Epidemiology & Public Health
Room 4.033
Hrb Centre For Diet and Health Research
Western Gateway Building
University College Cork

T: +353 (0) 21 420 5538
F: +353 (0) 21 490 1604
E: c.phillips@ucc.ie

Following a BSc. (Hons) in Biochemistry from University College Dublin and a Ph.D entitled Studies of Postprandial Lipoprotein Metabolism in Diabetes, from Trinity College Dublin, I continued my postdoctoral research in the Royal College of Surgeons of Ireland investigating aspects of postprandial lipoprotein metabolism in Type 2 diabetes and insulin resistance.
In 2004 I joined the Nutrigenomics Research Group, Trinity College Dublin (and later at University College Dublin) to work on two EU 6th Framework initiatives - NuGO (European Nutrigenomics Organisation) and LIPGENE (Diet, genomics and the metabolic syndrome: an integrated nutrition, agro-food, social and economic analysis). NuGO is a Network of Excellence, linking genomics, nutrition and health research (www.nugo.org). The LIPGENE project(www.ucd.ie/lipgene) involved a prospective genetic study and a human dietary intervention trial to test the interaction between dietary fat exposure and genetic risk of the metabolic syndrome. Within LIPGENE I coordinated the prospective case-control genetic study in collaboration with INSERM U476 & U557 (Marseille and Paris) which investigated genetic associations with metabolic syndrome and its phenotypes, and whether interaction with dietary fatty acid composition modulated these relationships. 
I joined the HRB Centre for Diet and Health Research, University College Cork in 2011 as a Principal Investigator on cluster 3 (the Cork and Kerry Study/Mitchelstown cohort). This cross-sectional study of middle-aged men and women is examining the effects of dietary exposures and lifestyle factors on obesity and the metabolic syndrome - a very common, multi-component, condition characterised by insulin resistance, dyslipidaemia, abdominal obesity and hypertension that is associated with increased risk of type 2 diabetes mellitus, cardiovascular disease and atherosclerosis. This study represents a valuable resource to additionally test a range of other hypotheses relevant to diet-related disease. Current research interests include obesity, diabetes and cardiometabolic risk prediction, determinants of and associations between inflammatory biomarkers, lipoprotein particle profiles and cardiometabolic risk, and examination of the metabolically healthy obese phenotype and its determinants.

Current research interests lie in nutrition, inflammation, genetics, their interactions (ie nutrigenetics), nutritional and genetic epidemiology in the context of metabolic syndrome and its phenotypes (obesity, insulin resistance, hypertension, dyslipidaemia). Specifically how dietary fat exposure modulates (genetic) risk of these phenotypes.



Book Chapters

 YearPublication
(2013)'Modulating the Risk of Obesity and Diabetes through Nutrigenetics'
Roche HM and Phillips CM (2013) 'Modulating the Risk of Obesity and Diabetes through Nutrigenetics' In: Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition. USA: CRC Press. [No details]
(2014)'Nutrigenetics and Metabolic Disease: Current Status and Implications for Personalised Nutrition'
Phillips CM (2014) 'Nutrigenetics and Metabolic Disease: Current Status and Implications for Personalised Nutrition' In: Functional Foods: The Connection Between Nutrition, Health, and Food Science. USA: Apple Academic Press. [No details]

Peer Reviewed Journals

 YearPublication
(2000)'Improved metabolic control reduces the number of postprandial apolipoprotein B-48-containing particles in type 2 diabetes'
Phillips C, Murugasu G, Owens D, Collins P, Johnson A, Tomkin GH; (2000) 'Improved metabolic control reduces the number of postprandial apolipoprotein B-48-containing particles in type 2 diabetes' [Details]
(2002)'Defective chylomicron synthesis as a cause of delayed particle clearance in diabetes?'
Phillips, C.,Madigan, C.,Owens, D.,Collins, P.,Tomkin, G. H.; (2002) 'Defective chylomicron synthesis as a cause of delayed particle clearance in diabetes?' [Details]
(2002)'Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes'
Phillips, C.,Bennett, A.,Anderton, K.,Owens, D.,Collins, P.,White, D.,Tomkin, G. H.; (2002) 'Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes' [Details]
(2002)'Microsomal triglyceride transfer protein: does insulin resistance play a role in the regulation of chylomicron assembly?'
Phillips C, Owens D, Collins P, Tomkin GH; (2002) 'Microsomal triglyceride transfer protein: does insulin resistance play a role in the regulation of chylomicron assembly?' [Details]
(2004)'Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes'
Phillips, C.,Mullan, K.,Owens, D.,Tomkin, G. H.; (2004) 'Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes' [Details]
(2005)'The metabolic syndrome: the crossroads of diet and genetics'
Roche, H. M.,Phillips, C.,Gibney, M. J.; (2005) 'The metabolic syndrome: the crossroads of diet and genetics' [Details]
(2005)'Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes'
Phillips C, Owens D, Collins P, Tomkin GH; (2005) 'Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes' [DOI] [Details]
(2006)'Genetic and nutrient determinants of the metabolic syndrome'
Phillips, C.,Lopez-Miranda, J.,Perez-Jimenez, F.,McManus, R.,Roche, H. M.; (2006) 'Genetic and nutrient determinants of the metabolic syndrome' [Details]
(2006)'Intestinal microsomal triglyceride transfer protein in type 2 diabetic and non-diabetic subjects: the relationship to triglyceride-rich postprandial lipoprotein composition'
Phillips C, Mullan K, Owens D, Tomkin GH; (2006) 'Intestinal microsomal triglyceride transfer protein in type 2 diabetic and non-diabetic subjects: the relationship to triglyceride-rich postprandial lipoprotein composition' [DOI] [Details]
(2008)'Gene-nutrient interactions in the metabolic syndrome'
Phillips, C. M.,Tierney, A. C.,Roche, H. M.; (2008) 'Gene-nutrient interactions in the metabolic syndrome' [Details]
(2008)'Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest'
Szabo de Edelenyi, F.,Goumidi, L.,Bertrais, S.,Phillips, C.,Macmanus, R.,Roche, H.,Planells, R.,Lairon, D.; (2008) 'Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest' [Details]
(2009)'Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome'
Phillips, C. M; Goumidi, L; Bertrais, S; Ferguson, J. F; Field, M. R; Kelly, E. D; Peloso, G. M; Cupples, L. A; Shen, J; Ordovas, J. M; McManus, R; Hercberg, S; Portugal, H; Lairon, D; Planells, R; Roche, H. M.; (2009) 'Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome' [Details]
(2009)'Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults'
Phillips, C. M; Goumidi, L; Bertrais, S; Field, M. R; Peloso, G. M; Shen, J; McManus, R; Hercberg, S; Lairon, D; Planells, R; Roche, H. M.; (2009) 'Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults' [Details]
(2010)'NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids'
Ferguson, J. F; Phillips, C. M; McMonagle, J; Perez-Martinez, P; Shaw, D. I; Lovegrove, J. A; Helal, O; Defoort, C; Gjelstad, I. M; Drevon, C. A; Blaak, E. E; Saris, W. H; Leszczynska-Golabek, I; Kiec-Wilk, B; Riserus, U; Karlstrom, B; Lopez-Miranda, J; Roche, H. M.; (2010) 'NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids' [Details]
(2010)'Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance'
Ferguson, J. F.,Phillips, C. M.,Tierney, A. C.,Perez-Martinez, P.,Defoort, C.,Helal, O.,Lairon, D.,Planells, R.,Shaw, D. I.,Lovegrove, J. A.,Gjelstad, I. M.,Drevon, C. A.,Blaak, E. E.,Saris, W. H.,Leszczynska-Golabek, I.,Kiec-Wilk, B.,Riserus, U.,Karlstrom, B.,Miranda, J. L.,Roche, H. M.; (2010) 'Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance' [Details]
(2010)'The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA'
Oliver, E.,McGillicuddy, F.,Phillips, C.,Toomey, S.,Roche, H. M.; (2010) 'The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA' [Details]
(2010)'ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat'
Phillips, C. M.,Goumidi, L.,Bertrais, S.,Field, M. R.,Cupples, L. A.,Ordovas, J. M.,McMonagle, J.,Defoort, C.,Lovegrove, J. A.,Drevon, C. A.,Blaak, E. E.,Kiec-Wilk, B.,Riserus, U.,Lopez-Miranda, J.,McManus, R.,Hercberg, S.,Lairon, D.,Planells, R.,Roche, H. M.; (2010) 'ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat' [Details]
(2010)'Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components'
Phillips, C. M; Goumidi, L; Bertrais, S; Ferguson, J. F; Field, M. R; Kelly, E. D; Mehegan, J; Peloso, G. M; Cupples, L. A; Shen, J; Ordovas, J. M; McManus, R; Hercberg, S; Portugal, H; Lairon, D; Planells, R; Roche, H. M.; (2010) 'Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components' [Details]
(2010)'Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome'
Phillips, C. M; Goumidi, L; Bertrais, S; Field, M. R; Cupples, L. A; Ordovas, J. M; Defoort, C; Lovegrove, J. A; Drevon, C. A; Gibney, M. J; Blaak, E. E; Kiec-Wilk, B; Karlstrom, B; Lopez-Miranda, J; McManus, R; Hercberg, S; Lairon, D; Planells, R; Roche, H. M.; (2010) 'Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome' [Details]
(2010)'Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults'
Phillips, C. M; Goumidi, L; Bertrais, S; Field, M. R; Ordovas, J. M; Cupples, L. A; Defoort, C; Lovegrove, J. A; Drevon, C. A; Blaak, E. E; Gibney, M. J; Kiec-Wilk, B; Karlstrom, B; Lopez-Miranda, J; McManus, R; Hercberg, S; Lairon, D; Planells, R; Roche, H. M.; (2010) 'Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults' [Details]
(2011)'Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study'
Delgado-Lista J, Perez-Martinez P, García-Rios A, Phillips CM, Williams CM, Gulseth HL, Helal O, Blaak EE, Kiec-Wilk B, Basu S, Drevon CA, Defoort C, Saris WH, Wybranska I, Riserus U, Lovegrove JA, Roche HM, Lopez-Miranda J (2011) 'Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study' [DOI] [Details]
(2011)'Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism'
Garcia-Rios A, Delgado-Lista J, Perez-Martinez P, Phillips CM, Ferguson JF, Gjelstad IM, Williams CM, Karlström B, Kieć-Wilk B, Blaak EE, Lairon D, Planells R, Malczewska-Malec M, Defoort C, Riserus U, Saris WH, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J (2011) 'Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism' [DOI] [Details]
(2011)'Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk'
Phillips, C. M.,Goumidi, L.,Bertrais, S.,Field, M. R.,McManus, R.,Hercberg, S.,Lairon, D.,Planells, R.,Roche, H. M.; (2011) 'Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk' [Details]
(2013)'Nutrigenetics and metabolic disease: current status and implications for personalised nutrition'
Phillips CM (2013) 'Nutrigenetics and metabolic disease: current status and implications for personalised nutrition' [DOI] [Details]
(2013)'Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype'
Phillips CM, Tierney AC, Perez-Martinez P, Defoort C, Blaak EE, Gjelstad IM, Lopez-Miranda J, Kiec-Klimczak M, Malczewska-Malec M, Drevon CA, Hall W, Lovegrove JA, Karlstrom B, Risérus U, Roche HM (2013) 'Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype' [DOI] [Details]
(2013)'Metabolically healthy obesity: Definitions, determinants and clinical implications'
Phillips CM (2013) 'Metabolically healthy obesity: Definitions, determinants and clinical implications' [DOI] [Details]
(2013)'Does inflammation determine metabolic health status in obese and nonobese adults?'
Phillips CM, Perry IJ (2013) 'Does inflammation determine metabolic health status in obese and nonobese adults?' [DOI] [Details]
(2013)'Defining metabolically healthy obesity: role of dietary and lifestyle factors'
Phillips CM, Dillon C, Harrington JM, McCarthy VJ, Kearney PM, Fitzgerald AP, Perry IJ (2013) 'Defining metabolically healthy obesity: role of dietary and lifestyle factors' [DOI] [Details]
(2012)'Obesity and Body Fat Classification in the Metabolic Syndrome: Impact on Cardiometabolic Risk Metabotype'
Phillips, C. M.,Tierney, A. C.,Perez-Martinez, P.,Defoort, C.,Blaak, E. E.,Gjelstad, I. M.,Lopez-Miranda, J.,Kiec-Klimczak, M.,Malczewska-Malec, M.,Drevon, C. A.,Hall, W.,Lovegrove, J. A.,Karlstrom, B.,Riserus, U.,Roche, H. M. (2012) 'Obesity and Body Fat Classification in the Metabolic Syndrome: Impact on Cardiometabolic Risk Metabotype' [Details]
(2012)'Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA'
Oliver, E.,McGillicuddy, F. C.,Harford, K. A.,Reynolds, C. M.,Phillips, C. M.,Ferguson, J. F.,Roche, H. M. (2012) 'Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA' [Details]
(2012)'A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome'
Garcia-Rios, A.,Perez-Martinez, P.,Delgado-Lista, J.,Phillips, C. M.,Gjelstad, I. M.,Wright, J. W.,Karlstrom, B.,Kiec-Wilk, B.,van Hees, A. M.,Helal, O.,Polus, A.,Defoort, C.,Riserus, U.,Blaak, E. E.,Lovegrove, J. A.,Drevon, C. A.,Roche, H. M.,Lopez-Miranda, J. (2012) 'A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome' [Details]
(2012)'A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome'
Delgado-Lista, J.,Perez-Martinez, P.,Garcia-Rios, A.,Phillips, C. M.,Hall, W.,Gjelstad, I. M.,Lairon, D.,Saris, W.,Kiec-Wilk, B.,Karlstrom, B.,Drevon, C. A.,Defoort, C.,Blaak, E. E.,Dembinska-Kiec, A.,Riserus, U.,Lovegrove, J. A.,Roche, H. M.,Lopez-Miranda, J. (2012) 'A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome' [Details]
(2012)'High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults'
Phillips, C. M.,Kesse-Guyot, E.,McManus, R.,Hercberg, S.,Lairon, D.,Planells, R.,Roche, H. M. (2012) 'High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults' [Details]
(2012)'Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk'
Phillips, C. M.,Kesse-Guyot, E.,Ahluwalia, N.,McManus, R.,Hercberg, S.,Lairon, D.,Planells, R.,Roche, H. M. (2012) 'Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk' [Details]
(2012)'Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome'
Phillips, C. M.,Goumidi, L.,Bertrais, S.,Field, M. R.,McManus, R.,Hercberg, S.,Lairon, D.,Planells, R.,Roche, H. M. (2012) 'Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome' [Details]

Honours and Awards

 YearTitleAwarding Body
2001Finalist, Young Investigator Award, European Atherosclerosis Society. European Atherosclerosis Society.
2000European Foundation for the Study of Diabetes and Merck Travel Fellowship for Young Scientists. European Foundation for the Study of Diabetes and Merck
1998Student Travel Fellowship, European Association for the Study of Diabetes. European Association for the Study of Diabetes
1998Finalist, RCSI Sheppard Trust Prize. RCSI Sheppard Trust
1999Irish Endocrine Society Travel Fellowship. Irish Endocrine Society

Associations

 AssocationFunctionFrom / To
Nutrition Society Member/
European Association for the Study of Diabetes Member/
European Nutrigenomics Organisation Member/