Research Profile

Anne Moore

Biography

Dr. Anne Moore graduated with a degree in Biochemistry University College Cork. She completed a PhD in HIV vaccine immunology with Professor Kingston Mills. Dr. Moore subsequently embarked upon post-doctoral work on defects in immune responses in HIV-infected individuals in the Wistar Institute in Philadelphia and further work on recombinant vaccines against viruses such as HIV and Ebola virus in Dr. Gary Nabel's lab then at the University of Michigan. As a senior immunologist in Prof. Adrian Hill's group in the University of Oxford, she developed several T cell inducing vaccine candidates against malaria and TB and was involved in clinical trials of these and other vaccine candidates in Oxford and malaria endemic areas in Africa. She took up a position as a Lecturer in Pharmacology, based in the School of Pharmacy, UCC in early 2007.

             

 

Research Interests


 The central aim of my group is to develop and translate innovative vaccines and immunoptherapies to address unmet clinical needs. Our research extends from basic cellular immunology to clinical translation with the aim of improving vaccine and immunotherapy efficacy and immunization programme logistics.  

VACCINES AND DRUG DELIVERY:
ImmuPatch is a microneedle-based platform technology for skin-based drug and vaccine delivery. Microneedles are micron-scale protrusions that penetrate into skin creating conduits for drug/vaccine administration. ImmuPatch is being designed to overcome logistic issues relating to vaccination programmes and to better deliver drugs to the body. It provides the convenience of self-administration in a small, low-cost system. We previously developed silicon and coated microneedle patches.  We now focus on developing and researching dissolvable microneedle patches.  The active vaccine or drug material is formulated into dissolvable microneedle (DMN) patches that are administered into the skin. Once the microneedle has inserted into the skin it dissolves, thereby delivering the drug/vaccine to the body. Complete dissolution of the microneedle in the skin has a number of advantages including removing the requirement of hazardous waste disposal, simple application, therefore improving patient compliance and acceptability and lack of requirement of prior reconstitution.
Some key outputs: We developed two novel processes to produce DMN which are unique to the ImmuPatch team and are patent protected. We demonstrated that DMN produced by both methods stabilise sensitive vaccines for greater than 6 months and DMN loaded with vaccine induce robust antibody and T cell responses in several pre-clinical models. We previously collaborated with a large EU-based drug manufacturer to develop a microneedle patch that delivered two of their drugs in a defined manner. The technology was fully transferred to this industrial partner who is now clinically developing this product.  

 Our current research focus is to determine the breadth of use of dissolvable microneedle patches for vaccine and drug delivery and the extent of the enhancement of stability, potency and efficacy of a range of drugs or vaccines in these patches. Specifically, we are interested in understanding (i) how the process and formulation can be optimised to produce physically, chemically and immunologically stable drug and vaccine-loaded DMN patches; (ii) the range of novel and licensed vaccine adjuvants that can be incorporated into microneedle patches and (iii) how and why delivery of drugs and vaccines into the skin modulates the quantity and quality of the immune response and the distribution of drug within the body. We are currently working with several vaccine manufacturers to incorporate their licensed and candidate vaccines into our ImmuPatch dissolvable skin patches. We are always interested in developing new collaborations to further develop this technology.    

 VACCINE DEVELOPMENT:
 In collaboration with the Jenner Institute, University of Oxford, we developed a T cell-inducing universal influenza virus vaccine that protects against multiple strains of the virus that cause both seasonal and pandemic infections. We demonstrated that this strategy protects against challenge by multiple influenza virus strains. This vaccine is being clinically tested by the Jenner Institute. Work within our group defined pre-clinical correlates of protective systemic and mucosal immunity.  We are also examining the induction of mucosal immunity in pre-clinical models by vaccines containing novel adjuvants with US colleagues.    


TUMOUR IMMUNOTHERAPY:

We are developing immune-based therapies for cancer. In collaboration with Pfizer and funded by the SFI Biotherapeutics Innovation Award Programme, we are developing a biological therapy that overcomes an immunosuppressive signal.  Removal of this inhibitory checkpoint should stimulate the immune system to recognise tumour cells and to kill these malignant cells.
 Secondly, we have developed productive collaborations with our clinical colleagues in Cork University Hospital to develop pre-clinical models that can better inform human tumour responses and are interested in further developing this research focus.
 Finally, in a combination of research strands, we are developing therapeutic cancer vaccines utilising both our core immunology and expanding tumour expertise.  

 Research funding is gratefully acknowledged from
  •  Science Foundation Ireland (15/BIAP/3181, 12/TIDA/I2351, National Access Programme 170, 280 and Equipment Award);  
  • Health Research Board of Ireland (RP2007/77, POR/2012/95 and summer student scholarships)
  • Enterprise Ireland (CFTD/07/117, CFTD 2011/1634 and EU Co-ordinator support); 
  • The European Union:  TRANSVAC and linked to SAPHIR 
  •  UCC College of Medicine and Health PhD studentship and UCC Research Investment 
  • Industrial collaborators.  

Publications

Peer Reviewed Journals

 YearPublication
(2017)'Acceptability of microneedle-patch vaccines: A qualitative analysis of the opinions of parents'
Marshall S;Fleming A;Moore AC;Sahm LJ; (2017) 'Acceptability of microneedle-patch vaccines: A qualitative analysis of the opinions of parents'. Vaccine, 35 (37) [DOI] [Details]
(2016)'The success of microneedle-mediated vaccine delivery into skin'
Marshall, S.,Sahm, L. J.,Moore, A. C. (2016) 'The success of microneedle-mediated vaccine delivery into skin'. Hum Vaccin Immunother, 12 (11):2975-2983 [DOI] [Details]
(2016)'Dissolvable microneedle fabrication using piezoelectric dispensing technology'
Allen, EA,O'Mahony, C,Cronin, M,O'Mahony, T,Moore, AC,Crean, AM (2016) 'Dissolvable microneedle fabrication using piezoelectric dispensing technology'. International Journal of Pharmaceutics, 500 :1-10 [DOI] [Details]
(2016)'Microneedle technology for immunisation: Perception, acceptability and suitability for paediatric use'
Marshall, S.,Sahm, L. J.,Moore, A. C. (2016) 'Microneedle technology for immunisation: Perception, acceptability and suitability for paediatric use'. Vaccine, 34 (6):723-34 [DOI] [Details]
(2016)'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods'
Vrdoljak, A;Allen, EA;Ferrara, F;Temperton, NJ;Crean, AM;Moore, AC (2016) 'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods'. Journal Of Controlled Release, 225 :192-204 [DOI] [Details]
(2015)'Induction of CD8(+) T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus-vectored malaria vaccine'
Pearson, F. E.,O'Mahony, C.,Moore, A. C.,Hill, A. V. (2015) 'Induction of CD8(+) T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus-vectored malaria vaccine'. Vaccine, 33 (28):3248-55 [DOI] [Details]
(2014)'Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration'
McGrath, M. G.,Vucen, S.,Vrdoljak, A.,Kelly, A.,O'Mahony, C.,Crean, A. M.,Moore, A. (2014) 'Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration'. Eur J Pharm Biopharm, 86 (2):200-11 [DOI] [Details]
(2014)'Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles'
Paleco R., Vučen S.R., Crean A.M., Moore A.C., Scalia S (2014) 'Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles'. International Journal of Pharmaceutics, [DOI] [Details]
(2014)'Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route'
Carey, John B.,Vrdoljak, Anto,O'Mahony, Conor,Hill, Adrian V. S.,Draper, Simon J.,Moore, Anne C. (2014) 'Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route'. Scientific Reports, 4 [DOI] [Details]
(2013)'The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment'
Goodman, Anna L.,Forbes, Emily K.,Williams, Andrew R.,Douglas, Alexander D.,de Cassan, Simone C.,Bauza, Karolis,Biswas, Sumi,Dicks, Matthew D. J.,Llewellyn, David,Moore, Anne C.,Janse, Chris J.,Franke-Fayard, Blandine M.,Gilbert, Sarah C.,Hill, Adrian V. S.,Pleass, Richard J.,Draper, Simon J. (2013) 'The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment'. Scientific Reports, 3 [DOI] [Details]
(2013)'Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1'
Lambe, T.,Carey, J. B.,Li, Y.,Spencer, A. J.,van Laarhoven, A.,Mullarkey, C. E.,Vrdoljak, A.,Moore, A. C.,Gilbert, S. C. (2013) 'Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1'. Sci Rep, 3 [DOI] [Details]
(2013)'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles'
Vucen, SR;Vuleta, G;Crean, AM;Moore, AC;Ignjatovic, N;Uskokovic, D (2013) 'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles'. Journal of Pharmacy and Pharmacology, 65 :1451-1462 [DOI] [Details]
(2013)'Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration'
McGrath MG, Vucen S, Vrdoljak A, Kelly A, O'Mahony C, Crean AM, Moore AC. (2013) 'Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration'. European Journal of Pharmaceutical Science, Epub ahead of print [DOI] [Details]
(2012)'Soluble IL-2Ralpha (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice'
Russell, S. E.,Moore, A. C.,Fallon, P. G.,Walsh, P. T. (2012) 'Soluble IL-2Ralpha (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice'. PLoS One, 7 (10) [DOI] [Details]
(2012)'Coated microneedle arrays for transcutaneous delivery of live virus vaccines'
Vrdoljak, Anto,McGrath, Marie G.,Carey, John B.,Draper, Simon J.,Hill, Adrian V. S.,O'Mahony, Conor,Crean, Abina M.,Moore, Anne C. (2012) 'Coated microneedle arrays for transcutaneous delivery of live virus vaccines'. Journal of Controlled Release, 159 (1):34-42 [DOI] [Details]
(2012)'Method for fabricating a microneedle, and produced microneedle'
Moore, A.,Vrdoljak, A. (2012) 'Method for fabricating a microneedle, and produced microneedle'. WO2012153266 A3, [Details]
(2012)'Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications'
Galvin, Paul,Thompson, Damien,Ryan, Katie B.,McCarthy, Anna,Moore, Anne C.,Burke, Conor S.,Dyson, Maya,MacCraith, Brian D.,Gun'ko, Yurii K.,Byrne, Michelle T.,Volkov, Yuri,Keely, Chris,Keehan, Enda,Howe, Michael,Duffy, Conor,MacLoughlin, Ronan (2012) 'Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications'. Cellular and Molecular Life Sciences, 69 (3):389-404 [DOI] [Details]
(2011)'Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria (vol 5, pg 95, 2009)'
Draper, Simon J.,Goodman, Anna L.,Biswas, Sumi,Forbes, Emily K.,Moore, Anne C.,Gilbert, Sarah C.,Hill, Adrian V. S. (2011) 'Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria (vol 5, pg 95, 2009)'. Cell Host & Microbe, 9 (3):252-252 [DOI] [Details]
(2011)'Microneedle Array Design Determines the Induction of Protective Memory CD8+ T cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'
Carey, J. B.,Pearson, F.E.,Vrdoljak, A.,McGrath, M. G.,Crean, A.,Walsh, P.T.,Doody, T.,O'Mahony, C.,Hill, A.V.,Moore, A.C. (2011) 'Microneedle Array Design Determines the Induction of Protective Memory CD8+ T cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'. PLoS One, 6 (7) [DOI] [Details]
(2011)'Determination of parameters for successful spray coating of silicon microneedle arrays'
McGrath MG, Vrdoljak A, O'Mahony C, Oliveira JC, Moore AC, Crean AM; (2011) 'Determination of parameters for successful spray coating of silicon microneedle arrays'. International Journal of Pharmaceutics, 415 :140-149 [DOI] [CORA Link] [Details]
(2011)'Microneedle Array Design Determines the Induction of Protective Memory CD8(+) T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'
Carey, JB,Pearson, FE,Vrdoljak, A,McGrath, MG,Crean, AM,Walsh, PT,Doody, T,O'Mahony, C,Hill, AVS,Moore, AC; (2011) 'Microneedle Array Design Determines the Induction of Protective Memory CD8(+) T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice'. Plos One, 6 [DOI] [Details]
(2011)'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei (vol 38, pg 732, 2008)'
Reyes-Sandoval, Arturo,Sridhar, Saranya,Berthoud, Tamara,Moore, Anne C.,Harty, John T.,Gilbert, Sarah C.,Gao, Guangping,Ertl, Hildegund C. J.,Wilson, James C.,Hill, Adrian V. S. (2011) 'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei (vol 38, pg 732, 2008)'. European Journal of Immunology, 41 (5):1501-1501 [DOI] [Details]
(2010)'Development of stabilized vaccines with needle-free devices for targeted skin immunization'
Moore, A. C., Crean, A. M., O¿Mahony; (2010) 'Development of stabilized vaccines with needle-free devices for targeted skin immunization'. European Pharmaceutical Review, 15 (6):56-60 [CORA Link] [Details]
(2010)'Development of stabilized vaccines with needle-free devices for targeted skin immunization'
Crean, A.,O'Mahony, C.,Moore, A.C. (2010) 'Development of stabilized vaccines with needle-free devices for targeted skin immunization'. European Pharmaceutical Review, 15 (6):56-60 [Details]
(2010)'Proof of concept study to investigate the efficacy of microneedle arrays in local anaesthetic administration to human skin'
McAleer, M.A.,Moore, A. C.,Crean, A.,O'Mahony, C.,Bourke, J. F. (2010) 'Proof of concept study to investigate the efficacy of microneedle arrays in local anaesthetic administration to human skin'. Br J Dermatol, 163 (Suppl 1) [Details]
(2009)'Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria'
Draper, Simon J.,Goodman, Anna L.,Biswas, Sumi,Forbes, Emily K.,Moore, Anne C.,Gilbert, Sarah C.,Hill, Adrian V. S. (2009) 'Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria'. Cell Host & Microbe, 5 (1):95-105 [DOI] [Details]
(2008)'Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A'
Sridhar, S.,Reyes-Sandoval, A.,Draper, S. J.,Moore, A. C.,Gilbert, S. C.,Gao, G. P.,Wilson, J. M.,Hill, A. V. (2008) 'Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A'. J Virol, 82 (8):3822-33 [DOI] [Details]
(2008)'Effective induction of high-titer antibodies by viral vector vaccines'
Draper, Simon J.,Moore, Anne C.,Goodman, Anna L.,Long, Carole A.,Holder, Anthony A.,Gilbert, Sarah C.,Hill, Fergal,Hill, Adrian V. S. (2008) 'Effective induction of high-titer antibodies by viral vector vaccines'. Nature Medicine, 14 (8):819-821 [DOI] [Details]
(2008)'New vectored vaccines for malaria'
Hill, Adrian V. S.,Reyes-Sandoval, Arturo,Draper, Simon,O'Hara, Geraldine,Spencer, Alex,Cottingham, Matt,Sridhar, Saranya,Moore, Anne,Goodman, Anna,Larsen, Karen,Saurya, Saroj,Calvert, Alice,Furze, Julie,Biswas, Sumi,Forbes, Emily,Berrie, Eleanor,Bird, Pru,Bregu, Migena,Rollier, Christine,Lawrie, Alison,Rowland, Res,Ertl, Hildegund,Nicosia, Alfredo,Siani, Loredana,Colloca, Stefano,Cortese, Riccardo,Wyllie, David,Gilbert, Sarah C. (2008) 'New vectored vaccines for malaria'. International Journal for Parasitology, 38 [Details]
(2008)'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei'
Reyes-Sandoval, Arturo,Sridhar, Saranya,Berthoud, Tamara,Moore, Anne C.,Harty, John T.,Gilbert, Sarah C.,Gao, Guangping,Ertl, Hildegund C. J.,Wilson, James C.,Hill, Adrian V. S. (2008) 'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei'. European Journal of Immunology, 38 (3):732-741 [DOI] [Details]
(2008)'Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria'
Schmidt, Nathan W.,Podyminogin, Rebecca L.,Butler, Noah S.,Badovinac, Vladimir P.,Tucker, Brad J.,Bahiat, Keith S.,Lauer, Peter,Reyes-Sandoval, Arturo,Hutchings, Claire L.,Moore, Anne C.,Gilbert, Sarah C.,Hill, Adrian V.,Bartholomay, Lyric C.,Harty, John T. (2008) 'Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria'. Proceedings of the National Academy of Sciences of the United States of America, 105 (37):14017-14022 [DOI] [Details]
(2008)'Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria'
Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, Lauer P, Reyes-Sandoval A, Hutchings CL, Moore AC, Gilbert SC, Hill AV, Bartholomay LC, Harty JT.; (2008) 'Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria'. Proceedings of The National Academy of Sciences of The United States of America, 105 (37):14017-14022 [DOI] [Details]
(2008)'Single dose protection against P. berghei by Simian Adenoviral vector using human CMV promoter containing Intron A'
Sridhar S., Reyes-Sandoval A., Draper S.J., Moore A.C., Gilbert S.C., Gao G.P., Wilson J.M. and Hill A.V.S. ; (2008) 'Single dose protection against P. berghei by Simian Adenoviral vector using human CMV promoter containing Intron A'. Journal of Virology, (82):3822-3833 [Details]
(2008)'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei'
Reyes-Sandoval A., Sridhar S., Berthoud T., Moore A.C., Harty J.T., Gilbert S.C., Gao G.P., Ertl H.C., Wilson J.M. and Hill A.V.S. ; (2008) 'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei'. European Journal of Immunology, (38):732-741 [DOI] [Details]
(2007)'Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge'
Hutchings C.L, Birkett A.J., Moore A.C., and Hill A.V.S. ; (2007) 'Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge'. Infection and Immunity, (95):5819-5826 [DOI] [Details]
(2007)'Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge'
Hutchings, Claire L.,Birkett, Ashley J.,Moore, Anne C.,Hill, Adrian V. S. (2007) 'Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge'. Infection and Immunity, 75 (12):5819-5826 [DOI] [Details]
(2008)'Multi-Stage Protection against Malaria using Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1'
Draper S.J, Moore A.C., Goodman A.L., Long C.A., Holder A.A., Gilbert S.C., Hill F., Hill A.V.S.; (2008) 'Multi-Stage Protection against Malaria using Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1'. Nature medicine, (14):819-821 [DOI] [Details]
(2007)'Combination Vaccines; synergistic simultaneous induction of antibody and T cell immunity results in enhanced vaccine efficacy'
Moore A.C. Hutchings C.L.; (2007) 'Combination Vaccines; synergistic simultaneous induction of antibody and T cell immunity results in enhanced vaccine efficacy'. Expert Review of Vaccines, 6 (1):111-121 [DOI] [Details]
(2007)'Combination vaccines: synergistic simultaneous induction of antibody and T-cell immunity'
Moore, A. C.,Hutchings, C. L. (2007) 'Combination vaccines: synergistic simultaneous induction of antibody and T-cell immunity'. Expert Rev Vaccines, 6 (1):111-21 [Details]
(2006)'Safety of Recombinant Fowlpox Strain 9 and Modified Vaccinia Virus Ankara Vaccines Against Liver-Stage P. falciparum Malaria in Non-Immune Volunteers'
Webster D.P., Dunachie S., McConkey S., Poulton I., Moore A.C., Walther M., Laidlaw S.M., Peto T., Skinner M.A., Gilbert S. C., Hill A.V.S.; (2006) 'Safety of Recombinant Fowlpox Strain 9 and Modified Vaccinia Virus Ankara Vaccines Against Liver-Stage P. falciparum Malaria in Non-Immune Volunteers'. Vaccine, (24):3026-3034 [DOI] [Details]
(2006)'Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein'
Walther, M.,Thompson, F. M.,Dunachie, S.,Keating, S.,Todryk, S.,Berthoud, T.,Andrews, L.,Andersen, R. F.,Moore, A.,Gilbert, S. C.,Poulton, I.,Dubovsky, F.,Tierney, E.,Correa, S.,Huntcooke, A.,Butcher, G.,Williams, J.,Sinden, R. E.,Hill, A. V. S. (2006) 'Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein'. Infection and Immunity, 74 (5):2706-2716 [DOI] [Details]
(2005)'Novel protein and poxvirus-based vaccine combinations for simultaneous induction of humoral and cell-mediated immunity'
Hutchings, C. L.,Gilbert, S. C.,Hill, A. V. S.,Moore, A. C. (2005) 'Novel protein and poxvirus-based vaccine combinations for simultaneous induction of humoral and cell-mediated immunity'. Journal of Immunology, 175 (1):599-606 [Details]
(2005)'Anti-CD25 Antibody Enhancement of Vaccine-Induced Immunogenicity: Increased Durable Cellular Immunity with Reduced Immunodominance'
Moore A.C., Gallimore A., Draper S., Watkins K.R., Gilbert S.C. and Hill A.V.S. ; (2005) 'Anti-CD25 Antibody Enhancement of Vaccine-Induced Immunogenicity: Increased Durable Cellular Immunity with Reduced Immunodominance'. Journal of Immunology, (175):7264-7273 [Details]
(2004)'Progress in DNA-based heterologous prime-boost immunization strategies for malaria'
Moore, A. C.,Hill, A. V. S. (2004) 'Progress in DNA-based heterologous prime-boost immunization strategies for malaria'. Immunological Reviews, 199 (1):126-143 [DOI] [Details]
(2004)'A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses'
Prieur E, Gilbert S.C., Schneider J ., Moore A.C. , Sheu E.G, Goonetilleke N., Robson K.J.H., and Hill A.V. ; (2004) 'A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses'. Proceedings of The National Academy of Sciences of The United States of America, (101):290-295 [DOI] [Details]
(2004)'Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction'
Behboudi, S.,Moore, A.,Gilbert, S. C.,Nicoll, C. L.,Hill, A. V. (2004) 'Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction'. Vaccine, 22 (31-32):4326-31 [Details]
(2004)'Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells'
Behboudi, S.,Moore, A.,Hill, A. V. S. (2004) 'Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells'. Cellular Immunology, 228 (1):15-19 [DOI] [Details]
(2002)'Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice'
Moore, A. C.,Kong, W. P.,Chakrabarti, B. K.,Nabel, G. J. (2002) 'Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice'. J Virol, 76 (1):243-50 [Details]
(2005)'Novel Protein and Poxvirus Based Vaccine Combinations for Simultaneous Induction of Humoral and Cell Mediated Immunity'
Hutchings C.L, Gilbert S.C., Hill A.V.S and Moore A.C.; (2005) 'Novel Protein and Poxvirus Based Vaccine Combinations for Simultaneous Induction of Humoral and Cell Mediated Immunity'. Journal of Immunology, (175):599-606 [Details]
(2004)'Progress in DNA-based heterologous prime-boost immunization strategies for malaria'
Moore AC, Hill AV; (2004) 'Progress in DNA-based heterologous prime-boost immunization strategies for malaria'. Immunological reviews, 199 :126-143 [DOI] [Details]
(2004)'Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction'
Behboudi, S.,Moore, A.,Gilbert, S. C.,Nicoll, C. L.,Hill, A. V. S. (2004) 'Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction'. Vaccine, 22 (31-32):4326-4331 [DOI] [Details]
(2004)'Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells'
Behboudi S., Moore A.C. and Hill A.V.S. ; (2004) 'Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells'. Cellular Immunology, (228):15-19 [DOI] [Details]
(2004)'Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction'
Behboudi S., Moore A.C., Gilbert S., Nicoll C.L. and Hill A.V.S. ; (2004) 'Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction'. Vaccine, 22 :4326-4331 [DOI] [Details]
(2004)'A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses'
Prieur, E.,Gilbert, S. C.,Schneider, J.,Moore, A. C.,Sheu, E. G.,Goonetilleke, N.,Robson, K. J. H.,Hill, A. V. S. (2004) 'A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses'. Proceedings of the National Academy of Sciences of the United States of America, 101 (1):290-295 [DOI] [Details]
(2002)'Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice'
Moore AC, Kong WP, Chakrabarti BK, Nabel GJ; (2002) 'Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice'. Journal of virology, 76 (1):243-250 [DOI] [Details]
(2000)'Inhibition of Interleukin-12 production in human monocyte-derived macrophages by Tumor Necrosis Factor'
Ma X., Sun J., Papasavvas E., Riemann H., Robertson S., Marshall J., Bailer R.T., Moore A.C., Donnelly R., Trinchieri G., Montaner L.J.,; (2000) 'Inhibition of Interleukin-12 production in human monocyte-derived macrophages by Tumor Necrosis Factor'. Journal of Immunology, 164 :1722-1729 [Details]
(2000)'Inhibition of IL-12 production in human monocyte-derived macrophages by TNF'
Ma, X.,Sun, J.,Papasavvas, E.,Riemann, H.,Robertson, S.,Marshall, J.,Bailer, R. T.,Moore, A.,Donnelly, R. P.,Trinchieri, G.,Montaner, L. J. (2000) 'Inhibition of IL-12 production in human monocyte-derived macrophages by TNF'. J Immunol, 164 (4):1722-9 [Details]
(1999)'The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1'
Moore, A.,McCarthy, L.,Mills, K. H. G. (1999) 'The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1'. Vaccine, 17 (20-21):2517-2527 [DOI] [Details]
(1998)'Approaches to new vaccines'
Mahon BP, Moore A, Johnson PA, Mills KH.; (1998) 'Approaches to new vaccines'. Critical Review of Biotechnology, 18 (4):257-282 [Details]
(1995)'Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells'
Moore, A.,McGuirk, P.,Adams, S.,Jones, W. C.,McGee, J. P.,O'Hagan, D. T.,Mills, K. H. (1995) 'Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells'. Vaccine, 13 (18):1741-9 [Details]
(1995)'An adjuvant formulation that switches Th2 to Th1 responses with soluble recombinant HIV proteins'
Moore A, Adams S., Garcon N., Delchambre M., Thriart C., Bruck C. and Mills KH.; (1995) 'An adjuvant formulation that switches Th2 to Th1 responses with soluble recombinant HIV proteins'. Immunology, 86 [Details]
(1994)'Factors affecting Th1 and Th2 cell induction and immunoglobulin class switching in the immune response to HIV proteins'
Moore A.C., Adams S., and Mills K.H.G.; (1994) 'Factors affecting Th1 and Th2 cell induction and immunoglobulin class switching in the immune response to HIV proteins'. Immunology, 83, S1 [Details]

Other Journals

 YearPublication
(2010)'Development of Stabilised Vaccines with Needle-Free Devices for Targeted Skin Immunization'
A. Crean, C. O’Mahony and A. C. Moore (2010) 'Development of Stabilised Vaccines with Needle-Free Devices for Targeted Skin Immunization' European Pharmaceutical Review, 15 (6) :56-60. [Details]

Conference Publications

 YearPublication
(2013)35th All-Ireland Schools of Pharmacy Conference
Allen, E.,Crean, A.,O’Mahony, C.,Moore, A. C. (2013) Influenza Vaccination using Dissolvable ImmuPatchInfluenza Vaccination using Dissolvable ImmuPatch 35th All-Ireland Schools of Pharmacy Conference Belfast, UK, [Details]
(2012)2nd International Conference on Microneedles: Microneedles 2012
A. M. Crean, M. G. McGrath, C. O’Mahony, A. Vrdoljak and A. C. Moore (2012) Dissolvable ImmuPatch Microneedles for Drug Delivery 2nd International Conference on Microneedles: Microneedles 2012 Cork, , 13-MAY-12 - 15-MAY-12 [Details]
(2011)38th Annual Meeting and Exposition of the Controlled Release Society
McGrath, M. G.,O'Mahony, C.,Vrdoljak, A.,Moore, A. C.,Crean, A. (2011) Design of Dissolvable Microneedles for Drug DeliveryDesign of Dissolvable Microneedles for Drug Delivery 38th Annual Meeting and Exposition of the Controlled Release Society Maryland, USA, [Details]
(2011)38th Annual Meeting and Exposition of the Controlled Release Society38th Annual Meeting and Exposition of the Controlled Release Society
Carey, J. B.,Pearson, F. E.,Vrdoljak, A.,Crean, A.,O'Mahony, C.,Hill, A. V. S.,Moore, A. C. (2011) Immunization using ImmuPatch silicon microneedles results in enhanced T-cell and antibody responses compare to traditional imunization routesImmunization using ImmuPatch silicon microneedles results in enhanced T-cell and antibody responses compare to traditional imunization routes 38th Annual Meeting and Exposition of the Controlled Release Society38th Annual Meeting and Exposition of the Controlled Release Society Maryland, USAMaryland, USA, [Details]
(2011)Skin Vaccination Summit 2011
Moore, A. C.,Pearson, F.,Vrdoljak, A.,McGrath, M. G.,Draper, S.,Hill, A. V. S.,Crean, A.,O'Mahony, C. (2011) ces for vaccination Skin Vaccination Summit 2011 Washington, USA, , 11-OCT-11 [Details]
(2011)Skin Vaccination Summit 2011Skin Vaccination Summit 2011
O'Mahony, C.,Moore, A. C.,Blake, A.,Scully, J.,O'Brien, J.,Hegarty, M. (2011) Silicon microneedles for vaccine deliverySilicon microneedles for vaccine delivery Skin Vaccination Summit 2011Skin Vaccination Summit 2011 Washington, USAWashington, USA, [Details]
(2011)38th Annual Meeting and Exposition of the Controlled Release Society
Vrdoljak, A.,McGrath, M. G.,Crean, A.,O'Mahony, C.,Moore, A. C. (2011) Development of ImmuPatch arrays coated with live vaccine 38th Annual Meeting and Exposition of the Controlled Release Society Maryland, USA, [Details]
(2011)38th Annual Meeting Controlled Release Society
John B. Carey, Frances E. Pearson, Anto Vrdoljak, Abina M. Crean, Conor O¿Mahony, Adrian V.S. Hill, Anne C. Moore; (2011) Immunization using ImmuPatch Silicon Microneedle Arrays results in Enhanced T 38th Annual Meeting Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2011)38th Annual Meeting Controlled Release Society
M.G. McGrath, C.O¿Mahony, A. Vrdoljak, A.C. Moore, A.M. Crean; (2011) Design of Dissolvable Microneedles for Drug Delivery 38th Annual Meeting Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2010)12th International Conference on Perspectives in Percutaneous Penetration
M. G. McGrath, C. O¿Mahony, J. B. Carey, A. Vrdoljak, A. C. Moore and A. M. Crean; (2010) Spray Coating of Silicon Microneedle Patches for Intradermal Drug Delivery 12th International Conference on Perspectives in Percutaneous Penetration [Details]
(2010)Perspectives in Percutaneous Penetreation
McGrath M., O¿Mahony C., Carey J.B., Vrdoljak A., Moore A.C. and Crean A; (2010) Spray Coating of Silicon Microneedle Patches for Intradermal Drug Delivery Perspectives in Percutaneous Penetreation La Grande Motte, France, , 06-APR-10 - 08-APR-10 [Details]
(2010)Modern Mucosal Vaccines and Adjuvants
Moore A.C., Carey J.B, Pearson F.E., Vrdoljak A., McGrath M., Draper S.J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C. ; (2010) Enhanced T cell and Antibody Responses induced by ImmuPatch Transdermal Vaccination Modern Mucosal Vaccines and Adjuvants Dublin, Ireland, , 28-APR-10 - 30-APR-10 [Details]
(2010)Microneedles 2010Microneedles 2010
Pearson, F. E.,Reyes-Sandoval, A.,O'Mahony, C.,Moore, A. C.,Hill, A. V. S. (2010) Delivery of Recombinant Adenoviral Vector malaria vaccines by ImmuPatch Induces Protective CD8+ T-cell Mediated Immunity Against Parasite ChallengeDelivery of Recombinant Adenoviral Vector malaria vaccines by ImmuPatch Induces Protective CD8+ T-cell Mediated Immunity Against Parasite Challenge Microneedles 2010Microneedles 2010 Atlanta, USAAtlanta, USA, [Details]
(2010)Perspectives in Percutaneous Penetration (PPP 2010)Perspectives in Percutaneous Penetration (PPP 2010)
O'Mahony, C.,Blake, A.,Scully, J.,O'Brien, J.,Moore, A. C. (2010) Silicon Microneedles for Painless Percutaneous PenetrationSilicon Microneedles for Painless Percutaneous Penetration Perspectives in Percutaneous Penetration (PPP 2010)Perspectives in Percutaneous Penetration (PPP 2010) La Grande Motte, FranceLa Grande Motte, France, [Details]
(2010)Molecules to Medicine Conference 2010Molecules to Medicine Conference 2010
O'Mahony, C.,Blake, A.,Scully, J.,O'Brien, J.,Moore, A. C. (2010) Silicon Microneedles for Painless Percutaneous PenetrationSilicon Microneedles for Painless Percutaneous Penetration Molecules to Medicine Conference 2010Molecules to Medicine Conference 2010 Cork, IrelandCork, Ireland, [Details]
(2010)MMVAM 2010
Moore, A. C.,Carey, J. B.,Pearson, F. E.,Vrdoljak, A.,McGrath, M. G.,Draper, S. J.,Gilbert, S. C.,Hill, A. V. S.,Crean, A.,O'Mahony, C. (2010) Enhanced T-cell and Antibody Responses Induced by ImmuPatch Transdermal Vaccination MMVAM 2010 Dublin, IrelandDublin, Ireland, [Details]
(2010)Microneedles 2010Microneedles 2010
Moore, A. C.,Carey, J. B.,Pearson, F. E.,Vrdoljak, A.,McGrath, M. G.,Draper, S. J.,Gilbert, S. C.,Hill, A. V. S.,Crean, A.,O'Mahony, C. (2010) Enhanced Immune Responses Induced by ImmuPatch Transcutaneous VaccinationEnhanced Immune Responses Induced by ImmuPatch Transcutaneous Vaccination Microneedles 2010Microneedles 2010 Atlanta, USAAtlanta, USA, [Details]
(2010)4th Vaccine and ISV Annual Global Congress4th Vaccine and ISV Annual Global Congress
Moore, A. C.,Carey, J. B.,Crean, A.,Vrdoljak, A.,McGrath, M. G.,O'Mahony, C. (2010) Percutaneous Immunization using ImmuPatch: Needle-free vaccination that results in stronger T-cell and antibody responses compared to traditional immunization routes 4th Vaccine and ISV Annual Global Congress4th Vaccine and ISV Annual Global Congress Vienna, Austria, [Details]
(2010)Microneedles 2010Microneedles 2010
McGrath, M. G.,Vrdoljak, A.,O'Mahony, C.,Carey, J. B.,Moore, A. C.,Crean, A. (2010) Percutaneous vaccine Delivery Using MicroneedlesPercutaneous vaccine Delivery Using Microneedles Microneedles 2010Microneedles 2010 Atlanta, USAAtlanta, USA, [Details]
(2010)Perspectives in Percutaneous Penetreation
Moore A.C., Carey J.B., McGrath M. Pearson F.E., Vrdoljak A. Hill A.V.S., Crean A. and O¿Mahony C. ; (2010) Percutaneous immununization using ImmuPatch: Comparison of vaccine localisation and induction of antibody and T cell responses in a pre-clinical model Perspectives in Percutaneous Penetreation La Grande Motte, France, , 06-APR-10 - 10-APR-10 [Details]
(2010)Molecules to Medicine Conference 2010Molecules to Medicine Conference 2010
Carey, J. B.,Moore, A. C.,McGrath, M. G.,Pearson, F.,Hill, A. V. S.,Moore, A. C. (2010) Percutaneous Immunization using Immupatch; Comparison of Vaccine Localisation and Induction of Antibody and T-cell responses in a Pre-clinical ModelPercutaneous Immunization using Immupatch; Comparison of Vaccine Localisation and Induction of Antibody and T-cell responses in a Pre-clinical Model Molecules to Medicine Conference 2010Molecules to Medicine Conference 2010 Cork, IrelandCork, Ireland, [Details]
(2010)Perspectives in Percutaneous Penetration (PPP 2010)
McGrath, M. G.,O'Mahony, C.,Carey, J. B.,Vrdoljak, A.,Moore, A. C.,Crean, A. (2010) Percutaneous Immunization Using ImmuPatch: Comparison of Vaccine Localisation and Induction of Antibody and T-cell responses in a Pre-clinical Model Perspectives in Percutaneous Penetration (PPP 2010) La Grande Motte, France, [Details]
(2010)First International Conference on Microneedles
Moore A.C., Carey J.B., Pearson F., Vrdoljak A., McGrath M., Draper S.J., Gilbert S.C., Hill A.V.S., Crean A. and O¿Mahony C., ; (2010) Enhanced Immune Responses induced by ImmuPatch Transcutaneous Vaccination First International Conference on Microneedles Atlanta, Georgia, , 24-MAY-10 - 26-MAY-10 [Details]
(2010)First International Conference on Microneedles
McGrath M., Vrdoljak A., O¿Mahony C., Carey J.B., Moore A.C. and Crean A.; (2010) Percutaneous Vaccine Delivery Using Microneedles First International Conference on Microneedles Atlanta, Georgia, , 24-MAY-10 - 26-APR-10 [Details]
(2010)4th Vaccine and ISV Annual Global Congress
A.C. Moore, J. Carey, F. Pearson, A. Vrdoljak, M. McGrath, S. Draper, S. Gilbert, A. Hill, A. Crean and C. O¿Mahony; (2010) Percutaneous Immunization using ImmuPatch: Needle-free vaccination that results in stronger T cell and antibody responses compared to traditional immunization routes 4th Vaccine and ISV Annual Global Congress Vienna, Austria, , 03-OCT-10 - 05-OCT-10 [Details]

Published Reports

 YearPublication
(2006)The use of non-human primates in research, chaired by Sir David Weatherall. Report to Wellcome Trust, MRC, Academy of Medical Sciences, The Royal Society.
Sir David Weatherall; (2006) The use of non-human primates in research, chaired by Sir David Weatherall. Report to Wellcome Trust, MRC, Academy of Medical Sciences, The Royal Society. Wellcome Trust, MRC, The Royal Society, UK. [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2013Joint Winner "Get Started Technology Venture Programme" SFI
2012UCC Research Team of the Year UCC

Professional Associations

 AssociationFunctionFrom / To
Burroughs-Wellcome sponsored; "Malaria Liver-stage Genomics and Proteomics", Washington DC Contributor/
"The use of non-human primates in research", chaired by Sir David Weatherall. Report to Wellcome Trust, MRC, Academy of Medical Sciences, The Royal Society Consultee to the working group/
Livestock Vaccine Enterprise Initiative Meeting, Wellcome Trust Centre for Human Genetics Invited delegate to initiate international veterinary vaccine consortium17-MAY-07 / 18-MAY-07
New Trends in Cancer Immunotherapy. Fondation Merieux Invited Participant08-JUL-07 / 11-JUL-07

Patents

 Patent NumberTitleGranted
WO2004110482Combination Vaccines 26-OCT-06
WO2005115451METHODS FOR GENERATING IMPROVED IMMUNE RESPONSE 08-DEC-05
UK1007204.9Microneedle Array 29-APR-10
UK 1007207.2Microneedle kits for vaccine delivery 29-APR-10
GB1107642.9Method for making dissolvable microneedle patches 09-MAY-11
GB1019577.4Method to prepare dissolvable microneedles. 18-NOV-10

Conference Contributions

 YearPublication
(2017)12th Annual Cochrane Conference,
Marshall S, Fleming A, Moore AC, Sahm LJ (2017) Systematic Review and meta-ethnographic synthesis protocol: opinions on HPV vaccination. [Invited Lectures (Conference)], 12th Annual Cochrane Conference, NUI Galway . [Details]
(2017)Health Services Research and Pharmacy Practice Conference,,
Marshall S, Fleming A, Moore AC, Sahm LJ. (2017) Acceptability of microneedle patch vaccines: a qualitative study into the opinions of Irish parents. [Poster Presentation], Health Services Research and Pharmacy Practice Conference,, University of Nottingham, UK . [Details]
(2017)Skin Vaccination Summit,
Agnese Donadei, Olga Resink, Ivo Ploemen, Olivia Flynn, Anne Moore (2017) Development of Dissolvable Microneedle Patches for Dermal Delivery of Polio Vaccines. [Poster Presentation], Skin Vaccination Summit, Leiden . [Details]
(2017)Modern Vaccines Adjuvants and Delivery Systems,
Agnese Donadei, Olga Ophorst, Rimko Ten Have, Heleen Kraan, Olivia Flynn, Ivo Ploemen, Anne Moore (2017) Effective Dermal Polio Vaccination through Dissolvable Microneedle Patches. [Poster Presentation], Modern Vaccines Adjuvants and Delivery Systems, Porto, Portugal . [Details]
(2017)Skin Vaccine Summit,,
A Moore (2017) Adenovirus and Subunit Vaccine Stabilization and Immunogenicity in Small and Large Animals”. [Invited Lectures (Conference)], Skin Vaccine Summit,, Leiden . [Details]
(2017)All-Ireland Schools of Pharmacy Conference,
Marshall S, Fleming A, Moore AC, Sahm LJ. (2017) Acceptability of microneedle-patch vaccines: a qualitative analysis of the opinions of parents. [Poster Presentation], All-Ireland Schools of Pharmacy Conference, UCC . [Details]
(2016)AAPS/PSJ Joint Symposium: More Than Skin Deep: Using Microstructural Delivery Technology To Breach Skin Barrier,
Anne Moore (2016) Microneedle Patches for Vaccine Stabilization and Enhanced Immunization”. [Invited Lectures (Conference)], AAPS/PSJ Joint Symposium: More Than Skin Deep: Using Microstructural Delivery Technology To Breach Skin Barrier, Denver CO, USA . [Details]
(2016)Irish Society for Immunology,
J. McCaffrey, C. Bernelin, N. Bertho, I. Schwartz, V. Jakob, C. Barnier, D. McDaid, A. Moore (2016) Development of the dissolving microneedle platform for delivery of veterinary vaccines. [Invited Lectures (Conference)], Irish Society for Immunology, Cork . [Details]
(2014)Vaccines2014,
Anne Moore (2014) Probing the effect of skin-based immunization using Pseudotyped virus-based assays. [Invited Oral Presentation], Vaccines2014, O2 London UK , 20-OCT-14 - 22-OCT-14. [Details]
(2014)The Modes of Action of Vaccine Adjuvants,
O. Flynn, E. Allen, K. Dillane, A. Crean , E. Norton and A. Moore (2014) Immunogenicity of dmLT Adjuvanted Vaccines in ImmuPatch Dissolvable Microneedle. [Oral Presentation], The Modes of Action of Vaccine Adjuvants, Seattle, WA, USA , 08-OCT-14 - 13-OCT-14. [Details]
(2014)Third International Conference on Microneedles,
Anne Moore (2014) Development of ImmuPatch Microneedle Systems for Immunization Programs. [Invited Oral Presentation], Third International Conference on Microneedles, Baltimore, MD, USA . [Details]
(2014)Third International Conference on Microneedles,
E. Allen, O. Flynn, K. Dillane, C. O’Mahony, A. Crean and A. Moore (2014) Immunogenicity and Stability of Trivalent Inactivated Influenza Virus Vaccine in ImmuPatch Dissolvable Microneedles. [Poster Presentation], Third International Conference on Microneedles, Baltimore, MD, USA , 19-MAY-14 - 21-MAY-14. [Details]
(2013)“The pig as model in human vaccine development,
Anne Moore (2013) Pig as a model for intradermal vaccination. [Invited Lectures (Workshops)], “The pig as model in human vaccine development, Central Veterinary Institute in Lelystad, NL , 20-SEP-03. [Details]
(2013)The pig as model in human vaccine development,
Anne Moore (2013) Pig as a model for intradermal vaccination. [Invited Oral Presentation], The pig as model in human vaccine development, Leylstad, NL . [Details]
(2013)Irish Medical Device Association (IMDA) and Enterprise Ireland hosted “R&D Funding Opportunities through Horizon 2020,
Anne Moore (2013) ImmuPatch. [Invited Oral Presentation], Irish Medical Device Association (IMDA) and Enterprise Ireland hosted “R&D Funding Opportunities through Horizon 2020, Galway . [Details]
(2012)Second International Conference on Microneedles,
Anne Moore (2012) Co-Chair of Conference. [Conference Organising Committee Chairperson], Second International Conference on Microneedles, Cork, Ireland . [Details]
(2012)Sharebiotech: Fostering Open Innovation in Biotechnology,
Crean, A.M., Moore A.C., O'Mahony C. (2012) ImmuPatch: a skin-deep approach to vaccination and drug delivery. [Invited Oral Presentation], Sharebiotech: Fostering Open Innovation in Biotechnology, Pamplona , 10-MAY-12 - 11-MAY-12. [Details]
(2011)Skin Vaccine Summit,
Anne Moore; (2011) Development of Silicon and Dissolvable ImmuPatch Microneedle Devices for Vaccination. [Oral Presentation], Skin Vaccine Summit, Washington DC , 12-OCT-11 - 14-OCT-11. [Details]
(2011)PharmSciFair,
A Moore; (2011) Development of Silicon and Dissolvable ImmuPatch Microneedle Devices for Vaccination. [Invited Oral Presentation], PharmSciFair, Prague , 11-OCT-11 - 14-OCT-11. [Details]
(2011)Insights into Successful Translational Research,
Anne Moore (2011) SFI/HRB/MMI organised event. [Invited Oral Presentation], Insights into Successful Translational Research, Dublin . [Details]
(2011)Insights into Successful Translational Research,
Anne Moore (2011) SFI/HRB/MMI organised national meeting. [Invited Seminars/Guest Lectures], Insights into Successful Translational Research, Dublin , 29-NOV-11. [Details]
(2010)First International Conference on Microneedles,
Pearson F.E., Reyes-Sandoval A.,. O'Mahony C, Moore A.C., Hill A.V.S, ; (2010) Delivery of Recombinant Adenoviral Vector Malaria Vaccines by ImmuPatch Induces Protective CD8+ T Cell Mediated Immunity Against Parasite Challenge. [Poster Presentation], First International Conference on Microneedles, Atlanta, Georgia, , 24-MAY-10 - 26-MAY-10. [Details]
(2010)Perspectives in Percutaneous Penetreation,
O'Mahony C, Blake A., Scully J., O'Brien J. and Moore A.C; (2010) Silicon Microneedles for Painless Percutaneous Penetration. [Poster Presentation], Perspectives in Percutaneous Penetreation, La Grande Motte, France , 06-APR-10 - 10-APR-10. [Details]
(2009)Modern Vaccines adjuvants and Delivery Systems,
Carey J.B., Gilbert S.C., Vrdoljak, A., Hill A.V.S and Moore A.C; (2009) T cell inducing flu vaccines; Protective Efficacy and Strain Specificity. [Poster Presentation], Modern Vaccines adjuvants and Delivery Systems, Vienna, Austria , 28-OCT-09 - 30-OCT-09. [Details]
(2009)European Congress of Immunology,
Carey J.B., Gilbert S.C., A., Hill A.V.S and Moore A.C. ; (2009) Immunogenicity and protective efficacy of a viral vectored candidate human pandemic influenza vaccine. [Oral Presentation], European Congress of Immunology, European Congress of Immunology, Berlin, Germany, , 13-SEP-09 - 16-SEP-09. [Details]
(2009)2nd Annual Oxford Avian Influenza Conference, BirdFlu2009,
Carey J.B., Gilbert S.C., A., Hill A.V.S and Moore A.C ; (2009) Pre-clinical assessment of a candidate T cell inducing viral vectored vaccine for human influenza viru. [Oral Presentation], 2nd Annual Oxford Avian Influenza Conference, BirdFlu2009, Oxford, UK , 10-SEP-09 - 11-SEP-09. [Details]
(2007)Unknown,
Moore, A. C. ; (2007) Anti-CD25 Antibody Enhancement of Vaccine-induced immunogenicity; translation form Mouse to Primates. [Oral Presentation], Unknown, Cork, Ireland , 01-JUN-07 - 01-JUN-07. [Details]
(2007)Vaccine Induced Immunity to Fight Disease,
Moore, A. C. ; (2007) unknown. [Oral Presentation], Vaccine Induced Immunity to Fight Disease, Biochemistry Dept., UCC, , 01-APR-07 - 01-APR-07. [Details]
(2009)Big Ideas Showcase 2009,
Moore, A. C.,Carey, J. B..,Vrdoljak, A.,McGrath, M. G.,Crean, A.,O'Mahony, C. (2009) ImmuPatch: Innovative Solutions to Vaccine Delivery Barriers. [Oral Presentation], Big Ideas Showcase 2009, Dublin, Ireland . [Details]
(2007)T cell Inducing Influenza Virus Vaccines,
Moore A.C., Gallimore A., Draper S., Watkins K.R., Gilbert S.C. and Hill A.V.S. ; (2007) unknown. [Oral Presentation], T cell Inducing Influenza Virus Vaccines, University of Johannesburg , 01-OCT-07 - 01-OCT-07. [Details]
(2006)Malaria and TB Vaccines; Modulating, Protective and Regulatory T cell responses,
Moore, A. C. ; (2006) Control of anti-tumoral and anti-infectious immune responses by Regulatory T cell subsets: potential clinical applications. [Oral Presentation], Malaria and TB Vaccines; Modulating, Protective and Regulatory T cell responses, Annecy, France , 01-SEP-06 - 01-SEP-06. [Details]
(2005)Virus Vector Based Vaccines,
Moore, A. C. ; (2005) unknown. [Oral Presentation], Virus Vector Based Vaccines, University of Nottingham , 01-APR-05 - 01-APR-05. [Details]
(2005)Assaying Potency of Novel Vaccines,
Moore, A. C. ; (2005) Potency of Poxviral Based Vectors for Malaria and TB vaccines. [Oral Presentation], Assaying Potency of Novel Vaccines, NIH, Bethesda, MD , 01-OCT-05 - 01-OCT-05. [Details]
(2005)Tropical Network Meeting,
Moore, A. C. ; (2005) Improving Immunogenicity by Deregulating Malaria Vaccines. [Oral Presentation], Tropical Network Meeting, Kilifi, Kenya , 01-SEP-05 - 01-SEP-05. [Details]
(2005)British Council, INYS meeting,
Moore, A. C. ; (2005) Progress in Virus Vector based Malaria and TB vaccines. [Oral Presentation], British Council, INYS meeting, Dunedin, New Zealand , 01-MAR-05 - 01-MAR-05. [Details]
(2004)Keystone Symposium: Rational Design of Vaccines and Immunotherapeutics,
Moore, A. C. ; (2004) PRE-EXISTING FOWLPOX IMMUNITY IS LESS INHIBITORY TO HETEROLOGOUS PRIME-BOOST VACCINE STRATEGIES COMPARED TO ANTI-MVA IMMUNITY. [Oral Presentation], Keystone Symposium: Rational Design of Vaccines and Immunotherapeutics, Keystone Resort, Keystone, Colorado , 01-MAR-04 - 01-MAR-04. [Details]
(2004)University of Wales College of Medicine BSI seminar series,
Moore, A. C. ; (2004) Prime Boost Malaria Vaccines. [Oral Presentation], University of Wales College of Medicine BSI seminar series, Wales , 01-DEC-04 - 01-DEC-04. [Details]
(2004)British Society for Immunology,
Moore, A. C. ; (2004) Progress in Malaria and TB vaccines; improved de-regulated vaccine strategies. [Oral Presentation], British Society for Immunology, Harrogate, UK , 01-DEC-04 - 01-DEC-04. [Details]
(2014)Third International Conference on Microneedles, Baltimore,
O. Flynn, E. Allen, K. Dillane, A. Quinlan, C. O’Mahony, A. Crean, E. Norton and A. Moore (2014) Immunogenicity of Adjuvanted Vaccines in ImmuPatch Dissolvable Microneedle Patches in Mice. [Poster Presentation], Third International Conference on Microneedles, Baltimore, Baltimore, MD, USA , 19-MAY-14 - 21-MAY-14. [Details]
(2014)Third International Conference on Microneedles,
K. Dillane, T. Aherne, A. Offroy, C. O’Mahony, A. Crean and A. Moore (2014) Assessment of the physical stability of trehalose dissolvable microneedles in an ambient temperature and humidity environment. [Poster Presentation], Third International Conference on Microneedles, Baltimore, MD , 19-MAY-14 - 21-MAY-14. [Details]
(2014)Third International Conference on Microneedles,
Sonja Vucen, Gordana Vuleta, Jela Milic, Abina Crean, Anne Moore, Nenad Ignjatovic, Dragan Uskokovic (2014) Short-term storage stability of dissolvable microneedles containing ketoprofen-loaded polymeric nanoparticles. [Oral Presentation], Third International Conference on Microneedles, Baltimore, MD, USA , 19-MAY-14 - 21-MAY-14. [Details]
(2014)Third International Conference on Microneedles,
C. O’Sullivan, M.A.P. McAuliffe, E. O’Neill, A. Moore, A. Crean (2014) Raman Spectroscopy as a Qualitative Tool to Characterise Solid State Properties of Drug-Loaded Dissolvable Microneedles. [Poster Presentation], Third International Conference on Microneedles, Baltimore, MD, USA , 19-MAY-04 - 21-MAY-14. [Details]

Disclosures

 TitleInventorSubmitted
Composition of microneedle patch for dermal drug delivery and method of production. Moore, A.C., Vucen, S, O’Sullivan, C, Crean, A.M16-DEC-14
T cell inducing influenza virus vaccines. Gilbert S.C., Moore A.C., and Hill A.V.S28-SEP-07
Method of fabrication and composition of dissolvable microneedles. Crean A, McGrath M., Vrdoljak A, O¿Mahony C. and Moore A.C Submitted April 201021-APR-10
Method of fabrication and composition of dissolvable microneedle patches Vrdoljak A, Crean A, McGrath M., O¿Mahony C. and Moore A.C21-APR-10
Methods of modulating cell surface expression of the IL-2 receptor Dev K.K., Moore A.C24-JUN-08

Committees

 CommitteeFunctionFrom / To
University BSU Policy Committee Represent CoMH2017 / 2017
School of Pharmacy Athena Swan Working Group Member2017 /
Organising Comittee for International Microneedle Conference Committee member2010 / 2017
School of Pharmacy, Research and Graduate Studies Committee Chair2008 / 2014
School of Pharmacy, Research Quality Review Committee Vice-Chair2008 / 2009
School of Pharmacy, Quality Review Committee Vice-Chair2008 / 2009
College of Medicine and Health Research Committee Member2009 /
University Genetically Modified Biological Organisms Committee. Member2009 / 2017
College of Medicine and Health Graduate School Committee Member2010 / 2014

Employment

 EmployerPositionFrom / To
University College Cork Lecturer01-JAN-07 /
University of Oxford Senior Immunologist01-JAN-02 / 01-JAN-06
University of Oxford Postdoctoral Associate01-JAN-01 / 01-JAN-02
University of Michigan Postdoctoral Associate01-JAN-98 / 01-JAN-01
The Wistar Institute, Philadelphia, USA Postdoctoral Scientist01-SEP-97 / 31-JUL-98

Outreach Activities

 Description

Erasmus Co-ordinator, School of Pharmacy (Dec 2007-present).


http://www.irishexaminer.com/viewpoints/analysis/cracking-the-vaccine-conundrum-307481.html

Developing women leaders in higher education. Identity, Imapct and Voice Session Thursday 7 January 2016. Dublin

Online event where school students meet and interact with scientists. It’s an X Factor-style competition between scientists, where the students are the judges. August 2015.

Pioneering science in Ireland: students can follow in their footsteps. Irish Times 26th May 2015. http://www.irishtimes.com/news/education/pioneering-science-in-ireland-students-can-follow-in-their-footsteps-1.2221296

Technology Ireland Newsletter Nov 2009

New technology to help combat malaria developed at UCC. Microneedle based patch said to require lower levels of vaccine to be effective. Irish Times Sep 3, 2014 http://www.irishtimes.com/news/ireland/irish-news/new-technology-to-help-combat-malaria-developed-at-ucc-1.1916744

UCC’s ‘malaria patch’ en route to Silicon Valley. Irish Examiner September 04, 2014 http://www.irishexaminer.com/ireland/uccs-malaria-patch-en-route-to-silicon-valley-284797.html

Journal Activities

 JournalRoleTo / From
Plos One Member of Editorial Board01-MAY-14 -
Scientific Reports Member of Editorial Board01-DEC-15 - 15-DEC-17
Vaccine Referee-
Expert Review Of Vaccines Referee-
Immunological Reviews Referee-
Journal Of Controlled Release : Official Journal Of The Controlled Release Society Referee-

Teaching Activities

Teaching Interests

PT6401: Pharmacology for M.Sc. in Pharmaceutical Technology and Quality Systems (module co-ordinator)
PT2448: Molecular Pharmacology 

PT1445: Foundation Pharmacology


Respiratory, Musculoskeletal and Dermatology Systems
 Gastrointestinal, Hepatic and Endocrine Systems







  • External Examiner for U. Glasgow Immunology Degree research section (2009).
  • External and internal examiner on Ph.D. and D.Phil. thesis examinations (University of Oxford, Imperial College London)

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2016Evin Allen NUI (UCC)PHDDevelopment of a Dissolvable Microneedle Influenza Vaccine Patch
2012Marie McGrath NUI (UCC)Ph.D. (NUI)Design and characterisation of Microneedles for Percutaneous Vaccine Delivery

Current Postgraduate Students

 StudentDegree Type
Marshall Sarah Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2019Pharmacology PT6401Pharmacology
2019Cellular and Molecular Basis of Drug Action and Toxicity PT2448Cellular and Molecular Basis of Drug Action and Toxicity
2019Foundation Pharmacology PT1445Foundation Pharmacology

Contact details

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School of Pharmacy

Cavanagh Pharmacy Building Room UG06 University College Cork

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