Lecturer In Pharmaceutics
School of Pharmacy
Cavanagh Pharmacy Building
University College Cork
Cork
Ireland

T: +353-21-490-1667
F: +353-21-490-1656
E: a.crean@ucc.ie

Dr. Abina Crean graduated with a degree in Pharmacy from Robert Gordon's University, Aberdeen, Scotland in 1992.  In 1997, she completed a PhD in Pharmaceutics in the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. Dr. Crean was employed as a formulation scientist with Elan Pharmaceutical Technologies between 1997 and 2001 and as a Process Development Pharmacist at Servier (Ireland) Industries between 2002 and 2003.

Since joining the School of Pharmacy in UCC in 2003 upon establishment, she has been actively involved in the development of the new research facilities and curriculum. As PI, she established a pharmaceutical technology research group in UCC and supervised a range research projects in the areas of pharmaceutical manufacturing and formulation science. A key element of her research is active collaborative projects with a number of pharmaceutical companies both SME and large multi-nationals. She is a funded researcher in the SFI funded SSPC - Synthesis and Solid State Pharmaceutical Research Centre , as well as PI in the EI/IDA funded Pharmaceutical Manufacturing Technology Centre.

Total Citations: 377

h-index: 10

Total Career Research Income: > €3  million

PhDs Graduated (Career): 8

Research Interests

My research interests are focused on the development of high quality, effective medicines through thorough investigation and understanding of the properties and associated behaviour of constituent materials (both API and excipients). 

Examples of current research projects include

  • Development of quality by design strategies to study the critical material attributes of pharmaceutical excipients
  • Enabling continuous pharmaceutical solid oral dosage from manufacture through identification, control and monitoring of critical material attributes 
  • Formulation and characterisation of microneedle drug and vaccine delivery systems
  • Development of silica-based drug formulations to enhance the oral bioavailability of therapeutic compounds challenged by poor-water solubility
  • Biophysical characterisation, processing and formulation of peptide, protein and vaccine materials
  • Manipulation of commercial dosage forms for administration to elderly patients

 
 

Peer Reviewed Journals

YearPublication
(2016)'ntegrated process standardisation as zero-based approach to bitter cassava waste elimination and widely-applicable industrial biomaterial derivatives'
TUMWESIGYE, K. S., PEDDAPATLA, R. V. G., CREAN, A., OLIVEIRA, J. C. & SOUSA-GALLAGHER, M. J. (2016) 'ntegrated process standardisation as zero-based approach to bitter cassava waste elimination and widely-applicable industrial biomaterial derivatives'. Chemical Engineering and Processing: Process Intensification, 108 :139-150 [DOI] [Details]
(2016)'Assessment of measurement characteristics for rehydration of milk protein based powders'
Ji, JF;Fitzpatrick, J;Cronin, K;Crean, A;Miao, S (2016) 'Assessment of measurement characteristics for rehydration of milk protein based powders'. Food Hydrocolloids, 54 :151-161 [DOI] [Details]
(2016)'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods'
Vrdoljak A, Allen EA1, Ferrara F, Temperton NJ, Crean AM, Moore AC (2016) 'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods'. Journal of controlled release : official journal of the Controlled Release Society, [DOI] [Details]
(2016)'Modification of oral dosage forms for the older adult: an Irish prevalence study'
Aoife Mc Gillicuddy , Maria Kellya, Catherine Sweeney, Ann Carmichael, Abina M Crean, Laura J Sahm (2016) 'Modification of oral dosage forms for the older adult: an Irish prevalence study'. International Journal of Pharmaceutics, [DOI] [Details]
(2015)'Dissolvable Microneedle Fabrication using Piezoelectric Dispensing Technology'
Allen EA, O'Mahony C, Cronin M, O'Mahony T, Moore AC, Crean AM. (2015) 'Dissolvable Microneedle Fabrication using Piezoelectric Dispensing Technology'. International Journal of Pharmaceutics, Globe icon [DOI] [Details]
(2015)'Quality by design in an evolving manufacturing sector'
Crowley M.E., Crean A. M, (2015) 'Quality by design in an evolving manufacturing sector'. European Journal of Parenteral and Pharmaceutical Sciences, 20 (2):63-69 [Details]
(2015)'Older adults with difficulty swallowing oral medicines: a systematic review of the literature'
Mc Gillicuddy A, Crean AM;Sahm LJ (2015) 'Older adults with difficulty swallowing oral medicines: a systematic review of the literature'. European Journal of Clinical Pharmacology, [DOI] [Details]
(2015)'Mesoporous silica formulation strategies for drug dissolution enhancement: a review'
Carol A. McCarthy, Robert J. Ahern, Rakesh Dontireddy, Katie B. Ryan, Abina M. Crean (2015) 'Mesoporous silica formulation strategies for drug dissolution enhancement: a review'. Expert Opinion in Drug Delivery, [DOI] [Details]
(2014)'Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles'
Paleco R., Vučen S.R., Crean A.M., Moore A.C., Scalia S (2014) 'Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles'. International Journal of Pharmaceutics, [DOI] [Details]
(2014)'The Use of PAT and Off-line Methods for Monitoring of Roller Compacted Ribbon and Granule Properties with a View to Continuous Processing'
M. A. P. McAuliffe, G. E. O’Mahony, C. A. Blackshields, J. A. Collins, D. P. Egan, L. Kiernan, E. O’Neill, S. Lenihan, G. M. Walker, A. M. Crean (2014) 'The Use of PAT and Off-line Methods for Monitoring of Roller Compacted Ribbon and Granule Properties with a View to Continuous Processing'. Organic Process Research & Development, Globe icon [DOI] [Details]
(2013)'Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration'
McGrath MG, Vucen S, Vrdoljak A, Kelly A, O'Mahony C, Crean AM, Moore AC. (2013) 'Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration'. European Journal of Pharmaceutical Science, Epub ahead of print Globe icon [DOI] [Details]
(2013)'Comparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug delivery'
Ahern, RJ,Hanrahan, JP,Tobin, JM,Ryan, KB,Crean, AM (2013) 'Comparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug delivery'. European Journal of Pharmaceutical Sciences, 50 :400-409 [DOI] [Details]
(2013)'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles'
Vucen, SR,Vuleta, G,Crean, AM,Moore, AC,Ignjatovic, N,Uskokovic, D (2013) 'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles'. Journal of Pharmacy and Pharmacology, 65 :1451-1462 [DOI] [Details]
(2012)'An Analysis of the Influence of Multiple Processing Factors on the Characteristics of Bioactive-Loaded Beads Prepared by Extrusion-Spheronisation'
Kuang, SS,Oliveira, JC,Crean, AM (2012) 'An Analysis of the Influence of Multiple Processing Factors on the Characteristics of Bioactive-Loaded Beads Prepared by Extrusion-Spheronisation'. Food and Bioprocess Technology, 5 :55-64 [DOI] [Details]
(2012)'Coated microneedle arrays for transcutaneous delivery of live virus vaccines'
Vrdoljak, A,McGrath, MG,Carey, JB,Draper, SJ,Hill, AVS,O'Mahony, C,Crean, AM,Moore, AC (2012) 'Coated microneedle arrays for transcutaneous delivery of live virus vaccines'. Journal of controlled release : official journal of the Controlled Release Society, 159 (1):34-42 [DOI] [Details]
(2012)'The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties'
Ahern, RJ,Crean, AM,Ryan, KB (2012) 'The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties'. International Journal of Pharmaceutics, 439 :92-99 [DOI] [Details]
(2011)'Evaluation of the influence of granulation processing parameters on the granule properties and dissolution characteristics of a modified release drug'
Ring, DT,Oliveira, JCO,Crean, A; (2011) 'Evaluation of the influence of granulation processing parameters on the granule properties and dissolution characteristics of a modified release drug'. Advanced Powder Technology, 22 :245-252 [DOI] [Details]
(2011)'Determination of parameters for successful spray coating of silicon microneedle arrays'
McGrath MG, Vrdoljak A, O'Mahony C, Oliveira JC, Moore AC, Crean AM; (2011) 'Determination of parameters for successful spray coating of silicon microneedle arrays'. International Journal of Pharmaceutics, 415 :140-149 [DOI] [CORA Link] [Details]
(2011)'A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions'
Rakesh Dontireddy, Abina M Crean; (2011) 'A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions'. Drug Development and Industrial Pharmacy, 37 (10):1141-1149 [DOI] [Details]
(2011)'Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'
John B. Carey, Frances E. Pearson, Anto Vrdoljak, Marie G. McGrath, Abina M. Crean, Patrick T. Walsh, Timothy Doody, Conor O'Mahony, Adrian V. S. Hill, Anne C. Moore; (2011) 'Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'. PloS ONE, 6 (7) Globe icon [DOI] [Details]
(2011)'A Modified Surface on Titanium Deposited by a Blasting Process'
C. O'Sullivan, P. O'Hare, G. Byrne, L. O'Neill, K. B. Ryan and A. M. Crean (2011) 'A Modified Surface on Titanium Deposited by a Blasting Process'. Coatings, 1 (1):53-71 Globe icon [Details]
(2010)'Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process'
O'Sullivan, C. and O'Hare, P. and O'Leary, N. D. and Crean, A. M. and Ryan, K. and Dobson, A. D. W. and O'Neill, L.; (2010) 'Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process'. Journal of Biomedical Materials Research, 95B (1):141-149 [DOI] [Details]
(2010)'Development of stabilized vaccines with needle-free devices for targeted skin immunization'
Moore, A. C., Crean, A. M., O¿Mahony; (2010) 'Development of stabilized vaccines with needle-free devices for targeted skin immunization'. European Pharmaceutical Review, 15 (6):56-60 Globe icon [CORA Link] [Details]
(2010)'A Methodology for Knowledge Management in Biopharmaceutical Production'
Coakley, Jennifer; Hogan, Nicola; McGuire, Linda; Griffin, Brendan; Casey, Colman; Campbell, Cliff; Crean, Abina; (2010) 'A Methodology for Knowledge Management in Biopharmaceutical Production'. Pharmaceutical Engineering, 30 (3):30-40 Globe icon [Details]
(2010)'Microencapsulation as a tool for incorporating bioactive ingredients into food'
Kuang, SS; Oliveira, JC; Crean, AM; (2010) 'Microencapsulation as a tool for incorporating bioactive ingredients into food'. Critical Reviews in Food Science and Nutrition, 50 (10):951-961 [Details]
(2002)'Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying'
Corrigan, O. I, Crean. A. M; (2002) 'Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying'. International Journal of Pharmaceutics, 245 (1-2):75-82 [Details]

Reviews

YearPublication
(2016)Older adults with difficulty swallowing oral medicines: a systematic review of the literature.
Mc Gillicuddy, A;Crean, AM;Sahm, LJ (2016) Older adults with difficulty swallowing oral medicines: a systematic review of the literature. HEIDELBERG: Reviews [DOI] [Details]
(2015)A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms.
Leane, M;Pitt, K;Reynolds, G (2015) A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms. LONDON: Reviews [DOI] [Details]

Other Journals

YearPublication
(2015)'The SSPC: leading the way for next-generation medicines manufacture'
Benjamin K. Hodnett, Anita R. Maguire, Pat J. Guiry, Ake C. Rasmuson, Brian Glennon and Abina M. Crean (2015) 'The SSPC: leading the way for next-generation medicines manufacture' European Pharmaceutical Review, . [Details]
(2010)'Development of Stabilised Vaccines with Needle-Free Devices for Targeted Skin Immunization'
A. Crean, C. O’Mahony and A. C. Moore (2010) 'Development of Stabilised Vaccines with Needle-Free Devices for Targeted Skin Immunization' European Pharmaceutical Review, 15 (6) :56-60. [Details]

Books

YearPublication
(2009)The Physicochemical Basis of Pharmaceuticals.
Humphrey Moynihan and Abina Crean; (2009) The Physicochemical Basis of Pharmaceuticals. Oxford: Oxford University Press. [Details]

Conference Publications

YearPublication
(2016)American Institute of Chemical Engineering Annual Meeting
Mary Ellen Crowley, Avril Hegarty, Michael McAuliffe, Graham O'Mahony, Luke Kiernan, Kevin Hayes and Abina Crean (2016) Overcoming the Challenges of Noisy Data during the Calibration of NIR As a PAT Technique to Measure Roller Compacted Ribbon Density American Institute of Chemical Engineering Annual Meeting Globe icon [Details]
(2016)American Institute of Chemical Engineering Annual Meeting
Mary Ellen Crowley and Abina Crean (2016) Microcrystalline Cellulose – Does Wood Pulp Source Impact the Direct Compression Performace of This Excipient? American Institute of Chemical Engineering Annual Meeting Globe icon [Details]
(2016)American Institute of Chemical Engineering Annual Meeting
Maryam Mohammadpour, Brian Kerins, Mary Ellen Crowley, Gavin Walker and Abina Crean (2016) HPMC Cloud Point: Exploring Hydroxypropylmethyl Cellulose Behavior in Pharmaceutical Formulations American Institute of Chemical Engineering Annual Meeting Globe icon [Details]
(2016)American Institute of Chemical Engineers Annual Meeting
Raghu V. G. Peddapatla, Caroline A. Blackshields, Michael F. Cronin and Abina Crean (2016) Behaviour of Magnesium Stearate in Continuous Feeding American Institute of Chemical Engineers Annual Meeting Globe icon [Details]
(2016)PRIMM Conference London 2016
McGillicuddy A, Crean AM, Kelly M, Sweeney C, Carmichael A, Sahm LJ (2016) Oral dosage form modifications for older adults; Is there an evidence base for current practices? PRIMM Conference London 2016 [Details]
(2013)EuPAT 6: Sixth pan-European QbD & PAT Science Conference
Graham E. O’Mahony, Michael A. P. McAuliffe, Caroline Blackshields, Sandra Lenihan, David Egan, John A. Collins, Luke Kiernan, Gavin M. Walker, Eamonn O’Neill and Abina M. Crean (2013) Near infrared spectroscopy for real-time monitoring of roller-compacted ribbon density EuPAT 6: Sixth pan-European QbD & PAT Science Conference Porto, , 23-SEP-13 - 24-SEP-13 [Details]
(2013)EuPAT 6: Sixth pan-European QbD & PAT Science Conference
O’Mahony G, McAuliffe M, Blackshields C, Collins JA, Egan D, Kiernan L, Crean AM, Lenihan S, Walker GM and O’Neill E (2013) A study of the effects of roller compaction parameters on ribbon and granule properties by off-line and in-line methods with a view to continuous processing EuPAT 6: Sixth pan-European QbD & PAT Science Conference Porto, , 23-SEP-13 - 24-SEP-13 [Details]
(2013)Skin Vaccination Summit
Moore, A.,Allen, E.,O'Mahony, C.,Crean, A. (2013) ImmuPatch microneedle systems for addressing unmet needs in immunization programmes Skin Vaccination Summit Seattle, USA, , 05-DEC-13 [Details]
(2013)UCC School of Pharmacy Research Day
Nicholas D. Mullins, Anita R. Maguire, Humphrey A. Moynihan, Florence O. McCarthy, Simon E. Lawrence, Abina Crean, and Jonathan Thompson (2013) Degradation of Gentamicin Sulfate on Coated Titanium Surfaces UCC School of Pharmacy Research Day University College Cork, , 23-SEP-13 [Details]
(2013)35th All-Ireland Schools of Pharmacy Conference
Allen, E.,Crean, A.,O’Mahony, C.,Moore, A. C. (2013) Influenza Vaccination using Dissolvable ImmuPatchInfluenza Vaccination using Dissolvable ImmuPatch 35th All-Ireland Schools of Pharmacy Conference Belfast, UK, [Details]
(2012)UKICRS annual meeting, Aston University
Ahern, R. J., Ryan, K. B., Crean. A. M. (2012) Investigation and comparison of various drug-loading processes onto Mesoporous Silica UKICRS annual meeting, Aston University [Details]
(2012)2nd International Conference on Microneedles: Microneedles 2012
A. M. Crean, M. G. McGrath, C. O’Mahony, A. Vrdoljak and A. C. Moore (2012) Dissolvable ImmuPatch Microneedles for Drug Delivery 2nd International Conference on Microneedles: Microneedles 2012 Cork, , 13-MAY-12 - 15-MAY-12 [Details]
(2012)Microneedles 2012
Moore, A.,Vrdoljak, A.,McGrath, M.,Draper, S.,Hill, A.,Crean, A.,O'Mahony, C. (2012) ImmuPatch vaccination Microneedles 2012 Cork, Ireland, [Details]
(2011)5th International Granulation Workshop
D.T, Ring, J.C. Oliveira and A. Crean; (2011) Developing better process understanding; the role of the granulation process, materials properties and storage environment on drug release from a matrix tablet 5th International Granulation Workshop [Details]
(2011)38th Annual Meeting Controlled Release Society
M.G. McGrath, C.O¿Mahony, A. Vrdoljak, A.C. Moore, A.M. Crean; (2011) Design of Dissolvable Microneedles for Drug Delivery 38th Annual Meeting Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2011)38th Annual Meeting Controlled Release Society
John B. Carey, Frances E. Pearson, Anto Vrdoljak, Abina M. Crean, Conor O¿Mahony, Adrian V.S. Hill, Anne C. Moore; (2011) Immunization using ImmuPatch Silicon Microneedle Arrays results in Enhanced T 38th Annual Meeting Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2011)Transactions of 38th Annual Meeting and Exposition of the Controlled Release Society
R. J. Ahern, K. B. Ryan, A. M. Crean. (2011) Enhanced dissolution and stability properties of supercritical fluid processed fenofibrate-silica systems Transactions of 38th Annual Meeting and Exposition of the Controlled Release Society Maryland, U.S.A, July 2011, , 30-JUL-11 - 03-AUG-11 [Details]
(2011)38th Annual Meeting and Exposition of the Controlled Release Society
Vrdoljak, A.,McGrath, M. G.,Crean, A.,O'Mahony, C.,Moore, A. C. (2011) Development of ImmuPatch arrays coated with live vaccine 38th Annual Meeting and Exposition of the Controlled Release Society Maryland, USA, [Details]
(2011)British Association for Crystal Growth Annual Conference 2011
D. E. Horgan, D. M. Kelly, K. S. Eccles, S. E. Lawrence, H. A. Moynihan, R. Aherne, D. Ring, A. Crean (2011) Phenacetin as a Model Compound for Particle Engineering British Association for Crystal Growth Annual Conference 2011 University College London, , 10-JUL-11 - 12-JUL-11 [Details]
(2011)XXth Conference of the Groupment des Pharmacochimistes de l'Arc Atlantiques
Danielle E. Horgan, Dawn, M. Kelly, Kevin S. Eccles, Robert Aherne, Denis Ring, Abina Crean, Simon E. Lawrence, Humphrey A. Moynihan (2011) Phenacetin as a Model Compound for Particle Engineering XXth Conference of the Groupment des Pharmacochimistes de l'Arc Atlantiques UCC, , 01-SEP-11 - 02-SEP-11 [Details]
(2010)All Ireland Schools of Pharmacy Research Seminar
McCarthy, C., Ahern, R., Crean, A.M., Ryan, K; (2010) Investigation of Process and Formulation Parameters Impacting on Mesoporous Silica as a Carrier for Poorly soluble Drugs All Ireland Schools of Pharmacy Research Seminar Queen's University Belfast, , 29-MAR-10 - 30-MAR-10 [Details]
(2010)AAPS National Biotechnology Conference
Farag, F.F., O'Driscoll, C.M., Crean, A.M.; (2010) Formulation and storage conditions affecting the conformation and degradation of salmon calcitonin delivery systems AAPS National Biotechnology Conference San Francisco, [Details]
(2010)90th Annual Meeting of the British Association of Dermatologists
McAleer, M.,Moore, A.,Crean, A.,O'Mahony, C.,Bourke, J. F. (2010) A proof of concept study to investigate the efficacy of microneedle arrays in the administration of local anaesthetic in human skin 90th Annual Meeting of the British Association of Dermatologists Manchester, UKManchester, UK, , pp.101-117101 [Details]
(2010)12th International Conference on Perspectives in Percutaneous Penetration
M. G. McGrath, C. O¿Mahony, J. B. Carey, A. Vrdoljak, A. C. Moore and A. M. Crean; (2010) Spray Coating of Silicon Microneedle Patches for Intradermal Drug Delivery 12th International Conference on Perspectives in Percutaneous Penetration [Details]
(2010)First International Conference on Microneedles
Moore A.C., Carey J.B., Pearson F., Vrdoljak A., McGrath M., Draper S.J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C., ; (2010) Enhanced Immune Responses induced by ImmuPatch Transcutaneous Vaccination First International Conference on Microneedles Atlanta, Georgia, , 24-MAY-10 - 26-MAY-10 [Details]
(2010)Perspectives in Percutaneous Penetreation
Moore A.C., Carey J.B., McGrath M. Pearson F.E., Vrdoljak A. Hill A.V.S., Crean A. and O¿Mahony C. ; (2010) Percutaneous immununization using ImmuPatch: Comparison of vaccine localisation and induction of antibody and T cell responses in a pre-clinical model Perspectives in Percutaneous Penetreation La Grande Motte, France, , 06-APR-10 - 10-APR-10 [Details]
(2010)First International Conference on Microneedles
McGrath M., Vrdoljak A., O¿Mahony C., Carey J.B., Moore A.C. and Crean A.; (2010) Percutaneous Vaccine Delivery Using Microneedles First International Conference on Microneedles Atlanta, Georgia, , 24-MAY-10 - 26-APR-10 [Details]
(2010)Modern Mucosal Vaccines and Adjuvants
Moore A.C., Carey J.B, Pearson F.E., Vrdoljak A., McGrath M., Draper S.J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C. ; (2010) Enhanced T cell and Antibody Responses induced by ImmuPatch Transdermal Vaccination Modern Mucosal Vaccines and Adjuvants Dublin, Ireland, , 28-APR-10 - 30-APR-10 [Details]
(2010)4th Vaccine and ISV Annual Global Congress
A.C. Moore, J. Carey, F. Pearson, A. Vrdoljak, M. McGrath, S. Draper, S. Gilbert, A. Hill, A. Crean and C. O¿Mahony; (2010) Percutaneous Immunization using ImmuPatch: Needle-free vaccination that results in stronger T cell and antibody responses compared to traditional immunization routes 4th Vaccine and ISV Annual Global Congress Vienna, Austria, , 03-OCT-10 - 05-OCT-10 [Details]
(2009)36rd Annual meeting of the Controlled Release Society
Blackshields, C., McHugh, C., Duffy, P., Madigan, K., Cullen, A., Leonard, T., Crean, A.; (2009) Impact of Film Properties and Drug Physicochemical Properties on Diffusion through a Poly (Vinyl Alcohol) Film for the development of GIRESTM 36rd Annual meeting of the Controlled Release Society [Details]
(2009)AAPS Annual Meeting
Caroline Blackshields, Catherine McHugh, Thomas Leonard, Alan Cullen, Kieran Madigan, Patricia Duffy, Abina Crean; (2009) Control of Rate of Gas Generation for a Gastrointestinal Retention System (GIRES) AAPS Annual Meeting Los Angeles, [Details]
(2009)Transactions of 36th Annual meeting of the Controlled Release Society
O'Callaghan, J, Ryan, K., Hanrahan, J. P., Crean, A. M.; (2009) Mesoporous Silica for Optimised Drug delivery Transactions of 36th Annual meeting of the Controlled Release Society [Details]
(2008)35th Annual meeting of the Controlled Release Society
Blackshields. C.A, Conway. E. C, Crean. A. M; (2008) Alginate based beads for controlled release of Lebobupivacaine Base 35th Annual meeting of the Controlled Release Society [Details]
(2008)35th Annual meeting of the Controlled Release Society
Reddy. R.D, Crean. A.M; (2008) Hydrocortisone - PVP solid dispersions prepared from aqueous-solutions 35th Annual meeting of the Controlled Release Society [Details]
(2006)British Pharmaceutical Conference
Ring, D, Oliveira, F.A.R ., Twomey, M., Crean, A.; (2006) Process Optimisation for a Modified Release (MR) Tablet Using Production Data British Pharmaceutical Conference [Details]
(2007)Workshop on Bioencapsulation XV
Kuang, S. S., Oliveira, J. C. and Crean, A.M.; (2007) Development and characterization of microcapsules containing acetylsalicylic acid for long term suspension in acidic aqueous environment Workshop on Bioencapsulation XV [Details]
(2006)33rd Annual meeting of the Controlled Relsease Society
Blackshields, C.A, Oliveira, J., Moynihan, H. A, Crean. A. M; (2006) The influence of Processing Parameters on Alginate-Chitosan Bead Formation 33rd Annual meeting of the Controlled Relsease Society [Details]
(2006)British Pharmaceutical Conference
Blackshields, C. A, Oliveira, J., Moynihan, H.A., Crean, A.M.; (2006) Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation British Pharmaceutical Conference [Details]
(2005)British Pharmaceutical Conference
Cararro, C., Crean, A.M.; (2005) A viscometric study of the critical concentration of PVP solutions British Pharmaceutical Conference [Details]
(2005)Schools of Pharmacy Research Seminar
Caroline A. Blackshields, Ken J. Devine, Humphrey. A. Moynihan, Abina M. Crean; (2005) The effect of pH on Levobupivacaine free base solubility and retention on reverse phase HPLC . In: * eds. Schools of Pharmacy Research Seminar Trinity College Dublin, , 21-MAR-05 - 22-MAR-05 , pp.*-* [Details]

Newsletter

YearPublication
(2011)Changing concepts for 21st Century Drug Product Manufacturing.
Abina Crean & Anne Marie Healy (2011) Changing concepts for 21st Century Drug Product Manufacturing. Newsletter [Details]
(2011)Dissolution enhancement of a poorly water soluble drug.
Robert Ahern, Abina Crean & Katie Ryan; (2011) Dissolution enhancement of a poorly water soluble drug. Newsletter [Details]

Abstract

YearPublication
(2013)A skin deep approach to modulating immunity.
Moore, A,O'Mahony, C,Crean, A (2013) A skin deep approach to modulating immunity. Abstract [Details]

Conference Contributions

YearPublication
(2016)EuPAT8,
McCarthy C., Faisal W., O'Shea J., Murphy C., Griffin B., Crean A. (2016) In-vitro models for the prediction of in-vivo performance of a mesoporous silica formulation. [Poster Presentation], EuPAT8, Cork, Ireland , 03-OCT-16 - 04-OCT-16. [Details]
(2016)EuPAT8,
Mohammadpour M.1,2, Kerins B.1, Crowely M.E., Walker G., Crean A. (2016) Effect of polymer cloud point on the dissolution. [Poster Presentation], EuPAT8, Cork, Ireland , 03-OCT-16 - 04-OCT-16. [Details]
(2016)EuPAT8,
Crowley M.E., Crean A. (2016) Microcrystalline cellulose direct compression performance: Impact of manufacturing history. [Poster Presentation], EuPAT8, Cork, Ireland , 03-OCT-16 - 04-OCT-16. [Details]
(2016)EuPAT8,
Peddapatla R.V.G.1,2, Rizwan Ahmed M.3, Blackshields C.A., Fitzpatrick D., Crean A.M. (2016) Broadband acoustic resonance dissolution spectroscopy: a novel at-line process analytical technology tool for the analysis of lubricated blends/tablets. [Oral Presentation], EuPAT8, Cork, Ireland , 03-OCT-16 - 04-OCT-16. [Details]
(2016)EuroSciCon Event: Vaccine Antigen Delivery,
Crean, A.M. (2016) Design of Microneedles Formulations for Vaccine Delivery. [Invited Lectures (Conference)], EuroSciCon Event: Vaccine Antigen Delivery, Online , 25-OCT-16 - 25-OCT-16. [Details]
(2016)EuPAT8,
Crean, A.M. (2016) The eighth pan-European Science Conference on QbD and PAT Sciences. [Conference Organising Committee Chairperson], EuPAT8, University College Cork, Ireland , 02-OCT-16 - 04-OCT-16. [Details]
(2014)Third International Conference on Microneedles,
K. Dillane, T. Aherne, A. Offroy, C. O’Mahony, A. Crean and A. Moore (2014) Assessment of the physical stability of trehalose dissolvable microneedles in an ambient temperature and humidity environment. [Poster Presentation], Third International Conference on Microneedles, Baltimore, MD , 19-MAY-14 - 21-MAY-14. [Details]
(2014)13th International Ceramics Congress,
Abina M. Crean, Robert J. Ahern, Rakesh Dontireddy, Walid Faisil, John P. Hanrahan, Brendan T. Griffin, Katie B. Ryan (2014) Porous Silicas for Enhanced Drug Release. [Oral Presentation], 13th International Ceramics Congress, Montecantini Terme, Italy . [Details]
(2014)APS PharmSci 2014,
M.E. Crowley, G.E. O’Mahony, R.C. Dontireddy, A.M. Crean, (2014) Moisture sorption and desorption behavior in Microcrystalline Cellulose. [Poster Presentation], APS PharmSci 2014, University of Hertfordshire , 08-SEP-14. [Details]
(2014)American Institute of Chemical Engineers Conference,
Graham O'Mahony, Mary Ellen Crowley, Rakesh Dontireddy, Michael McAuliffe and Abina Crean (2014) Behaviour of HPMC and Microcrystalline Cellulose during a Roller Compaction Process. [Oral Presentation], American Institute of Chemical Engineers Conference, Atlana, USA . [Details]
(2014)American Institute of Chemical Engineers Conference,
Rakesh Reddy, Graham O'Mahony, Mary Ellen Crowley and Abina Crean (2014) Investigation of Impact of Roller Compaction Process Parameters on Critical Product Attributes. [Poster Presentation], American Institute of Chemical Engineers Conference, Atlanta, USA . [Details]
(2014)Third International Conference on Microneedles,
C. O’Sullivan, M.A.P. McAuliffe, E. O’Neill, A. Moore, A. Crean (2014) Raman Spectroscopy as a Qualitative Tool to Characterise Solid State Properties of Drug-Loaded Dissolvable Microneedles. [Poster Presentation], Third International Conference on Microneedles, Baltimore, MD, USA , 19-MAY-04 - 21-MAY-14. [Details]
(2014)Third International Conference on Microneedles, Baltimore,
O. Flynn, E. Allen, K. Dillane, A. Quinlan, C. O’Mahony, A. Crean, E. Norton and A. Moore (2014) Immunogenicity of Adjuvanted Vaccines in ImmuPatch Dissolvable Microneedle Patches in Mice. [Poster Presentation], Third International Conference on Microneedles, Baltimore, Baltimore, MD, USA , 19-MAY-14 - 21-MAY-14. [Details]
(2014)Third International Conference on Microneedles,
Sonja Vucen, Gordana Vuleta, Jela Milic, Abina Crean, Anne Moore, Nenad Ignjatovic, Dragan Uskokovic (2014) Short-term storage stability of dissolvable microneedles containing ketoprofen-loaded polymeric nanoparticles. [Oral Presentation], Third International Conference on Microneedles, Baltimore, MD, USA , 19-MAY-14 - 21-MAY-14. [Details]
(2014)Microneedles 2014,
Allen, E.,Flynn, O.,O’Mahony, C.,Crean, A.,Moore, A. (2014) Immunogenicity and Stability of Trivalent Inactivated Influenza Virus Vaccine in ImmuPatch Dissolvable Microneedles. [Poster Presentation], Microneedles 2014, Baltimore, Maryland, USA . [Details]
(2014)Pharmacists in Industry Education and Regulatory AGM,
A. M. Crean (2014) Microneedles; Delivery and Diagnostics. [Invited Oral Presentation], Pharmacists in Industry Education and Regulatory AGM, Dublin , 13-DEC-14. [Details]
(2013)School of Pharmacy, UCC, 10 Year Anniversary Research Conference,
Nicholas D. Mullins, Anita R. Maguire, Humphrey A. Moynihan, Florence O. McCarthy, Simon E. Lawrence, Abina Crean, Jonathan Thompson (2013) A Study of Gentamicin Degradation on Coated Surfaces. [Poster Presentation], School of Pharmacy, UCC, 10 Year Anniversary Research Conference, Cork , 27-SEP-13 - 27-SEP-13. [Details]
(2013)EuPAT 6: Sixth pan-European QbD & PAT Science Conference,
M.A.P. McAuliffe, C.A. Blackshields, G.E. O’Mahony, D.P. Egan, G.M. Walker, E. O’Neill, S. Lenihan and A.M. Crean (2013) Study of the relationships between the compressibility of roller-compacted granules, the hardness of granule compacts and compact Raman spectra. [Oral Presentation], EuPAT 6: Sixth pan-European QbD & PAT Science Conference, Porto , 23-SEP-13 - 24-SEP-13. [Details]
(2012)All Ireland Schools of Pharmacy Research Seminar, UCC,
Ahern R.J., Crean A. M., Ryan K. B. (2012) Investigating the impact the method of drug loading has on drug physicochemical properties. [Oral Presentation], All Ireland Schools of Pharmacy Research Seminar, UCC, University College Cork . [Details]
(2011)UKICRS annual meeting, Queen's University Belfast,
Ahern, R., Ryan, K., Crean, A.M., (2011) Investigation into Mesoporous Silica as a Carrier for Poorly Water Soluble Drugs,. [Oral Presentation], UKICRS annual meeting, Queen's University Belfast, Queen's University Belfast , 29-MAR-10 - 30-MAR-10. [Details]
(2010)All Ireland Schools of Pharmacy Research Seminar,,
O Sullivan, C., Crean, A.M., Ryan, K., ; (2010) Novel Coatings for Hard Tissue Implants. [Oral Presentation], All Ireland Schools of Pharmacy Research Seminar,, Queen's University Belfast , 29-MAR-10 - 30-MAR-10. [Details]
(2014)Design of amorphous drug systems optimised for enhanced dissolution,
Crean A.M. (2014) Amorphous by Design. [Invited Oral Presentation], Design of amorphous drug systems optimised for enhanced dissolution, University of Bradford, UK , 23-APR-14. [Details]
(2014)The Modes of Action of Vaccine Adjuvants,
O. Flynn, E. Allen, K. Dillane, A. Crean , E. Norton and A. Moore (2014) Immunogenicity of dmLT Adjuvanted Vaccines in ImmuPatch Dissolvable Microneedle. [Oral Presentation], The Modes of Action of Vaccine Adjuvants, Seattle, WA, USA , 08-OCT-14 - 13-OCT-14. [Details]
(2013)Almac Symposium, Cork 2013,
Crean A.M. (2013) Stabilisation of the amorphous drug state for enhanced oral delivery. [Invited Oral Presentation], Almac Symposium, Cork 2013, University College Cork , 09-SEP-13. [Details]
(2012)Sharebiotech: Fostering Open Innovation in Biotechnology,
Crean, A.M., Moore A.C., O'Mahony C. (2012) ImmuPatch: a skin-deep approach to vaccination and drug delivery. [Invited Oral Presentation], Sharebiotech: Fostering Open Innovation in Biotechnology, Pamplona , 10-MAY-12 - 11-MAY-12. [Details]
(2008)Amorphous Materials, Challenge or Opportunity,
Crean, A.M; (2008) Preparation of Amorphous Material using Solid Dispersions. [Invited Oral Presentation], Amorphous Materials, Challenge or Opportunity, Bath, UK , 18-MAR-08 - 18-MAR-08. [Details]
(2006)2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
Caroline A. Blackshields, Jorge Oliveira, Humphrey A. Moynihan and Abina M. Crean; (2006) Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation. [Poster Presentation], 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast School of Pharmacy , 10-APR-06 - 11-APR-06. [Details]
(2008)British Pharmaceutical Conference,
Crean, A.M; (2008) Solid Dispersion Technology. [Oral Presentation], British Pharmaceutical Conference, Manchester, UK , 08-OCT-08 - 08-OCT-08. [Details]

Professional Associations

 AssociationFunctionFrom / To
United Kingdom Ireland Controlled Release Society (UKICRS) Committee member01-JAN-05 /
International Society of Pharmaceutical Engineering Member01-NOV-13 /
Pharmacists in Industry Education and Regulatory Member01-SEP-14 /
Pharmaceutical Society of Ireland Member01-SEP-93 /
Pharma Industry Awards Judge20-JUL-14 / 04-AUG-15

Honours and Awards

 YearTitleAwarding Body
2011Short Listed Finalise for Invention of the Year Award 2011 Technology Transfer Office, University College Cork
2014Helping Hand Award UCC Pharmacy students society
2012Research Team of the Year member (UCC) University College Cork
2013Member of IPN Dynamic 100 Irish Pharmacy News
2012Recognition award, Technology Transfer Office, University College Cork Technology Transfer Office, University College Cork

Patents

 Patent NumberTitleGranted
US20130110078Vaccination Method Using Microneedle Arrays 02-MAY-13
WO2012066506Method 23-AUG-12

Committees

 CommitteeFunctionFrom / To
College of Medicine and Heath Athena Swan Committee member2016 /
College of Medicine and Health Fitness to Practice Member2013 /
SSPC Structured PhD Subcommittee Member2013 /
School of Pharmacy Teaching and Curriculum Committee Committee Member2011 /
College of Medicine and Health Teaching and Curriculum Committee Committee Member2011 /
UK Ireland Controlled Release Society Membership2006 /

Employment

 EmployerPositionFrom / To
School of Pharmacy, University College Cork Lecturer in Pharmaceutics01-JUN-03 /
Elan Pharmaceuticals Formulation Scientist01-OCT-97 / 01-FEB-01
Servier (Ireland) Industries Technical Industrial Pharmacist01-JAN-02 / 01-JUN-03

Education

 YearInstitutionQualificationSubject
1992Robert Gordon's University BSc PharmPharmacy
2015University College Cork Postgraduate Certificate in Teaching and Learning in Higher Ed.Teaching and Learning
1997Trinity College Dublin PHDPharmaceutics

Outreach Activities

 Description

Smart Future volunteer. Smart Futures programme trains people with science and technology backgrounds to give career talks to students in secondary schools around Ireland. Career talks are aimed at Junior Cycle and Transition Year students, with a view to encouraging them to keep on STEM subjects, but may also be available for Senior Cycle students. 

Promotion of the discipline of pharmacy at UCC open days for secondary school students, access and UCC plus students and mature students

Teaching Interests

Undergraduate teaching: Pharmacy degree course module coordinator for module Introduction to Pharmaceutics: Formulation Science and major contributor to modules Pharmaceutical Technology, Novel Drug Delivery Systems and Pharmaceutical Biotechnology 

Postgraduate teaching: 

Director of PG Certificate in (Bio)Pharma 

MSc (Pharmaceutical Technology and Quality Systems) module coordinator for modules in; Pharmaceutical Manufacturing - API to Finished Product and  Pharmaceutical Plant and Process: From Design through Validation. Masters in Applied Sciences (Biotechnology) a contributor to module Biopharmaceuticals; Formulation Design, Secondary Processing and Regulatory Compliance. 

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2016Evin Allen University College CorkPHDDevelopment of a Dissolvable Microneedle Influenza Vaccine Patch
2012Denis Ring University College CorkPHDAnalysis and modelling of the influence of high shear wet granulation process parameters on critical quality attributes of an active pharmaceutical ingredient using robust design of experiments
2012Caroline O’Sullivan University College CorkPHDNovel coatings for hard tissue implants
2013Sean Cullen University College CorkM.Sc.The impact of excipient state on the structure and stability of lyophilized biopharmaceuticals
2011Marie McGrath University College CorkPHDDesign and characterisation of Microneedles for Percutaneous Vaccine Delivery
2012Fatma Farag PHDAn investigation of the chemical and physical stability of salmon calcitonin formulations
2013Robert Ahern University College CorkPHDApplication of mesoporous silica for the oral delivery of poorly water-soluble drugs
2010Rakesh Dontireddy University College CorkPHDInvestigation of dissolution properties of amorphous drug and drug-carrier systems
2008Caroline Blackshields University College CorkPHDDevelopment of hydrogel based drug delivery systems of local anaesthetics
2014Aisling Sheehan University College CorkM.Sc.An investigation into influenza vaccine stability in a dissolvable microneedle formulation

Current Postgraduate Students

 StudentDegree Type
Peddapatla Raghu Vamshi Goud Doctoral Degree
Gervasi Valeria Doctoral Degree
Mc Gillicuddy Aoife Catherine Doctoral Degree
Mc Carthy Carol Doctoral Degree
Crowley Mary Ellen Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2017Pharmaceutical Manufacturing - API to Finished Product PF6202Pharmaceutical Manufacturing - API to Finished Product
2017Transitioning to the Workplace PF6602Transitioning to the Workplace
2017Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance PF6301Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance
2017Pharmaceutical Process Technology PF6604Pharmaceutical Process Technology
2017Pharmaceutical Process Design from Plant to Continuous Process Verification PF6607Pharmaceutical Process Design from Plant to Continuous Process Verification
2017Placement (Postgraduate) PF6608Placement (Postgraduate)
2017Pharmaceutical Technology - Solid Oral and Sterile Dosage Forms PF2009Pharmaceutical Technology - Solid Oral and Sterile Dosage Forms
2017Pharmaceutical Plant and Process: From Design through Validation PF6207Pharmaceutical Plant and Process: From Design through Validation