Lecturer In Pharmaceutics
School of Pharmacy
Cavanagh Pharmacy Building
University College Cork
Cork
Ireland

T: +353-21-490-1667
F: +353-21-490-1656
E: a.crean@ucc.ie

Dr. Abina Crean graduated with a degree in Pharmacy from Robert Gordon's University, Aberdeen, Scotland in 1992.  In 1997, she completed a PhD in Pharmaceutics with Professor Owen Corrigan in the School of Pharmacy, Trinity College Dublin, on the effects of processing on the physicochemical properties of solid dispersions. 
Upon completion of her PhD, Dr. Crean worked as a formulation scientist with Elan Pharmaceutical Technologies both at the Trinity College and Athlone sites, focusing primarily on the area of solid dosage form development.  In 2002, she joined Servier (Ireland) Industries as a Process Development Pharmacist. 
In 2003 Dr. Crean was appointed as a lecturer in the newly established School of Pharmacy at UCC. She was actively involved in the development of the curriculm and research facilities of the newly established School of Pharmacy. She is involved in both undergraduate and postgraduate teaching in the area of pharmaceutical science and technology. She has established and is currently supervising an active research group in the area of pharmaceutical technology and drug delivery.

General research interests involve studying the impact of pharmaceutical formulation and processing technologies on drug physicochemical properties

Current research projects involve,

  • Application of quality by design principles to a dry granulation process
  • Development of silica-based drug formulations to enhance the oral bioavailability of therapeutic compounds challenged by poor-water solubility
  • Formulation and characterisation of microneedle drug and vaccine delivery systems
  • Troubleshooting issues relating solid oral dosage form manufacture
  • Biophysical characterisation, processing and formulation of peptide, protein and vaccine materials
  • Investigating critical attributes of drugs and excipients that impact on processing and performance of drug products

 
 

Books

 YearPublication
(2009)The Physicochemical Basis of Pharmaceuticals.
Humphrey Moynihan and Abina Crean; (2009) The Physicochemical Basis of Pharmaceuticals. Oxford: Oxford University Press. [Details]

Peer Reviewed Journals

 YearPublication
(2013)'Comparison of fenofibrate – mesoporous silica drug-loading processes for enhanced drug delivery'
Robert J. Ahern, John P. Hanrahan, Joseph M. Tobin, Katie B. Ryan, Abina M. Crean (2013) 'Comparison of fenofibrate – mesoporous silica drug-loading processes for enhanced drug delivery' [Details]
(2013)'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles'
Sonja R. Vucˇen, Gordana Vulet, Abina M. Crean, Anne C. Moore, Nenad Ignjatovic´and Dragan Uskokovic´ (2013) 'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles' [DOI] [Details]
(2013)'Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration'
McGrath MG, Vucen S, Vrdoljak A, Kelly A, O'Mahony C, Crean AM, Moore AC. (2013) 'Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration' [DOI] [Details]
(2012)'An Analysis of the Influence of Multiple Processing Factors on the Characteristics of Bioactive-Loaded Beads Prepared by Extrusion-Spheronisation'
Kuang, SS,Oliveira, JC,Crean, AM (2012) 'An Analysis of the Influence of Multiple Processing Factors on the Characteristics of Bioactive-Loaded Beads Prepared by Extrusion-Spheronisation' [DOI] [Details]
(2012)'Coated microneedle arrays for transcutaneous delivery of live virus vaccines'
Vrdoljak, A.,McGrath, M. G.,Carey, J. B.,Draper, S. J.,Hill, A. V.,O'Mahony, C.,Crean, A. M.,Moore, A. C. (2012) 'Coated microneedle arrays for transcutaneous delivery of live virus vaccines' [Details]
(2012)'The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties'
Robert J. Ahern, Abina M. Crean, Katie B. Ryan (2012) 'The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties' [DOI] [Details]
(2011)'Evaluation of the influence of granulation processing parameters on the granule properties and dissolution characteristics of a modified release drug'
Ring, DT,Oliveira, JCO,Crean, A; (2011) 'Evaluation of the influence of granulation processing parameters on the granule properties and dissolution characteristics of a modified release drug' [DOI] [Details]
(2011)'Determination of parameters for successful spray coating of silicon microneedle arrays'
McGrath MG, Vrdoljak A, O'Mahony C, Oliveira JC, Moore AC, Crean AM; (2011) 'Determination of parameters for successful spray coating of silicon microneedle arrays' [DOI] [Full Text] [Details]
(2011)'A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions'
Rakesh Dontireddy, Abina M Crean; (2011) 'A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions' [DOI] [Details]
(2011)'Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'
John B. Carey, Frances E. Pearson, Anto Vrdoljak, Marie G. McGrath, Abina M. Crean, Patrick T. Walsh, Timothy Doody, Conor O'Mahony, Adrian V. S. Hill, Anne C. Moore; (2011) 'Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice' [DOI] [Details]
(2011)'A Modified Surface on Titanium Deposited by a Blasting Process'
C. O¿Sullivan, P. O¿Hare, G. Byrne, L. O¿Neill, K. B. Ryan and A. M. Crean; (2011) 'A Modified Surface on Titanium Deposited by a Blasting Process' [Details]
(2010)'Development of stabilized vaccines with needle-free devices for targeted skin immunization'
Moore, A. C., Crean, A. M., O¿Mahony; (2010) 'Development of stabilized vaccines with needle-free devices for targeted skin immunization' Kent, United Kingdom [Full Text] [Details]
(2010)'Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process'
O'Sullivan, C. and O'Hare, P. and O'Leary, N. D. and Crean, A. M. and Ryan, K. and Dobson, A. D. W. and O'Neill, L.; (2010) 'Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process' [DOI] [Details]
(2010)'A Methodology for Knowledge Management in Biopharmaceutical Production'
Coakley, Jennifer; Hogan, Nicola; McGuire, Linda; Griffin, Brendan; Casey, Colman; Campbell, Cliff; Crean, Abina; (2010) 'A Methodology for Knowledge Management in Biopharmaceutical Production' US [Details]
(2010)'Microencapsulation as a tool for incorporating bioactive ingredients into food'
Kuang, SS; Oliveira, JC; Crean, AM; (2010) 'Microencapsulation as a tool for incorporating bioactive ingredients into food' [Details]
(2002)'Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying'
Corrigan, O. I, Crean. A. M; (2002) 'Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying' [Details]

Other Journals

 YearPublication
(2011)'Changing concepts for 21st Century Drug Product Manufacturing'
Abina Crean & Anne Marie Healy (2011) 'Changing concepts for 21st Century Drug Product Manufacturing' UKICRS Newsletter, . [Details]
(2011)'Dissolution enhancement of a poorly water soluble drug'
Robert Ahern, Abina Crean & Katie Ryan; (2011) 'Dissolution enhancement of a poorly water soluble drug' UKICRS Newsletter, . [Details]

Conference Publications

 YearPublication
(2011)5th International Granulation Workshop
D.T, Ring, J.C. Oliveira and A. Crean; (2011) Developing better process understanding; the role of the granulation process, materials properties and storage environment on drug release from a matrix tablet 5th International Granulation Workshop [Details]
(2011)38th Annual Meeting Controlled Release Society
John B. Carey, Frances E. Pearson, Anto Vrdoljak, Abina M. Crean, Conor O¿Mahony, Adrian V.S. Hill, Anne C. Moore; (2011) Immunization using ImmuPatch Silicon Microneedle Arrays results in Enhanced T 38th Annual Meeting Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2011)38th Annual Meeting of Controlled Release Society
F. F. Farag, M. I. Amaro, A.M. Healy, C. M. O¿Driscoll, A. M. Crean; (2011) Stability of Salmon Calcitonin-Sugar Nanoporous Microparticles 38th Annual Meeting of Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2011)38th Annual Meeting Controlled Release Society
M.G. McGrath, C.O¿Mahony, A. Vrdoljak, A.C. Moore, A.M. Crean; (2011) Design of Dissolvable Microneedles for Drug Delivery 38th Annual Meeting Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2011)38th Annual Meeting and Exposition of the Controlled Release Society
R. J. Ahern, K. B. Ryan, A. M. Crean. (2011) Enhanced dissolution and stability properties of supercritical fluid processed fenofibrate-silica systems 38th Annual Meeting and Exposition of the Controlled Release Society Maryland, U.S.A, July 2011, , 30-JUL-11 - 03-AUG-11 [Details]
(2010)AAPS National Biotechnology Conference
Farag, F.F., O'Driscoll, C.M., Crean, A.M.; (2010) Formulation and storage conditions affecting the conformation and degradation of salmon calcitonin delivery systems AAPS National Biotechnology Conference San Francisco, [Details]
(2010)British Association of Dermatologists Annual Meeting
M.A. McAleer, A. Moore, A. Crean, C. O¿Mahony, and J. Bourke; (2010) A proof of concept study to investigate the efficacy of microneedle arrays in local anaesthetic administration to human skin British Association of Dermatologists Annual Meeting [Details]
(2010)First International Conference on Microneedles
Moore A.C., Carey J.B., Pearson F., Vrdoljak A., McGrath M., Draper Simon J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C; (2010) Enhanced Immune Responses induced by ImmuPatch Transcutaneous Vaccination First International Conference on Microneedles Atlanta, [Details]
(2010)12th International Conference on Perspectives in Percutaneous Penetration
M. G. McGrath, C. O¿Mahony, J. B. Carey, A. Vrdoljak, A. C. Moore and A. M. Crean; (2010) Spray Coating of Silicon Microneedle Patches for Intradermal Drug Delivery 12th International Conference on Perspectives in Percutaneous Penetration [Details]
(2010)First International Conference on Microneedles
McGrath M., Vrdoljak A., O¿Mahony C., Carey J.B., Moore A.C., Crean A.; (2010) Percutaneous Vaccine Delivery Using Microneedles First International Conference on Microneedles Atlanta, [Details]
(2009)36rd Annual meeting of the Controlled Release Society
O'Callaghan, J, Ryan, K., Hanrahan, J. P., Crean, A. M.; (2009) Mesoporous Silica for Optimised Drug delivery 36rd Annual meeting of the Controlled Release Society [Details]
(2009)AAPS Annual Meeting
Caroline Blackshields, Catherine McHugh, Thomas Leonard, Alan Cullen, Kieran Madigan, Patricia Duffy, Abina Crean; (2009) Control of Rate of Gas Generation for a Gastrointestinal Retention System (GIRES) AAPS Annual Meeting Los Angeles, [Details]
(2009)36rd Annual meeting of the Controlled Release Society
Blackshields, C., McHugh, C., Duffy, P., Madigan, K., Cullen, A., Leonard, T., Crean, A.; (2009) Impact of Film Properties and Drug Physicochemical Properties on Diffusion through a Poly (Vinyl Alcohol) Film for the development of GIRESTM 36rd Annual meeting of the Controlled Release Society [Details]
(2008)35th Annual meeting of the Controlled Release Society
Reddy. R.D, Crean. A.M; (2008) Hydrocortisone - PVP solid dispersions prepared from aqueous-solutions 35th Annual meeting of the Controlled Release Society [Details]
(2008)35th Annual meeting of the Controlled Release Society
Blackshields. C.A, Conway. E. C, Crean. A. M; (2008) Alginate based beads for controlled release of Lebobupivacaine Base 35th Annual meeting of the Controlled Release Society [Details]
(2007)Workshop on Bioencapsulation XV
Kuang, S. S., Oliveira, J. C. and Crean, A.M.; (2007) Development and characterization of microcapsules containing acetylsalicylic acid for long term suspension in acidic aqueous environment Workshop on Bioencapsulation XV [Details]
(2006)British Pharmaceutical Conference
Blackshields, C. A, Oliveira, J., Moynihan, H.A., Crean, A.M.; (2006) Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation British Pharmaceutical Conference [Details]
(2006)British Pharmaceutical Conference
Ring, D, Oliveira, F.A.R ., Twomey, M., Crean, A.; (2006) Process Optimisation for a Modified Release (MR) Tablet Using Production Data British Pharmaceutical Conference [Details]
(2006)33rd Annual meeting of the Controlled Relsease Society
Blackshields, C.A, Oliveira, J., Moynihan, H. A, Crean. A. M; (2006) The influence of Processing Parameters on Alginate-Chitosan Bead Formation 33rd Annual meeting of the Controlled Relsease Society [Details]
(2005)British Pharmaceutical Conference
Cararro, C., Crean, A.M.; (2005) A viscometric study of the critical concentration of PVP solutions British Pharmaceutical Conference [Details]

Conference Contributions

 YearPublication
(2005)Schools of Pharmacy Research Seminar,
Caroline A. Blackshields, Ken J. Devine, Humphrey. A. Moynihan, Abina M. Crean; (2005) The effect of pH on Levobupivacaine free base solubility and retention on reverse phase HPLC. [Poster Presentation], Schools of Pharmacy Research Seminar, Trinity College Dublin , 21-MAR-05 - 22-MAR-05
(2006)2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
Caroline A. Blackshields, Jorge Oliveira, Humphrey A. Moynihan and Abina M. Crean; (2006) Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation. [Invited Oral Presentation], 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast School of Pharmacy , 10-APR-06 - 11-APR-06
(2006)2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
Caroline A. Blackshields, Jorge Oliveira, Humphrey A. Moynihan and Abina M. Crean; (2006) Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation. [Poster Presentation], 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast School of Pharmacy , 10-APR-06 - 11-APR-06
(2012)Sharebiotech: Fostering Open Innovation in Biotechnology,
Crean, A.M. (2012) ImmuPatch: a skin-deep approach to vaccination and drug delivery. [Oral Presentation], Sharebiotech: Fostering Open Innovation in Biotechnology, Pamplona , 10-MAY-12 - 11-MAY-12
(2012)2nd International Conference on Microneedles: Microneedles 2012,
A. M. Crean, M. G. McGrath, C. O’Mahony, A. Vrdoljak and A. C. Moore (2012) Dissolvable ImmuPatch Microneedles for Drug Delivery. [Poster Presentation], 2nd International Conference on Microneedles: Microneedles 2012, Cork , 13-MAY-12 - 15-MAY-12
(2010)Joint Schools of Pharmacy Research Seminar,
Ahern, R., Ryan, K., Crean, A.M., ; (2010) Investigation into Mesoporous Silica as a Carrier for Poorly Water Soluble Drugs,. [Poster Presentation], Joint Schools of Pharmacy Research Seminar, Queen¿s University Belfast , 29-MAR-10 - 30-MAR-10
(2010)First International Conference on Microneedles,
Moore A.C., Carey J.B., Pearson F., Vrdoljak A., McGrath M., Draper S.J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C., ; (2010) Enhanced Immune Responses induced by ImmuPatch Transcutaneous Vaccination. [Oral Presentation], First International Conference on Microneedles, Atlanta, Georgia , 24-MAY-10 - 26-MAY-10
(2010)First International Conference on Microneedles,
McGrath M., Vrdoljak A., O¿Mahony C., Carey J.B., Moore A.C. and Crean A.; (2010) Percutaneous Vaccine Delivery Using Microneedles. [Poster Presentation], First International Conference on Microneedles, Atlanta, Georgia, , 24-MAY-10 - 26-APR-10
(2010)Perspectives in Percutaneous Penetreation,
Moore A.C., Carey J.B., McGrath M. Pearson F.E., Vrdoljak A. Hill A.V.S., Crean A. and O¿Mahony C. ; (2010) Percutaneous immununization using ImmuPatch: Comparison of vaccine localisation and induction of antibody and T cell responses in a pre-clinical model. [Poster Presentation], Perspectives in Percutaneous Penetreation, La Grande Motte, France, , 06-APR-10 - 10-APR-10
(2010)Perspectives in Percutaneous Penetreation,
McGrath M., O¿Mahony C., Carey J.B., Vrdoljak A., Moore A.C. and Crean A; (2010) Spray Coating of Silicon Microneedle Patches for Intradermal Drug Delivery. [Poster Presentation], Perspectives in Percutaneous Penetreation, La Grande Motte, France , 06-APR-10 - 08-APR-10
(2010)Joint Research Schools of Pharmacy Research Seminar,,
O Sullivan, C., Crean, A.M., Ryan, K., ; (2010) Novel Coatings for Hard Tissue Implants. [Oral Presentation], Joint Research Schools of Pharmacy Research Seminar,, Queen¿s University Belfast , 29-MAR-10 - 30-MAR-10
(2010)Joint Schools of Pharmacy Research Seminar,,
McCarthy, C., Ahern, R., Crean, A.M., Ryan, K; (2010) Investigation of Process and Formulation Parameters Impacting on Mesoporous Silica as a Carrier for Poorly soluble Drugs. [Poster Presentation], Joint Schools of Pharmacy Research Seminar,, Queen¿s University Belfast , 29-MAR-10 - 30-MAR-10
(2010)4th Vaccine and ISV Annual Global Congress,
A.C. Moore, J. Carey, F. Pearson, A. Vrdoljak, M. McGrath, S. Draper, S. Gilbert, A. Hill, A. Crean and C. O¿Mahony; (2010) Percutaneous Immunization using ImmuPatch: Needle-free vaccination that results in stronger T cell and antibody responses compared to traditional immunization routes. [Oral Presentation], 4th Vaccine and ISV Annual Global Congress, Vienna, Austria , 03-OCT-10 - 05-OCT-10
(2010)Modern Mucosal Vaccines and Adjuvants,
Moore A.C., Carey J.B, Pearson F.E., Vrdoljak A., McGrath M., Draper S.J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C. ; (2010) Enhanced T cell and Antibody Responses induced by ImmuPatch Transdermal Vaccination. [Oral Presentation], Modern Mucosal Vaccines and Adjuvants, Dublin, Ireland , 28-APR-10 - 30-APR-10
(2009)Transactions of the 36th Annual meeting of the Controlled Release Society,
O¿Callaghan, J., Ryan, K., Hanrahan, J., Crean, A.; (2009) Mesoporous Silica for optimised Drug. [Poster Presentation], Transactions of the 36th Annual meeting of the Controlled Release Society, Copenhagen, Denmark, July 2009 , 18-JUL-09 - 22-JUL-09
(2008)British Pharmaceutical Conference,
Crean, A.M; (2008) Solid Dispersion Technology. [Oral Presentation], British Pharmaceutical Conference, Manchester, UK , 08-OCT-08 - 08-OCT-08
(2008)UK and Ireland Controlled Release Society Conference,
Crean, A. M; (2008) Merck Sharpe and Dohme. [Conference Organising Committee Member], UK and Ireland Controlled Release Society Conference, Hoddesdon, UK , 23-JAN-08 - 23-JAN-08
(2008)Amorphous Materials, Challenge or Opportunity,
Crean, A.M; (2008) Preparation of Amorphous Material using Solid Dispersions. [Oral Presentation], Amorphous Materials, Challenge or Opportunity, Bath, UK , 18-MAR-08 - 18-MAR-08

Honours and Awards

 YearTitleAwarding Body
2012Research Team of the Year member (UCC) University College Cork
2012Recognition award Technology Transfer Office, University College Cork

Associations

 AssocationFunctionFrom / To
Pharmaceutical Society of Ireland Member/
United Kingdom Ireland Controlled Release Society (UKICRS) Committee member/
Controlled Release Society (CRS) Member/

Committees

 CommitteeFunctionFrom / To
School of Pharmacy Teaching and Curriculum Committee Committee Member2011 /
UK Ireland Controlled Release Society Membership/
College of Medicine and Health Teaching and Curriculum Committee Committee Member/

Employment

 EmployerPositionFrom / To
School of Pharmacy, University College Cork Lecturer in Pharmaceutics01-JUN-03 /
Servier (Ireland) Industries Technical Industrial Pharmacist01-JAN-02 / 01-JUN-03
Elan Pharmaceuticals Formulation Scientist01-OCT-97 / 01-FEB-01

Education

 YearInstituionQualificationSubject
1992Robert Gordon's University BSc PharmPharmacy
1997Trinity College Dublin PHDPharmaceutics

Undergraduate teaching: Pharmacy degree course module coordinator for module Introduction to Pharmaceutics: Formulation Science and major contributor to modules Pharmaceutical Technology, Novel Drug Delivery Systems and Pharmaceutical Biotechnology 

Postgraduate teaching: MSc (Pharmaceutical Technology and Quality Systems) module coordinator for modules in; Pharmaceutical Manufacturing - API to Finished Product and  Pharmaceutical Plant and Process: From Design through Validation. Masters in Applied Sciences (Biotechnology) a contributor to module Biopharmaceuticals; Formulation Design, Secondary Processing and Regulatory Compliance. 

Allen Evin AnthonyDoctoral DegreeCo-Supervised
 Term (ID))TitleLinkSubject
2014Pharmaceutical Biotechnology PF4109Pharmaceutical Biotechnology
2014Pharmaceutical Technology PF2008Pharmaceutical Technology
2014Pharmaceutical Development of Investigational Medicinal Products PF6204Pharmaceutical Development of Investigational Medicinal Products
2014Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance PF6301Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance
2014Novel Drug Delivery Systems PF4008Novel Drug Delivery Systems
2014Pharmaceutical Plant and Process: From Design through Validation PF6207Pharmaceutical Plant and Process: From Design through Validation
2014Pharmaceutical Manufacturing - API to Finished Product PF6202Pharmaceutical Manufacturing - API to Finished Product
2014Introduction to Pharmaceutics: Formulation Science PF1008Introduction to Pharmaceutics: Formulation Science