOI] [Details]
(2014)The microbiome: stress, health and disease.
Moloney, RD,Desbonnet, L,Clarke, G,Dinan, TG,Cryan, JF (2014) The microbiome: stress, health and disease. Reviews [DOI] [Details]
(2014)Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour.
Clarke, G,O'Mahony, SM,Dinan, TG,Cryan, JF (2014) Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour. Reviews [DOI] [Details]
(2014)A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.
Naughton, M,Clarke, G,O'Leary, OF,Cryan, JF,Dinan, TG (2014) A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. Reviews [DOI] [Details]
(2014)Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test.
Allen, AP,Kennedy, PJ,Cryan, JF,Dinan, TG,Clarke, G (2014) Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test. Reviews [DOI] [Details]
(2014)Minireview: Gut Microbiota: The Neglected Endocrine Organ.
Clarke, G,Stilling, RM,Kennedy, PJ,Stanton, C,Cryan, JF,Dinan, TG (2014) Minireview: Gut Microbiota: The Neglected Endocrine Organ. Reviews [DOI] [Details]
(2014)Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory.
Kennedy, PJ,Clarke, G,O'Neill, A,Groeger, JA,Quigley, EMM,Shanahan, F,Cryan, JF,Dinan, TG (2014) Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory. Reviews [DOI] [Details]

Honours and Awards

 YearTitleAwarding Body
2007National Institutes for Mental Health, NIH, USA. Distinguished Lecturer National Institutes for Mental Health, NIH, USA.
2006European College of Neuropsychopharmacology Fellowship Award European College of Neuropsychopharmacology
2006Wyeth Psychopharmacology Award of British Association of Psychopharmacology British Association of Psychopharmacology
2005Keynote speaker at New York Academy of the Sciences New York Academy of the Sciences
2005Young Scientist Award from Foundation of the European Behavioural Pharmacology Society Foundation of the European Behavioural Pharmacology Society
2005Novartis Neuroscience Recognition Award Novartis Pharma AG

Patents

 Patent NumberTitleInventorGranted
WO/2011/058535Probiotic bifidobacterium strain O'Mahony, L, Kiely B, Cryan JF, Dinan T, Murphy E.19-MAY-11
WO 2004/071152Use of S-10 hydroxy-10, 11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders Bilbe G, Cryan JF, Gentsch C, McAllister KH, Schmutz M, Vassout A01-JAN-04

Conference Contributions

YearPublication
(2012)Neurogastroenterology and Motility, Bologna, Italy, 2012,
Clarke G, Grenham S, Scully P, Fitzgerald P, Shanahan F, Dinan TG, Cryan JF (2012) The Microbiome-Gut-Brain Axis as a Regulator of Serotonergic Neurotransmission and Behaviour. [Poster Presentation], Neurogastroenterology and Motility, Bologna, Italy, 2012, Bologna , 06-SEP-12 - 08-SEP-12. [Details]
(2012)Neurogastroenterology and Motility, Bologna, Italy, 2012,
Kennedy PJ, Clarke G, O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2012) An evaluation of neuropsychological performance in Irritable Bowel Syndrome (IBS): Relationship between altered visuo-spatial memory function, salivary cortisol levels and tryptophan metabolism along the kynurenine pathway. [Poster Presentation], Neurogastroenterology and Motility, Bologna, Italy, 2012, Bologna , 06-SEP-12 - 08-SEP-12. [Details]
(2012)Neuroscience Ireland, RCSI, Dublin, 2012,
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein restricts blood-brain barrier transport of the antidepressant escitalopram: converging evidence from in vitro and in vivo studies. [Poster Presentation], Neuroscience Ireland, RCSI, Dublin, 2012, Dublin , 06-SEP-12 - 07-SEP-12. [Details]
(2012)American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012,
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein limits antidepressant transport across the blood-brain barrier: converging evidence from in vitro and in vivo studies. [Poster Presentation], American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012, Chicago , 03-OCT-12 - 04-OCT-12. [Details]
(2012)British Pharmacological Society (BPS) Winter Meeting, London, December 2012,
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) The Influence of P-glycoprotein on the Blood-Brain Barrier Transport of the Antidepressant Escitalopram: Converging Evidence from In Vivo and In Vitro Studies. [Poster Presentation], British Pharmacological Society (BPS) Winter Meeting, London, December 2012, London , 17-DEC-12 - 19-DEC-12. [Details]
(2007)European College of Neuropsychopharmacology (ECNP), 20th ECNP Congress, Vienna, Austria, September 2007,
O' Mahony SM, Clarke G, O' Mahony L, Quigley EMM, Cryan JF, Dinan TG (2007) Depressive behaviours and alterations in the immune and stress response systems following neonatal maternal separation. [Poster Presentation], European College of Neuropsychopharmacology (ECNP), 20th ECNP Congress, Vienna, Austria, September 2007, Vienna , 13-OCT-07 - 17-OCT-07. [Details]
(2008)Digestive Disease Week, San Diego, USA, May 2008,
Fitzgerald P, Clarke G, Scully P, Cryan JF, Shanahan F, Quigley EMM, Cassidy EM, Dinan TG (2008) Tryptophan catabolism in irritable bowel syndrome: Relationship to cytokines, severity and psychiatric comorbidity. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2008, San Diego , 17-MAY-08 - 22-MAY-08. [Details]
(2008)Digestive Disease Week, San Diego, USA, May 2008,
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM,Quigley EMM, Dinan TG (2008) Altered kynurenine pathway metabolism in Irritable Bowel Syndrome (IBS)-Evidence of indoleamine 2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2008, San Diego , 17-MAY-08 - 22-MAY-08. [Details]
(2008)European Behavioural Pharmacology Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders, Cork, Ireland, September 2008,
Clarke G, O’Mahony SM, Hyland, NP, Fitzgerald P, Cryan JF, Dinan TG (2008) Beta3 adrenoceptor modulation of visceral pain-a possible role for the kynurenine pathway?. [Poster Presentation], European Behavioural Pharmacology Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders, Cork, Ireland, September 2008, Cork , 25-AUG-08 - 27-AUG-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008,
Clarke G, Fitzgerald P, Cryan JF, Dinan TG. (2008) Increased tryptophan metabolism in irritable bowel syndrome (IBS)–an immune mediated phenomenon?. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008, Lucerne , 06-NOV-08 - 09-NOV-08. [Details]
(2008)Beta3 Adrenoceptor Modulation of Visceral Pain - A Possible Role For The Kynurenine Pathway?,
Clarke, G, O'Mahony, S, Hyland, NP, Fitzgerald, P, Dinan, TG, Cryan, JF; (2008) Beta3 Adrenoceptor Modulation of Visceral Pain - A Possible Role For The Kynurenine Pathway?, . [Details]
(2008)International Neuroimmunology Symposium, University College Dublin, Dublin, Ireland, March 2008,
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM,Quigley EMM, Dinan TG (2008) Tryptophan Degradation and Irritable Bowel Syndrome (IBS)-Evidence of an immune mediated indoleamine-2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], International Neuroimmunology Symposium, University College Dublin, Dublin, Ireland, March 2008, Dublin , 13-MAR-08 - 14-MAR-08. [Details]
(2009)Neuroscience Ireland, Trinity College Dublin, September 2009,
Browne CA, Clarke, G, Dinan TG, Cryan JF. (2009) Behavioural effects of dietary trypotphan manipulations on c57bl/6j and balb/c mice. [Poster Presentation], Neuroscience Ireland, Trinity College Dublin, September 2009, Dublin , 10-SEP-09 - 11-SEP-09. [Details]
(2009)Digestive Disease Week, Chicago, USA, June 2009,
Clarke G, Fitzgerald P, Hennessy AA, Cassidy EM, Quigley EMM, Ross P, Stanton C, Cryan JF, Dinan TG (2009) Polyunsaturated fatty acids contribute to the inflammatory phenotype in irritable bowel syndrome. [Poster Presentation], Digestive Disease Week, Chicago, USA, June 2009, Chicago , 31-MAY-09 - 03-JUN-09. [Details]
(2009)European College of Neuropsychopharmacology, Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2009,
Browne CA, Clarke G., Dinan TG, Cryan JF (2009) Restraint stress alters tryptophan hydroxylase 2 activity in BALB/c mice: relevance to depression. [Poster Presentation], European College of Neuropsychopharmacology, Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2009, Nice , 05-MAR-09 - 08-MAR-09. [Details]
(2009)European College of Neuropsychopharmacology, Istanbul, Turkey, September 2009,
Clarke G, O'Mahony SM, Hennessy AA, Ross P, Stanton C, Cryan JF, Dinan TG (2009) Chain reactions: Polyunsaturated fatty acids and the depressive phenotype in maternally separated rodents. [Poster Presentation], European College of Neuropsychopharmacology, Istanbul, Turkey, September 2009, Istanbul , 12-SEP-09 - 16-SEP-09. [Details]
(2010)7th World Congress on Stress, Leiden, Holland, August 2010,
Julio M, O’Mahony C, Clarke G, Bravo J, Dinan TG, Cryan JF (2010) Strain-specific alterations in colon 5-HT levels correlate to defecation responses in chronically stressed mice. [Poster Presentation], 7th World Congress on Stress, Leiden, Holland, August 2010, Leiden , 25-AUG-12 - 27-AUG-12. [Details]
(2010)Psychoneuroimmunology Research Society, Trinity College, Dublin, June 2010,
Scully P, Clarke G, Grenham S, Fitzgerald P, O’Mahony CM, ,McKernan DP,Tramullas M,Shanahan F, Dinan TG, & Cryan JF (2010) Gender-Dependent Influence of the Gut Microbiome on the Hippocampal 5-HT System. [Poster Presentation], Psychoneuroimmunology Research Society, Trinity College, Dublin, June 2010, Dublin , 02-JUN-10 - 05-JUN-10. [Details]
(2010)Health and Medicine Research Day, Brookfield, Cork, June 2010,
Scully P, Clarke G, Grenham S, Fitzgerald P, O’Mahony CM,McKernan DP,Tramullas M,Shanahan F, Dinan TG, & Cryan JF (2010) Gender-Dependent Influence of the Gut Microbiome on the Hippocampal 5-HT System. [Poster Presentation], Health and Medicine Research Day, Brookfield, Cork, June 2010, Cork , 16-JUN-10 - 16-JUN-10. [Details]
(2010)Society for Neuroscience, San Diego, USA, November 2010,
Cryan JF, Clarke G, Grenham S, Scully P, Shanahan F, Dinan TG (2010) The gut microbiome markedly influences hippocampal neurotransmission in the mouse: Role of gender. [Poster Presentation], Society for Neuroscience, San Diego, USA, November 2010, San Diego , 13-NOV-10 - 17-NOV-10. [Details]
(2010)Society for Neuroscience, San Diego, USA, November 2010,
Tramullas M, Clarke G, Shanahan F, Dinan TG, Cryan JF (2010) The gut microbiome alters toll-like receptor and cytokine expression levels in the spinal cord: Role of gender. [Poster Presentation], Society for Neuroscience, San Diego, USA, November 2010, San Diego , 13-NOV-10 - 17-NOV-10. [Details]
(2011)College of Medicine and Health Research Day, UCC, June 2011,
O’Brien FE, Clarke G, Fitzgerald P, Griffin BT, Cryan JF (2011) An integrated microdialysis model for the analysis of blood-brain barrier drug transport in the conscious freely moving rat. [Poster Presentation], College of Medicine and Health Research Day, UCC, June 2011, Cork , 22-JUN-11 - 22-JUN-11. [Details]
(2012)Digestive Disease Week, San Diego, USA, May 2012,
Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney, RD, Shanahan F, Dinan TG, Cryan JF (2012) Regulation of Serotonergic Neurotransmission and Behaviour by the Brain-Gut-Microbiome Axis. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2012, San Diego , 19-MAY-12 - 22-MAY-12. [Details]
(2012)Digestive Disease Week, San Diego, USA, May 2012,
Kennedy PJ, Clarke G, O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2012) Are deficits in episodic memory stress-related and mediated by tryptophan metabolism along the kynurenine pathway?. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2012, San Diego , 19-MAY-12 - 22-MAY-12. [Details]
(2008)European Behavioural Pharmacology Society Meeting,
Cryan, J. F.; (2008) From Mouse to Man: Behavioural Genetics and its Relevance to Psychiatric Disorders. [Conference Organising Committee Member], European Behavioural Pharmacology Society Meeting, Cork, Ireland , 01-JAN-08 - 01-JAN-08. [Details]
(2008)XXVIth Congress of the Collegium Internationale Neuro-Psychopharmacologium,
Cryan, J. F.; (2008) Corticolimbic dysfunction in stress-related disorders: From mouse to man, from molecule to medicine. [Conference Organising Committee Member], XXVIth Congress of the Collegium Internationale Neuro-Psychopharmacologium, Munich, Germany , 01-JUL-08 - 01-JUL-08. [Details]
(2008)FENS Meeting,
Cryan, J. F.; (2008) New insights into Cortico-Amygdala interactions: implications for disorders of emotion. [Conference Organising Committee Member], FENS Meeting, Geneva, Switzerland , 01-JUL-08 - 01-JUL-08. [Details]
(2007)Ninth Annual Meeting of the International Behavioural and Neural Genetics Society,
Cryan, J. F.; (2007) Genetic Approaches to Study Depression and the Antidepressant response. [Conference Organising Committee Member], Ninth Annual Meeting of the International Behavioural and Neural Genetics Society, Doorwerth, The Netherlands , 21-MAY-07 - 25-MAY-07. [Details]
(2006)Young Scientist Workshop of the European College of Neuropsychopharmacology,
L. Lhuillier, C. Mombereau, J.F. Cryan, K. Kaupmann; (2006) The GABAB receptor positive allosteric modulator GS39783 attenuates selected molecular markers and behavioral effects relevant to both cocaine and nicotine dependence. [Poster Presentation], Young Scientist Workshop of the European College of Neuropsychopharmacology, Nice, France , 01-MAR-06 - 01-MAR-06. [Details]
(2006)XXVth Congress of the Collegium Internationale Neuro-Psychopharmacologium,
Cryan, J. F.; (2006) Recent advances in understanding the neural substrates of anxiety using rodent models. [Conference Organising Committee Member], XXVth Congress of the Collegium Internationale Neuro-Psychopharmacologium, Chicago , 01-JUL-06 - 01-JUL-06. [Details]
(2005)The Society for Neuroscience 35th Annual Meeting,
C. Mombereau, L.C. Lhuillier, K. Kaupmann, J.F. Cryan; (2005) The GABAB Receptor-Positive Modulator GS39783 blocks the acquisition of nicotine place preference in the rat. [Poster Presentation], The Society for Neuroscience 35th Annual Meeting, Washington, USA , 01-NOV-05 - 01-NOV-05. [Details]
(2005)The Society for Neuroscience 35th Annual Meeting,
D.A. Slattery, A. Markou, W. Froestl, J.F. Cryan; (2005) The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat. [Poster Presentation], The Society for Neuroscience 35th Annual Meeting, Washington, USA , 01-NOV-05 - 01-NOV-05. [Details]
(2005)The Society for Neuroscience 35th Annual Meeting,
P.J. Flor, K. Mitsukawa, C. Mombereau, E. Ltscher, D.P. Uzunov, H. van der Putten, J.F. Cryan; (2005) Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders. [Poster Presentation], The Society for Neuroscience 35th Annual Meeting, Washington, USA , 01-NOV-05 - 01-NOV-05. [Details]
(2005)The Society for Neuroscience 35th Annual Meeting,
Mitsukawa, R. Yamamoto, J. Nozulak, S. Ofner, O. Pescott, S. Lukic, N. Stoehr, S. Urwyler, R. Kuhn, P. Herrling, J.F. Cryan, P.J. Flor; (2005) AMN082, the first selective metabotropic glutamate receptor subtype 7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain. [Poster Presentation], The Society for Neuroscience 35th Annual Meeting, Washington, USA , 01-NOV-05 - 01-NOV-05. [Details]
(2005)The Society for Neuroscience 35th Annual Meeting,
L.H. Jacobson, K. Kaupmann, B. Bettler, J.F. Cryan; (2005) differential influence of GABAB(1) receptor subunit isoforms on baseline but not GABAB agonist-induced behavioural changes in mice. [Poster Presentation], The Society for Neuroscience 35th Annual Meeting, Washington, USA , 01-NOV-05 - 01-NOV-05. [Details]
(2005)Young Scientist Workshop of the European College of Neuropsychopharmacology,
D.A. Slattery, C. Mombereau, W. Froestl, A. Markou, K. Kaupmann, and Cryan, J.F; (2005) GABAB receptor positive modulation as a novel therapeutic approach to drug dependence: Blockade of the rewarding and psychostimulant effects of cocaine. [Poster Presentation], Young Scientist Workshop of the European College of Neuropsychopharmacology, Nice, France , 01-MAR-05 - 01-MAR-05. [Details]
(2005)Experimental Biology Meeting,
D.R. Thakker, F. Natt, D. Hüsken, M. Mller, R. Maier, H. van der Putten, D. Hoyer, Cryan, J.F.; (2005) Behavioural and neurochemical consequences of siRNA-induced knockdown of serotonin and dopamine transporters in the adult mouse brain: Implications for validation of novel therapeutic targets for psychiatric illnesses. [Poster Presentation], Experimental Biology Meeting, San Diego, USA , 01-APR-05 - 01-APR-05. [Details]
(2005)The American College of Neuropsychopharmacology 44th Annual Meeting,
A. Markou; N.E. Paterson; P.J. Kenny; S. Semenova; J.F.Cryan; (2005) Measuring anhedonia in animals: Reversal by Antidepressant Treatments. [Poster Presentation], The American College of Neuropsychopharmacology 44th Annual Meeting, Hawaii , 01-DEC-05 - 01-DEC-05. [Details]
(2005)European Brain and Behaviour Society,
Cryan, J. F.; (2005) ETH Zurich on Neurogenetics and Behaviour. [Conference Organising Committee Member], European Brain and Behaviour Society, Dublin, Ireland , 01-SEP-05 - 01-SEP-05. [Details]
(2003)The Society for Neuroscience 33rd Annual Meeting,
Kaupmann, K., Cryan, J.F., Wellendorph, P. Mombereau, C. Sansig, G. Klebs, K., Schmutz, M., Froestl, W. van der Putten, H., Mosbacher, J., Bräuner-Osborne, H., Waldmeier, P., and Bettler, B.; (2003) Effects of g-hydroxybutyrate in GABA-B receptor deficient mice. [Poster Presentation], The Society for Neuroscience 33rd Annual Meeting, New Orleans, USA , 01-NOV-03 - 01-NOV-03. [Details]
(2003)The Society for Neuroscience 33rd Annual Meeting,
Cryan, J.F. , Szeliga, P.J., Gasparini, F. Page. M.E.; (2003) Potential anxiolytic-like actions of metabotropic glutamate receptor 5 (mGluR5) antagonists revealed by neurochemical and behavioral studies. [Poster Presentation], The Society for Neuroscience 33rd Annual Meeting, New Orleans, USA , 01-NOV-03 - 01-NOV-03. [Details]
(2003)Experimental Biology Meeting,
Cryan, J.F. Kelly, P.H. Sansig, G., Flor P.J. and van Der Putten, H.; (2003) Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7 `03 E. [Poster Presentation], Experimental Biology Meeting, San Diego, USA , 01-APR-03 - 01-APR-03. [Details]
(2008)In search of a depressed mouse: Genetic and behavioural approaches to understand the pathophysiology of depression,
Cryan, J. F. ; (2008) unknown. [Oral Presentation], In search of a depressed mouse: Genetic and behavioural approaches to understand the pathophysiology of depression, University of Newcastle, UK , 01-OCT-08 - 01-OCT-08. [Details]
(2008)Unknown,
Cryan, J. F. ; (2008) Stress and the Brain-Gut Axis: From the Bowel to Behaviour. [Oral Presentation], Unknown, MacMaster University, Hamilton, Canada , 01-SEP-08 - 01-SEP-08. [Details]
(2008)Irish Society of Gastroenterology Spring Conference,
Clarke G, Fitzgerald P, Cassidy E, Cryan JF, Quigley EM, Dinan TG; (2008) Increased tryptophan degradation along the kynurenine pathway in Irritable Bowel Syndrome (IBS)-Evidence of an immune mediated indoleamine 2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], Irish Society of Gastroenterology Spring Conference, Sligo, Ireland , 01-APR-08 - 01-APR-08. [Details]
(2008)Irish Society of Gastroenterology Spring Conference,
Hyland NP, O¿Mahony SM, Bulmer DC, Lee K, Dinan TG & Cryan JF; (2008) Do mast cells contribute to visceral hypersensitivity in adult rats following neonatal psychological stress?. [Poster Presentation], Irish Society of Gastroenterology Spring Conference, Sligo, Ireland , 01-APR-08 - 01-APR-08. [Details]
(2008)Irish Society of Gastroenterology Spring Conference,
Gibney SM, Gosselin RD, O¿Malley DM, Dinan TG & Cryan JF; (2008) Imaging distinct patterns of cortical brain activation following colorectal distension in an animal model of Irritable Bowel Syndrome. [Poster Presentation], Irish Society of Gastroenterology Spring Conference, Sligo, Ireland , 01-JAN-08 - 01-JAN-08. [Details]
(2008)International neuroimmunology symposium,
Bravo JA, Dinan TG & Cryan JF; (2008) The effects of the acetylcholinesterase inhibitor pyridostigmine on inflammatory responses in an animal model of irritable bowel syndrome. [Poster Presentation], International neuroimmunology symposium, UCD, Dublin, Ireland , 01-MAR-08 - 01-MAR-08. [Details]
(2008)Digestive Disease Week,
Clarke G, Fitzgerald P, Cassidy E, Cryan JF, Quigley EM, Dinan TG; (2008) Altered kynurenine pathway metabolism in Irritable Bowel Syndrome (IBS)-Evidence of indoleamine 2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], Digestive Disease Week, San Diego, USA , 01-MAY-08 - 01-MAY-08. [Details]
(2008)Digestive Disease Week,
Bulmer DC, O' Mahony, SM, Coelho A-M, Gray K, Taylor CM, Dinan TG, Cryan JF, Lee K, Winchester WJ; (2008) Analgesic effects of 5-HT2B antagonists in pre-clinical models of colorectal pain. [Poster Presentation], Digestive Disease Week, San Diego, USA , 01-JAN-08 - 01-JAN-08. [Details]
(2008)Digestive Disease Week,
Coelho AM, O 'Mahony SM, Taylor CM, Wheeldon A, Fitzgerald P, Dinan T, Cryan JF, Lee K, Winchester WJ.; (2008) Gabapentin reverses colorectal distension-induced visceral pain behaviours in rat models of acute and chronic visceral hypersensitivity. [Poster Presentation], Digestive Disease Week, San Diego, USA , 01-JAN-08 - 01-JAN-08. [Details]
(2008)Digestive Disease Week,
Hyland NP, Gibney SM, Gosselin RD, Lee K, Dinan TG & Cryan JF; (2008) Assessment of colonic secretory function and faecal output in viscerally hypersensitive Wistar Kyoto rats. [Poster Presentation], Digestive Disease Week, San Diego, USA , 01-JAN-08 - 01-JAN-08. [Details]
(2008)All Ireland Schools of Pharmacy Research Conference,
Savignac HM, Hyland NP, Dinan TG & Cryan JF (2008) Social stress induces mild colonic damage and altered anti-inflammatory cytokines in the mouse. [Poster Presentation], All Ireland Schools of Pharmacy Research Conference, Cork, Ireland , 01-APR-08 - 01-APR-08. [Details]
(2008)British Association for psychoparmacology, Summer meeting,
O¿ Mahony Cliona M, Bravo J, Dinan TG, Cryan JF; (2008) Comparison of stress-induced alterations in hippocampal mGluR7 mRNA in two animal models of depression. [Poster Presentation], British Association for psychoparmacology, Summer meeting, Harrogate, UK , 01-JUL-08 - 01-JUL-08. [Details]
(2008)6th Meeting on Metabotropic Glutamate receptors,
Fendt, M., Schmid, S., Thakker, D.R., Jacobson, L.H., Yamamota, R. Mitsukawa, K. Maier, R, McAllister, K.H., Hoyer, D. van der Putten, H. Cryan JF and Flor, P.J; (2008) Control of stress- and anxiety- related physiology and behavior by mGluR7 modulation. [Poster Presentation], 6th Meeting on Metabotropic Glutamate receptors, Taormina, Sicily Italy , 01-SEP-08 - 01-SEP-08. [Details]
(2008)European-Behavioural-Pharmacology-Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders,
Clarke G, O'Mahony S, Hyland NP, Dinan TG & Cryan JF; (2008) Beta3 adrenoceptor modulation of visceral pain - A possible role for the kynurenine pathway?. [Poster Presentation], European-Behavioural-Pharmacology-Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders, Cork, Ireland , 01-AUG-08 - 01-AUG-08. [Details]
(2008)Unknown,
Cryan, J. F. ; (2008) Genetic and Pharmacological Tools to Unravel the Role of mGluR7 in Stress-related Behavioural Disorders. [Oral Presentation], Unknown, Samuel Lunenfeld Research Center, Mt Sinai Hospital, Univ. Toronto, Canada , 01-SEP-08 - 01-SEP-08. [Details]
(2008)Unknown,
Cryan, J. F. ; (2008) In vivo Genetic Approaches to Aid in Development of Novel Therapeutic Targets for Stress-related Disorders: Focus on mGluR7. [Oral Presentation], Unknown, Helmholz Zentrum Muenchen, Institute of Developmental Genetics, Munich , 01-JUL-08 - 01-JUL-08. [Details]
(2008)Unknown,
Cryan, J. F. ; (2008) In vivo Genetic Approaches to Understand the Role of mGluR7 in Stress-Related Disorders. [Oral Presentation], Unknown, Ruhr Univ. Bochum, Germany , 01-JUL-08 - 01-JUL-08. [Details]
(2008)Unknown,
Cryan, J. F. ; (2008) Silencing the Unquiet Mind: Knockout and RNA Interference-based approaches to Understand Depression and Anxiety. [Oral Presentation], Unknown, Univ Oxford, Dept Pharmacology, UK , 01-JUN-08 - 01-JUN-08. [Details]
(2008)XVIII Asociación Latino- Americana de Farmacología Congress,
Cryan, J. F.; (2008) Novel pharmacological and genetic tools to unravel GABA-Glutamate imbalance in anxiety. [Invited Oral Presentation], XVIII Asociación Latino- Americana de Farmacología Congress, Coquimbo, Chile , 01-OCT-08 - 01-OCT-08. [Details]
(2008)XXVIth Congress of the Collegium Internationale Neuro-Psychopharmacologium,
Cryan, J. F.; (2008) Genetic and pharmacological tools to unravel the role of mGluR7 in stress-related disorders. [Invited Oral Presentation], XXVIth Congress of the Collegium Internationale Neuro-Psychopharmacologium, Chicago , 01-JUL-08 - 01-JUL-08. [Details]
(2008)Meeting for Neurogastroenterology and Motility Second Joint International M,
Hyland NP, O¿Mahony SM, Bongiovanni C, Julio-Pieper, M, Bulmer DC, Dinan TG, Cryan JF; (2008) Beta3-adrenoceptor mediated secretion and localisation in the submucosal plexus of descending colon from maternally separated animals. [Poster Presentation], Meeting for Neurogastroenterology and Motility Second Joint International M, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility,,
Clarke G., Fitzgerald P, Cryan JF, Dinan TG; (2008) Increased tryptophan metabolism in irritable bowel syndrome (IBS)¿an immune mediated phenomenon?. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility,, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility,
Gibney SM, Gosselin RD, O¿Malley D, Dinan TG & Cryan JF; (2008) Altered colonic rectal distension-induced activation of the prefrontal cortex in two animals models of irritable bowel syndrome (IBS). [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility,,
Hyland NP, O¿Callaghan K., O¿Malley D, Dinan TG & Cryan JF; (2008) Differential cholinergic sensitivity in the enteric nervous system in two models of visceral hypersensitivity. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility,, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility,
O¿Mahony SM, Fitzgerald P, Bulmer DC, Coelho AM, Dinan TG & Cryan JF; (2008) Central 5-HT2B receptors modulate visceral hypersensitivity in a genetic model of irritable bowel syndrome. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility,
O¿Malley D, Julio-Pieper M, Dinan TG & Cryan JF; (2008) The effects of stress on colonic morphology in two animal models of irritable bowel syndrome. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility,
O¿Malley D, Julio-Pieper M, Dinan TG & Cryan JF; (2008) CRF receptor expression in the brain and colon of WKY rats following colorectal distension. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland , 01-NOV-08 - 01-NOV-08. [Details]
(2008)European-Behavioural-Pharmacology-Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders,
Gosselin RD, Gibney S, O'Malley D, Dinan TG & Cryan JF; (2008) Region specific decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the brain of a genetic rat model of depression. [Poster Presentation], European-Behavioural-Pharmacology-Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders, Cork, Ireland , 01-AUG-08 - 01-AUG-08. [Details]
(2007)Irish Society of Gastroenterology, Winter Meeting,
Hyland NP, Dinan TG, Cryan JF; (2007) Stress susceptible Wistar Kyoto rats display altered epithelial cholinergic sensitivity in the distal colon. [Poster Presentation], Irish Society of Gastroenterology, Winter Meeting, Dublin, Ireland , 01-DEC-07 - 01-DEC-07. [Details]
(2007)European Graduate School of Neuroscience workshop,
Clarke G, Barry S, Scully P, Cryan JF, Dinan T; (2007) Simultaneous measurement of tryptophan and it¿s kynurenine pathway metabolites by HPLC: evidence of increased tryptophan degradation in psychosis. [Poster Presentation], European Graduate School of Neuroscience workshop, Bad Honnef, Germany , 01-NOV-07 - 01-NOV-07. [Details]
(2007)Unknown,
Cryan, J. F. ; (2007) Using novel genetic and pharmacological tools to unravel the role of GABAB receptors in anxiety, depression and drug abuse. [Oral Presentation], Unknown, Univ. Birmingham, UK , 01-FEB-07 - 01-FEB-07. [Details]
(2007)Unknown,
Cryan, J. F. ; (2007) GABAB receptors Play a Key Role in Neuropsychiatric Disorders: Recent Developments with Novel Genetic and Pharmacological Tools. [Oral Presentation], Unknown, Univ. Copenhagen, Denmark , 01-MAR-07 - 01-MAR-07. [Details]
(2007)Unknown,
Cryan, J. F. ; (2007) Silencing the Unquiet Mind: Knockout and RNA Interference-based approaches to Understand Depression and Anxiety. [Oral Presentation], Unknown, National Institute of Health, Bethesda USA, Mood and Anxiety Disorders Program Distinguished Lecturer , 01-APR-07 - 01-APR-07. [Details]
(2007)Unknown,
Cryan, J. F. ; (2007) Silencing the Unquiet Mind: Knockout and RNA Interference-based Approaches to Understand Depression and Anxiety. [Oral Presentation], Unknown, Sepracor Corp, Marlborough MA, USA, , 01-AUG-07 - 01-AUG-07. [Details]
(2007)19th congress of the European College of Neuropharmacology,
O' Mahony SM, Clarke G, O' Mahony L, Quigley EMM, Cryan JF, Dinan TG; (2007) Depressive behaviours and alterations in the immune and stress response systems following neonatal maternal separation. [Poster Presentation], 19th congress of the European College of Neuropharmacology, Vienna, Austria , 01-JAN-07 - 01-JAN-07. [Details]
(2007)Brainstorming session, 20th Congress of European College of Neuropsychopharmacology,
Clarke G, Cryan JF, Dinan TG; (2007) An important subplot in the inflammatory theory of depression?. [Poster Presentation], Brainstorming session, 20th Congress of European College of Neuropsychopharmacology, Vienna, Austria , 01-OCT-07 - 01-OCT-07. [Details]
(2007)The College of Medicine & Health, UCC Joint Health Research Day incorporating Cork University Hospital Research Day,
O' Mahony SM, Fitzgerald P, Coehlo A-M, Taylor C, Cryan JF, Dinan TG.; (2007) Visceral hypersensitivity in two potential animal models of Irritable Bowel Syndrome. [Poster Presentation], The College of Medicine & Health, UCC Joint Health Research Day incorporating Cork University Hospital Research Day, Cork, Ireland , 01-JAN-07 - 01-JAN-07. [Details]
(2007)The Irish Society of Gastroenterology Winter meeting,
Savignac HM, Hyland NP, Dinan TG, Cryan JF ; (2007) Social stress induces mild colonic damage and altered pro- and anti-inflammatory cytokines in the mouse. [Poster Presentation], The Irish Society of Gastroenterology Winter meeting, Clontarf Castle Hotel, Dublin, Ireland , 01-NOV-07 - 01-NOV-07. [Details]
(2007)British Neuroscience Association Annual Meeting,
Cryan, J. F.; (2007) Novel therapeutic targets for stress-related disorders. [Invited Oral Presentation], British Neuroscience Association Annual Meeting, Harrogate, UK , 01-APR-07 - 01-APR-07. [Details]
(2007)Unknown,
Cryan, J. F.; (2007) In search of depressed mouse: Using genetically modified mice to understand depression. [Invited Oral Presentation], Unknown, Doorwerth, The Netherlands , 01-MAY-07 - 01-MAY-07. [Details]
(2007)Royal Academy of Medicine in Ireland, Summer Meeting,
Cryan, J. F.; (2007) Anatomy of emotion: Corticolimbic modulation of depression and anxiety-related behaviour in animal models. [Invited Oral Presentation], Royal Academy of Medicine in Ireland, Summer Meeting, Cork, Ireland , 01-JUN-07 - 01-JUN-07. [Details]
(2007)European Graduate School of Neuroscience (EURON),
Browne, CA, O¿Brien, F, Connor TJ, Dinan, TG, & Cryan JF; (2007) Differential LPS-induced cytokine responses in C57BL/6J and BALB/c mice following stress: Relevance to depression. [Poster Presentation], European Graduate School of Neuroscience (EURON), Bad Honnef, Germany , 01-NOV-07 - 01-NOV-07. [Details]
(2006)Unknown,
Cryan, J. F. ; (2006) Silencing the Unquiet Mind: The Emerging use of RNAi to Understand the Pathophysiology of Neuropsychiatric Disorders. [Oral Presentation], Unknown, Solvay Duphar, Weesp, The Netherlands , 01-OCT-06 - 01-OCT-06. [Details]
(2006)Uncle Tom's Cabin and the Irish National Tale,
Cryan, J. F. ; (2006) Silencing the Unquiet Mind: The Emerging use of RNAi in Preclinical Neuropsychiatric Research. [Oral Presentation], Uncle Tom's Cabin and the Irish National Tale, International Symposium RNAi in vivo Technologies¿, Munich, Germany , 01-OCT-06 - 01-OCT-06. [Details]
(2006)Unknown,
Cryan, J. F.; (2006) Genetic and behavioural approaches to understand the pathophysiology of depression. [Oral Presentation], Unknown, European Science Foundation (ESF) Workshop on Links between Visceral Dysfunction and Affective Disorders, Graz, Austria , 01-AUG-06 - 01-AUG-06. [Details]
(2006)Unknown,
Cryan, J. F.; (2006) In vivo Genetic Approaches to Understand the Role of mGluR7 in Brain Function. [Oral Presentation], Unknown, Wyeth Pharma, Princeton New Jersey, USA , 01-JUL-06 - 01-JUL-06. [Details]
(2006)Unknown,
Cryan, J. F.; (2006) Mouse models of psychiatric illness. [Oral Presentation], Unknown, Hi Q Workshop on Assessing Cognition in Animal Models of Huntington Disease, Cambridge, UK , 01-JUL-06 - 01-JUL-06. [Details]
(2006)Unknown,
Cryan, J. F.; (2006) Silencing the Unquiet Mind: The Emerging use of RNAi to understand the pathophysiology of neurological and psychiatric disorders. [Oral Presentation], Unknown, Roche Pharma AG, Basel, Switzerland , 01-MAR-06 - 01-MAR-06. [Details]
(2006)Unknown,
Cryan, J. F.; (2006) Modifying Mood: From molecule to mouse to man- A personal perspective on neuropharmacological research in industry and academia. [Oral Presentation], Unknown, Galway-Mayo Institute of Technology, Galway, Ireland , 01-JAN-06 - 01-JAN-06. [Details]
(2006)European College of Neuropsychopharmacology,
Cryan, J. F.; (2006) Anxiety viewed as a GABA-ergic and glutamatergic disbalance, perspectives for development of new anxiolytic drugs. [Invited Oral Presentation], European College of Neuropsychopharmacology, Paris , 01-SEP-06 - 01-SEP-06. [Details]
(2006)Neuroscience Ireland Inaugural meeting,
Cryan, J. F.; (2006) Widespread gene knockdown in the adult brain using RNA Interference. [Invited Oral Presentation], Neuroscience Ireland Inaugural meeting, Cork, Ireland , 01-SEP-06 - 01-SEP-06. [Details]
(2006)XXVth Congress of the Collegium Internationale Neuro-Psychopharmacologium,
Cryan, J. F.; (2006) Academia-Industry Interactions in Neuropsychopharmacology Research. [Invited Oral Presentation], XXVth Congress of the Collegium Internationale Neuro-Psychopharmacologium, Chicago , 01-JUL-06 - 01-JUL-06. [Details]
(2006)Neuroscience Ireland inaugural conference,
O¿ Mahony Cliona, Daly E, Dinan TG, Cryan JF.; (2006) Genetic influence on stress-induced changes in brain activation in the mouse. [Poster Presentation], Neuroscience Ireland inaugural conference, Cork, Ireland , 01-SEP-06 - 01-SEP-06. [Details]
(2006)Program No. 67.26. 2006 Neuroscience Meeting Planner,
Bissiere, S., Plachta, N., McAllister, K., Hoyer, D., Olpe, HR, Grace, AA, Cryan, JF; (2006) The rostral anterior cingulate cortex determines the efficiency of amygdala-dependent fear learning. [Poster Presentation], Program No. 67.26. 2006 Neuroscience Meeting Planner, Atlanta, Georgia , 01-JAN-06 - 01-JAN-06. [Details]
(2006)Program No. 72.17. 2006 Neuroscience Meeting Planner,
Jacobson LH, Kaupmann, K., Bettler., Cryan JF; (2006) GABAB(1) receptor subunit isoforms: A role in anxiety?. [Poster Presentation], Program No. 72.17. 2006 Neuroscience Meeting Planner, Atlanta, Georgia , 01-JAN-06 - 01-JAN-06. [Details]
(2006)Program No. 72.18. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience,
Jacobson LH, Kaupmann, K., Bettler., Cryan JF; (2006) The GABAB(1a) receptor subunit isoform mediates antidepressant-like effects: role of 5-HT1A receptors. [Poster Presentation], Program No. 72.18. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, Atlanta, Georgia , 01-JAN-06 - 01-JAN-06. [Details]
(2006)Program No. 370.15. 2006 Neuroscience Meeting Planner,
Fendt, M., Schmid, S., Thakker, D.R., Jacobson, L.H., Yamamota, R. Mitsukawa, K. Maier, R, McAllister, K.H., Hoyer, D. van der Putten, H. Cryan JF and Flor, P.J; (2006) Activation of mGluR7 alters amygdala plasticity and facilitates extinction of fear memories. [Poster Presentation], Program No. 370.15. 2006 Neuroscience Meeting Planner, Atlanta, Georgia , 01-JAN-06 - 01-JAN-06. [Details]
(2006)2nd Interdisciplinary research day of the college of medicine and health,
O¿ Mahony Cliona, Daly E, Dinan TG, Cryan JF; (2006) Genetic influence on stress-induced changes in brain activation in the mouse. [Poster Presentation], 2nd Interdisciplinary research day of the college of medicine and health, University College Cork, Ireland , 01-NOV-06 - 01-NOV-06. [Details]
(2006)19th Congress of European College of Neuropsychopharmacology,
Slattery DA, Markou A, Cryan JF; (2006) Evaluation of reward processes in an animal model of depression. [Poster Presentation], 19th Congress of European College of Neuropsychopharmacology, Paris , 01-SEP-06 - 01-SEP-06. [Details]
(2006)XXVth Congress of the Collegium Internationale Neuro-Psychopharmacologium,
Slattery DA, Markou A, Cryan JF; (2006) Evaluation of reward processes in an animal model of depression. [Poster Presentation], XXVth Congress of the Collegium Internationale Neuro-Psychopharmacologium, Chicago , 01-JUL-06 - 01-JUL-06. [Details]
(2005)Interfering with the brain : The use of siRNA to understand the roles of genes in neuropsychiatric,
Cryan J.F.; (2005) Interfering with the brain : The use of siRNA to understand the roles of genes in neuropsychiatric. [Invited Lectures (Conference)], Interfering with the brain : The use of siRNA to understand the roles of genes in neuropsychiatric, . [Details]
(2005)Interfering with Brain Function: Emerging use of siRNA to unravel the roles of genes in psychiatric and neurological disorders,
Cryan J.F.; (2005) Interfering with Brain Function: Emerging use of siRNA to unravel the roles of genes in psychiatric and neurological disorders. [Invited Lectures (Conference)], Interfering with Brain Function: Emerging use of siRNA to unravel the roles of genes in psychiatric and neurological disorders, . [Details]
(2005)Unknown,
Cryan, J. F.; (2005) Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric disorders. [Oral Presentation], Unknown, University of Innsbruck, Department of Pharmacology and Toxicology, Austria , 01-JAN-05 - 01-JAN-05. [Details]
(2005)Unknown,
Cryan, J. F.; (2005) Interfering with the brain : The use of siRNA to understand the roles of genes in neuropsychiatric disorders. [Oral Presentation], Unknown, Rockefeller University, New York, USA , 01-NOV-05 - 01-NOV-05. [Details]
(2005)A role for GABAB receptors in anxiety, depression and drug abuse: Recent developments with novel genetic and pharmacological tools,
Cryan J.F.; (2005) A role for GABAB receptors in anxiety, depression and drug abuse: Recent developments with novel genetic and pharmacological tools. [Invited Lectures (Conference)], A role for GABAB receptors in anxiety, depression and drug abuse: Recent developments with novel genetic and pharmacological tools, . [Details]
(2005)Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric and neurological disorders,
Cryan J.F.; (2005) Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric and neurological disorders. [Invited Lectures (Conference)], Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric and neurological disorders, . [Details]
(2005)siRNA-Induced Widespread Gene Knockdown in the Adult Mouse Brain: Utility for studying the molecular basis of neuropsychiatric disorders,
Cryan J.F.; (2005) siRNA-Induced Widespread Gene Knockdown in the Adult Mouse Brain: Utility for studying the molecular basis of neuropsychiatric disorders. [Invited Lectures (Conference)], siRNA-Induced Widespread Gene Knockdown in the Adult Mouse Brain: Utility for studying the molecular basis of neuropsychiatric disorders, . [Details]
(2005)Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric disorders,
Cryan J.F.; (2005) Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric disorders. [Invited Lectures (Conference)], Interfering with Brain Function: Emerging use of siRNA to understand the roles of genes in psychiatric disorders, . [Details]
(2005)The American College of Neuropsychopharmacology 44th Annual Meeting,
Cryan, J. F.; (2005) mGluR7: A novel therapeutic target for stress-related disorders. [Invited Oral Presentation], The American College of Neuropsychopharmacology 44th Annual Meeting, Hawaii , 01-DEC-05 - 01-DEC-05. [Details]
(2004)From Academia to Industry: A Personal Perspective,
Cryan J.F.; (2004) From Academia to Industry: A Personal Perspective. [Invited Lectures (Conference)], From Academia to Industry: A Personal Perspective, . [Details]
(2003)Unknown,
Cryan, J. F.; (2003) In search of a depressed mouse: models for studying depression-related behaviour in genetically modified mice. [Oral Presentation], Unknown, ETH Zurich , 01-OCT-03 - 01-OCT-03. [Details]
(2003)Utility of models for studying depression and anxiety-related behavior in genetically modified mice,
Cryan J.F.; (2003) Utility of models for studying depression and anxiety-related behavior in genetically modified mice. [Invited Lectures (Conference)], Utility of models for studying depression and anxiety-related behavior in genetically modified mice, . [Details]
(2003)In search of a depressed mouse: models for studying depression-related behaviour in genetically modified mice,
Cryan J.F.; (2003) In search of a depressed mouse: models for studying depression-related behaviour in genetically modified mice. [Invited Lectures (Conference)], In search of a depressed mouse: models for studying depression-related behaviour in genetically modified mice, . [Details]

Committees

 CommitteeFunctionFrom / To
External Examiner: University Birmingham, BMed Sci Degree 2008 /
External Examiner: Galway-Mayo Institute of Technology, Bachelor of Science (Honours) in Applied Biology and Biopharmaceutical Science 2008 / 2008
PhD Examiner Mr. Lucas Lecourtier, University of Bordeaux /
PhD Examiner Mr Danny Allen, Genetics Dept., Trinity College Dublin /
PhD Examiner Mr. Lawrence Tam, Genetics Dept., Trinity College Dublin /
Quality Review: NUI Galway, BSc Biotechnology Programme /

Employment

 EmployerPositionFrom / To
School of Pharmacy, University College Cork Senior Lecturer/Principal Investigator01-JUL-06 /
University College Cork Lecturer01-JAN-05 / 31-DEC-06
Novartis Institutes for BioMedical Research LabHead Behavioural Pharmacology01-JAN-02 / 31-DEC-05
The Scripps Research Institute Senior Postdoctoral Fellow01-JAN-01 / 31-DEC-01

Education

 YearInstitutionQualificationSubject
1995NUI Galway BSc Hons, (NUI,Galway)Biochemistry
1998NUI Galway PHDPharmacology

Consultancy

 ClientDescription
National Institutes for Drug Abuse (NIDA): Review and Evaluation of NIDA Targets for Potential NIH Roadmap Library Screening

Journal Activities

 JournalRoleTo / From
Proceedings Of The National Academy Of Science Usa Referee-
Science Referee-
Frontiers In Pharmacology Editor-
Science Referee-
Plos Biology Referee-
Neuropharmacology Editor-
Psychopharmacology Editor-
Brain Research Member of Editorial Board-
Behavioural Pharmacology Member of Editorial Board-
Neuroscience And Biobehavioral Reviews Member of Editorial Board-
Behavioural Brain Research Referee-
Behavior Genetics Referee-
Behavioural Pharmacology Referee-
Brain Research Referee-
British Journal Of Pharmacology Editor-
European Journal Of Pharmacology Referee-
Experimental Brain Research Referee-
Genome Research Referee-
Human Psychopharmacology Referee-
Human Molecular Genetics Referee-
Neuropsychopharmacology Referee-
Journal Of Neural Transmission Referee-
Journal Of Neurochemistry Referee-
Journal Of Neuroscience Referee-
Journal Of Pharmacology And Experimental Therapeutics Referee-
Journal Of Psychopharmacology Referee-
Neuropharmacology Referee-
Neuropsychopharmacology Referee-
Neuroscience Referee-
Neuroscience And Biobehavioral Reviews Referee-
Pharmacogenomics Referee-
Pharmacology Biochemistry And Behavior Referee-
Proceedings Of The National Academy Of Sciences Of The United States Of America Referee-
Psychiatry Research Referee-
Psychopharmacology Referee-
Psychoneuroendocrinology Referee-
Stress And Health Referee-
Synapse (New York, N.Y.) Referee-
Trends In Pharmacological Sciences Referee-

Modules Taught

 Term (ID))TitleLinkSubject
2015Neurobiology of Disease AN3013Neurobiology of Disease