Professor/Head of School
School of Mathematical Sciences
Western Gateway Building
University College Cork

T: +353 21 4205836
F: +353 21 4205364
W: http://euclid.ucc.ie/pages/staff/DIG/index.html

Dr O’Sullivan is Professor of Statistics at UCC and Head of School of Mathematical Sciences. He has over 30 years academic research experience with over 75 peer-reviewed publications (excluding abstracts, conference records and book chapters).  He has given numerous invited presentations at international and national conferences.   He has served as associate editor of  the SIAM Journal on Scientific and Statistical Computing (1985-1990) and the Journal of the American Statistical Association(1991-1997) and  of  Biostatistics (1998-2008).  Dr O’Sullivan has had 11PhD students graduate under his supervision and currently supervises 3 such students who are in various stages of completion of their degrees. Dr O’Sullivan maintains a strong collaboration with the Positron Emission Tomography imaging group at the University of Washington, where he holds an appointment as Affiliate Professor of Radiology. He has served on the Scientific Co-ordinating Committee for the UW PET Oncology Program (1990-1997).  He also collaborates with other researchers on other imaging projects in the US and Ireland.  Among these researchers are The American College of Radiology Imaging Network and the University of Wisconsin, where he also holds an appointment as affiliate professor of Statistics.

Research Interests

[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif][if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif][if !mso]><object classid="clsid:38481807-CA0E-42D2-BF39-B33AF135CC4D" id=ieooui></object> <style> st1\:*{behavior:url(#ieooui) } </style> <![endif] /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif][if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif][if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif][if !mso]><object classid="clsid:38481807-CA0E-42D2-BF39-B33AF135CC4D" id=ieooui></object> <style> st1\:*{behavior:url(#ieooui) } </style> <![endif] /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0pt; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:35.4pt; mso-footer-margin:35.4pt; mso-paper-source:0;} div.Section1 {page:Section1;} [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0pt 5.4pt 0pt 5.4pt; mso-para-margin:0pt; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]

Methodological Interests: Function and functional  inference, emission tomography, spatial analysis of heterogeneity, inverse problems, non-linear regularization,  outcomes analysis.

 

Application Focus: Metabolic imaging of cancer and its response to therapy using positron emission tomography (PET).  There has been rapid development of technologies for quantitative image data capture in biology and medicine. Increasingly diagnostic medical information consists of sequences of 3-D (volumetric) imaging data, in-vivo.  However, local biologic variability of the target,  as well as fundamental restrictions in resolution characteristics (often related to doseimetry considerations),  produce data that are limited by noise.  As is the case in a number of fields, advances in instrumentation and data generation capabilities have far out-paced the development of statistical analysis tools that are capable of extracting useful scientific information from that data. This is especially the case with technologies used for in-vivo imaging studies with  PET,  fMRI and dynamic contrast CT.

 

Collaboration

: Since 1990  I have worked closely with the PET cancer imaging program at the University of  Washington (group leaders Professors Janet F Eary and Kenneth A Krohn). I am involved in number of other current medical imaging related collaborations with PET/MR and CT groups in Ireland and the United States, these are concerned with diagnostic neuro-imaging studies of Alzheimer’s disease, Multiple Sclerosis and Stroke.

Book Chapters

YearPublication
(2006)'Detection of Proliferation in Gliomas by Positron Emission Tomography Imaging'
Spence AM, Mankoff D, Wells J, Muzi M, Grierson J, Eary JF, O'Sullivan F, Link JM, Silbergeld DL and Krohn K; (2006) 'Detection of Proliferation in Gliomas by Positron Emission Tomography Imaging' In: The Cell Cycle in the Central Nervous System. -: Humana Press. [Details]
(2001)'Regional FDG Lumped Constant in the Normal Human Brain'
Graham MM, Muzi M, Spence AM O'Sullivan F; (2001) 'Regional FDG Lumped Constant in the Normal Human Brain' In: Physiological Imaging of the Brain with PET. -: Academic Press Inc. [Details]
(1996)'Parametric Imaging by Mixture Analysis in 3-D: Validation for Dual-Tracer Glucose Studies'
O'Sullivan F, Muzi M, Graham MM, Spence A; (1996) 'Parametric Imaging by Mixture Analysis in 3-D: Validation for Dual-Tracer Glucose Studies' In: Quantification of brain function with PET. San Diego: Academic Press. [Details]
(1996)'Parameter Estimation of the Fluorodeoxyglucose Model with a Neural Network'
O'Sullivan F, Graham MM; (1996) 'Parameter Estimation of the Fluorodeoxyglucose Model with a Neural Network' In: Quantification of brain function with PET. San Diego: Academic Press. [Details]
(1988)'Robust smoothing'
S. Kotz, NL Johnson & C. Read, eds; (1988) 'Robust smoothing' In: Encyclopedia of Statistical Sciences, Vol. 8. New York: Wiley. [Details]

Peer Reviewed Journals

YearPublication
(2014)'Sarcoma Mid-Therapy [F-18]Fluorodeoxyglucose Positron Emission Tomography (FDG PET) and Patient Outcome'
Eary, JF,Conrad, EU,O'Sullivan, J,Hawkins, DS,Schuetze, SM,O'Sullivan, F (2014) 'Sarcoma Mid-Therapy [F-18]Fluorodeoxyglucose Positron Emission Tomography (FDG PET) and Patient Outcome'. The Journal of bone and joint surgery. American volume, 96A :152-158 [DOI] [Details]
(2014)'VOXEL-LEVEL MAPPING OF TRACER KINETICS IN PET STUDIES: A STATISTICAL APPROACH EMPHASIZING TISSUE LIFE TABLES'
O'Sullivan, F,Muzi, M,Mankoff, DA,Eary, JF,Spence, AM,Krohn, KA (2014) 'VOXEL-LEVEL MAPPING OF TRACER KINETICS IN PET STUDIES: A STATISTICAL APPROACH EMPHASIZING TISSUE LIFE TABLES'. Annals of Applied Statistics, 8 :1065-1094 [DOI] [Details]
(2014)'Voxel-level mapping of tracer kinetics in PET studies: A statistical approach emphasizing tissue life tables'
O’Sullivan, Finbarr and Muzi, Mark and Mankoff, David A and Eary, Janet F and Spence, Alexander M and Krohn, Kenneth A and others (2014) 'Voxel-level mapping of tracer kinetics in PET studies: A statistical approach emphasizing tissue life tables'. Annals of Applied Statistics, 8 (2):1065-1094 [Details]
(2014)'An Analysis of Whole Body Tracer Kinetics in Dynamic PET Studies With Application to Image-Based Blood Input Function Extraction'
Huang, J,O'Sullivan, F (2014) 'An Analysis of Whole Body Tracer Kinetics in Dynamic PET Studies With Application to Image-Based Blood Input Function Extraction'. IEEE Transactions On Medical Imaging, 33 :1093-1108 [DOI] [Details]
(2014)'Activity of P-Glycoprotein, a beta-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease'
Deo, AK,Borson, S,Link, JM,Domino, K,Eary, JF,Ke, B,Richards, TL,Mankoff, DA,Minoshima, S,O'Sullivan, F,Eyal, S,Hsiao, P,Maravilla, K,Unadkat, JD (2014) 'Activity of P-Glycoprotein, a beta-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease'. Journal of Nuclear Medicine, 55 :1106-1111 [DOI] [Details]
(2012)'Plane-wave Sf S reconstruction of water surface characteristics from Lambertian reflectance data'
Huang, J,O'Sullivan, F,Jike, L (2012) 'Plane-wave Sf S reconstruction of water surface characteristics from Lambertian reflectance data'. Inverse Problems, 28 [DOI] [Details]
(2012)'Kinetic Analysis of Dynamic Positron Emission Tomography Data using Open-Source Image Processing and Statistical Inference Tools'
Hawe D, Hernández Fernández FR, O'Suilleabháin L, Huang J, Wolsztynski E, O'Sullivan F (2012) 'Kinetic Analysis of Dynamic Positron Emission Tomography Data using Open-Source Image Processing and Statistical Inference Tools'. Wiley interdisciplinary reviews. Computational statistics, 4 (3):316-322 [DOI] [Details]
(2012)'A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments'
Roy Choudhury, K.,O'Sullivan, F.,Kasman, I.,Plowman, G. D. (2012) 'A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments'. Statistics In Medicine, 31 (2929):4061-734061 Globe icon [Details]
(2012)'A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments'
Choudhury, KR,O'Sullivan, F,Kasman, I,Plowman, GD (2012) 'A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments'. Statistics In Medicine, 31 :4061-4073 [DOI] [Details]
(2012)'Quantitative assessment of dynamic PET imaging data in cancer imaging'
Muzi, M,O'Sullivan, F,Mankoff, DA,Doot, RK,Pierce, LA,Kurland, BF,Linden, HM,Kinahan, PE (2012) 'Quantitative assessment of dynamic PET imaging data in cancer imaging'. Magnetic resonance imaging, 30 :1203-1215 [DOI] [Details]
(2012)'A Fully Automatic Procedure for Image Derived Blood Extraction, Including Assessment of Metabolite, in Dynamic PET Fluorothymidine (FLT) Studies'
F. O'Sullivan , M. Muzi , J. Huang , J.F. Eary , J. Link , K.A. Krohn (2012) 'A Fully Automatic Procedure for Image Derived Blood Extraction, Including Assessment of Metabolite, in Dynamic PET Fluorothymidine (FLT) Studies'. European Journal of Cancer, 48 (6) [DOI] [Details]
(2011)'Statistical Analysis of Tubular Structures in PET Imaging Data of Human Sarcoma'
Richards T, O’Sullivan F., Conrad E, Eary J.F. (2011) 'Statistical Analysis of Tubular Structures in PET Imaging Data of Human Sarcoma'. Journal of Biomedical Graphics and Computing, [Details]
(2011)'A Statistical Modeling Approach to the Analysis of Spatial Patterns of FDG-PET Uptake in Human Sarcoma'
O’Sullivan F, Wolsztynski E, O’Sullivan J, Richards T, Conrad E, Eary JF (2011) 'A Statistical Modeling Approach to the Analysis of Spatial Patterns of FDG-PET Uptake in Human Sarcoma'. IEEE Transactions On Medical Imaging, 30 (12):2059-2071 [Details]
(2011)'A statistical modeling approach to the analysis of spatial patterns of FDG-PET uptake in human sarcoma'
O'Sullivan F, Wolsztynski E, O'Sullivan J, Richards T, Conrad EU, Eary JF (2011) 'A statistical modeling approach to the analysis of spatial patterns of FDG-PET uptake in human sarcoma'. IEEE transactions on medical imaging, 30 (12):2059-2071 [DOI] [Details]
(2010)'Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate'
Chung, FS; Eyal, S; Muzi, M; Link, JM; Mankoff, DA; Kaddoumi, A; O'Sullivan, F; Hsiao, P; Unadkat, JD; (2010) 'Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate'. British Journal of Pharmacology, :394-404 [Details]
(2010)'Reconstruction of wave height and slope fields from refracted images of water'
Choudhury, K; O'Sullivan, K; Samanta, F; Cauliez, G; Shrira, V; (2010) 'Reconstruction of wave height and slope fields from refracted images of water'. J.American Statist.Assoc, (105):36-47 [Details]
(2010)'Kinetic quantitation of cerebral PET-FDG studies without concurrent blood sampling: statistical recovery of the arterial input function'
O'Sullivan, F; Kirrane, J; Muzi, M; O'Sullivan, JN; Spence, AM; Mankoff, DA; Krohn, KA; (2010) 'Kinetic quantitation of cerebral PET-FDG studies without concurrent blood sampling: statistical recovery of the arterial input function'. IEEE Transactions in Medical Imaging, :610-624 [Details]
(2010)'Regularized Reconstruction of Wave Height and Slope Fields From Refracted Images of Water'
Choudhury, KR,O'Sullivan, F,Samanta, M,Caulliez, G,Shrira, V; (2010) 'Regularized Reconstruction of Wave Height and Slope Fields From Refracted Images of Water'. Journal of The American Statistical Association, 105 :36-47 [DOI] [Details]
(2010)'Regularized Reconstruction of wave height and slope fields from refracted images of water'
Roy Choudhury, K., ,O’Sullivan, F., ,Samanta, M., ,Caulliez, G., ,Shrira, V. (2010) 'Regularized Reconstruction of wave height and slope fields from refracted images of water'. Journal of the American Statistical Association, 105 [Details]
(2010)'Kinetic Quantitation of Cerebral PET-FDG Studies Without Concurrent Blood Sampling: Statistical Recovery of the Arterial Input Function'
O'Sullivan, F,Kirrane, J,Muzi, M,O'Sullivan, JN,Spence, AM,Mankoff, DA,Krohn, KA (2010) 'Kinetic Quantitation of Cerebral PET-FDG Studies Without Concurrent Blood Sampling: Statistical Recovery of the Arterial Input Function'. IEEE Transactions On Medical Imaging, 29 :610-624 [DOI] [Details]
(2009)'A statistical analysis of the hypothesis of the standard two-compartment model for dynamic PET-FDG data in normal brain'
O'sullivan, F,Fitzgerald, N,O'sullivan, J,Muzi, M,Mankoff, DA,Spence, AM,Krohn, KA (2009) 'A statistical analysis of the hypothesis of the standard two-compartment model for dynamic PET-FDG data in normal brain'. Blood, 29 :313-313 [Details]
(2009)'Nonparametric residue analysis of dynamic PET data with application to cerebral fdg studies in normals'
O'Sullivan, F. and Muzi, M. and Spence, A.M. and Mankoff, D.M. and O'Sullivan, J.N. and Fitzgerald, N. and Newman, G.C. and Krohn, K.A. (2009) 'Nonparametric residue analysis of dynamic PET data with application to cerebral fdg studies in normals'. Journal of the American Statistical Association, 104 (486):556-571 [Details]
(2009)'NCI-Sponsored trial for the evaluation of safety and preliminary efficacy of 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) as a marker of proliferation in patients with recurrent gliomas: Preliminary efficacy studies'
Spence AM, Muzi M, Link JM, O'Sullivan F, Eary JF, Hoffman JM, Shankar LK, Krohn KA; (2009) 'NCI-Sponsored trial for the evaluation of safety and preliminary efficacy of 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) as a marker of proliferation in patients with recurrent gliomas: Preliminary efficacy studies'. Molecular Imaging and Biology, :343-355 [Details]
(2009)'Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate'
Eyal S, Chung FS, Muzi M, Link JM, Mankoff DA, Kaddoumi A, O'Sullivan F, Hebert MF, Unadkat JD; (2009) 'Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate'. Journal of Nuclear Medicine, :798-806 [Details]
(2009)'Nonparametric residue analysis of dynamic PET data with application to cerebral FDG studies in normals'
O'Sullivan F, Muzi M, Spence AM, Mankoff DA, O'Sullivan JN, Fitzgerald N, Newman GC, Krohn KA; (2009) 'Nonparametric residue analysis of dynamic PET data with application to cerebral FDG studies in normals'. Journal of The American Statistical Association, :556-571 [Details]
(2008)'Regularized reconstruction of water surfaces from noisy gradient information via plane-wave superposition'
O'Sullivan, F,Huang, J,Choudhury, KR,Caulliez, G,Shrira, V; (2008) 'Regularized reconstruction of water surfaces from noisy gradient information via plane-wave superposition'. Inverse Problems, 24 [DOI] [Details]
(2008)'Regional Hypoxia In Glioblastoma Multiforme Quantified With [F-18] Fluoromisonidazole Positron Emission Tomography Before Radiotherapy: Correlation With Time to Progression and Survival'
Spence, AM, Muzi, M, Swanson, KR, O'Sullivan, F, Rockhill, JK, Rajendran, JG, Adamsen, TCH, Link, JM, Swanson, PE, Yagle, KJ, Rostomily, RC, Silbergeld, DL, Krohn, KA; (2008) 'Regional Hypoxia In Glioblastoma Multiforme Quantified With [F-18] Fluoromisonidazole Positron Emission Tomography Before Radiotherapy: Correlation With Time to Progression and Survival'. Clinical Cancer Research, 14 (9):2623-2630 [DOI] [Details]
(2008)'Spatial Heterogeneity in Sarcoma 18F-FDG Uptake as a Predictor of Patient Outcome'
Eary J, O'Sullivan F, O'Sullivan J, Conrad E; (2008) 'Spatial Heterogeneity in Sarcoma 18F-FDG Uptake as a Predictor of Patient Outcome'. The Journal of Nuclear Medicine, 49 (12):1973-1979 [Details]
(2007)'Bayesian use of historical data to guide blood input function extraction from dynamic PET studies'
O'Sullivan, F. and Kirrane, J. and Muzi, M. and O'Sullivan, J. and Spence, A. and Krohn, K. (2007) 'Bayesian use of historical data to guide blood input function extraction from dynamic PET studies'. J Nucl Med, 48 (suppl 2) [Details]
(2007)'Molecular imaging research in the outcomes era: measuring outcomes for individualized cancer therapy'
Mankoff DA, O'Sullivan F, Barlow WE, Krohn KA; (2007) 'Molecular imaging research in the outcomes era: measuring outcomes for individualized cancer therapy'. Academic Radiology, 14 (4):398-405 [Details]
(2007)'Challenges in clinical studies with multiple imaging probes'
Krohn KA, O'Sullivan F, Crowley J, Eary JF, Linden HM, Link JM, Mankoff DA, Muzi M, Rajendran JG, Spence AM, Swanson KR ; (2007) 'Challenges in clinical studies with multiple imaging probes'. Nuclear Medicine and Biology, 34 (7):879-885 [Details]
(2006)'Kinetic analysis of 3'-deoxy-3'-18F-fluorothymidine in patients with gliomas'
Muzi M, Spence AM, O'Sullivan F, Mankoff DA, Wells JM, Grierson JR,Link JM, Krohn KA ; (2006) 'Kinetic analysis of 3'-deoxy-3'-18F-fluorothymidine in patients with gliomas'. The Journal of Nuclear Medicine, 47 (10):1612-1621 [Details]
(2006)'Experimental estimates of the constants relating signal change to contrast concentration for cerebral blood volume by T2* MRI'
Newman GC, Hospod FE, Patlak CS, Fain SE, Pulfer KA, Cook TD, O'Sullivan F ; (2006) 'Experimental estimates of the constants relating signal change to contrast concentration for cerebral blood volume by T2* MRI'. Journal of Cerebral Blood Flow & Metabolism, 26 (6):760-770 [Details]
(2006)'A Statistical Measure of Regularity for the Study of Wind-Generated Wave Field Images'
O¿Sullivan, F., Roy Choudhury, K; (2006) 'A Statistical Measure of Regularity for the Study of Wind-Generated Wave Field Images'. J.American Statist.Assoc, 101 (475):1119-1131 [Details]
(2006)'A statistical measure of regularity for the study of wind-generated wave field images'
O'Sullivan, F,Choudhury, KR; (2006) 'A statistical measure of regularity for the study of wind-generated wave field images'. Journal of The American Statistical Association, 101 :1119-1131 [DOI] [Details]
(2006)'Locally constrained mixture representation of dynamic imaging data from PET and MR studies'
O'Sullivan, F; (2006) 'Locally constrained mixture representation of dynamic imaging data from PET and MR studies'. Biostatistics, 7 :318-338 [DOI] [Details]
(2005)'Incorporation of tumor shape into an assessment of spatial heterogeneity for human sarcomas imaged with FDG-PET'
O'Sullivan F., Roy S., O'Sullivan J., Vernon C., and Eary JF. ; (2005) 'Incorporation of tumor shape into an assessment of spatial heterogeneity for human sarcomas imaged with FDG-PET'. Biostatistics, 6 (2):293-301 [Details]
(2005)'An adaptation of ridge regression for improved estimation of kinetic model parameters from PET studies'
Byrtek, M., O'Sullivan, F., Muzi, M., Spence, A.M. ; (2005) 'An adaptation of ridge regression for improved estimation of kinetic model parameters from PET studies'. Nuclear Science, IEEE Transactions, 52 (1):63-68 [Details]
(2004)'18F-FDG PET of gliomas at delayed intervals: improved distinction between tumor and normal gray matter'
Spence AM, Muzi M, Mankoff DA, O'Sullivan F, Link JM, Lewellen TK, Lewellen B, Pham P, Minoshima S, Swanson K, Krohn KA; (2004) '18F-FDG PET of gliomas at delayed intervals: improved distinction between tumor and normal gray matter'. The Journal of Nuclear Medicine, 45 (10):1653-1659 [Details]
(2004)'Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging'
Rajendran JG, Mankoff DA, O'Sullivan F, Peterson LM, Schwartz DL, Conrad EU, Spence AM, Muzi M, Farwell DG, Krohn KA.; (2004) 'Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging'. Clinical Cancer Research, 10 (7):2245-2252 [Details]
(2003)'Delayed FDG imaging enhances relative tumor to brain uptake due to k4 difference'
Muzi, M, Spence, AM, O'Sullivan, F, Mankoff, DA, Minoshima, S, Lewellen, B, Krohn, KA; (2003) 'Delayed FDG imaging enhances relative tumor to brain uptake due to k4 difference'. The Journal of Nuclear Medicine, 44 :241-242 [Details]
(2003)'A statistical measure of tissue heterogeneity with application to 3D PET sarcoma data'
O'Sullivan F, Roy S, Eary J.: ; (2003) 'A statistical measure of tissue heterogeneity with application to 3D PET sarcoma data'. Biostatistics, 4 (3):433-448 [Details]
(2003)'Modelling multivariate biomechanical measurements of the spine during a rowing exercise'
O'Sullivan, F,O'Sullivan, J,Bull, AMJ,McGregor, AH; (2003) 'Modelling multivariate biomechanical measurements of the spine during a rowing exercise'. Clinical Biomechanics, 18 :488-493 [DOI] [Details]
(2003)'A Statistical Measure of Tissue Heterogeneity with Application to 3-D PET Sarcoma Data'
Roy S., O’Sullivan, F., Eary JF. (2003) 'A Statistical Measure of Tissue Heterogeneity with Application to 3-D PET Sarcoma Data'. Biostatistics, 4 (3):433-448 [Details]
(2003)'A statistical measure of tissue heterogeneity with application to 3D PET sarcoma data'
O'Sullivan, F,Roy, S,Eary, J (2003) 'A statistical measure of tissue heterogeneity with application to 3D PET sarcoma data'. Biostatistics, 4 :433-448 [Details]
(2003)'Finite strain estimation using the mean radial length of elliptical objects with bootstrap confidence intervals'
Mulchrone, K. F., O'Sullivan, F. & Meere, P. A. ; (2003) 'Finite strain estimation using the mean radial length of elliptical objects with bootstrap confidence intervals'. Journal of Structural Geology, 25 (4):529-538 [Details]
(2002)'2-[18F] Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas Before and After Radiotherapy: Correlation with Outcome'
Spence AM, Muzi M, Graham MM, O'Sullivan, F, Link J; (2002) '2-[18F] Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas Before and After Radiotherapy: Correlation with Outcome'. Clinical Cancer Research, 8 :971-979 [Details]
(2002)'Fluorodeoxyglucose Lumped Constant in Normal Brain'
Graham MM, Muzi M, Spence AM, O'Sullivan F; (2002) 'Fluorodeoxyglucose Lumped Constant in Normal Brain'. The Journal of Nuclear Medicine, 43 :1157-1166 [Details]
(2002)'Sarcoma Tumor FDG Uptake Measured by PET and Patient Outcome: A Retrospective Analysis'
Eary JF, O'Sullivan F, Vernon C, Bruckner JD; (2002) 'Sarcoma Tumor FDG Uptake Measured by PET and Patient Outcome: A Retrospective Analysis'. European Journal of Nuclear Medicine, 29 (9):1149-1154 [Details]
(2002)'Kinetic Analysis of 2-[ ]-Thymidine PET Imaging Studies of Malignant Brain Tumors: Preliminary Patient Results'
Wells JM, Mankoff DA, O'Sullivan F ,Eary JF; (2002) 'Kinetic Analysis of 2-[ ]-Thymidine PET Imaging Studies of Malignant Brain Tumors: Preliminary Patient Results'. Molecular Imaging, 1 (3):151-159 [Details]
(2002)'Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis'
Eary, JF,O'Sullivan, F,Powitan, Y,Chandhury, KR,Vernon, C,Bruckner, JD,Conrad, EU; (2002) 'Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis'. Journal of Nuclear Medicine, 29 :1149-1154 [DOI] [Details]
(2001)'An Analysis of the Role of Positivity and Mixture Model Constraints in Poisson Deconvolution Problems'
Roy Choudhury, K., O¿Sullivan, F.; (2001) 'An Analysis of the Role of Positivity and Mixture Model Constraints in Poisson Deconvolution Problems'. J. Computational Graphics and Statistics, 10 (4):673-696 [Details]
(2001)'An analysis of the role of positivity and mixture model constraints in Poisson deconvolution problems'
O'Sullivan, F,Choudhury, KR; (2001) 'An analysis of the role of positivity and mixture model constraints in Poisson deconvolution problems'. Rna-A Publication of The Rna Society, 10 :673-696 [Details]
(2001)'An analysis of the role of positivity and mixture model constraints in Poisson deconvolution problems'
O'Sullivan, Finbarr and Roy Choudhury, Kingshuk; (2001) 'An analysis of the role of positivity and mixture model constraints in Poisson deconvolution problems'. J. Comput. Graph. Statist, 10 (4):673-696 Globe icon [DOI] [Details]
(1999)'2-[C-11]Thymidine Imaging of Malignant Brain Tumors'
Eary JF, Mankoff DA, Spence AM, Berger MS, Olshen A, Link JM, O'Sullivan F, Krohn KA.; (1999) '2-[C-11]Thymidine Imaging of Malignant Brain Tumors'. Cancer Research, 59 (3):615-621 [Details]
(1999)'Use of ridge regression for improved estimation of kinetic constants from PET data'
O'Sullivan, F,Saha, A; (1999) 'Use of ridge regression for improved estimation of kinetic constants from PET data'. IEEE Transactions On Medical Imaging, 18 :115-125 [Details]
(1998)'Variability assessment in positron emission tomography and related generalized deconvolution models'
Maitra, R,O'Sullivan, F; (1998) 'Variability assessment in positron emission tomography and related generalized deconvolution models'. Journal of The American Statistical Association, 93 :1340-1355 [Details]
(1998)'Glucose Metabolism in Human Malignant Gliomas Measured Quantitatively with PET, 1-[C-11] Glucose and FDG: Analysis of the FDG Lumped Constant'
Spence AM, Muzi M, Graham MM, O'Sullivan F, Krohn KA, Link JM, Lewellen TK, Lewellen B, Freeman SD, Berger MS, Ojemann GA; (1998) 'Glucose Metabolism in Human Malignant Gliomas Measured Quantitatively with PET, 1-[C-11] Glucose and FDG: Analysis of the FDG Lumped Constant'. The Journal of Nuclear Medicine, 39 (3):440-448 [Details]
(1997)'A Region Based Image Segmentation Method for Multi-Channel Data [B1362]'
Bose, S.; O'Sullivan, F.; (1997) 'A Region Based Image Segmentation Method for Multi-Channel Data [B1362]'. Journal of The American Statistical Association, 437 :92-106 [Details]
(1997)'Camouflaged Deconvolution With Application to Blood Curve Modeling in FDG PET Studies'
Olshen, A.; O'Sullivan, F.; (1997) 'Camouflaged Deconvolution With Application to Blood Curve Modeling in FDG PET Studies'. Journal of the American Statistical Association, 92 :1293-1303 [Details]
(1997)'Feasibility of Imaging Pentose Cycle Glucose Metabolism in Gliomas With PET: Studies in Rat Brain Tumour Models [B1364]'
Spence, A. M.; Graham, M. M.; Muzi, M.; Freeman, S. D.; Link, J. M.; Grierson, J. R.; O'Sullivan, F.; Stein, D.; Abbott, G. L.; Krohn, K. A.; (1997) 'Feasibility of Imaging Pentose Cycle Glucose Metabolism in Gliomas With PET: Studies in Rat Brain Tumour Models [B1364]'. Journal of Nuclear Medicine, 38 :617-624 [Details]
(1997)'PET Calibration and Attenuation Correction [B1363]'
Pawitan, Y.; Kohlmyer, S.; Lewellen, T.; O'Sullivan, F.; (1997) 'PET Calibration and Attenuation Correction [B1363]'. IEEE Transactions On Nuclear Science, 44 :1249-1253 [Details]
(1996)'Bandwidth selection for indirect density estimation based on corrupted histogram data'
O'Sullivan, Finbarr and Pawitan, Yudi; (1996) 'Bandwidth selection for indirect density estimation based on corrupted histogram data'. J. Amer. Statist. Assoc, 91 (434):610-626 [Details]
(1996)'Predictive oscillation patterns: a synthesis of methods for spatial-temporal decomposition of random fields'
Kooperberg, Charles and O'Sullivan, Finbarr; (1996) 'Predictive oscillation patterns: a synthesis of methods for spatial-temporal decomposition of random fields'. J. Amer. Statist. Assoc, 91 (436):1485-1496 [Details]
(1996)'Penalized likelihood-type estimators for generalized nonparametric regression'
Cox, Dennis D. and O'Sullivan, Finbarr; (1996) 'Penalized likelihood-type estimators for generalized nonparametric regression'. J. Multivariate Anal, 56 (2):185-206 Globe icon [DOI] [Details]
(1995)'A study of least squares and maximum likelihood for image reconstruction in positron emission tomography'
O'Sullivan, Finbarr; (1995) 'A study of least squares and maximum likelihood for image reconstruction in positron emission tomography'. Ann. Statist, 23 (4):1267-1300 Globe icon [DOI] [Details]
(1994)'On the Sobolev Class of a Composite Function'
Dennis D. Cox, Finbarr O'Sullivan; (1994) 'On the Sobolev Class of a Composite Function'. Proceedings of The American Mathematical Society, [Details]
(1994)'A Regularized Contrast Statistic for Object Boundary Estimation-Implementation and Statistical Evaluation'
O'Sullivan, F ,M. Qian; (1994) 'A Regularized Contrast Statistic for Object Boundary Estimation-Implementation and Statistical Evaluation'. IEEE Transactions on Pattern Analysis and Machine Intelligence, 16 (6):561-570 [Details]
(1994)'Metabolic images from dynamic positron emission tomography studies'
O'Sullivan F. ; (1994) 'Metabolic images from dynamic positron emission tomography studies'. Statistical Methods in Medical Research, 3 :87-101 [Details]
(1993)'Imaging radiotracer model parameters in PET: A mixture analysis approach'
O'Sullivan F ; (1993) 'Imaging radiotracer model parameters in PET: A mixture analysis approach'. The IEEE Transactions on Medical Imaging, 12 :399-412 [Details]
(1993)'Data-dependent bandwidth selection for emission computed tomography reconstruction'
Pawitan, Y., O'Sullivan, F. ; (1993) 'Data-dependent bandwidth selection for emission computed tomography reconstruction'. The IEEE Transactions on Medical Imaging, 12 (2):167-172 [Details]
(1993)'Reducing negative artifacts in emission tomography reconstructions: post-processing filtered backprojection solutions'
O'Sullivan F., Pawitan Y ,and Haynor D.R.:; (1993) 'Reducing negative artifacts in emission tomography reconstructions: post-processing filtered backprojection solutions'. The IEEE Transactions on Medical Imaging, 12 :653-663 [Details]
(1993)'Smooth mixture estimation with multichannel image data'
F. O'Sullivan; (1993) 'Smooth mixture estimation with multichannel image data'. Journal of The American Statistical Association, [Details]
(1993)'Multidimensional density estimation by tomography'
O'Sullivan F, Pawitan Y; (1993) 'Multidimensional density estimation by tomography'. Journal of the Royal Statistical Society, Series B, [Details]
(1993)'Nonparametric estimation in the Cox model'
O'Sullivan, Finbarr; (1993) 'Nonparametric estimation in the Cox model'. Ann. Statist, 21 (1):124-145 Globe icon [DOI] [Details]
(1991)'Discretized Laplacian Smoothing by Fourier Methods'
F. O'Sullivan; (1991) 'Discretized Laplacian Smoothing by Fourier Methods'. Journal of The American Statistical Association, [Details]
(1991)'Discussion: Multivariate Adaptive Regression Splines'
O'Sullivan F ; (1991) 'Discussion: Multivariate Adaptive Regression Splines'. Annals of Statistics, 19 (1):99-102 [Details]
(1991)'Sensitivity analysis for regularized estimation in some system identification problems'
O'Sullivan, Finbarr; (1991) 'Sensitivity analysis for regularized estimation in some system identification problems'. SIAM J. Sci. Statist. Comput, 12 (6):1266-1283 Globe icon [DOI] [Details]
(1990)'An Iterative Approach to Two-Dimensional Laplacian Smoothing with Application Image Restoration'
F. O'Sullivan; (1990) 'An Iterative Approach to Two-Dimensional Laplacian Smoothing with Application Image Restoration'. Journal of The American Statistical Association, [Details]
(1990)'Convergence characteristics of methods of regularization estimators for nonlinear operator equations'
O'Sullivan, Finbarr; (1990) 'Convergence characteristics of methods of regularization estimators for nonlinear operator equations'. SIAM J. Numer. Anal, 27 (6):1635-1649 Globe icon [DOI] [Details]
(1990)'Rain Estimation from Infrared and Visible GOES Satellite Data'
Wash CH, Stewart M, O'Sullivan F, Motell CE ; (1990) 'Rain Estimation from Infrared and Visible GOES Satellite Data'. Journal of Applied Meteorology, 29 (3):209-223 [Details]
(1990)'Asymptotic analysis of penalized likelihood and related estimators'
Cox, Dennis D. and O'Sullivan, Finbarr; (1990) 'Asymptotic analysis of penalized likelihood and related estimators'. Ann. Statist, 18 (4):1676-1695 Globe icon [DOI] [Details]
(1988)'Deconvolution of Episodic Hormone Data: An analysis of the Role of Season on the Onset of Puberty in Cows'
Finbarr O'Sullivan and Janet O'Sullivan; (1988) 'Deconvolution of Episodic Hormone Data: An analysis of the Role of Season on the Onset of Puberty in Cows'. Biometrics, [Details]
(1988)'Fast computation of fully automated log-density and log-hazard estimators'
O'Sullivan, Finbarr; (1988) 'Fast computation of fully automated log-density and log-hazard estimators'. SIAM J. Sci. Statist. Comput, 9 (2):363-379 Globe icon [DOI] [Details]
(1988)'Nonparametric estimation of relative risk using splines and cross-validation'
O'Sullivan, Finbarr; (1988) 'Nonparametric estimation of relative risk using splines and cross-validation'. SIAM J. Sci. Statist. Comput, 9 (3):531-542 Globe icon [DOI] [Details]
(1988)'Deconvolution of episodic hormone data: An analysis of the role of season on the onset of puberty in cows'
O'Sullivan, F. and O'Sullivan, J. (1988) 'Deconvolution of episodic hormone data: An analysis of the role of season on the onset of puberty in cows'. Biometrics, :339-353 [Details]
(1987)'Non-Gaussian State-Space Modeling of Nonstationary Time Series: Comment'
F. O'Sullivan; (1987) 'Non-Gaussian State-Space Modeling of Nonstationary Time Series: Comment'. Journal of The American Statistical Association, [Details]
(1986)'A statistical perspective on ill-posed inverse problems'
O'Sullivan, Finbarr; (1986) 'A statistical perspective on ill-posed inverse problems'. Statist. Sci, 1 (4):502-527 Globe icon [Details]
(1986)'Automatic Smoothing of Regression Functions in Generalized Linear Models'
O'Sullivan,F ,Yandell BF, Raynor WJ; (1986) 'Automatic Smoothing of Regression Functions in Generalized Linear Models'. Journal of the American Statistical Association, 81 :96-104 [Details]
(1985)'A cross validated Bayesian retrieval algorithm for non-linear remote sensing experiments'
O'Sullivan,F, Wahba G; (1985) 'A cross validated Bayesian retrieval algorithm for non-linear remote sensing experiments'. Journal of Computational Physics, 59 :441-455 [Details]
(1985)'Discussion of some aspects of the spline smoothing approach to non-parametric regression curve fitting'
F. O'Sullivan; (1985) 'Discussion of some aspects of the spline smoothing approach to non-parametric regression curve fitting'. Journal of the Royal Statistical Society, Series B, [Details]
(1984)'The Analysis of Repeated Measures Experiments in Endocrinology'
F. O'Sullivan, P. Whitney, M. M. Hinshelwood and E. R. Hauser; (1984) 'The Analysis of Repeated Measures Experiments in Endocrinology'. Journal of Animal Science, [Details]

Conference Publications

YearPublication
(2010)Conference of Applied Statistics in Ireland (CASI)
O'Sullivan, F; Wolsztynski, E; Eary, JF (2010) A semi-automated segmentation procedure for PET imaging data of sarcoma tumours Conference of Applied Statistics in Ireland (CASI) Portrush, Northern Ireland, UK, , 16-MAY-10 - 18-MAY-10 [Details]

Books

YearPublication
(1988)Complex Mixtures:Methods for In Vivo Toxicity Testing.
Committee of the Board of Environmental Studies and Toxicology, National Research Council; (1988) Complex Mixtures:Methods for In Vivo Toxicity Testing. Washington: National Academies Press. [Details]

Abstract

YearPublication
(2010)Multiparameter PET imaging for assessing risk/outcome in sarcoma.
Eary, JF,Link, JM,Conrad, EU,Muzi, M,O'Sullivan, F,Krohn, KA (2010) Multiparameter PET imaging for assessing risk/outcome in sarcoma. Abstract [Details]
(2009)Use of residue constraints and stochastic properties of noise improves the accuracy of perfusion information recovered from dynamic contrast MR/CT.
Fitzgerald, N,O'Sullivan, F,Newman, G (2009) Use of residue constraints and stochastic properties of noise improves the accuracy of perfusion information recovered from dynamic contrast MR/CT. Abstract [Details]
(2007)Bayesian use of historical data to guide blood input function extraction from dynamic PET studies.
O'Sullivan F, Kirrane J, Muzi M, O'Sullivan J, Spence A, and Krohn K ; (2007) Bayesian use of historical data to guide blood input function extraction from dynamic PET studies. Abstract [Details]
(2006)Image Based Recovery of an Arterial Input Function in a Cerebral PET Study with FDG Instrumentation & Data Analysis: Data Analysis & Management Modeling Methods.
O'Sullivan, F, Kirrane, J, Muzi, M, O'Sullivan, J, Spence, A, and Krohn, K; (2006) Image Based Recovery of an Arterial Input Function in a Cerebral PET Study with FDG Instrumentation & Data Analysis: Data Analysis & Management Modeling Methods. Abstract [Details]
(2005)Risk assessment for treatment outcome in cancer using PET: the sarcoma population.
Eary, JF,Conrad, EU,Butrynski, J,Link, J,O'Sullivan, F (2005) Risk assessment for treatment outcome in cancer using PET: the sarcoma population. Abstract [Details]
(2005)Assessment of various quantitative methods of determining [18F]-fluoromisonidazole uptake in glioma patients.
Muzi M, Spence AM, O'Sullivan F, Scharnhorst JA, Swanson KR, Adamsen TCh, Krohn KA; (2005) Assessment of various quantitative methods of determining [18F]-fluoromisonidazole uptake in glioma patients. Abstract [Details]
(2005)Kinetic analysis of 3-deoxy-3[18F]fluorothymidine (FLT) PET imaging studies of malignant brain tumors.
Muzi M, Spence AM, O'Sullivan F, Mankoff DA, Grierson JR, Krohn KA; (2005) Kinetic analysis of 3-deoxy-3[18F]fluorothymidine (FLT) PET imaging studies of malignant brain tumors. Abstract [Details]
(2004)Tumor heterogeneity in sarcoma patients is a significant predictor of survival.
Eary, JF,Brenner, W,Vernon, C,O'Sullivan, F (2004) Tumor heterogeneity in sarcoma patients is a significant predictor of survival. Abstract [Details]
(2004)Initial Assessment of [18F]3Deoxy-3-Fluorothymidine (FLT) for PET Imaging of DNA Biosynthesis in Glioma Patients.
Spence AM, Muzi M, Grierson JR, Swanson KR, Link JM, Mankoff DA, O'Sullivan F, Minoshima S, Krohn KA ; (2004) Initial Assessment of [18F]3Deoxy-3-Fluorothymidine (FLT) for PET Imaging of DNA Biosynthesis in Glioma Patients. Abstract [Details]
(2003)Hypoxia guided treatment selection: The rationale for using [F-18] FMISO PET in identifying and quantifying hypoxia in head and neck cancer.
Rajendran JG, Schwartz DL, O'Sullivan F, Ng P, Peterson LM, Krohn KA; (2003) Hypoxia guided treatment selection: The rationale for using [F-18] FMISO PET in identifying and quantifying hypoxia in head and neck cancer. Abstract [Details]
(2003)Hypoxia guided treatment selection: The rationale for using [F-18] FMISO PET in identifying and quantifying hypoxia in head and neck cancer.
Rajendan, JG,Schwartz, DL,O'Sullivan, F,Ng, P,Peterson, LM,Krohn, KA (2003) Hypoxia guided treatment selection: The rationale for using [F-18] FMISO PET in identifying and quantifying hypoxia in head and neck cancer. Abstract [Details]
(2003)Delayed FDG imaging enhances relative tumor to brain uptake due to k4 difference.
Muzi, M,Spence, AM,O'Sullivan, F,Mankoff, DA,Minoshima, S,Lewellen, B,Krohn, KA (2003) Delayed FDG imaging enhances relative tumor to brain uptake due to k4 difference. Abstract [Details]
(2003)Heterogeneity measure in hypoxia: a novel way to characterize FMISO PET hypoxia imaging.
Rajendran JG, O'Sullivan F, Peterson LM, O'Sullivan J, Muzi M, Schwartz DL, Conrad EU, Eary JF, Krohn KA; (2003) Heterogeneity measure in hypoxia: a novel way to characterize FMISO PET hypoxia imaging. Abstract [Details]
(2002)2-[18F]Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas before and after Radiotherapy.
Alexander M. Spence, Mark Muzi, Michael M. Graham, Finbarr O'Sullivan, Jeanne M. Link, Thomas K. Lewellen, Barbara Lewellen, Scott D. Freeman, David A. Mankoff, Janet F. Eary and Kenneth A. Krohn ; (2002) 2-[18F]Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas before and after Radiotherapy. Abstract [Details]
(2002)2- 11 C Thymidine PET to Measure Cellular Proliferation in Malignant Brain Tumors.
Wells JM, Mankoff DA, Spence AM, O'Sullivan F; (2002) 2- 11 C Thymidine PET to Measure Cellular Proliferation in Malignant Brain Tumors. Abstract [Details]
(2002)18F-FDG PET of Malignant Gliomas at Delayed Intervals: Improved Distinction between Tumor and Gray Matter.
Spence AM, Muzi M, Minoshima S, O'Sullivan F; (2002) 18F-FDG PET of Malignant Gliomas at Delayed Intervals: Improved Distinction between Tumor and Gray Matter. Abstract [Details]
(2001)Measurement of heterogeneity in the glucose utilization of human sarcomas based on 3-D FDG PET data.
Eary, JF,O'Sullivan, F,Roy, S,Vernon, C (2001) Measurement of heterogeneity in the glucose utilization of human sarcomas based on 3-D FDG PET data. Abstract [Details]
(2001)Kinetic analysis of 2-C-11 thymidine pet imaging studies of malignant brain tumors.
Wells, JM,Mankoff, DA,Spence, AM,Muzi, M,O'Sullivan, F,Eary, JF,Link, JM,Krohn, KA (2001) Kinetic analysis of 2-C-11 thymidine pet imaging studies of malignant brain tumors. Abstract [Details]
(2000)FDG PET as a predictor of treatment outcome in sarcoma: A preliminary analysis.
Eary, JF,O'Sullivan, F,Powitan, Y,Conrad, EU,Vernon, C (2000) FDG PET as a predictor of treatment outcome in sarcoma: A preliminary analysis. Abstract [Details]
(1998)1-[C-11]-Glucose and FDG Uptake in Malignant Gliomas: Response to Radiotherapy.
Olshen A, O'Sullivan F, Link JM, Stelzer K; (1998) 1-[C-11]-Glucose and FDG Uptake in Malignant Gliomas: Response to Radiotherapy. Abstract [Details]
(1998)Quantitation of Brain Tumor Proliferation with [C-11]Thymidine PET Imaging.
Eary JF, Mankoff DA, Spence AM, Berger MS, Olshen A, Link JM, O'Sullivan F, Krohn KA ; (1998) Quantitation of Brain Tumor Proliferation with [C-11]Thymidine PET Imaging. Abstract [Details]
(1997)The Fluorodeoxyglucose Lumped Constant in the Normal Human Brain.
Graham MM, O'Sullivan F, Muzi M, Spence AM; (1997) The Fluorodeoxyglucose Lumped Constant in the Normal Human Brain. Abstract [Details]
(1995)In Vivo Determination of the Fluorodeoxyglucose Lumped Constant.
Graham MM, Spence AM, O'Sullivan F, Muzi M; (1995) In Vivo Determination of the Fluorodeoxyglucose Lumped Constant. Abstract [Details]

Review Articles

YearPublication
(2005)Incorporation of tumor shape into an assessment of spatial heterogeneity for human sarcomas imaged with FDG-PET.
Roy, S., O'Sullivan F, J. O'Sullivan, C. Vernon, and J. Eary; (2005) Incorporation of tumor shape into an assessment of spatial heterogeneity for human sarcomas imaged with FDG-PET. Review Articles [Details]
(2003)A Statistical Measure of Tissue Heterogeneity with Application to 3-D PET Sarcoma Data.
Roy S., O¿Sullivan F, Eary JF; (2003) A Statistical Measure of Tissue Heterogeneity with Application to 3-D PET Sarcoma Data. Review Articles [Details]

Conference Contributions

YearPublication
(2010)Conference of Applied Statistics in Ireland,
E. Corkery, R. Dool, D.M. Mankoff, F. O'Sullivan; (2010) Quantitation of Dynamic [15O] Water and [18F] FDG Data from PET imaging of a Breast Cancer Patient. [Poster Presentation], Conference of Applied Statistics in Ireland, Portrush, Co. Antrim , 16-MAY-10 - 18-MAY-10. [Details]
(2010)Conference of Applied Statistics in Ireland,
D.Hawe and F. O'Sullivan ; (2010) A Markov Chain Interpretation of Compartmental Models for Blood Tissue Exchange in Positron Emission Tomography (PET) studies. . [Poster Presentation], Conference of Applied Statistics in Ireland, Portrush, Co. Antrim , 16-MAY-10 - 18-MAY-10. [Details]
(2010)IEEE 2010 Nuclear Science Symposium and Medical Imaging Conference,
J. Huang, F. O'Sullivan, N. Fitzgerald, M. Muzi, J. D. Unadkat, K. A. Krohn; (2010) Image Based Extraction of the Artieral Input Function in Cerebral PET Studies with O-15 Water. [Poster Presentation], IEEE 2010 Nuclear Science Symposium and Medical Imaging Conference, Knoxville, Tennessee , 30-OCT-10 - 06-NOV-10. [Details]
(2010)IEEE 2010 Nuclear Science Symposium and Medical Imaging Conference,
E. Wolsztynski, F. O'Sullivan, E. Conrad, J. F. Eary; (2010) A Novel Approach to the Assessment of Response to Chemotherapy in Human Sarcoma Imaged with PET-FDG. [Poster Presentation], IEEE 2010 Nuclear Science Symposium and Medical Imaging Conference, Knoxville, Tennessee , 30-OCT-10 - 06-NOV-10. [Details]
(2010)IEEE Nuclear Science Symposium and Medical Imaging Conference,
F. O'Sullivan, E. Wolsztynski, J. N. O'Sullivan, E. Conrad, J. F. Eary; (2010) An Automated Approach to Tumor ROI Definition for Routine Implementation of Spatial Heterogeneity Analysis in PET-FDG Studies of Sarcoma. [Oral Presentation], IEEE Nuclear Science Symposium and Medical Imaging Conference, Knoxville, Tennessee , 30-OCT-10 - 06-NOV-10. [Details]
(2010)Conference of Applied Statistics in Ireland,
E. Wolsztynski, F. O'Sullivan, J. O'Sullivan, J.F. Eary; (2010) Automated Tumor Region Identification for Assessment of Heterogeneity in Human Sarcoma Imaged with FDG-PET. [Oral Presentation], Conference of Applied Statistics in Ireland, Portrush, Co Antrim , 16-MAY-10 - 18-MAY-10. [Details]
(2010)IEEE 2010 Nuclear Science Symposium and Medical Imaging Conference,
N. Fitzgerald, F. O'Sullivan, J. Huang, M. Muzi, G. S. Newman, J. D. Unadkat, T. L. Richards, K. A. Krohn; (2010) A Physiological Model for Representation of Arterial Tracer Concentration Time Courses in Dynamic Imaging Studies with CT, PET and MR. [Poster Presentation], IEEE 2010 Nuclear Science Symposium and Medical Imaging Conference, Knoxville, Tennessee , 30-OCT-10 - 06-NOV-10. [Details]
(2009)Conference on Applied Statistics in Ireland,
Kirrane J, O'Sullivan F, Muzi M, Spence AM; (2009) Statistical identification of blood signals from abdominal cancer and glioma PET-FDG data. [Oral Presentation], Conference on Applied Statistics in Ireland, Mullingar, Co Westmeath , 13-MAY-09 - 15-MAY-09. [Details]
(2009)IEEE Nuclear Science Symposium and Medical Imaging Conference,
Fitzgerald N., O'Sullivan F., Newman G; (2009) Cerebral Perfusion Maps from Dynamic Contrast MRI Data Utilizing Rician Statistics. [Poster Presentation], IEEE Nuclear Science Symposium and Medical Imaging Conference, Orlando, FL , 25-OCT-09 - 31-OCT-09. [Details]
(2009)Conference on Applied Statistics in Ireland,
Fitzgerald N., O'Sullivan F., Newman G; (2009) Residue Function Reconstruction from Dynamic Bolus Tracking with MRI by Iteratively Re-Weighted Nonlinear Least Squares. [Oral Presentation], Conference on Applied Statistics in Ireland, Dublin, Ireland , 13-MAY-09 - 15-MAY-09. [Details]
(2009)International Symposium on Cerebral Blood Flow, Metabolism and Function,
O'Sullivan F, Fitzgerald N, O'Sullivan J, Muzi M, Mankoff DA, Spence AM and Krohn KA; (2009) A statistical analysis of the hypothesis of the standard two-compartment model for dynamic PET-FDG data in normal brain. [Poster Presentation], International Symposium on Cerebral Blood Flow, Metabolism and Function, Chicago, IL , 29-JUN-09 - 03-JUL-09. [Details]
(2009)Society of Nuclear medicine, annual meeting,
O'Sullivan F, Eary J., Roy S., Wolsztynski, O'Sullivan J and Conrad E and Krohn KA; (2009) An Examination of a Threshold-volume Characteristic for Heterogeneity Assessment in Human Sarcomas Imaged with FDG-PET. [Poster Presentation], Society of Nuclear medicine, annual meeting, Toronto, Canada , 13-JUN-09 - 17-JUN-09. [Details]
(2009)Society of Nuclear medicine, annual meeting, Toronto, Canada,
O'Sullivan F, Muzi M, Mankoff D, Spence A, Eary J and Krohn KA; (2009) Metabolic analysis of dynamic PET studies using non-parametric residues and image derived arterial input functions. [Poster Presentation], Society of Nuclear medicine, annual meeting, Toronto, Canada, Toronto, Canada , 13-JUN-09 - 17-JUN-09. [Details]
(2009)Conference on Applied Statistics in Ireland,
Flannery E and O'Sullivan, F; (2009) Utilisation of cross sectional data to develop tooth eruption models for permanent molars in the Republic of Ireland. [Oral Presentation], Conference on Applied Statistics in Ireland, Mullingar, Co Westmeath , 13-MAY-09 - 15-MAY-09. [Details]
(2009)International Symposium on Cerebral Blood Flow, Metabolism and Function,
Fitzgerald N., O'Sullivan F., Newman G., O'Mahony D., O'Donovan N; (2009) Use of residue constraints and stochastic properties of noise improves the accuracy of perfusion information recovered from dynamic contrast CT/MRI. [Poster Presentation], International Symposium on Cerebral Blood Flow, Metabolism and Function, Chicago, IL , 29-JUN-09 - 03-JUL-09. [Details]
(2008)International Biometric Conference,
Kirrane J, O'Sullivan F, Muzi M, Spence ; (2008) Image-Derived Estimation of Arterial Input Function From Dynamic FDG-PET Studies. [Poster Presentation], International Biometric Conference, Dublin , 13-JUL-08 - 18-JUL-08. [Details]
(2008)IEEE Nuclear Science Symposium Conference Record,
N. Fitzgerald, F. O'Sullivan, G. Newman, D. O'Mahony and N. O'Donovan; (2008) Maximum Likelihood Deconvolution of Dynamic Contrast MRI Data via Weighted Nonlinear Least Squares. [Poster Presentation], IEEE Nuclear Science Symposium Conference Record, Dresden, Germany , 19-OCT-08 - 25-OCT-08. [Details]
(2008)IEEE Nuclear Science Symposium Conference Record,
O'Sullivan F, Muzi M, Spence AM, Mankoff DM, O'Sullivan J, Fitzgerald N, and Krohn K ; (2008) Nonparametric Residue Analysis of Dynamic PET Data with Application to Cerebral FDG Studies in Normals. [Poster Presentation], IEEE Nuclear Science Symposium Conference Record, Dresden, Germany , 19-OCT-08 - 25-OCT-08. [Details]
(2008)International Biometric Conference,
Fitzgerald N., O'Sullivan F., Newman G., O'Mahony D., O'Donovan N.. ; (2008) Quantification of Cerebral Blood Flow by Reconstruction of the Tissue Residue Function Using Regularization from Dynamic CT/MRI Scanning Data. [Poster Presentation], International Biometric Conference, Dublin , 13-JUL-08 - 18-JUL-08. [Details]
(2008)CASI (keynote address),
O'Sullivan F ; (2008) Statistical Aspects of Quantitative Imaging with PET for Cancer Applications. [Invited Oral Presentation], CASI (keynote address), Dublin, Ireland , 16-JUL-08 - 16-JUL-08. [Details]

Employment

 EmployerPositionFrom / To
UCC Professor 1996-present01-SEP-96 /
University of Washington-Seattle Associate/Full Professor (Statistics and Biostatistics) 1987-199801-JAN-87 / 01-JAN-98
University of California-Berkeley Assistant/Associate Professor 1983-198801-JAN-83 / 01-JAN-88
University of Washington Affiliate Professor (Radiology) 1998-present10-JAN-98 /

Education

 YearInstitutionQualificationSubject
1983University of Wisconsin PhDStatistics
1979UCC BScMathematical Sciences

Journal Activities

 JournalRoleTo / From
Siam Journal Of Scientific And Statistical Computing Member of Editorial Board01-JAN-85 - 01-JAN-90
Biostatistics Member of Editorial Board01-JAN-98 - 01-JAN-06
Journal Of The American Statistical Association Member of Editorial Board01-JAN-91 - 01-JAN-95
Biostatistics Referee01-JAN-84 -
Journal Of The American Statistical Association Referee01-JAN-84 -
Annals Of Statistics Referee01-JAN-84 -
Research Proposal Reviewer, National Science Foundation (Usa) Referee-

Other Activities

 Description

Featured in Science Spin, article by S. Duke, July 2008

Teaching Interests

ST4054

           

Statistical Methods for Life Table Data

ST2054

           

Probability & Mathematical Statistics

ST3300

           

Data Analysis I

ST3067

           

Life Contingencies II

ST3064

           

Time Series

ST2011

           

Social Statistics

ST2001

           

Introduction to Biostatistics

ST4400

           

Data Analysis II

ST4491

           

Introduction to Operations Research

ST4050

           

Statistical Consulting

ST3051

           

Statistical Theory

MS3012

         

Introduction to Statistics

ST5005

           

Introduction to Probability and Statistics

ST4401

           

Introduction to Operations Research

MF4055

         

Statistical Methods in Insurance

ST3054

           

Survival Analysis

ST3053

           

Stochastic Modelling I

ST3055

           

Generalised Linear Models

MF2903

         

Data Collection and Analysis:

ST2005

           

Social Research and Survey Methods

MF2052

         

Introduction to Financial Mathematics

ST3905

           

Applied Probability and Statistics

ST1051

           

Introduction to Probability and Statistics

ST3050

           

Case Studies in Data Analysis

ST5003

           

Intro to Statistics and Design of Experiments

ST3066

           

Life Contingencies I

ST4202

           

Applied Environmental Statistics

ST3090

           

Current Topics in Statistics I

ST1023

           

Introduction to Business Statistics

Current Postgraduate Students

 StudentDegree Type
Hawe David Doctoral Degree