Research Profile

Aideen Sullivan

Biography

Professor Aideen Sullivan is Head of the Department of Anatomy and Neuroscience. She leads an active research group, focused on novel approaches to the treatment of Parkinson's disease. Her particular interest is the development of neuroprotective therapies, which have the potential to slow or reverse the progression of this debilitating disease.

Aideen Sullivan graduated from University College Dublin in 1992 with a BSc (First Class Honours) in Pharmacology. She obtained a PhD in Neuropharmacology from the University of Cambridge, UK, in 1995. She worked in Imperial College London School of Medicine as a post-doctoral researcher from 1995-1998, on a project funded by the Parkinson's Disease Society. In 1998, she was appointed as Lecturer in the Department of Anatomy at UCC; she was promoted to Senior Lecturer in 2006 and to Professor (Scale 2) in 2014 and appointed Head of the Department of Anatomy and Neuroscience in March 2021.

Upon her appointment to UCC, Aideen was actively involved in establishing the BSc in Neuroscience, the first Neuroscience degree in Ireland, and she taught on this degree since 1998, and was Academic Director until 2017. Recently, she led the development of a new cross-College BSc degree programme in Medical and Health Sciences (CK707), which had its first student intake in 2018. 

In 2006, Aideen was awarded a Postgraduate Certificate in Teaching and Learning in Higher Education from UCC. She practices research-led teaching and encourages capable students to pursue research careers. She provides mentoring to undergraduate and postgraduate students and to colleagues. In 2010, she attained a FETAC certificate (awarded Distinction) in Peer-Mentoring. She has been an active participant in UCC's "Through the Glass Ceiling" Programme for Female Academics and Researchers (2011-13). In 2015, she was awarded a scholarship to participate in the Leadership Foundation's Aurora programme for women in Higher Education. She is Chair of the 'Flexible Working' Working Group for UCC's Athena SWAN Institutional application in 2020, and a member of UCC's main Athena SWAN steering group and of the College of Medicine and Health's Athena SWAN steering group.

Aideen is active in promoting Neuroscience and stem cell research in Ireland. She visits Parkinson’s support groups throughout Ireland, speaking to patients and their carers, clinicians and nurses, about recent advances in the research field. She has organised several conferences in the areas of Parkinson’s disease, stem cells and Neuroscience research, including the highly successful BRAINTALK Parkinson’s Community Meeting and Exhibition in 2015 (https://www.ucc.ie/en/braintalk/) and Brain Connections in 2018 (https://www.ucc.ie/en/cns/news/cork-neuroscience-centre--brain-connections-open-day.html). She undertakes visits to primary and secondary schools, to promote understanding and awareness of science and medicine. She has delivered talks and organised the Neuroscience information stand at each of UCC's Open Days for Schools since 1998.

Professor Sullivan is Editor-in-Chief of Neuronal Signaling, an Open Access peer-reviewed journal published by the Biochemical Socierty through Portland Press (http://www.neuronalsignaling.org). She is a member of Neuroscience Ireland, FENS (Federation of European Neurosciences), NECTAR (Network of European CNS Transplantation and Restoration), the Anatomical Society of Great Britain and Ireland, and the Irish Network of Neural Stem Cell Investigators.

Research Interests

Research Interests

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting ~2% of people aged over 65. Since PD is an age-related disorder, its incidence is steadily escalating, due to increases in life-expectancy. Current treatments are successful in alleviating symptoms in the short-term but their long-term use is associated with significant side-effects, and they have no effect to slow down the disease progression. The immediate future holds a significant challenge for researchers to develop novel treatments for PD, which will be efficacious and safe for long-term use by patients. Such developments will be driven by advances in the understanding of neuropathology of PD as well as the development, maintenance and health of dopamine neurons, the cells that degenerate in PD. My research programme aims to address these challenges through a coherently-linked program focused on key thematic areas, using in vitro and in vivo models:

  • Optimisation of neuroprotective therapies by the use of viral vectors to achieve long-term and targeted delivery of dopaminergic neurotrophic factors to the nigrostriatal system.
  • Elucidation of the molecular mechanisms mediating the protective effects of neurotrophic factors, to facilitate the development of drugs for PD which target these signalling pathways.
  • Discovery of biomarkers for PD, to enable earlier diagnosis and personalised medicine.
  • Investigation of the mechanisms of neuronal cell degeneration in PD, using new animal models which closely mimic the neuropathology which occurs in this disease.
  • Characterisation of the mechanisms of dopaminergic neuronal development and survival, to enhance the development of stem cell-based treatments for PD.
  • Investigation of the role of epigenetic mechanisms in the neurodegenerative pathomechanics of PD. 

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
[IC/2003/42] {Sullivan Dr. A} NEnterprise Irl01-APR-0301-APR-04€6,700.00
Determining the neuroprotective and neurorestorative efficacy of AAV-hGDF5 in the AAV-a-synuclein rat model of Parkinson's.Foundation Funded Research04-JAN-2203-JAN-25€226,032.00
Research DonationIrish Charities01-OCT-2031-DEC-21€15,000.00
'Identification of Smad-interacting protein 1 as a novel regulator of ventral midbrain dopaminergic neuron development.’Health Research Board01-OCT-1430-SEP-15€45,000.00
[HEA 3 NNN-TCD] {Scallan,Dr.Martina} NHigher Education authority01-JUN-0230-SEP-08€92,109.00
[WELLCOME TRUST] {Sullivan Dr. A} VForeign Research Institute17-JUN-0212-AUG-02€1,811.00
[HEA 3 NNN-TCD] {Sullivan,Dr.Aideen} NHigher Education authority01-JUN-0230-SEP-08€364,574.00
[RP/150/2002] {Dr A Sullivan } NHealth Research Board01-OCT-0230-SEP-05€131,900.00
‘Roles of Sip-1 in the development of midbrain dopaminergic neurons’Irish Research Council01-OCT-1430-SEP-15€45,828.00
‘Characterisation of cognitive deficits in the alpha-synuclein rat model of Parkinson’s disease.’Molecular Medicine Ireland01-OCT-1330-SEP-16€32,100.00
The role of Smad transcription in dopanimergic neuron survival.Foreign Research Institute01-JUN-1227-JUL-12€1,768.00
Support for ‘Parkinson’s Disease: from Molecules to Movement’ conferenceNeuroscience Ireland01-JAN-1231-DEC-12€1,000.00
‘Potential biomarkers for Parkinson’s disease: comparison of levels of neurotrophic factors in cerebrospinal fluid and serum of Parkinson’s disease patients with those in healthy controls.’UCC TRAP (Translational Research Access Programme)01-JAN-1231-DEC-12€9,750.00
‘The role of Smad transcription factors in dopaminergic neuron survival.’Wellcome Trust01-JUN-1227-JUL-12€1,768.00
‘NF-kappaB transcription factors as a molecular target for Parkinson’s disease therapy’Irish Research Council01-JUL-1130-JUN-13€75,962.00
The role of Smad transcription factors in dopaminergic neuron survival.Irish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-1030-SEP-13€72,000.00
‘The role of Smad transcription factors in dopaminergic neuron survival’Irish Research Council01-OCT-1030-SEP-13€72,000.00
‘Defining the potential of GDF-5 as a novel therapeutic for Parkinson’s disease’Health Research Board01-OCT-0930-SEP-12€147,051.00
‘ Investigation of the effects of VP025 in progressive rat models of Parkinson’s disease: proteasome inhibition and 6-OHDA striatal lesion’Vasogen Inc., Canada01-JAN-0631-DEC-07€118,250.00
HRB "Embryonic stem cells for Parkinson's disease"Health Research Board01-JAN-0630-SEP-10€195,373.00
‘Effect of pro-inflammatory cytokines on the fate of embryonic hippocampal neural precursor cells’Vasogen Inc., Canada01-JAN-0631-DEC-08€48,000.00
‘Embryonic stem cells for Parkinson’s diseaseHealth Research Board01-JAN-0630-SEP-10€195,373.00
‘Investigation of stem cell properties’Health Research Board01-JAN-0631-DEC-06€32,700.00
‘Analysis of the anti-inflammatory/neuroprotective effects of VP025 in progressive models of Parkinson’s disease’Vasogen Inc., Canada31-JAN-0531-DEC-06€115,250.00
‘The role of inflammation and p38 in 6-hydroxydopamine-induced dopaminergic neuronal death – implications for Parkinson’s disease’Irish Research Council01-JAN-0431-MAR-08€75,962.00
The role of inflammation and p38 in 6-hydroxydopamin-induced dopaminergic neuronal ..Irish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-0431-MAR-08€75,962.00
‘Analysis of the anti-inflammatory/neuroprotective effects of novel phospholipids-based drug formulation in a rat model of Parkinson’s disease’Vasogen Inc., Canada01-JAN-0431-DEC-05€115,250.00
‘Confocal Imaging System’Health Research Board01-JAN-0431-DEC-04€327,068.00
‘Wnts and TGF-beta interactions in midbrain dopaminergic neuron development’Enterprise Ireland01-APR-0301-APR-04€6,700.00
‘Viral vectors for delivery of neurotrophins in models of Parkinson's disease’Higher Education Authority (HEA)01-JUN-0230-SEP-08€92,109.00
'Development of new therapies for Parkinson's disease'Higher Education Authority01-JUN-0230-SEP-08€364,574.00
‘Generation of an enriched population of dopaminergic neurons for transplantation in Parkinson's disease'Irish Research Council01-JAN-0231-DEC-06€66,675.00
‘Astroglial diversity and selective dopaminergic neuronal degeneration: implications for Parkinson's disease’Health Research Board01-JAN-0230-DEC-05€103,200.00
‘Establishment of neurotrophin-expressing dopaminergic cells for transplantation in Parkinson's disease’Health Research Board01-OCT-0230-SEP-05€131,900.00
‘Investigation of the role of GDF-5 in the developing and adult brain.’Irish Research Council01-JAN-0231-DEC-04€51,000.00
‘Stem cells for Parkinson's disease’Enterprise Ireland01-JAN-0231-DEC-02€6,700.00
‘Investigation of the immune response to a neurotrophin-expressing cell line in a rat model of Parkinson's disease’Health Research Board01-JUN-0201-OCT-02€1,280.00
‘Examination of a GDF5-expressing cell line in a rat model of Parkinson's disease’Wellcome Trust17-JUN-0212-AUG-02€1,811.00
‘Use of a cell line expressing the neurotrophin GDF-5 to enhance the efficacy of transplanted dopaminergic neurons in a rat model of Parkinson's disease’Health Research Board01-JAN-0031-DEC-01€38,105.00
‘The use of the neurotrophin GDF-5 to enhance transplantation in Parkinson's disease’Health Research Board01-JAN-0001-JAN-01€640.00
‘The role of GDF-5 and GDNF neurotrophins and glial-neuronal interactions in models of Parkinson's disease’Health Research Board01-JAN-9930-DEC-02€45,820.00

Contract Researchers

 Researcher NameProjectRoleFunding Body
Dr Shane Hegarty'Identification of Smad-interacting protein 1 as a novel regulator of ventral midbrain dopaminergic neuron development.’Postdoctoral ResearcherNational University of Ireland (NUI)
Dr Louise Collins‘Molecular mechanisms of dopaminergic neuronal development’Postdoctoral ResearcherHealth Research Board
Dr Sinead Walsh‘NF-kappaB transcription factors as a molecular target for Parkinson’s disease therapy’Postdoctoral ResearcherIrish Research Council
Dr Andre Toulouse‘Development of new therapies for Parkinson's disease’Postdoctoral ResearcherHigher Education Authority
Dr David O’Sullivan‘Embryonic stem cells for Parkinson’s disease’Postdoctoral ResearcherHealth Research Board
Dr Tara Kelly‘Viral vectors for delivery of neurotrophins in models of Parkinson's disease’Postdoctoral ResearcherHigher Education Authority
Dr Andrew Fisher‘Analysis of the anti-inflammatory / neuroprotective effects of novel phospholipids-based drug formulation in a rat model of Parkinson’s disease’ (co-supervised by Dr. Yvonne Nolan).Postdoctoral ResearcherVasogen Inc., Canada
Patrick FitzgeraldAnalysis of the anti-inflammatory/neuroprotective effects of VP025 in progressive models of Parkinsons disease. (co-supervised by Dr. Yvonne Nolan).Research AssistantVasogen Inc., Canada
Eleanor TuohyAnalysis of the anti-inflammatory/neuroprotective effects of novel phospholipids-based drug formulation in a rat model of Parkinsons disease (co-supervised by Dr. Yvonne Nolan).Research AssistantVasogen Inc., Canada
Suzanne CrottyAnalysis of the anti-inflammatory/neuroprotective effects of VP025 in progressive models of Parkinsons disease (co-supervised by Dr. Yvonne Nolan).Research AssistantVasogen Inc., Canada
Dawn HarrisAnalysis of the anti-inflammatory/neuroprotective effects of novel phospholipids-based drug formulation in a rat model of Parkinsons disease (co-supervised by Dr. Yvonne Nolan).Research AssistantVasogen Inc., Canada

Publications

Peer Reviewed Journals

 YearPublication
(2021)'NME1 Protects Against Neurotoxin-, a-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease'
Anantha J;Goulding SR;Tuboly E;O'Mahony AG;Moloney GM;Lomansey G;McCarthy CM;Collins LM;Sullivan AM;O'Keeffe GW; (2021) 'NME1 Protects Against Neurotoxin-, a-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease'. Molecular Neurobiology, [DOI] [Details]
(2021)'Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease'
Stockdale SR;Draper LA;O'Donovan SM;Barton W;O'Sullivan O;Volpicelli-Daley LA;Sullivan AM;O'Neill C;Hill C; (2021) 'Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease'. Communications Biology, 4 (1) [DOI] [Details]
(2021)'LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and a-synuclein-induced degeneration in cellular models of Parkinson's disease'
Mazzocchi M;Goulding SR;Wyatt SL;Collins LM;Sullivan AM;O'Keeffe GW; (2021) 'LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and a-synuclein-induced degeneration in cellular models of Parkinson's disease'. Molecular and Cellular Neuroscience, 115 [DOI] [Details]
(2022)'Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease'
Goulding SR;Anantha J;Collins LM;Sullivan AM;O'Keeffe GW; (2022) 'Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease'. Neural Regeneration Research, 17 (1) [DOI] [Details]
(2021)'Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and a-Synuclein-Induced Neurodegeneration'
Goulding, Susan R.; Lévesque, Martin; Sullivan, Aideen M.; Collins, Louise M.; O’Keeffe, Gerard W. (2021) 'Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and a-Synuclein-Induced Neurodegeneration'. Molecular Neurobiology, [DOI] [Full Text] [Details]
(2020)'Growth differentiation factor 5 exerts neuroprotection in an a-synuclein rat model of Parkinson's disease'
Goulding, Susan R.; Concannon, Ruth M.; Morales-Prieto, Noelia; Villalobos-Manriquez, Francisca; Clarke, Gerard; Collins, Louise M.; Lévesque, Martin; Wyatt, Sean L.; Sullivan, Aideen M.; O’Keeffe, Gerard W. (2020) 'Growth differentiation factor 5 exerts neuroprotection in an a-synuclein rat model of Parkinson's disease'. Brain, [DOI] [Full Text] [Details]
(2020)'STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5'
Anantha J.;Goulding S.R.;Wyatt S.L.;Concannon R.M.;Collins L.M.;Sullivan A.M.;O'Keeffe G.W. (2020) 'STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5'. Iscience, 23 (9) [DOI] [Details]
(2020)'Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury'
Casey S.;Goasdoue K.;Miller S.M.;Brennan G.P.;Cowin G.;O’Mahony A.G.;Burke C.;Hallberg B.;Boylan G.B.;Sullivan A.M.;Henshall D.C.;O’Keeffe G.W.;Mooney C.;Bjorkman T.;Murray D.M. (2020) 'Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury'. Molecular Neurobiology, [DOI] [Details]
(2020)'The class II histone deacetylases as therapeutic targets for Parkinson's disease'
Mazzocchi M;Collins LM;Sullivan AM;O'Keeffe GW; (2020) 'The class II histone deacetylases as therapeutic targets for Parkinson's disease'. Neuronal Signaling, 4 (2) [DOI] [Details]
(2020)'Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma'
Alshangiti AM;Wyatt SL;McCarthy E;Collins LM;Hegarty SV;Sullivan AM;O'Keeffe GW; (2020) 'Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma'. Neuronal Signaling, 4 (1) [DOI] [Details]
(2019)'The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells'
Alshangiti AM;Togher KL;Hegarty SV;Sullivan AM;O'Keeffe GW; (2019) 'The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells'. Neuronal Signaling, 3 (1) [DOI] [Details]
(2020)'The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease'
Goulding SR;Sullivan AM;O'Keeffe GW;Collins LM; (2020) 'The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease'. Neural Regeneration Research, 15 (8) [DOI] [Details]
(2020)'Alterations in a-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons'
Furlong R.;O'Keeffe G.;O'Neill C.;Sullivan A. (2020) 'Alterations in a-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons'. Neuroscience Letters, 720 [DOI] [Details]
(2019)'4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells'
Alshangiti AM;Tuboly E;Hegarty SV;McCarthy CM;Sullivan AM;O'Keeffe GW; (2019) '4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells'. Oxidative Medicine and Cellular Longevity, 2019 [DOI] [Details]
(2019)'Nigral overexpression of alpha-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome'
O’Donovan, S.M., Crowley, E.K., Brown, J.R.-M., O’Sullivan, O., O’Leary, O.F., Timmons, S., Nolan, Y.M., Clarke, D.J., Hyland, N.P., Joyce, S.A., Sullivan, A.M., O’Neill, C (2019) 'Nigral overexpression of alpha-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome'. Neurogastroenterology and Motility, [DOI] [Details]
(2019)'Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T a-synuclein'
Goulding, Susan R.; Sullivan, Aideen M.; O'Keeffe, Gerard W.; Collins, Louise M. (2019) 'Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T a-synuclein'. Parkinsonism & related disorders,   [DOI] [Full Text] [Details]
(2019)'The Parkinson' disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P-3'
Furlong, RM;Lindsay, A;Anderson, KE;Hawkins, PT;Sullivan, AM;O'Neill, C (2019) 'The Parkinson' disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P-3'. Journal of Cell Science, 132 [DOI] [Details]
(2019)'Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling'
Mazzocchi, M;Wyatt, SL;Mercatelli, D;Morari, M;Morales-Prieto, N;Collins, LM;Sullivan, AM;O'Keeffe, GW (2019) 'Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling'. Frontiers In Cell And Developmental Biology, 7 [DOI] [Details]
(2019)'Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson's disease: Evidence from rodent models'
Crowley EK;Nolan YM;Sullivan AM; (2019) 'Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson's disease: Evidence from rodent models'. Progress In Neurobiology, 172 [DOI] [Details]
(2019)'Trophic factors for Parkinson's disease: Where are we and where do we go from here?'
Paul, Gesine,Sullivan, Aideen M. (2019) 'Trophic factors for Parkinson's disease: Where are we and where do we go from here?'. European Journal of Neuroscience, 49 (4):440-452   [DOI] [Full Text] [Details]
(2018)'Exercise as therapy for Parkinson's?'
Crowley EK;Nolan YM;Sullivan AM; (2018) 'Exercise as therapy for Parkinson's?'. Aging, 10 (7) [DOI] [Details]
(2018)'Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease'
O'Keeffe, Gerard W.; Sullivan, Aideen M. (2018) 'Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease'. Parkinsonism & related disorders,   [DOI] [Full Text] [Details]
(2018)'Neuroprotective effects of voluntary running on cognitive dysfunction in an alpha-synuclein rat model of Parkinson's disease'
Crowley, EK;Nolan, YM;Sullivan, AM (2018) 'Neuroprotective effects of voluntary running on cognitive dysfunction in an alpha-synuclein rat model of Parkinson's disease'. Neurobiology of Aging, 65 :60-68 [DOI] [Details]
(2018)'Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson's disease'
Hegarty SV;Sullivan AM;O'Keeffe GW; (2018) 'Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson's disease'. Neuronal Signaling, 2 (1) [DOI] [Details]
(2017)'An Attitudinal Survey of Undergraduate Neuroscience Students Regarding Their Views on the Relevance of Lectures to their Education'
O'Keeffe GW;Sullivan AM;McCarthy MM; (2017) 'An Attitudinal Survey of Undergraduate Neuroscience Students Regarding Their Views on the Relevance of Lectures to their Education'. Journal of Undergraduate Neuroscience Education, 16 (1) [Details]
(2017)'Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease'
Hegarty SV;Sullivan AM;O'Keeffe GW; (2017) 'Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease'. Neural Regeneration Research, 12 (11) [DOI] [Details]
(2017)'Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation'
Shane V. Hegarty, Sean L. Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M. Sullivan & Gerard W. O’Keeffe (2017) 'Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation'. Scientific Reports, 7 (1)   [DOI] [Details]
(2017)'Romidepsin induces caspase-dependent cell death in human neuroblastoma cells'
Hegarty, SV;Togher, KL;O'Leary, E;Solger, F;Sullivan, AM;O'Keeffe, GW (2017) 'Romidepsin induces caspase-dependent cell death in human neuroblastoma cells'. Neuroscience Letters, 653 :12-18 [DOI] [Details]
(2017)'Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease'
O’Keeffe, G.W., Hegarty, S.V., Sullivan, A.M. (2017) 'Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease'. Neuronal Signaling, 1 (2)   [DOI] [Full Text] [Details]
(2017)'Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis'
Hegarty, S.V., Lee, D.J., O'Keeffe, G.W., Sullivan, A.M. (2017) 'Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis'. Parkinsonism & related disorders, 38 :19-25   [DOI] [Full Text] [Details]
(2017)'Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth'
Hegarty, S.V., Sullivan, A.M., O’Keeffe, G.W. (2017) 'Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth'. Neuroscience Letters, 643 :32-37   [DOI] [Full Text] [Details]
(2016)'Protocol for evaluation of neurotrophic strategies in Parkinson’s disease-related dopaminergic and sympathetic neurons in vitro'
Hegarty, Shane V.; Sullivan, Aideen M.; O’Keeffe, Gerard W. (2016) 'Protocol for evaluation of neurotrophic strategies in Parkinson’s disease-related dopaminergic and sympathetic neurons in vitro'. Journal of Biological Methods, 3 (3)   [DOI] [Full Text] [Details]
(2016)'The epigenome as a therapeutic target for Parkinson’s disease'
Hegarty, S.V., Sullivan, A.M., O'Keeffe, G.W. (2016) 'The epigenome as a therapeutic target for Parkinson’s disease'. Neural Regeneration Research, 11 (11):1735-1738   [DOI] [Full Text] [Details]
(2016)'Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation'
Straley ME;Van Oeffelen W;Theze S;Sullivan AM;O'Mahony SM;Cryan JF;O'Keeffe GW; (2016) 'Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation'. Brain Behav Immun, [DOI] [Details]
(2016)'A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease'
Hegarty S.V., O'Leary E., Solger F., Stanicka J., Sullivan A.M., O'Keeffe G.W. (2016) 'A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease'. Neurotoxicity Research, 30 (3):510-520   [DOI] [Full Text] [Details]
(2016)'Neurotrophic factor therapy for Parkinson's disease: past, present and future'
Sullivan AM;O'Keeffe GW; (2016) 'Neurotrophic factor therapy for Parkinson's disease: past, present and future'. Neural Regeneration Research, (11):205-207 [DOI] [Details]
(2016)'Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms'
Felice, V.D., Quigley, E.M., Sullivan, A.M., O'Keeffe, G.W., O'Mahony, S.M. (2016) 'Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms'. Parkinsonism & related disorders, [Details]
(2015)'Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism'
Collins LM;Dal Bo G;Calcagno M;Monzón-Sandoval J;Sullivan AM;Gutierrez H;Morari M;O'Keeffe GW; (2015) 'Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism'. Molecular Neurobiology, [DOI] [Details]
(2015)'Zeb2: A multifunctional regulator of nervous system development'
Hegarty S.V., Sullivan A.M., O'Keeffe G.W.; (2015) 'Zeb2: A multifunctional regulator of nervous system development'. Progress In Neurobiology, 132 :81-95   [DOI] [Details]
(2015)'Viral vector delivery of neurotrophic factors for Parkinson’s disease therapy'
Kelly MJ, O'Keeffe GW, Sullivan AM (2015) 'Viral vector delivery of neurotrophic factors for Parkinson’s disease therapy'. Expert Reviews in Molecular Medicine, (8):13-17 [DOI] [Details]
(2014)'Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease'
Hegarty, SV, O'Keeffe, GW*, Sullivan, AM.* (2014) 'Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease'. Neural Regeneration Research, 9 (19):1708-1711 [DOI] [Details]
(2015)'Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult'
Collins L.M., Adriaanse L.J., Theratile S.D., Hegarty S.V., Sullivan A.M., O'Keeffe G.W. (2015) 'Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult'. Molecular Neurobiology, 51 (3):1432-1442   [DOI] [Details]
(2014)'Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease'
Collins LM, Gavin AM, Walsh S, Sullivan AM, Wyatt SL, O'Keeffe GW, Nolan YM, Toulouse A (2014) 'Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease'. SpringerPlus, 3 [DOI] [Details]
(2014)'Canonical BMP-Smad Signalling Promotes Neurite Growth in Rat Midbrain Dopaminergic Neurons'
Hegarty, SV;Collins, LM;Gavin, AM;Roche, SL;Wyatt, SL;Sullivan, AM;O'Keeffe, GW (2014) 'Canonical BMP-Smad Signalling Promotes Neurite Growth in Rat Midbrain Dopaminergic Neurons'. Neuromolecular medicine, 16 :473-489 [DOI] [Details]
(2014)'Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease'
Walsh, S., Gavin, A., Wyatt, S., O'Connor, C., Keeshan, K., Nolan, Y.M., O'Keeffe, G.W., Sullivan, A.M. (2014) 'Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease'. The International journal of neuroscience, 125 (1):70-77 [DOI] [Details]
(2014)'Roles for the TGFβ Superfamily in the Development and Survival of Midbrain Dopaminergic Neurons'
Shane V. Hegarty, Aideen M. Sullivan, Gerard W. O’Keeffe (2014) 'Roles for the TGFβ Superfamily in the Development and Survival of Midbrain Dopaminergic Neurons'. Molecular Neurobiology, :559-573   [DOI] [Details]
(2014)'6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo'
Gavin AM, Walsh S, Wyatt SL, O'Keeffe GW*, Sullivan AM* (2014) '6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo'. Neuroscience Letters, (561):176-181 [Details]
(2014)'Ventral midbrain neural stem cells have delayed neurogenic potential in vitro'
Hegarty S.V., Spitere K., O'Keeffe G.W., Sullivan A.M. (2014) 'Ventral midbrain neural stem cells have delayed neurogenic potential in vitro'. Neuroscience Letters, 559 :193-198   [DOI] [Details]
(2013)'BMP-Smad 1/5/8 signalling in the development of the nervous system'
Hegarty S.V., O'Keeffe G.W., Sullivan A.M. (2013) 'BMP-Smad 1/5/8 signalling in the development of the nervous system'. Progress In Neurobiology, 109 :28-41   [DOI] [Details]
(2013)'BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons'
Hegarty S.V., Sullivan A.M., O'Keeffe G.W. (2013) 'BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons'. Molecular and Cellular Neuroscience, 56 :263-271   [DOI] [Details]
(2013)'Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development'
Hegarty, S.V., Sullivan, A.M., O'Keeffe, G.W. (2013) 'Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development'. Developmental Biology, 379 (2):123-138   [DOI] [Details]
(2013)'Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons'
Collins, L.M., O'Keeffe, G.W., Long-Smith, C.M., Wyatt, S.L., Sullivan, A.M., Toulouse, A., Nolan, Y.M. (2013) 'Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons'. NeuroMolecular Medicine, 15 (2):435-446 [DOI] [Details]
(2013)'Parkinson's Disease in the Nuclear Age of Neuroinflammation'
Nolan Y.M., Sullivan A.M., Toulouse A. (2013) 'Parkinson's Disease in the Nuclear Age of Neuroinflammation'. Trends In Molecular Medicine, 19 :187-196 [DOI] [Details]
(2012)'Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease'
Costello, D. J.,O'Keeffe, G. W.,Hurley, F. M.,Sullivan, A. M. (2012) 'Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease'. Journal of Cellular and Molecular Medicine, 16 (10):2451-2460   [DOI] [Details]
(2012)'A role for interleukin-1 beta in determining the lineage fate of embryonic rat hippocampal neural precursor cells'
Green, HF;Treacy, E;Keohane, AK;Sullivan, AM;O'Keeffe, GW;Nolan, YM (2012) 'A role for interleukin-1 beta in determining the lineage fate of embryonic rat hippocampal neural precursor cells'. Molecular and Cellular Neuroscience, 49 :311-321 [DOI] [Details]
(2012)'Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line'
Toulouse, A., Collins, G., Sullivan, A.M. (2012) 'Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line'. Neurotoxicity Research, 21 (3):256-265 [DOI] [Details]
(2011)'Neurotrophic factors for the treatment of Parkinson's disease'
Sullivan A.M., Toulouse A. (2011) 'Neurotrophic factors for the treatment of Parkinson's disease'. Cytokine & Growth Factor Reviews, (22):157-165 [DOI] [Full Text] [Details]
(2010)'Interleukin-1 beta contributes to dopaminergic neuronal death induced by lipopolysaccharide-stimulated rat glia in vitro'
Long-Smith, C.M., Collins, L., Toulouse, A., Sullivan, A.M., Nolan Y.M. (2010) 'Interleukin-1 beta contributes to dopaminergic neuronal death induced by lipopolysaccharide-stimulated rat glia in vitro'. Journal of Neuroimmunology, 226 (1-2):20-26 [DOI] [Details]
(2010)'Effects of GDF5 overexpression on embryonic rat dopaminergic neurones in vitro and in vivo'
O’Sullivan, D.B., Harrison, P.T., Sullivan, A.M. (2010) 'Effects of GDF5 overexpression on embryonic rat dopaminergic neurones in vitro and in vivo'. Journal of Neural Transmission, 117 (5):559-572 [DOI] [Details]
(2010)'Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1'
Keohane, A., Ryan, S., Maloney, E., Sullivan, A.M., Nolan Y.M. (2010) 'Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1'. Molecular and cellular neurosciences, 43 (1):127-135 [DOI] [Details]
(2009)'The influence of microglia on the pathogenesis of Parkinson's disease'
Long-Smith CM;Sullivan AM;Nolan YM; (2009) 'The influence of microglia on the pathogenesis of Parkinson's disease'. Progress In Neurobiology, 89 ((3)):277-287 [DOI] [Details]
(2008)'Treatment with phosphotidylglycerol-based nanoparticles prevents motor deficits induced by proteasome inhibition: implications for Parkinson's disease'
Fitzgerald, P., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y.M. (2008) 'Treatment with phosphotidylglycerol-based nanoparticles prevents motor deficits induced by proteasome inhibition: implications for Parkinson's disease'. Behavioural Brain Research, 195 (2):271-274 [DOI] [Details]
(2008)''Progress in Parkinson's disease - Where do we stand?''
Toulouse A., Sullivan A.M. (2008) ''Progress in Parkinson's disease - Where do we stand?''. Progress In Neurobiology, :376-392 [DOI] [Details]
(2008)'TAT-PAX6 protein transduction in neural progenitor cells: a novel approach for generation of dopaminergic neurones in vitro'
Spitere, K., Toulouse, A., O’Sullivan, D.B., Sullivan, A.M. (2008) 'TAT-PAX6 protein transduction in neural progenitor cells: a novel approach for generation of dopaminergic neurones in vitro'. Brain Research, 1208 :25-34 [DOI] [Details]
(2008)'Neuroprotective effects of novel phosphatidylglycerol-based phospholipids in the 6-hydroxydopamine model of Parkinson's disease'
Crotty, S., Fitzgerald, P., Tuohy, E., Harris, D.M., Fisher, A., Mandel, A., Bolton, A. E., Sullivan, A.M., Nolan, Y.M. (2008) 'Neuroprotective effects of novel phosphatidylglycerol-based phospholipids in the 6-hydroxydopamine model of Parkinson's disease'. The European Journal of Neuroscience, 27 (2):294-300 [DOI] [Details]
(2007)'Differential effects of GDF5 on the medial and lateral rat ventral mesencephalon'
Clayton, K.B. and Sullivan, A.M. (2007) 'Differential effects of GDF5 on the medial and lateral rat ventral mesencephalon'. Neuroscience Letters, 427 (3):132-137 [DOI] [Details]
(2007)'Expression of the cell surface markers mAb 2F7 and PSA-NCAM in the embryonic rat brain'
Shanley, D.K. and Sullivan, A.M. (2007) 'Expression of the cell surface markers mAb 2F7 and PSA-NCAM in the embryonic rat brain'. Neuroscience Letters, 424 (3):165-169 [DOI] [Details]
(2006)'Alterations in cellular phenotypes differentiating from embryonic rat brain neurosphere cultures by immunoselection of neuronal progenitors'
Shanley, D.K. and Sullivan, A.M. (2006) 'Alterations in cellular phenotypes differentiating from embryonic rat brain neurosphere cultures by immunoselection of neuronal progenitors'. Brain Research, 1067 (1):85-94 [DOI] [Details]
(2005)'The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment'
Sullivan, A.M., O'Keeffe, G.W. (2005) 'The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment'. Journal of Anatomy, 207 (3):219-226 [DOI] [Details]
(2005)'Differential effects of growth/differentiation factor 5 and glial cell line-derived neurotrophic factor on dopaminergic neurons and astroglia in cultures of embryonic rat midbrain'
Wood, T.K., McDermott, K.W., Sullivan, A.M. (2005) 'Differential effects of growth/differentiation factor 5 and glial cell line-derived neurotrophic factor on dopaminergic neurons and astroglia in cultures of embryonic rat midbrain'. Journal of Neuroscience Research, 80 (6):759-766 [DOI] [Details]
(2005)'Donor age affects differentiation of rat ventral mesencephalic stem cells'
O' Keeffe, G.W., Sullivan, A.M. (2005) 'Donor age affects differentiation of rat ventral mesencephalic stem cells'. Neuroscience Letters, 375 (2):101-106 [DOI] [Details]
(2004)'Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro'
O'Keeffe, G.W., Dockery, P., Sullivan, A.M. (2004) 'Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro'. Journal of Neurocytology, 33 (5):479-488 [DOI] [Details]
(2004)'Expression of growth differentiation factor-5 in the developing and adult rat brain'
O'Keeffe, G.W., Hanke, M., Pohl, J., Sullivan, A.M. (2004) 'Expression of growth differentiation factor-5 in the developing and adult rat brain'. Brain research. Developmental brain research, 151 (1-2):199-202 [DOI] [Details]
(2004)'Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo'
Hanke, M., Farkas, L., Jakob, M., Ries, R., Pohl, J., Sullivan, A.M. (2004) 'Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo'. Neuroscience, 124 (4):757-766 [DOI] [Details]
(2004)'Neuroprotective effects of delayed administration of growth/ differentiation factor-5 in the partial lesion model of Parkinson's disease'
Hurley, F. M.,Costello, D. J.,Sullivan, A. M. (2004) 'Neuroprotective effects of delayed administration of growth/ differentiation factor-5 in the partial lesion model of Parkinson's disease'. Experimental Neurology, 185 (2):281-289   [DOI] [Details]
(2003)'Viability of dopaminergic neurones is influenced by serum and astroglial cells in vitro'
Wood, TK;Sullivan, AM;McDermott, KW (2003) 'Viability of dopaminergic neurones is influenced by serum and astroglial cells in vitro'. Journal of Neurocytology, 32 :97-103 [Details]
(2003)'Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-beta superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning'
Strelau, J., Sullivan, A., Bottner, M., Lingor, P., Falkenstein, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Krieglstein, K., Unsicker, K. (2003) 'Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-beta superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning'. Journal of neural transmission. Supplementum, (65):197-203   [Details]
(2002)'Growth Differentiation Factor-5 (GDF-5) expression in the rat brain: developmental regulator, potential treatment?'
O'keeffe G;Costello Dj;Hanke M;Sullivan A; (2002) 'Growth Differentiation Factor-5 (GDF-5) expression in the rat brain: developmental regulator, potential treatment?'. Journal of Anatomy, 201 (5) [Details]
(2002)'TGF-beta and the regulation of neuron survival and death'
Krieglstein, K;Strelau, J;Schober, A;Sullivan, A;Unsicker, K (2002) 'TGF-beta and the regulation of neuron survival and death'. Journal of physiology, Paris, 96 :25-30 [Details]
(2000)'GDF-15/MIC-1 a novel member of the TGF-beta superfamily'
Strelau, J., Bottner, M., Lingor, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Sullivan, A., Schober, A., Krieglstein, K., Unsicker, K. (2000) 'GDF-15/MIC-1 a novel member of the TGF-beta superfamily'. Journal of neural transmission. Supplementum, (60):273-276 [Details]
(2000)'Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo'
Strelau, J., Sullivan, A., Bottner, M., Lingor, P., Falkenstein, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Krieglstein, K., Unsicker, K. (2000) 'Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo'. The Journal of Neuroscience, 20 (23):8597-8603 [Details]
(1999)'Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration'
Sullivan, AM;Opacka-Juffry, J;Pohl, J;Blunt, SB (1999) 'Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration'. Brain Research, 818 :176-179 [Details]
(1998)'Growth/differentiation factor 5 and glial cell line-derived neurotrpphic factor enhance survival and function of dopaminergic grafts in a rat model of Parkinson's disease'
Sullivan A.;Pohl J.;Blunt S. (1998) 'Growth/differentiation factor 5 and glial cell line-derived neurotrpphic factor enhance survival and function of dopaminergic grafts in a rat model of Parkinson's disease'. The European Journal of Neuroscience, 10 (12):3681-3688 [DOI] [Details]
(1998)'Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo'
Sullivan, A.M. Opacka-Juffry, J., Blunt, S.B. (1998) 'Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo'. The European Journal of Neuroscience, 10 (1):57-63 [Details]
(1997)'Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson's disease'
Sullivan, A.M. Opacka Juffry, J., Hotten, G., Pohl, J., Blunt, S.B. (1997) 'Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson's disease'. Neuroscience Letters, 233 (2-3):73-76 [Details]
(1996)'Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum. Short communication'
Opacka-Juffry, J., Ashworth, S., Sullivan, A.M. Banati, R.B., Blunt, S.B. (1996) 'Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum. Short communication'. Journal of Neural Transmission, 103 (12):1429-1434 [DOI] [Details]
(1996)'Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors'
Sullivan, A.M. Reynolds, D.S., Thomas, K.L., Morton, A.J. (1996) 'Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors'. Neuroreport, 8 (1):211-216 [Details]
(1996)'Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum'
Sullivan, A.M. and Morton, A.J. (1996) 'Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum'. Journal of Neurochemistry, 67 :1409-1418 [DOI] [Details]

Reviews

 YearPublication
(2020)The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease.
Goulding S.;Sullivan A.;O'Keeffe G.;Collins L. (2020) The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease. Reviews [DOI] [Details]
(2019)Trophic factors for Parkinson's disease: Where are we and where do we go from here?.
Paul, G;Sullivan, AM (2019) Trophic factors for Parkinson's disease: Where are we and where do we go from here?. HOBOKEN: Reviews [DOI] [Details]
(2019)Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson's disease: Evidence from rodent models.
Crowley, EK;Nolan, YM;Sullivan, AM (2019) Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson's disease: Evidence from rodent models. OXFORD: Reviews [DOI] [Details]
(2018)Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease.
O'Keeffe, GW;Sullivan, AM (2018) Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease. OXFORD: Reviews [DOI] [Details]
(2017)Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.
Hegarty, SV;Lee, DJ;O'Keeffe, GW;Sullivan, AM (2017) Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis. OXFORD: Reviews [DOI] [Details]
(2016)The Epigenome as a therapeutic target for Parkinson's disease.
Hegarty, SV;Sullivan, AM;O'Keeffe, GW (2016) The Epigenome as a therapeutic target for Parkinson's disease. MUMBAI: Reviews [DOI] [Details]
(2015)Viral vector delivery of neurotrophic factors for Parkinson's disease therapy.
Kelly, MJ;O'Keeffe, GW;Sullivan, AM (2015) Viral vector delivery of neurotrophic factors for Parkinson's disease therapy. NEW YORK: Reviews [DOI] [Details]
(2015)Zeb2: A multifunctional regulator of nervous system development.
Hegarty, SV;Sullivan, AM;O'Keeffe, GW (2015) Zeb2: A multifunctional regulator of nervous system development. OXFORD: Reviews [DOI] [Details]
(2014)Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.
Hegarty, SV;O'Keeffe, GW;Sullivan, AM (2014) Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease. SHENYANG: Reviews [DOI] [Details]
(2011)Neurotrophic factors for the treatment of Parkinson's disease.
Sullivan, AM;Toulouse, A (2011) Neurotrophic factors for the treatment of Parkinson's disease. OXFORD: Reviews [DOI] [Details]
(2009)The influence of microglia on the pathogenesis of Parkinson's disease.
Long-Smith, CM;Sullivan, AM;Nolan, YM (2009) The influence of microglia on the pathogenesis of Parkinson's disease. OXFORD: Reviews [DOI] [Details]
(2008)Progress in Parkinson's disease - Where do we stand?.
Toulouse, A;Sullivan, AM (2008) Progress in Parkinson's disease - Where do we stand?. OXFORD: Reviews [DOI] [Details]
(2005)The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: Relevance to Parkinson's disease treatment.
Sullivan A.;O'Keeffe G. (2005) The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: Relevance to Parkinson's disease treatment. Reviews [DOI] [Details]

Conference Publications

 YearPublication
(2017)AD/PDTM 2017, the 13th​ International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders
O’Donovan SM, Crowley E, Browne J, O’Sullivan O, O’Leary OF, Timmons S, Nolan YM, O’Toole PW, Clarke DJ, Hyland NP, Joyce SA, Sullivan AM, O’Neill C (2017) The brain ↔gut axis in Parkinson’s disease: defining gut pathology and the impact of exercise in the rAAV-­α-­synuclein rat model of PD AD/PDTM 2017, the 13th​ International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders , 29-MAR-17 - 02-APR-17 [Details]
(2017)Neurogastroenterology and Motiltiy
S O'Donovan, EK Crowley, J Browne, O O'Sullivan, OF O'Leary, S Timmons, YM Nolan, PW O'Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O'Neill (2017) Investigation of the brain gut axis in the rAAV-alpha-synuclein PD model: Reveals enteric nervous system pathology and alterations in the gut microbiome Neurogastroenterology and Motiltiy , pp.33-34   [DOI] [Details]
(2017)NEUROGASTROENTEROLOGY AND MOTILITY
S O'Donovan, EK Crowley, J Browne, O O'Sullivan, OF O'Leary, S Timmons, YM Nolan, PW O'Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O'Neill (2017) Investigation of the brain gut axis in the rAAV-alpha-synuclein PD model: Reveals enteric nervous system pathology and alterations in the gut microbiome NEUROGASTROENTEROLOGY AND MOTILITY [Details]
(2017)Neuroscience Ireland
SM O’Donovan, EK Crowley, J Browne, O O’Sullivan, OF O’Leary, S Timmons, YM Nolan, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2017) Investigation of the brain ↔ gut axis in the raav2/6-alpha-synuclein pd model: alterations in enteric nervous system pathology and the gut microbiome Neuroscience Ireland NUI Galway, , 28-AUG-17 - 29-AUG-17 [Details]
(2005)JOURNAL OF ANATOMY
Sullivan, AM;O'Keeffe, GW (2005) The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment JOURNAL OF ANATOMY , pp.219-226 [Details]
(2003)JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
Strelau, J;Schober, A;Sullivan, A;Schilling, L;Unsicker, K (2003) Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-beta superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT , pp.197-203 [Details]
(2003)Journal of Neural Transmission, Supplement
Strelau J.;Schober A.;Sullivan A.;Schilling L.;Unsicker E. (2003) Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-ß superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning Journal of Neural Transmission, Supplement , pp.197-203 [Details]
(2002)Journal of Physiology Paris
Krieglstein K.;Strelau J.;Schober A.;Sullivan A.;Unsicker K. (2002) TGF-ß and the regulation of neuron survival and death Journal of Physiology Paris , pp.25-30 [DOI] [Details]
(2016)Young Neuroscientists Symposium 2016
Grant Hanni M., Sullivan A.M., Toulouse A. (2016) SHSY-5Y cell model:differentiation and neuroprotection Young Neuroscientists Symposium 2016 Trinity College, Dublin. Ireland, , 01-SEP-16 [Details]
(2016)New Horizons in Translational Research 2016
Grant Hanni M., Sullivan A.M., Toulouse A. (2016) SHSY-5Y cell model:differentiation and neuroprotection New Horizons in Translational Research 2016 University College Cork, Cork, Ireland, , 08-DEC-16 [Details]
(2016)New Horizons in Medical Research, December 8th 2016, University College Cork
SM O’Donovan, E Dolan, OF O’Leary, S Timmons, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2016) The brain ↔ gut axis in Parkinson’s disease (PD): Central nervous system administration of rAAV-α-synuclein altered gut pathophysiology and increased gut inflammation in the rAAV-α-synuclein rat model of PD New Horizons in Medical Research, December 8th 2016, University College Cork [Details]
(2016)APC Microbiome Institute Symposium
SM O’Donovan, E Dolan, OF O’Leary, S Timmons, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2016) The brain ↔ gut axis in Parkinson’s disease: defining gut pathophysiology in the rAAV-α-synuclein rat model of PD APC Microbiome Institute Symposium [Details]
(2016)2016 Biochemical Society Meeting: Inflammatory diseases - mechanisms and clinical perspectives, 3—4 November 2016, Maynooth University, Ireland
SM O’Donovan, E Dolan, OF O’Leary, S Timmons, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2016) The brain ↔ gut axis in Parkinson’s disease (PD): Central nervous system administration of rAAV-α-synuclein altered gut pathophysiology and increased gut inflammation in the rAAV-α-synuclein rat model of PD 2016 Biochemical Society Meeting: Inflammatory diseases - mechanisms and clinical perspectives, 3—4 November 2016, Maynooth University, Ireland [Details]
(2016)29th ECNP Congress of Applied & Translational Neuroscience
Hegarty S.V., O'Leary E., Solger F., Wyatt S.L., Sullivan A.M., O'Keeffe G.W.. (2016) S.12.01. Novel neurotrophic strategy: interrogation of intracellular molecules regulating growth of midbrain dopaminergic neurons 29th ECNP Congress of Applied & Translational Neuroscience 26 (S2), , pp.S127-S127 [DOI] [Details]
(2014)RAMI Section of Biomedical Sciences Annual Meeting 2014
Hegarty S.V., Collins L.M., Gavin A.M., Roche S.L., Wyatt S.L., Sullivan A.M., O'Keeffe G.W. (2014) Canonical BMP-SMAD Signalling Promotes Neurite Growth in Embryonic Rat Midbrain Dopaminergic Neurons RAMI Section of Biomedical Sciences Annual Meeting 2014 [DOI] [Details]
(2012)Neuroscience Ireland Conference, Dublin
Collins, L.M., O'Keeffe, G.W., Long-Smith, C.M., Sullivan, A.M., Toulouse, A., Nolan, Y.M. (2012) Mitogen-activated protein kinase phosphatase (MKP)-1 promotes the morphological development of midbrain dopaminergic neurons. Poster Prize . In: Irish J. Med. Sci eds. Neuroscience Ireland Conference, Dublin [Details]
(2012)Neuroscience Ireland Conference, Dublin
Hegarty, S.V., Sullivan, A.M., O'Keeffe G.W. (2012) GDF5 and BMP2 have differential effects on rat ventral mesencephalic neural stem cells, depending on their developmental stage . In: Irish J. Med. Sci eds. Neuroscience Ireland Conference, Dublin [Details]
(2012)Neuroscience Ireland Conference, Dublin
Walsh, S., Keeshan, K., Nolan, Y.M., O'Keeffe, G.W., Sullivan, A.M. (2012) The effect of IL-1R1 shRNA intra-nigral administration in a hemi-parkinsonian 6-hydroxydopamine rat model . In: Irish J. Med. Sci eds. Neuroscience Ireland Conference, Dublin [Details]
(2011)IBRO World Congress of Neuroscience, Florence, Italy
Gavin, A., Wyatt, S., Sullivan, A.M., O'Keeffe, G.W. (2011) Analysis of the temporal expression and neurotrophic effects of GDNF in the developing rat nigrostriatal system IBRO World Congress of Neuroscience, Florence, Italy [Details]
(2011)Neuroscience Ireland Conference, Maynooth
Hegarty, S.V., Sullivan, A.M., O'Keeffe G.W. (2011) The Development of Rat Ventral Mesencephalic Neural Stem Cells in vitro . In: Irish J. Med. Sci eds. Neuroscience Ireland Conference, Maynooth [Details]
(2010)Neuroscience Ireland Conference, Dublin
Crampton, S.J., Sullivan, A.M., O'Keeffe, G.W. (2010) Stereological analysis of the brachypod mouse brain . In: Irish J. Med. Sci eds. Neuroscience Ireland Conference, Dublin [Details]
(2010)Neuroscience Ireland Conference, Dublin
Gavin, A., Wyatt, S., Sullivan, A.M., O'Keeffe, G.W. (2010) Spatiotemporal analysis of GDF-5 expression in the developing rat nigrostriatal system . In: Irish J. Med. Sci eds. Neuroscience Ireland Conference, Dublin [Details]
(2009)International Conference on Alzheimer's and Parkinson's Diseases
Toulouse A., Collins G.C., Sullivan, A.M. (2009) The neurotrophic effects of Growth/Differentiation Factor 5 in a neuronal cell line International Conference on Alzheimer's and Parkinson's Diseases Prague, Czech Republic, , 11-MAR-09 - 15-MAR-09 [Details]
(2006)Neuroscience Ireland Meeting, Cork
Crotty, S., Fitzgerald, P., Harris, D.M., Fisher, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y.M. (2006) Neuroprotective evidence of a novel phospholipid-based drug formulation in a rat model of Parkinson’s disease . In: Irish J Med Sci eds. Neuroscience Ireland Meeting, Cork Cork, [Details]
(2005)Society for Neuroscience meeting, Washington, USA
Shanley, D.K., Sullivan, A.M. (2005) Identification, isolation and expansion of neuronal precursor cells: A step-by-step process involving microarray analysis, immunoselection and neurosphere culture . In: Soc. Neurosci. Abs. 708.2 eds. Society for Neuroscience meeting, Washington, USA [Details]
(2005)VII European Meeting on Glial Cell Function in Health and Disease. Amsterdam
Barrett, R.J., McDermott, K.W., Sullivan, A.M. (2005) The effects of astroglial and neurotrophic interactions on the survival of dopaminergic neurons in vitro VII European Meeting on Glial Cell Function in Health and Disease. Amsterdam [Details]
(2005)Royal Academy of Medicine in Ireland Biomedical Section Meeting, Dublin
Harris, D.M., Fisher, A., Harkin, A.J., Bolton, A.E., Sullivan, A.M., Nolan Y.M. (2005) Novel phospholipid-based drug formulation prevents degeneration of dopaminergic neurons from substantia nigra in a rat model of Parkinson’s disease . In: Irish J Med Sci 174 eds. Royal Academy of Medicine in Ireland Biomedical Section Meeting, Dublin [Details]
(2005)International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany
Toulouse, A., Sullivan, A.M. (2005) Investigation of the neurotrophic effects of growth/differentiation factor 5 in an in vitro model of Parkinson’s disease. Prize for Best Poster . In: Parkinsonism and Related Disorders, Vol. 11 eds. International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany [Details]
(2005)Society for Neuroscience meeting, Washington, USA
Spitere, K., Toulouse, A., Sullivan, A.M. (2005) T.A.T-Pax6 protein transduction in neural progenitor cells: A novel strategy for dopaminergic neuron generation . In: Soc. Neurosci. Abs. 142.2 eds. Society for Neuroscience meeting, Washington, USA [Details]
(2005)16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2005) Lentiviral-mediated delivery of growth/differentiation factor-5 attenuates parkinsonian symptoms in the rat . In: Parkinsonism & Related Disorders Volume 11, Supplement 2 eds. 16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany Berlin, [Details]
(2004)4th Forum of European Neuroscience Lisbon Portugal
Shanley, D.K., Sullivan, A.M. (2004) Cellular differentiation in neurosphere cultures of embryonic day 14 rat cortical and striatal tissue . In: FENS Abstr. Vol.2, A107.15 eds. 4th Forum of European Neuroscience Lisbon Portugal [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Barrett, R.J., McDermott, K.W., Sullivan, A.M. (2004) The effects of GDNF, GDF-5 and astroglia on the survival of rat mesencephalic dopaminergic neurons in vitro . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
O’Sullivan, D.B., Harrison, P.T., Sullivan, A.M. (2004) Rat ventral mesencephalic cultures transfected with a plasmid expressing growth/differentiation factor 5 exhibit improved dopaminergic neuronal survival . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Toulouse, A., Sullivan, A.M. (2004) Investigation of the effects of the neurotrophin GDF-5 on the growth and differentiation of SH-SY5Y cells . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)15th Biennial Meeting of the International Society for Developmental Neuroscience, Edinburgh, Scotland, United Kingdom
Spitere, K., Sullivan, A.M. (2004) A comparison of genetic cascades involved in induction of dopaminergic neuronal fate in the developing rodent ventral mesencephalon, embryonic stem cells and neural stem cells . In: Int. J. Dev. Neurosci., Vol. 22 eds. 15th Biennial Meeting of the International Society for Developmental Neuroscience, Edinburgh, Scotland, United Kingdom , pp.601-728 [Details]
(2004)4th Forum of European Neuroscience Lisbon Portugal
Clayton, K.B., McDonnell, E., Sullivan, A.M. (2004) Growth/differentiation factor 5 (GDF5) expression in the developing rat brain . In: FENS Abstr. Vol.2, A0732.6 eds. 4th Forum of European Neuroscience Lisbon Portugal [Details]
(2004)4th Forum of European Neuroscience Lisbon Portugal. July 2004
Barrett, R.J., McDermott, K.W., Sullivan, A.M. (2004) The roles of GDNF, GDF-5 and astroglia on the survival of mesencephalic dopaminergic neurons in vitro . In: FENS Abstr. Vol.2, A019.4 eds. 4th Forum of European Neuroscience Lisbon Portugal. July 2004 [Details]
(2004)4th Forum of European Neuroscience Lisbon Portugal
O’Sullivan, D.B., Sullivan, A.M., Harrison, P.T. (2004) Establishment of neurotrophin-expressing dopaminergic cells for transplantation in Parkinson’s disease . In: FENS Abstr. Vol.2, A053.17 eds. 4th Forum of European Neuroscience Lisbon Portugal [Details]
(2004)4th Forum of European Neuroscience Lisbon Portugal
Toulouse, A., Sullivan, A.M. (2004) Investigation of the role of GDF-5 in the growth and differentiation of human neuroblastoma cells . In: FENS Abstr. Vol.2, A196.18 eds. 4th Forum of European Neuroscience Lisbon Portugal [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Harty, M., Sullivan, A.M., McDermott, K.W. (2004) Astroglial diversity in rat dopaminergic nuclei: implications for selective neuronal degeneration and Parkinson’s disease . In: J. Anat. 205 (6) 529 eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Shanley, D.K., Sullivan, A.M. (2004) In vitro expansion and differentiation of neurospheres derived from embryonic day 14 rat cortical and striatal tissue . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Sullivan, A.M. (2004) Effects of growth/differentiation factor 5 (GDF5) on the induction and survival of midbrain dopaminergic neurons . In: J. Anat. 205 (6) 524 eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Clayton, K.B., McDonnell, E., Sullivan, A.M. (2004) Investigation of the spatio-temporal pattern of expression of the neurotrophin growth/differentiation factor 5 in the developing and adult rat brain . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Spitere, K., Sullivan, A.M. (2004) Characterisation of the cellular populations and dopaminergic gene cascade in rat ventral mesencephalic neural stem cell cultures . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Society for Neuroscience Meeting, San Diego, USA
Toulouse, A., O’Keeffe, G.W., Sullivan, A.M. (2004) Dopaminergic induction from expanded rat ventral mesencephalic progenitor cells by GDF5 and BMP2 requires signalling through BMPR1b . In: Soc. Neurosci. Abs. 677.11 eds. Society for Neuroscience Meeting, San Diego, USA [Details]
(2004)Society for Neuroscience Meeting, San Diego, USA
Toulouse, A., Sullivan, A.M. (2004) Roles of type 1 BMP receptors in the induction of midbrain dopaminergic neurones by GDF5 . In: Soc. Neurosci. Abs. 677.11 eds. Society for Neuroscience Meeting, San Diego, USA [Details]
(2004)15th Biennial Meeting of the International Society for Developmental Neuroscience, Edinburgh, Scotland, United Kingdom
Shanley, D.K., Sullivan, A.M. (2004) Expression and characterisation of the neuronal cell surface markers 2F7 and E-NCA.M. within the developing rat brain: An in vitro analysis of the development of neuronal restricted precursors . In: Int. J. Dev. Neurosci., Vol. 22 eds. 15th Biennial Meeting of the International Society for Developmental Neuroscience, Edinburgh, Scotland, United Kingdom , pp.601-728 [Details]
(2004)4th Forum of European Neuroscience Lisbon Portugal
Spitere, K., Sullivan, A.M. (2004) Cellular composition and gene expression in embryonic rat ventral mesencephalic neurosphere cultures . In: FENS Abstr. Vol.2, A107.16 eds. 4th Forum of European Neuroscience Lisbon Portugal [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Crotty, S.G., Sullivan, A.M., So K.F., Chau, W.K.D., Sharma, A.K., Dockery, P. (2004) Cytoskeletal reorganization in neurons: a stereological approach . In: J. Anat. 205 (60) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2003)Anatomical Society of Great Britain and Ireland Winter Meeting. Egham, Surrey, United Kingdom
O’Keeffe, G.W., Hanke, M., Sullivan, A.M. (2003) Growth/differentiation factor-5, a growth factor with potential for therapeutic approaches to Parkinson’s disease. Oral presentation prize . In: J. Anat. Vol. 203 eds. Anatomical Society of Great Britain and Ireland Winter Meeting. Egham, Surrey, United Kingdom [Details]
(2003)International Conference on Alzheimer’s and Parkinson’s Diseases, Seville, Spain
Costello, D.J., O'Keeffe, G.W., Hurley, FM, Hanke, M, Sullivan, A.M. (2003) A growth/differentiation factor 5-producing CHO cell line enhances the survival and function of dopaminergic grafts in a 6-OHDA rodent model of Parkinsonism International Conference on Alzheimer’s and Parkinson’s Diseases, Seville, Spain [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland
Costello, D.J., O'Keeffe, G.W., Hurley, F.M., Hanke, M., Sullivan, A.M. (2002) Neuroprotective effects of growth / differentiation factor-5 in a rat model of Parkinson's disease . In: J Anat. Vol. 200 (2) eds. Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland Dublin, Ireland, [Details]
(2002)FENS Forum of Neuroscience, Paris. France
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2002) In vitro analysis of the effects of the neurotrophins GDF-5, GDNF and glial cells on dopaminergic neurone survival in the ventral mesencephalon . In: FENS Abs eds. FENS Forum of Neuroscience, Paris. France Paris. France, [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer meeting 2002 Dundee Scotland
O’Keeffe, G.W., Costello, D.J., Sullivan, A.M. (2002) Growth/differentiation factor-5: developmental regulator, potential treatment . In: J. Anat eds. Anatomical Society of Great Britain and Ireland Summer meeting 2002 Dundee Scotland Dundee, Scotland, [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin
O’Keeffe, G.W., Sullivan, A.M. (2002) Investigation of the expression of growth/differentiation factor-5 in the developing rat brain. Poster prize . In: J. Anat. 200 (2) 212 eds. Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin Dublin, [Details]
(2002)FENS Forum of Neuroscience, Paris. France
Sullivan, A.M., Hurley FM, Costello D.J. (2002) Restorative effects of growth/differentiation factor-5 (GDF-5) in a rat model of Parkinson's disease . In: FENS eds. FENS Forum of Neuroscience, Paris. France Paris. France, [Details]
(2002)Glia
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2002) In vitro analysis of astroglial-neuronal interactions in the ventral mesencephlon . In: Glia eds. Glia [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2002) Antimitotic treatment to achieve neurone enriched ventral mesencephalic cultures for studies of neurotrophins . In: J Anat. 200 (2) eds. Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland Dublin, Ireland, [Details]
(2002)In vitro analysis of astroglial-neuronal interactions in the ventral mesencephalon
Wood, TK,Sullivan, AM,McDermott, KW (2002) GLIA In vitro analysis of astroglial-neuronal interactions in the ventral mesencephalon , pp.37-37 [Details]
(2002)Biochem. Soc
O’Keeffe, G.W., Crotty, S.G., Dockery, P., Sullivan, A.M. (2002) The type of cell death induced by MPP+ is both concentration-and time-dependent . In: Biochem. Soc. Trans. 29 (5), 117 eds. Biochem. Soc [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland
Costello, D.J., Hurley, F.M., Sullivan, A.M. (2002) Growth/differentiation factor-5 enhances graft survival and reverses motor asymmetry in a rat model of Parkinson's disease . In: J Anat. Vol. 200 (2) eds. Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland Dublin, Ireland, [Details]
(2000)FENS Forum of Neuroscience, Brighton, UK
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2000) Glia-depleted mesencephalic cultures for investigation of the action of the dopaminergic neurotrophin GDF-5 . In: Eur. J. Neurosci. 12, Suppl. 11 eds. FENS Forum of Neuroscience, Brighton, UK Brighton, UK, [Details]
(1997)Society for Neuroscience meeting, New Orleans, USA
Sullivan, A.M., Opacka-Juffry J, Hotten G, Pohl J, Blunt S.B. (1997) Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson’s disease . In: Soc. Neurosci. Abs. 23, p622 eds. Society for Neuroscience meeting, New Orleans, USA New Orleans, USA, [Details]
(1997)Movement Disorders
Sullivan, A.M., Opacka-Juffry, J., Blunt, S.B. (1997) Long-term protection of the rat nigrostriatal dopaminergic system by GDNF in vivo . In: Movement Disorders Vol 12, p157 eds. Movement Disorders [Details]
(1997)British Neuroscience Association meeting
Sullivan, A.M., Opacka-Juffry, J., Blunt, S.B. (1997) Long-term protection of the rat nigrostriatal dopaminergic system by GDNF in vivo . In: Brain Res. Assoc. Abs. Vol. 14 eds. British Neuroscience Association meeting [Details]
(1995)British Neuroscience Association meeting
Sullivan, A.M., Morton A.J. (1995) Induction of Fos protein in organotypic cultures of rat cerebellum by endothelins . In: Brain Res. Assoc. Abs. Vol. 12 eds. British Neuroscience Association meeting [Details]
(1994)British Neuroscience Association meeting
Sullivan, A.M., Morton A.J. (1994) Glutamate-induced expression of Fos protein by granule cells in organotypic cultures of rat cerebellum . In: Brain Res. Assoc. Abs. Vol. 11 eds. British Neuroscience Association meeting [Details]
(1994)British Neuroscience Association meeting
Sullivan, A.M., Morton A.J. (1994) Is the development of Purkinje cell dendrites in organotypic culture of rat cerebellum dependent on granule cells? . In: Brain Res. Assoc. Abs. Vol. 11 eds. British Neuroscience Association meeting [Details]

Abstract

 YearPublication
(2020)Sleep and Depression in Parkinson's Disease: Investigating the Relationship between Sleep and Depression Using a Combination of Subjective and Objective Sleep Assessment Methods.
Mulryan, P;Affonso, S;Sullivan, A (2020) Sleep and Depression in Parkinson's Disease: Investigating the Relationship between Sleep and Depression Using a Combination of Subjective and Objective Sleep Assessment Methods. HOBOKEN: Abstract [Details]
(2017)Investigation of the brain gut axis in the rAAV-alpha-synuclein PD model: Reveals enteric nervous system pathology and alterations in the gut microbiome.
O'Donovan, S;Crowley, EK;Browne, J;O'Sullivan, O;O'Leary, OF;Timmons, S;Nolan, YM;O'Toole, PW;Clarke, DJ;Hyland, NP;Joyce, SA;Sullivan, AM;O'Neill, C (2017) Investigation of the brain gut axis in the rAAV-alpha-synuclein PD model: Reveals enteric nervous system pathology and alterations in the gut microbiome. HOBOKEN: Abstract [Details]
(2016)Novel neurotrophic strategy: interrogation of intracellular molecules regulating growth of midbrain dopaminergic neurons.
Hegarty, S;O'Leary, E;Wyatt, S;Sullivan, A;O'Keeffe, G (2016) Novel neurotrophic strategy: interrogation of intracellular molecules regulating growth of midbrain dopaminergic neurons. AMSTERDAM: Abstract [Details]
(2016)Novel neurotrophic strategy: interrogation of intracellular molecules regulating growth of midbrain dopaminergic neurons.
Hegarty, SV;O'Leary, E;Solger, F;Wyatt, SL;Sullivan, AM;O'Keeffe, GW (2016) Novel neurotrophic strategy: interrogation of intracellular molecules regulating growth of midbrain dopaminergic neurons. AMSTERDAM: Abstract [Details]
(2016)Canonical BMP-SMAD Signalling Promotes Neurite Growth in Embryonic Rat Midbrain Dopaminergic Neurons.
Hegarty, SV;Collins, LM;Gavin, AM;Roche, SL;Wyatt, SL;Sullivan, AM;O'Keeffe, GW (2016) Canonical BMP-SMAD Signalling Promotes Neurite Growth in Embryonic Rat Midbrain Dopaminergic Neurons. LONDON: Abstract [Details]
(2011)STEREOLOGICAL ANALYSIS OF THE BRACHYPOD MOUSE BRAIN.
Crampton, S;Sullivan, A;O'Keeffe, G (2011) STEREOLOGICAL ANALYSIS OF THE BRACHYPOD MOUSE BRAIN. LONDON: Abstract [Details]
(2011)SPATIOTEMPORAL ANALYSIS OF GDF-5 EXPRESSION IN THE DEVELOPING RAT NIGROSTRIATAL SYSTEM.
Gavin, AM;Wyatt, S;Sullivan, AM;O'Keeffe, GW (2011) SPATIOTEMPORAL ANALYSIS OF GDF-5 EXPRESSION IN THE DEVELOPING RAT NIGROSTRIATAL SYSTEM. LONDON: Abstract [Details]
(2010)EFFECTS OF TUMOUR NECROSIS FACTOR-A ON PROLIFERATION AND DIFFERENTATION OF EMBRYONIC RAT HIPPOCAMPAL NEURAL PRECURSOR CELLS: A ROLE FOR HES1.
Ryan, S;Keohane, A;Maloney, E;Sullivan, AM;Nolan, Y (2010) EFFECTS OF TUMOUR NECROSIS FACTOR-A ON PROLIFERATION AND DIFFERENTATION OF EMBRYONIC RAT HIPPOCAMPAL NEURAL PRECURSOR CELLS: A ROLE FOR HES1. LONDON: Abstract [Details]
(2008)IL-1 beta released from LPS-stimulated cortical glial cultures exacerbates 6-OHDA-induced dopaminergic neuronal cell death in vitro.
Long, CM;Sullivan, AM;Nolan, Y (2008) IL-1 beta released from LPS-stimulated cortical glial cultures exacerbates 6-OHDA-induced dopaminergic neuronal cell death in vitro. AMSTERDAM: Abstract [Details]
(2008)The effects of the pro-intlanumatory cytokine TNF-alpha on the proliferation and differentiation of embryonic rat hippocampal neural precursor cells.
Keohanc, A;Sullivan, AM;Nolan, Y (2008) The effects of the pro-intlanumatory cytokine TNF-alpha on the proliferation and differentiation of embryonic rat hippocampal neural precursor cells. AMSTERDAM: Abstract [Details]
(2002)In vitro analysis of astroglial-neuronal interactions in the ventral mesencephalon.
Wood, TK;Sullivan, AM;McDermott, KW (2002) In vitro analysis of astroglial-neuronal interactions in the ventral mesencephalon. NEW YORK: Abstract [Details]

Editorship

 YearPublication
(2021)Neuronal Signaling: A reflection on the Biochemical Society's newest journal and an exciting outlook on its next steps.
Sullivan AM;Stanford SC; (2021) Neuronal Signaling: A reflection on the Biochemical Society's newest journal and an exciting outlook on its next steps. Editorship [DOI] [Details]
(2020)Editorial: The Role of Stem Cells, Epigenetics and MicroRNAs in Parkinson's Disease.
Hegarty S.V.;Green H.F.;Niclis J.;O'Keeffe G.W.;Sullivan A.M. (2020) Editorial: The Role of Stem Cells, Epigenetics and MicroRNAs in Parkinson's Disease. Editorship [DOI] [Details]
(2018)Exercise as therapy for Parkinson's?.
Crowley, EK;Nolan, YM;Sullivan, AM (2018) Exercise as therapy for Parkinson's?. ORCHARD PARK: Editorship [DOI] [Details]
(2017)Neuronal Signaling: an introduction.
Sullivan, A.M. (2017) Neuronal Signaling: an introduction. Editorship [DOI] [Details]
(2017)Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease.
Hegarty, SV;Sullivan, AM;O'Keeffe, GW (2017) Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease. MUMBAI: Editorship [DOI] [Details]
(2016)Neurotrophic factor therapy for Parkinsons disease: past, present and future.
Sullivan, AM;O'Keeffe, GW (2016) Neurotrophic factor therapy for Parkinsons disease: past, present and future. MUMBAI: Editorship [DOI] [Details]
(2005)Symposium on ‘Neural stem and progenitor cells: biology and clinical potential’, part two.
Sullivan AM, McDermott KW, Butt A, Fraher J (2005) Symposium on ‘Neural stem and progenitor cells: biology and clinical potential’, part two. Editorship [DOI] [Details]
(2005)Symposium on ‘Neural stem and progenitor cells: biology and clinical potential’ Part 1.
Butt A, Sullivan A, McDermott KW, Fraher J (2005) Symposium on ‘Neural stem and progenitor cells: biology and clinical potential’ Part 1. Editorship [DOI] [Details]

Book Chapters

 YearPublication
(2011)'The potential of neurotrophic factors in the treatment of Parkinson’s disease'
Sullivan, A.M. and Toulouse, A. (2011) 'The potential of neurotrophic factors in the treatment of Parkinson’s disease' In: David I. Finkelstein (eds). Parkinson's Disease / Book 4. Croatia: InTech. [DOI] [Details]

Unpublished work

 YearPublication
(2014)Sympathetic innervation depends on target-derived growth differentiation factor 5.
O’Keeffe, G.W., Gutierrez, H., Laurie, C., Osorio, C., Sullivan, A.M. Gavaldà, N. Wyatt, S.L., Davies, A.M. (2014) Sympathetic innervation depends on target-derived growth differentiation factor 5. Unpublished work [Details]
(2014)Smad-interacting protein 1 (Sip1) is a novel regulator of the development of ventral midbrain dopaminergic neurons.
Hegarty, S.V., Wyatt, S.L., Sullivan, A.M., O'Keeffe, G.W (2014) Smad-interacting protein 1 (Sip1) is a novel regulator of the development of ventral midbrain dopaminergic neurons. Unpublished work [Details]
(2014)Neurotrophic and neuroprotective effects of class-specific Histone deacetylase (HDAC) inhibitors in cellular models of Parkinson’s disease.
Collins, L.M., Adriaanse, L., Hegarty, S.V., Sullivan A.M, O’Keeffe, G.W. (2014) Neurotrophic and neuroprotective effects of class-specific Histone deacetylase (HDAC) inhibitors in cellular models of Parkinson’s disease. Unpublished work [Details]
(2014)Mood disorders and cognitive dysfunction in Parkinson’s disease: role of alpha-synuclein transmission.
Kelly, M.J., O’Keeffe, G.W., Sullivan, A.M (2014) Mood disorders and cognitive dysfunction in Parkinson’s disease: role of alpha-synuclein transmission. Unpublished work [Details]
(2014)Cognitive dysfunction in alpha-synuclein animal models of Parkinson’s disease.
Dolan, E. Nolan, Y.M., Sullivan, A.M. (2014) Cognitive dysfunction in alpha-synuclein animal models of Parkinson’s disease. Unpublished work [Details]
(2014)Pain in Parkinson’s disease: Relevance of gut to brain signalling.
Felice, V.D., Quigley, E.M. Sullivan, A.M, O’Sullivan, S., O’Keeffe, G.W., O’Mahony, S.M. (2014) Pain in Parkinson’s disease: Relevance of gut to brain signalling. Unpublished work [Details]
(2014)Differential requirement for dynamin-dependent endocytosis by bone morphogenetic proteins in the promotion of neurite growth in a model of human midbrain dopaminergic neurons.
Hegarty, S.V., Sullivan, A.M.*, O'Keeffe, G.W.* (JOINT SENIOR AUTHOR) (2014) Differential requirement for dynamin-dependent endocytosis by bone morphogenetic proteins in the promotion of neurite growth in a model of human midbrain dopaminergic neurons. Unpublished work [Details]
(2014)The role of Nociceptin/Orphanin FQ in the development of midbrain dopaminergic neurons.
Dal Bo, G. Collins, L.M., Sullivan, A.M., Morari, M., O’Keeffe, G.W. (2014) The role of Nociceptin/Orphanin FQ in the development of midbrain dopaminergic neurons. Unpublished work [Details]

Professional Activities

Education

 YearInstitutionQualificationSubject
2005University College Cork Postgraduate Certificate in Teaching and Learning in Higher Ed.Teaching and Learning in Higher Education
1995University of Cambridge PhDNeuropharmacology
1992University College Dublin BScPharmacology

Professional Associations

 AssociationFunctionFrom / To
Federation of European Neuroscience Societies Member/
Network of European Cerebral Transplantation and Repair Member/
Neuroscience Ireland Member/
Irish Institute of Clinical Neuroscience Member/

Employment

 EmployerPositionFrom / To
University College Cork Senior Lecturer01-OCT-98 /
University College Cork College Lecturer01-OCT-98 / 30-SEP-06
Imperial College London Post-doctoral researcher01-OCT-95 / 30-SEP-98

Honours and Awards

 YearTitleAwarding Body
2013Neuroscience Ireland Conference, Cork. Prize for Best Poster Neuroscience Ireland
2012Neuroscience Ireland Conference, Dublin. Prize for Best Poster. Neuroscience Ireland
2010Certificate in Peer-Mentoring (Distinction) FETAC
2007British Neuroscience Association meeting, Harrogate, UK. Prize for Best Poster. British Neuroscience Association
2006Royal Academy of Medicine in Ireland Biomedical Section Winter Meeting, Dublin. Prize for Best Poster. Royal Academy of Medicine in Ireland
2005International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany. Prize for Best Poster. International Congress on Parkinson’s Disease and Related Disorders
2003Anatomical Society of Great Britain and Ireland Winter Meeting, UK. Oral presentation prize. Anatomical Society of Great Britain and Ireland
2002Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin. Prize for Best Poster. Anatomical Society of Great Britain and Ireland

Journal Activities

 JournalRoleTo / From
Editor-
Behavioural Brain Research Referee-
Biomedcentral Neuroscience Referee-
Biomedicine And Biotechnology Referee-
Bioscience Reports Referee-
Brain Research Referee-
Brain Research Bulletin Referee-
Cns Neuroscience And Therapeutics Referee-
Current Stem Cell Research And Therapy Referee-
Cytotherapy Referee-
European Journal Of Neuroscience Referee-
Experimental Neurology Referee-
International Journal Of Molecular Sciences Referee-
International Journal Of Neuroscience Referee-
Journal Of Anatomy Referee-
Journal Of Anatomy Editor-
Journal Of Biomaterials And Tissue Engineering Referee-
Journal Of Cell And Molecular Biology Referee-
Journal Of Neural Transmission Referee-
Journal Of Neurodegenerative Diseases Referee-
Journal Of Neuroscience Referee-
Journal Of Neuroscience Methods Referee-
Journal Of Neuroscience Research Referee-
Molecular Therapy Referee-
Neural Regeneration Research Referee-
Neurobiology Of Disease Referee-
Neuronal Signaling Referee-
Neuropharmacology Referee-
Neuropsychobiology Referee-
Neuroreport Referee-
Neuroreport Member of Editorial Board-
Neuroscience Referee-
Neuroscience Letters Referee-
Neurotoxicology Referee-
Neurotoxicity Research Referee-
Parkinson’S Disease Referee-
Parkinsonism & Related Disorders Referee-
Physiology And Behaviour Referee-
Science Referee-
Science Signaling Referee-
Scientific Reports Referee-
Stem Cell Research And Therapy Referee-
Stem Cell Reviews And Reports Referee-

Committees

 CommitteeFunctionFrom / To
Fulbright Commission, Ireland. Panel Member. Science and Technology Scholarship Awards Reviewer2014 /
ERASMUS Scheme Departmental Co-ordinator2004 /
NECTAR International Conference. Organising Committee. Committee Member2014 / 2014
First Irish Parkinson's Disease Meeting Organiser2013 / 2013
Neuroscience Ireland Conference. Organising Committee. Committee Member2013 / 2013
Cork NeuroScience Group Secretary2010 /
Health Research Board, Ireland. Postdoctoral Fellowship Scheme Grant Reviewer 2009-2010 Grant Reviewer2009 / 2010
Anatomical Society of Great Britain and Ireland. Elected Council Member 2006 - 2009 Council member2006 / 2009
Neuroscience Ireland Conference. Organising Committee. Committee Member2006 / 2006
College of SEFS Board of Studies for CK402 degree Committee Member2014 /
National University of Ireland. Grant Reviewer 2006 - current Grant Reviewer2006 /
Wellcome Trust, London. Grant Reviewer 2006 - current Grant reviewer2006 /
Medical Research Council, London. Grant Reviewer 2006 - current Grant reviewer2006 /
Anatomical Society of Great Britain and Ireland. Grant Reviewer 2005 - 2010 Grant Reviewer2005 / 2009
Health Research Board, Ireland. Neuroscience Clinical Neurology and Mental Health Grant Review Panel 2005-2008 Grant Reviewer2005 / 2008
Irish Network of Neural Stem Cell Investigators Committee member2004 / 2008
Parkinson's UK, London. Grant Reviewer 2004-current Grant Reviewer2004 /
Anatomical Society of Great Britain and Ireland Conference. Organising Committee. Committee Member2004 / 2004
UCC International Education Office Departmental Representative2004 /
College of SEFS Academic Programmes and Curriculum Development Committee Committee Member2002 /
Curriculum Committee for BSc Neuroscience Chair1998 /
Disability Support Service Departmental Representative1999 / 2005
Department of Anatomy and Neuroscience Graduate Studies Committee Chair1999 / 2007

Outreach Activities

 Description

NEUROSCIENCE OUTREACH ACTIVITIES BY POSTGRADUATES

  • Professor Aideen Sullivan encourages her students to see the wider relevance of their research, and to learn effective ways of disseminating their data to public audiences, as well as to the scientific community. 
  • She encourages all of her students to participate in schemes where they get opportunities to present their research to the public. 
  • In 2005, her PhD student Katie Spitere won the first ‘Science For All’ competition with a talk entitled ‘Making Connections: Using Stem Cells to Rebuild the Parkinson’s Disease Brain’, and subsequently presented her research to general audiences at the Conference of the Heads of Irish Universities and the BT Young Scientists exhibition in Dublin. Several others from Professor Sullivan’s research group have reached the finals of this competition (now called ‘UCC Doctoral Showcase’). 
  • Two of her postgraduates have published articles in UCC’s ‘The Boolean’, which are aimed at a lay audience (Shane Hegarty ‘Parkinson’s Disease: can we move in the right direction?’ 2012; Grace Crotty, ‘Biomarkers for Parkinson’s Disease’ 2014).



SCHOOL LIAISON ACTIVITIES

  • Professor Sullivan has been responsible for delivering talks and organising the Neuroscience information stand at each of UCC's biannual ‘Open Days for Schools’ since 1998.
  • She speaks about Neuroscience at the UCC Plus Easter School for secondary schools in designated socio-economically disadvantaged areas.
  • Professor Sullivan has presented lectures and organised tours of the Neuroscience research laboratories for female secondary school students as part of the ‘Women in Science and Engineering’ event each year.
  • In order to promote understanding and awareness of science and medicine, amongst young students, she undertakes visits to primary and secondary schools throughout Munster.
  • She has been approached to assist teams of schoolchildren with their projects for the BT Young Scientist and Technology Exhibition and the RDS Primary Science Fairs.
  • Professor Sullivan co-ordinates placements for transition year students from secondary schools in several counties, facilitating laboratory placements in the Department’s Neuroscience research laboratories for one or two students each year.




PUBLIC AWARENESS OF PARKINSON’S DISEASE AND NEURODEGENERATIVE DISORERS

  • Professor Aideen Sullivan is active in promoting public awareness and disseminating information about Parkinson’s disease and other neurodegenerative disorders.
  • In 2012, she organised two evening seminars, aimed at the general public, about current research and treatments, one on Parkinson's disease and one on Multiple Sclerosis. These seminars were aimed at promoting public awareness about these debilitating disorders, and disseminating information about advances in their treatments to patients and their families. These events were very well-attended by patients, their families and the interested public.
  • As a founding member of the Parkinson’s Disease Research Cluster (http://www.ucc.ie/en/pdrc/), Professor Sullivan is one of a group of researchers working together to better understand Parkinson’s disease, its causes, symptoms, diagnosis and treatments, with the aim of improving quality-of-life for patients and their carers.
  • She visits Parkinson’s disease support groups throughout Ireland, speaking to patients and their carers, clinicians and nurses, about recent advances in the research field. She engages with the Parkinson’s Association of Ireland to organise and promote these seminars and information events.
  • Articles have been published about Professor Sullivan's research in several national newspapers (Irish Times, Irish Examiner, Evening Herald, Evening Echo) and she is regularly contected by the media to comment on research advances in Parkinson’s disease or stem cell therapies.

Other Activities

 Description

External Examiner, MSc in Stem Cells and Regeneration. Bristol University, UK. (2013-2018)

External Examiner for PhD thesis. Trinity College Dublin, Dept. of Physiology. 2012.

External Examiner for PhD thesis. Trinity College Dublin, Dept. of Biochemistry. 2011.

External Examiner for PhD thesis. National University of Ireland Galway, Dept. of Biochemistry. 2009.

External Examiner for PhD thesis. Edinburgh University. 2007.

External Examiner for PhD thesis. Trinity College Dublin, Dept. of Physiology. 2007.

External Examiner for PhD thesis. Cardiff University, School of Biosciences. 2005.

External Examiner for PhD thesis. Trinity College Dublin, Dept. of Physiology. 2003.

External Examiner in Anatomy for the Membership of the Faculty of Dental Surgeons (MFDS/MFD), Royal College of Surgeons in Ireland. (2001-2007)

External Examiner in Pharmacology for examinations for non-EEA-trained dentists, Dental Council of Ireland. (2000-2006).

Languages

 LanguageReadingWritingSpeaking
French FunctionalFunctionalFunctional
English FluentFluentFluent
Irish FunctionalFunctionalFunctional

Conference Contributions

 YearPublication
(2017)AD/PDTM 2017,
O’Donovan SM, Crowley E, Browne J, O’Sullivan O, O’Leary OF, Timmons S, Nolan YM, O’Toole PW, Clarke DJ, Hyland NP, Joyce SA, Sullivan AM, O’Neill C (2017) The brain ↔gut axis in Parkinson’s disease: defining gut pathology and the impact of exercise in the rAAV-­α-­synuclein rat model of PD AD/PDTM 2017, the 13th​ International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders. [Invited Lectures (Conference)], AD/PDTM 2017, Vienna,Austria . [Details]
(2017)Neurogastroenterology and Motiltiy,
S O'Donovan, EK Crowley, J Browne, O O'Sullivan, OF O'Leary, S Timmons, YM Nolan, PW O'Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O'Neill (2017) Investigation of the brain gut axis in the rAAV-alpha-synuclein PD model: Reveals enteric nervous system pathology and alterations in the gut microbiome. [Poster Presentation], Neurogastroenterology and Motiltiy, Cork Ireland . [Details]
(2017)AD/PDTM 2017,
O’Donovan SM, Crowley E, Browne J, O’Sullivan O, O’Leary OF, Timmons S, Nolan YM, O’Toole PW, Clarke DJ, Hyland NP, Joyce SA, Sullivan AM, O’Neill C (2017) The brain ↔gut axis in Parkinson’s disease: defining gut pathology and the impact of exercise in the rAAV-­α-­synuclein rat model of PD AD/PDTM 2017, the 13th​ International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders. [Poster Presentation], AD/PDTM 2017, Vienna,Austria . [Details]
(2017)Neuroscience Ireland,
SM O’Donovan, EK Crowley, J Browne, O O’Sullivan, OF O’Leary, S Timmons, YM Nolan, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2017) Investigation of the brain gut axis in the rAAV-alpha-synuclein PD model: Reveals enteric nervous system pathology and alterations in the gut microbiome. [Poster Presentation], Neuroscience Ireland, NUI Galway , 24-AUG-17. [Details]
(2016)HEC 2016: The Scholarship of Teaching, Learning and Organising,
O'Mahony, C., Higgs, B. and O'Sullivan, A. (2016) Building institutional capacity for a whole programme approach to undergraduate research. [Oral Presentation], HEC 2016: The Scholarship of Teaching, Learning and Organising, Amsterdam , 13-JUL-16 - 15-JUL-16. [Details]
(2014)Molecular Medicine Ireland Education and Training Annual Scientific Meeting,
Dolan, E. Nolan, Y.M., Sullivan, A.M. (2014) Characterisation of cognitive deficits in an alpha-synuclein model of Parkinson’s disease. [Invited Lectures (Conference)], Molecular Medicine Ireland Education and Training Annual Scientific Meeting, Trinity College Dublin . [Details]
(2014)EURON workshop: New Targets in Neurodegenerative Diseases,
Dolan, E. Nolan, Y.M., Sullivan, A.M. (2014) Motor effects of unilateral and bilateral lesions induced by viral vector-mediated overexpression of alpha-synuclein in a rodent model of Parkinson’s disease. [Invited Lectures (Conference)], EURON workshop: New Targets in Neurodegenerative Diseases, Braga, Portugal . [Details]
(2014)Molecular Medicine Ireland Education and Training Annual Scientific Meeting,
Dolan, E. Nolan, Y.M., Sullivan, A.M. (2014) Cognitive dysfunction in alpha-synuclein animal models of Parkinson’s disease. [Invited Lectures (Conference)], Molecular Medicine Ireland Education and Training Annual Scientific Meeting, Trinitry College Dublin . [Details]
(2013)8th Neuroscience Ireland Conference,
Hegarty, S.V., Sullivan, A.M., O'Keeffe G.W. (2013) BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons. Prize for best poster. [Poster Presentation], 8th Neuroscience Ireland Conference, Cork, Ireland , 03-SEP-13 - 05-SEP-13. [Details]
(2011)8th IBRO World Congress of Neuroscience,
O’Brien, I., Sullivan, A.M., Nolan, Y.M., Toulouse, A. (2011) Expression of the 2F7 epitope in the rat embryo, and adult brain. [Invited Lectures (Conference)], 8th IBRO World Congress of Neuroscience, Florence, Italy , 14-JUL-11 - 18-JUL-11. [Details]
(2010)Neuroscience Ireland Conference, Dublin,
Ryan, S., Keohane, A., Maloney, E., Sullivan, A.M., Nolan, Y. (2010) Effects of TNF-alpha on proliferation and differentiation of embryonic rat hippocampal neural precursor cells: a role for Hes1. [Invited Lectures (Conference)], Neuroscience Ireland Conference, Dublin, Ireland . [Details]
(2010)Neuroscience Ireland Conference, Dublin,
Ryan, S., Keohane, A., Maloney, E., Sullivan, A.M., Nolan, Y. (2010) Effects of tumour necrosis factor-a on proliferation and differentation of embryonic rat hippocampal neural precursor cells: a role for HES1. [Invited Lectures (Conference)], Neuroscience Ireland Conference, Dublin, Ireland . [Details]
(2009)International conference on Alzheimer's and Parkinson's diseases,
Long, C., Sullivan, A.M., Nolan, Y. (2009) The effect of pharmacological and endogenous p38 inhibition on 6-hydroxydopamine-treated rat ventral mesencephalic neurons in vitro. [Invited Lectures (Conference)], International conference on Alzheimer's and Parkinson's diseases, Prague, Czech Republic . [Details]
(2008)International Neuroimmunology Symposium, Dublin,
Long, C., Sullivan, A.M., Nolan, Y. (2008) IL-1β released from LPS-stimulated cortical glial cultures exacerbates 6-OHDA-induced dopaminergic neuronal cell death in vitro. [Invited Lectures (Conference)], International Neuroimmunology Symposium, Dublin, Ireland . [Details]
(2008)2nd Neuroscience Ireland Conference, NUI Galway,
Keohane, A., Sullivan, A.M., Nolan, Y. (2008) IL-1 receptor antagonist prevents the effects of the pro-inflammatory cytokine, IL-1β on differentiating embryonic rat hippocampal neuronal precursor cells. [Invited Lectures (Conference)], 2nd Neuroscience Ireland Conference, NUI Galway, Ireland . [Details]
(2008)Neuroscience Ireland Conference, Galway,
Ryan, S., Maloney, E., Keohane, A., Sullivan, A.M., Nolan, Y.M. (2008) TNF-a affects the proliferation and differentiation of embryonic rat hippocampal neural precursor cells. [Invited Lectures (Conference)], Neuroscience Ireland Conference, Galway, Ireland . [Details]
(2008)International Neuroimmunology Symposium, Dublin,
Long, C., Sullivan, A.M., Nolan, Y. (2008) Il-1 Beta Released From Lps-Stimulated Cortical Glial Cultures Exacerbates 6-Ohda-Induced Dopaminergic Neuronal Cell Death In Vitro. [Invited Lectures (Conference)], International Neuroimmunology Symposium, Dublin, Ireland . [Details]
(2008)International Neuroimmunology Symposium, Dublin, Ireland,
Keohane, A., Sullivan, A.M., Nolan, Y. (2008) The effect of the pro-inflammatory cytokine, TNFα, on the proliferation and differentiation of embryonic hippocampal neural cells. [Invited Lectures (Conference)], International Neuroimmunology Symposium, Dublin, Ireland, Ireland . [Details]
(2008)Neuroscience Ireland Conference, Galway,
Long, C., Sullivan, A.M., Nolan, Y. (2008) The role of IL-1b in mediating the effects of LPS-stimulated rat glia on dopaminergic neuronal death in vitro. [Invited Lectures (Conference)], Neuroscience Ireland Conference, Galway, Ireland . [Details]
(2007)XVIIth World Federation of Neurology World Congress on Parkinson's Disease and Related Disorders, Amsterdam,
Long, C., Sullivan, A.M., Nolan, Y. (2007) The effect of p38 inhibition on the survival of 6-hydroxydopamine-treated rat ventral mesencephalic neurons in vitro. [Invited Lectures (Conference)], XVIIth World Federation of Neurology World Congress on Parkinson's Disease and Related Disorders, Amsterdam, Netherlands . [Details]
(2007)British Neuroscience Association meeting, Harrogate, UK. Brit. Neurosci. Assoc,
Long, C., Sullivan, A.M., Nolan, Y; (2007) The effect of conditioned media from LPS-stimulated rat mixed glial cultures on 6-OHDA-treated rat ventral mesencephalic neurons in vitro. Prize for Best Poster. [Invited Lectures (Conference)], British Neuroscience Association meeting, Harrogate, UK. Brit. Neurosci. Assoc, UK . [Details]
(2007)British Neuroscience Association Meeting,
Keohane, A., Sullivan, A.M., Nolan, Y. (2007) The effect of pro-inflammatory cytokines, IL-1β and TNFα on embryonic rat hippocampal neuronal precursor cells. [Invited Lectures (Conference)], British Neuroscience Association Meeting, UK . [Details]
(2006)New Horizon's in Medical Research,
Keohane, A., Sullivan, A.M., Nolan, Y. (2006) Characterisation of embryonic rat hippocampal neuronal precursor cells in neurosphere cultures. [Invited Lectures (Conference)], New Horizon's in Medical Research, Cork . [Details]
(2006)Neuroscience Ireland Meeting, Cork,
Long, C., Sullivan, A.M., Nolan, Y. (2006) 6-hydroxydopamine induces a direct neurotoxic effect on embryonic rat midbrain dopaminergic neurons independent of microglial activation in vitro. [Invited Lectures (Conference)], Neuroscience Ireland Meeting, Cork, Ireland . [Details]
(2006)Society for Neuroscience meeting, Atlanta, USA,
Crotty,S., Fitzgerald, P., Mandel,A.,Bolton, A.E., Sullivan, A.M., Nolan, Y. (2006) Treatment with a novel phospholipid-based drug formulation prevents behavioural deficits induced by proteasome inibition: implications for Parkinson's disease. [Invited Lectures (Conference)], Society for Neuroscience meeting, Atlanta, USA, Atlanta, USA . [Details]
(2006)FENS Forum of Neuroscience, Vienna, Austria,
Long, C., Sullivan, A.M., Nolan, Y. (2006) 6-hydroxydopamine induces a direct neurotoxic effect on embryonic rat midbrain dopaminergic neurons independent of microglial activation in vitro. [Invited Lectures (Conference)], FENS Forum of Neuroscience, Vienna, Austria, Vienna, Austria . [Details]
(2006)Royal Academy of Medicine in Ireland Biomedical Section Winter Meeting, Dublin,
Long, C., Nolan, Y.M., Sullivan, A.M. (2006) Effects of 6-hydroxydopamine on the survival of embryonic rat midbrain dopamine neurons in vitro. Poster Prize. [Invited Lectures (Conference)], Royal Academy of Medicine in Ireland Biomedical Section Winter Meeting, Dublin, Ireland . [Details]
(2006)Royal Academy of Medicine in Ireland Biomedical Section Meeting, Dublin,
Crotty, S., Fitzgerald, P., Harris, D.M., Fisher, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y. (2006) 6-hydroxydopamine-induced p38 activation in rat nigral dopaminergic neurons is reduced by treatment with a novel phospholipid-based drug formulation. [Invited Lectures (Conference)], Royal Academy of Medicine in Ireland Biomedical Section Meeting, Dublin, Ireland . [Details]
(2005)Society for Neuroscience meeting, Washington, USA,
O’Sullivan, D.B., Harrison, P.T., Nolan, Y.M., Sullivan, A.M. (2005) Prevention of apoptosis in cultured dopaminergic neurons by GDNF and GDF5. [Invited Lectures (Conference)], Society for Neuroscience meeting, Washington, USA, Washington DC, USA , 12-NOV-05 - 16-NOV-05. [Details]
(2005)Royal Academy of Medicine in Ireland Biomedical Section Meeting, Dublin,
Fitzgerald, P., Harris, D.M., Crotty, S., Fisher, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y.M. (2005) 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons and microglial activation is reduced by treatment with a novel phospholipid-based drug formulation. [Invited Lectures (Conference)], Royal Academy of Medicine in Ireland Biomedical Section Meeting, Dublin, Ireland . [Details]
(2005)International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany,
Harris, D.M., Fisher, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y. (2005) 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons and microglial activation is reduced by treatment with a novel phospholipid-based drug formulation. [Invited Lectures (Conference)], International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany, Berlin, Germany , 05-JUN-05 - 08-JUN-06. [Details]
(2005)Society for Neuroscience meeting, Washington, USA,
Fitzgerald, P., Harris, D.M., Crotty, S., Harkin, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y. (2005) Treatment with a novel phospholipid-based drug formulation inhibits 6-hydroxydopamine-induced p38 activation in rat substantia nigra. [Invited Lectures (Conference)], Society for Neuroscience meeting, Washington, USA, Washington DC, USA , 11-DEC-05 - 16-NOV-05. [Details]
(2004)Society for Neuroscience Meeting, San Diego, USA,
Fisher, A., Harris, D.M., Harkin, A.J., Bolton, A.E., Sullivan, A.M., Nolan Y.M. (2004) Novel phospholipid-based drug formulation retards the 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons. [Invited Lectures (Conference)], Society for Neuroscience Meeting, San Diego, USA, San Diego, USA . [Details]
(2002)3rd Forum of European Neuroscience,
O’Keeffe, G.W., Costello, D.J., Sullivan, A.M. (2002) Restorative effects of growth/differentiation factor-5 (GDF-5) in a rat model of Parkinson's disease. [Poster Presentation], 3rd Forum of European Neuroscience, Paris, France , 13-JUL-02 - 17-JUL-02. [Details]
(2012)7th Neuroscience Ireland Conference,
Walsh S, Keeshan K, Nolan Y, O’Keeffe GW, Sullivan AM. (2012) The effect of IL-1R1 shRNA intra-nigral administration in a hemi-parkinsonian 6-hydroxydopamine rat model. [Poster Presentation], 7th Neuroscience Ireland Conference, Dublin, Ireland , 05-SEP-12 - 06-SEP-12. [Details]
(2012)7th Neuroscience Ireland Conference,
Collins LM, O'Keeffe GW, Long-Smith CM, Sullivan AM, Toulouse A, Nolan YM. (2012) Mitogen-activated protein kinase phosphatase (MKP)-1 promotes the morphological development of midbrain dopmainergic neurons. [Poster Presentation], 7th Neuroscience Ireland Conference, Dublin, Ireland , 05-SEP-12 - 05-SEP-12. [Details]
(2013)Young Life Scientists Conference 2013,
Hegarty, S.V., Sullivan, A.M., O'Keeffe G.W. (2013) BMP2 and GDF5 induce neurite extension in ventral midbrain dopaminergic neurons through a Smad dependent pathway. [Oral Presentation], Young Life Scientists Conference 2013, UCC, Cork , 11-SEP-13 - 11-SEP-13. [Details]
(2013)8th Neuroscience Ireland Conference 2013,
Collins, L.M., O'Keeffe, G.W., Gavin, A.M., Wyatt, S.L., Sullivan, A.M., Toulouse, A., Nolan, Y.M. (2013) Expression of endogenous MKP-1 in the adult rat nigrostriatal system following a unilateral 6-hydroxydopamine striatal and medial forebrain lesion. [Poster Presentation], 8th Neuroscience Ireland Conference 2013, Cork, Ireland , 03-SEP-13 - 06-SEP-13. [Details]
(2012)7th Neuroscience Ireland Conference,
Gavin A, Wyatt S, Sullivan AM, O'Keeffe GW (2012) Expression of endogenous GDF5, GDNF, and their receptors in the rat nigrostriatal pathway following a unilateral 6-hydroxydopamine terminal lesion. [Poster Presentation], 7th Neuroscience Ireland Conference, Dublin, Ireland , 05-SEP-12 - 06-SEP-12. [Details]
(2012)UCC Doctoral Showcase [Finalist],
Hegarty SV, O’Keeffe GW, Sullivan AM. (2012) Parkinson’s disease: Can we move in the right direction?. [Oral Presentation], UCC Doctoral Showcase [Finalist], Cork, Ireland , 07-JUN-12 - 07-JUN-12. [Details]
(2012)7th Neuroscience Ireland Conference,
Hegarty SV, Sullivan AM, O’Keeffe GW. (2012) GDF5 and BMP2 have differential effects on rat ventral mesencephalic neural stem cells, depending on their developmental stage. [Poster Presentation], 7th Neuroscience Ireland Conference, Dublin, Ireland , 05-SEP-12 - 06-SEP-12. [Details]
(2011)IBRO World Congress of Neuroscience 2011,
Gavin A, Wyatt S, Sullivan AM, O'Keeffe GW. (2011) Analysis of the temporal expression and neurotrophic effects of GDNF in the developing rat nigrostriatal system. [Poster Presentation], IBRO World Congress of Neuroscience 2011, Florence, Italy , 14-JUL-11 - 18-JUL-11. [Details]
(2011)6th Neuroscience Ireland 2011,
Hegarty SV, Sullivan AM, O'Keeffe GW. (2011) The Development of Rat Ventral Mesencephalic Neural Stem Cells in vitro. [Poster Presentation], 6th Neuroscience Ireland 2011, Maynooth, Ireland , 01-SEP-11 - 02-SEP-11. [Details]
(2010)Neuroscience Ireland 2010,
Crampton SJ, Sullivan AM, O'Keeffe GW. (2010) Stereological analysis of the brachypod mouse brain. [Poster Presentation], Neuroscience Ireland 2010, Dublin, Ireland , 02-SEP-10 - 03-SEP-10. [Details]
(2010)5th Neuroscience Ireland,
Gavin A, Wyatt S, Sullivan AM, O'Keeffe GW. (2010) Spatiotemporal analysis of GDF-5 expression in the developing rat nigrostriatal system. [Poster Presentation], 5th Neuroscience Ireland, Dublin, Ireland , 02-SEP-10 - 03-SEP-10. [Details]
(2007)Irish Network of Neural Stem Cell Investigators,
Sullivan, A.M. (2007) rish Network of Neural Stem Cell Investigators. [Conference Organising Committee Member], Irish Network of Neural Stem Cell Investigators, Dublin , 01-JAN-07 - 01-JAN-07. [Details]
(2006)Irish Society for Gene and Cell Therapy meeting,
Sullivan, A.M. (2006) Neuroprotective and restorative therapies for Parkinson's disease. [Oral Presentation], Irish Society for Gene and Cell Therapy meeting, Galway , 01-JAN-06 - 01-JAN-06. [Details]
(2006)Irish Network of Neural Stem Cell Investigators,
Sullivan, A.M. (2006) Organising Committee Member. [Conference Organising Committee Member], Irish Network of Neural Stem Cell Investigators, Dublin , 01-JAN-06 - 01-JAN-06. [Details]
(2005)16th International Conference on Parkinson's Disease,
Harris, D.M., Fisher, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y. (2005) 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons and microglial activation is reduced by treatment with a novel phospholipid-based drug formulation. [Poster Presentation], 16th International Conference on Parkinson's Disease, Berlin, Germany , 05-JUN-05 - 09-JUN-05. [Details]
(2005)16th International Conference on Parkinson's Disease,
Toulouse, A., Sullivan, A.M. (2005) Investigation of the neurotrophic effects of growth/differentiation factor 5 in an in vitro model of Parkinson' s disease. [Poster Presentation], 16th International Conference on Parkinson's Disease, Berlin, Germany , 05-JUN-05 - 09-JUN-05. [Details]
(2005)16th International Conference on Parkinson's Disease,
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2005) Lentiviral-mediated delivery of growth/differentiation factor 5 attenuates parkinsonian symptoms in the rat. [Poster Presentation], 16th International Conference on Parkinson's Disease, Berlin, Germany , 05-JUN-05 - 09-JUN-05. [Details]
(2005)Irish Network of Neural Stem Cell Investigators,
Sullivan, A.M. (2005) Irish Network of Neural Stem Cell Investigators. [Conference Organising Committee Member], Irish Network of Neural Stem Cell Investigators, Dublin , 01-JAN-05 - 01-JAN-05. [Details]
(2005)School of Biosciences,
Sullivan, A.M. (2005) GDF5 and neural stem cells for the treatment of Parkinson's disease. [Oral Presentation], School of Biosciences, Cardiff University , 01-JAN-05 - 01-JAN-05. [Details]
(2005)Launch of Institute of Neuroscience,
Sullivan, A.M. (2005) Neuroprotective therapies. [Invited Oral Presentation], Launch of Institute of Neuroscience, Trinity College Dublin , 01-JAN-05 - 01-JAN-05. [Details]
(2005)Royal Irish Academy of Medicine,
Fitzgerald, P., Harris, D.M., Crotty, S., Fisher, A., Mandel, A., Bolton, A.E., Sullivan, A.M., Nolan, Y.M. (2005) 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons and microglial activation is reduced by treatment with a novel phospholipid-based drug formulation. [Poster Presentation], Royal Irish Academy of Medicine, Dublin, Ireland , 05-JUN-05 - 06-JUN-05. [Details]
(2005)7th European Meeting in Glial Cell Function in Health and Disease,
Barrett, R.J., McDermott, K.W., Sullivan, A.M. (2005) The effects of astroglial and neurotrophic interactions on the survival of dopaminergic neurons in vitro. [Poster Presentation], 7th European Meeting in Glial Cell Function in Health and Disease, Amsterdam, Holland , 20-MAY-05 - 23-MAY-05. [Details]
(2005)School of Biosciences Cardiff University,
Sullivan, A.M. (2005) GDF5 and neural stem cells for the treatment of Parkinson's disease. [Oral Presentation], School of Biosciences Cardiff University, School of Biosciences Cardiff University , 01-JAN-05 - 01-JAN-05. [Details]
(2005)launch of Institute of Neuroscience Trinity College Dublin,
Sullivan, A.M. (2005) Neuroprotective therapies for Parkinson's disease. [Oral Presentation], launch of Institute of Neuroscience Trinity College Dublin, Trinity College Dublin , 01-JAN-05 - 01-JAN-05. [Details]
(2005)Meeting of the Physiological Society,
Flynn, R., O’Sullivan, D., Sullivan, A.M., Harrison, P. (2005) Use of pCEP4 Vector for Simple and Rapid Establishment of Stable Cell-Lines and Long-Term Gene Expression. [Poster Presentation], Meeting of the Physiological Society, Bristol, UK , 02-AUG-05 - 04-AUG-05. [Details]
(2005)Royal Irish Academy of Medicine,
Harris, D.M., Fisher, A., Harkin, A.J., Bolton,A.E., Sullivan, A.M., Nolan, Y.M. (2005) Novel phospholipid-based drug formulation prevents degeneration of dopaminergic neurons from substantia nigra in a rat model of Parkinson’s disease. [Poster Presentation], Royal Irish Academy of Medicine, Dublin, Ireland , 05-JAN-05 - 06-JAN-05. [Details]
(2005)13th Annual Medical Faculty Research Day. Cork, June 2005,
Barrett, R.J., McDermott, K.W. & Sullivan, A.M. (2005) The effects of astroglial and dopaminergic neurotrophins on the survival of dopaminergic neurons in vitro. [Poster Presentation], 13th Annual Medical Faculty Research Day. Cork, June 2005, Cork , 01-MAY-05 - 01-MAY-05. [Details]
(2004)Irish Network of Stem Cell Investigators meeting,
Sullivan, A.M. (2004) Neuronal stem cells for the treatment of Parkinson¿s disease. [Oral Presentation], Irish Network of Stem Cell Investigators meeting, Dublin , 01-JAN-04 - 01-JAN-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland meeting,
Sullivan, A.M. (2004) Effects of GDF5 on the induction and survival of dopaminergic neurones. [Oral Presentation], Anatomical Society of Great Britain and Ireland meeting, Cork , 01-JAN-04 - 01-JAN-04. [Details]
(2004)Irish Network of Neural Stem Cell Investigators,
Sullivan, A.M. (2004) Irish Network of Neural Stem Cell Investigators. [Conference Organising Committee Member], Irish Network of Neural Stem Cell Investigators, Dublin , 01-JAN-04 - 01-JAN-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland,
Sullivan, A.M. (2004) Anatomical Society of Great Britain and Ireland. [Conference Organising Committee Member], Anatomical Society of Great Britain and Ireland, Cork , 01-JAN-04 - 01-JAN-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Sullivan A.M. (2004) Effects of growth / differentiation factor 5 (GDF5) on the induction and survival of midbrain dopaminergic neurones. [Invited Oral Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)4th Forum of European Neuroscience,
Barrett, R.J., McDermott, K.W., Sullivan, A.M. (2004) The roles of GDNF GDF-5 and astroglia on the survival of mesencephalic dopaminergic neurons in vitro. [Poster Presentation], 4th Forum of European Neuroscience, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04. [Details]
(2004)4th Forum of European Neuroscience,
Clayton, K.B., Sullivan, A.M. (2004) Growth/differentiation factor-5 (GDF-5) expression in the developing and adult rat brain. [Poster Presentation], 4th Forum of European Neuroscience, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04. [Details]
(2004)4th Forum of European Neuroscience,
O’Sullivan, D.B., Harrison, P.T., Sullivan, A.M. (2004) Establishment of neurotrophin-expressing dopaminergic cells for transplantation in Parkinson’s disease. [Poster Presentation], 4th Forum of European Neuroscience, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04. [Details]
(2004)4th Forum of European Neuroscience,
Shanley, D.K., Sullivan, A.M. (2004) Cellular differentiation in neurosphere cultures of embryonic day 14 rat cortical and striatal tissue. [Poster Presentation], 4th Forum of European Neuroscience, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04. [Details]
(2004)4th Forum of European Neuroscience,
Spitere, K., Sullivan, A.M. (2004) Cellular composition and gene expression in embryonic rat ventralmesencephalic neurosphere cultures. [Poster Presentation], 4th Forum of European Neuroscience, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04. [Details]
(2004)4th Forum of European Neuroscience,
Toulouse, A., Sullivan, A.M. (2004) Investigation of the role of GDF-5 in the growth and differentiation of human neuroblastoma cells. [Poster Presentation], 4th Forum of European Neuroscience, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Shanley, D.K., Sullivan, A.M. (2004) In vitro expansion and differentiation of neurospheres derived from embryonic day 14 rat cortical and striatal tissue. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Spitere, K., Sullivan, A.M. (2004) Characterisation of the cellular populations and dopaminergic gene cascade in rat ventral mesencephalic neural stem cell cultures. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 06-AUG-04. [Details]
(2004)34th Annual Meeting of the Society for Neuroscience,
Fisher, A., Harris, D.M., Harkin, A.J., Bolton, A.E., Sullivan, A.M., Nolan Y.M. (2004) Novel phospholipid-based drug formulation retards the 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons. [Poster Presentation], 34th Annual Meeting of the Society for Neuroscience, San Diego USA , 23-OCT-04 - 27-OCT-04. [Details]
(2004)34th Annual Meeting of the Society for Neuroscience,
O’Keeffe, G.W., Toulouse, A., Sullivan, A.M. (2004) Dopaminergic induction from expanded rat ventral mesencephalic progenitor cells by GDF5 and BMP2 requires signalling through BMPR-Ib. [Poster Presentation], 34th Annual Meeting of the Society for Neuroscience, San Diego, USA , 23-OCT-04 - 27-OCT-04. [Details]
(2004)34th Annual Meeting of the Society for Neuroscience,
Toulouse, A., Sullivan, A.M. (2004) Roles of type 1 BMP receptors in the induction of midbrain dopaminergic neurones by GDF5. [Poster Presentation], 34th Annual Meeting of the Society for Neuroscience, San Diego USA , 23-OCT-04 - 27-OCT-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Harty, M., Sullivan, A.M., McDermott, K.W. (2004) Astroglial diversity in dopaminergic nuclei implications for selective neuronal degeneration and Parkinson’s disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
O’Sullivan, D.B., Harrison, P.T., Sullivan, A.M. (2004) Rat ventral mesencephalic cultures transfected with a plasmid expressing growth/differentiation factor 5 exhibit improved dopaminergic neuronal survival. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)15th Biennial Meeting of the International Society for Developmental Neuroscience,,
Shanley, D.K., Sullivan, A.M. (2004) Expression and characterisation of the neuronal cell surface markers 2F7 and E-NCAM within the developing rat brain: An in vitro analysis of the development of neuronal restricted precursors. [Poster Presentation], 15th Biennial Meeting of the International Society for Developmental Neuroscience,, Edinburgh, UK , 04-AUG-04 - 07-AUG-04. [Details]
(2004)15th Biennial Meeting of the International Society for Developmental Neuroscience,
Spitere, K., Sullivan, A.M. (2004) A comparison of genetic cascades involved in induction of dopaminergic neuronal fate in the developing rodent ventral mesencephalon embryonic stem cells and neural stem cells. [Poster Presentation], 15th Biennial Meeting of the International Society for Developmental Neuroscience, Edinburgh, UK , 04-AUG-04 - 07-AUG-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Barrett, R.J., McDermott, K.W., Sullivan, A.M. (2004) The effects of GDNF GDF5 and astroglia on the survival of rat mesencephalic dopaminergic neurons in vitro. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Clayton, K.B., Sullivan, A.M. (2004) Investigation of the spatio-temporal pattern of expression of the neurotrophin growth/differentiation factor 5 in the developing and adult rat brain. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Crotty, S., Sullivan, A.M., So, K.F., Chau, W.K.D., Sharma, A.K., Dockery, P. (2004) Cytoskeletal Reorganisation in Neurons: A Stereological Approach. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Physiological Society meeting,
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease. [Poster Presentation], Physiological Society meeting, Bristol, UK , 11-SEP-04 - 12-SEP-04. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Toulouse, A., Sullivan, A.M. (2004) Investigation of the effects of the neurotrophin GDF-5 on the growth and differentiation of SHSY-5Y cells. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2003)Brain Repair Group,
Sullivan, A.M. (2003) GDF-5: a dopaminergic neurotrophin with potential for use in Parkinson's disease. [Oral Presentation], Brain Repair Group, Cardiff University , 01-JAN-03 - 01-JAN-03. [Details]
(2003)Dept. of Zoology Trinity College Dublin,
Sullivan, A.M. (2003) Neuroprotective approaches to the treatment of Parkinson's disease. [Oral Presentation], Dept. of Zoology Trinity College Dublin, Dept. of Zoology Trinity College Dublin , 01-JAN-03 - 01-JAN-03. [Details]
(2003)6th International Conference on Alzheimer`s and Parkinson`s Disease,
Costello, D.J., O’Keeffe, G.W., Hurley, F.M., Hanke, M., Sullivan, A.M. (2003) A growth/differentiation factor 5-producing CHO cell line enhances the survival and function of dopaminergic grafts in a 6-OHDA rodent model of Parkinsonism. [Oral Presentation], 6th International Conference on Alzheimer`s and Parkinson`s Disease, Seville Spain , 08-MAY-03 - 12-MAY-03. [Details]
(2003)Anatomical Society of Great Britain and Ireland Winter Meeting,,
O’Keeffe, G.W., Hanke, M., Sullivan, A.M. (2003) Growth/differentiation factor-5, a growth factor with potential for therapeutic approaches for Parkinson's disease. [Oral Presentation], Anatomical Society of Great Britain and Ireland Winter Meeting,, Egham, UK , 07-JAN-03 - 09-JAN-03. [Details]
(2003)5th European Meeting on Glial Cell Function in Health and Disease,
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2003) In vitro analysis of astroglial-neuronal interactions in the ventral mesencephlon. [Poster Presentation], 5th European Meeting on Glial Cell Function in Health and Disease, Rome, Ital , 21-MAY-03 - 25-MAY-03. [Details]
(2003)3rd Forum of European Neuroscience,
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2003) In vitro analysis of the effects of the neurotrophins GDF-5 GDNF and glial cells on dopaminergic neurone survival in the ventral mesencephalon. [Poster Presentation], 3rd Forum of European Neuroscience, Paris, France , 13-JUL-03 - 17-JUL-03. [Details]
(2003)Alzheimer’s and Parkinson’s diseases: New perspectives,,
Costello, D.J., O’Keeffe,G.W., Hurley, F.M., Hanke, M., Sullivan, A.M. (2003) A growth/differentiation factor 5-producing CHO cell line enhances the survival and function of dopaminergic grafts in a 6-OHDA rodent model of Parkinsonism. [Poster Presentation], Alzheimer’s and Parkinson’s diseases: New perspectives,, Seville, Spain , 08-MAY-03 - 12-MAY-03. [Details]
(2003)Anatomical Society of Great Britain and Ireland,
O’Keeffe, G.W., Hanke, M., Sullivan, A.M. (2003) Growth/differentiation factor-5, a growth factor with potential for therapeutic approaches to Parkinson’s disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland, Egham,UK , 07-JAN-03 - 10-JAN-03. [Details]
(2003)Anatomical Society of Great Britain and Ireland Winter Meeting 2003,
O’Keeffe, G.W., Hanke, M., Sullivan, A.M. (2003) Growth/differentiation factor-5, a growth factor with potential for therapeutic approaches for Parkinson's disease. [Best oral presentation]. [Oral Presentation], Anatomical Society of Great Britain and Ireland Winter Meeting 2003, Egham, UK , 07-JAN-03 - 10-JAN-03. [Details]
(2003)6th International Conference on Alzheimer`s and Parkinson`s Disease,
Costello, D.J., O'Keeffe, G.W., Hurley, F.M., Hanke, M., Sullivan, A.M. (2003) A growth/differentiation factor 5-producing CHO cell line enhances the survival and function of dopaminergic grafts in a 6-OHDA rodent model of Parkinsonism. [Poster Presentation], 6th International Conference on Alzheimer`s and Parkinson`s Disease, Seville, Spain , 08-MAY-03 - 12-MAY-03. [Details]
(2003)Annual Medical Research Day Cork University Hospital, June 2003,
Harty, M., Barrett, R., Mc Dermott, K., Sullivan. A; (2003) Characterisation of the populations of dopaminergic neurons and astroglia in rat ventral mesencephalic and hypothalamic cultures. [Oral Presentation], Annual Medical Research Day Cork University Hospital, June 2003, Cork Hospital , 01-JUN-03 - 01-JUN-03. [Details]
(2003)Irish Society for Neurology meeting 2003,
Costello, D.J., O'Keeffe, G.W., Hurley, F.M., Sullivan, A.M. (2003) A growth/differentiation factor 5 producing CHO cell line enhances the survival and function of dopaminergic grafts in a 6-OHDA rodent model of Parkinsonism. [Poster Presentation], Irish Society for Neurology meeting 2003, Cork, Ireland . [Details]
(2003)BioResearch Day, University College Cork, September 2003,
Harty, M., Barrett, R., Mc Dermott, K., Sullivan. A. (2003) Characterisation of the populations of dopaminergic neurons and astroglia in rat ventral mesencephalic and hypothalamic cultures. [Poster Presentation], BioResearch Day, University College Cork, September 2003, University College Cork , 01-SEP-03 - 01-SEP-03. [Details]
(2002)National Parkinson's Disease Study Day,
Sullivan, A.M. (2002) Stem cells and growth factors for Parkinson¿s disease. [Oral Presentation], National Parkinson's Disease Study Day, Dublin , 01-JAN-02 - 01-JAN-02. [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer meeting 2002,
O’Keeffe, G.W., Costello, D.J., Sullivan, A.M. (2002) Growth/differentiation factor-5: developmental regulator, potential treatment. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer meeting 2002, Dundee, Scotland , 23-JUL-12 - 26-JUL-12. [Details]
(2002)Irish Neuroscience Group meeting,
Sullivan, A.M. (2002) Neuroprotective and restorative approaches to Parkinson¿s disease. [Oral Presentation], Irish Neuroscience Group meeting, Tullamore , 01-JAN-02 - 01-JAN-02. [Details]
(2002)3rd Forum of European Neuroscience,
O’Keeffe, G.W., Costello, D.J., Sullivan, A.M. (2002) Expression of the dopaminergic neurotrophin Growth differentiation factor-5 in the developing ventral mesencephalon and its effect on the differentiation of neural stem cells. [Poster Presentation], 3rd Forum of European Neuroscience, Paris, France , 13-JUL-02 - 17-JUL-02. [Details]
(2002)Anatomical Society of Great Britain and Ireland,
O’Keeffe, G.W., Costello, D.J., Sullivan, A.M. (2002) Growth/differentiation factor-5: developmental regulator, potential treatment. [Poster Presentation], Anatomical Society of Great Britain and Ireland, Dundee, Scotland , 23-JUL-02 - 26-JUL-02. [Details]
(2002)Anatomical Society of Great Britain and Ireland Summer Meeting,
O’Keeffe, G.W., Hanke, M., Sullivan, A.M. (2002) Growth/differentiation factor-5 (GDF-5) and dopaminergic neurones: developmental regulator potential treatment. [Oral Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Dundee, Scotland , 23-JUL-02 - 25-JUL-02. [Details]
(2002)3rd Forum of European Neuroscience,
O’Keeffe, G.W., Costello, D.J., Sullivan, A.M. (2002) Expression of the dopaminergic neurotrophin Growth differentiation factor-5 in the developing ventral mesencephalon and its effect on the differentiation of neural stem cells. [Poster Presentation], 3rd Forum of European Neuroscience, Paris, France , 13-JUL-02 - 17-JUL-02. [Details]
(2001)Beaumont Hospital Neurology meeting,
Sullivan, A.M. (2001) Cell transplantation for Parkinson¿s disease. [Oral Presentation], Beaumont Hospital Neurology meeting, Dublin , 01-JAN-01 - 01-JAN-01. [Details]
(2001)Anatomical Society of Great Britain and Ireland Summer Meeting 2001,
O’Keeffe, G.W., Sullivan, A.M. (2001) Investigation of the expression of growth/differentiation factor-5 in the developing rat brain. [Best poster presentation]. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting 2001, Dublin, Ireland , 10-JUL-01 - 12-JUL-01. [Details]
(2001)Anatomical Society of Great Britain and Ireland Summer Meeting,
Hurley, F.M., Costello, D.J., Sullivan, A.M. (2001) Neuroprotective effects of growth/differentiation factor-5 in a rat model of Parkinson's disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland , 10-JUL-01 - 12-JUL-01. [Details]
(2001)Anatomical Society of Great Britain and Ireland Summer Meeting,
Costello, D.J., Hurley, F.M., Sullivan, A.M. (2001) Growth/differentiation factor-5 enhances graft survival and reverses motor asymmetry in a rat model of Parkinson's disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland, , 10-JUL-01 - 12-JUL-01. [Details]
(2001)Anatomical Society of Great Britain and Ireland Summer Meeting, 10-12th July 2001,
O’Keeffe, G.W., Sullivan, A.M. (2001) Investigation of the expression of growth/differentiation factor-5 in the developing rat brain. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, 10-12th July 2001, Dublin, Ireland , 10-JUL-01 - 12-JUL-01. [Details]
(2001)Anatomical Society of Great Britain and Ireland Summer Meeting,
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2001) Antimitotic treatment to achieve neurone enriched ventral mesencephalic cultures for studies of neurotrophins. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Dublin, Ireland , 10-JUL-01 - 12-JUL-01. [Details]
(2000)2nd Forum of European Neuroscience,
Wood, T.K., Sullivan, A.M., McDermott, K.W. (2000) Glia-depleted mesencephalic cultures for investigation of the action of the dopaminergic neurotrophins GDF-5 and GDNF. [Poster Presentation], 2nd Forum of European Neuroscience, Brighton, UK , 24-JUN-00 - 28-JUN-00. [Details]
(2000)Mater Hospital Neurology meeting,
Sullivan, A.M. (2000) Neuroprotective approaches to Parkinson's disease. [Oral Presentation], Mater Hospital Neurology meeting, Dublin , 01-JAN-00 - 01-JAN-00. [Details]
(1999)Irish Neuroscience Group meeting,
Sullivan, A.M. (1999) GDF5, a neurotrophic factor with potential for Parkinson's disease. [Oral Presentation], Irish Neuroscience Group meeting, Galway , 01-JAN-99 - 01-JAN-99. [Details]
(1998)Hammersmith Hospital Neurology meeting,
Sullivan, A.M. (1998) Effects of GDF5 and GDNF in animal models of Parkinson's disease. [Oral Presentation], Hammersmith Hospital Neurology meeting, London , 01-JAN-98 - 01-JAN-98. [Details]
(1998)Charing Cross & Westminster Hospital Neuroscience meeting,
Sullivan, A.M. (1998) GDF5, a neuroprotective protein with potential for Parkinson's disease treatment. [Oral Presentation], Charing Cross & Westminster Hospital Neuroscience meeting, London , 01-JAN-98 - 01-JAN-98. [Details]
(1997)XIIth International Symposium on Parkinson's Disease,
Sullivan, A.M., Opacka-Juffry, J., Blunt, S.B.; (1997) Long-term protection of the rat nigrostriatal dopaminergic system by GDNF in vivo. [Poster Presentation], XIIth International Symposium on Parkinson's Disease, London, UK , 23-MAR-97 - 26-MAR-97. [Details]
(1997)14th Meeting of Brain Research Association,
Sullivan, A.M., Opacka-Juffry, J., Blunt, S.B. (1997) Long-term protection of the rat nigrostriatal dopaminergic system by GDNF in vivo. [Poster Presentation], 14th Meeting of Brain Research Association, Liverpool, UK , 07-APR-97 - 09-APR-97. [Details]
(1997)27th Annual Meeting of the Society for Neuroscience,
Sullivan, A.M., Opacka-Juffry J, Hotten G, Pohl J, Blunt S.B. (1997) Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson’s disease. [Poster Presentation], 27th Annual Meeting of the Society for Neuroscience, New Orleans, USA , 25-OCT-97 - 30-OCT-97. [Details]
(1996)13th Meeting of Brain Research Association,
Ashworth, S., Opacka-Juffry, J., Sullivan, A.M., Banati, R.B., Blunt, S.B. (1996) Lack of functional nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the striatum. [Poster Presentation], 13th Meeting of Brain Research Association, Newcastle, UK , 25-MAR-96 - 27-MAR-96. [Details]
(1995)12th Meeting of Brain Research Association,
Sullivan, A.M., Morton, A.J. (1995) Induction of Fos protein in organotypic cultures of rat cerebellum by endothelins. [Poster Presentation], 12th Meeting of Brain Research Association, Oxford, UK , 29-MAR-95 - 31-MAR-95. [Details]
(1994)11th Meeting of Brain Research Association,
Sullivan, A.M., Morton, A.J. (1994) Glutamate-induced expression of Fos protein by granule cells in organotypic cultures of rat cerebellum. [Poster Presentation], 11th Meeting of Brain Research Association, Southampton, UK , 10-APR-94 - 13-APR-94. [Details]
(1994)11th Meeting of Brain Research Association,
Sullivan, A.M., Morton, A.J. (1994) Is the development of Purkinje cell dendrites in organotypic culture of rat cerebellum dependent on granule cells?. [Poster Presentation], 11th Meeting of Brain Research Association, Southampton, UK , 10-APR-94 - 13-APR-94. [Details]

Teaching Activities

Teaching Interests

  • Professor Aideen Sullivan is Programme Director of the BSc in Medical and Health Science (CK707), a cross-College multidisciplinary degree which will begin student intake in 2018
  • She was actively involved in the establishment and development of the BSc in Neuroscience in UCC, which started in 1998. She was Director and 4th Year co-ordinator of this degree from 1998 until 2016. She co-ordinates and teaches several modules on this degree, and practices research-led teaching in all modules.
  • She is module co-ordinator and lecturer for the Neuroscience modules: AN2004, AN3003 and AN4009. She also lectures on modules AN3001, AN3011, AN3012, AN3013, AN4008, AN4013 and AN4014.
  • In addition to the above modules on the BSc Neuroscience, Professor Sullivan co-ordinates and delivers lectures to other programmes, including AN1074 (Pharmacy), AN2007 (Dentistry), AN1004 (Dental Hygiene) and FM2101 (Medicine).
  • She is a member of the programme committee for the MSc in Molecular Cell Biology with Innovation, and delivers lectures on module ML6002 for this course.
  • Professor Sullivan supervises laboratory research projects each year for BSc Neuroscience (AN4011), and occasionally for intercalated BSc in Anatomy or Neuroscience (AN4011), BSc Genetics (GN4002), BSc Pharmacy (PF4004). She also supervises Masters-level laboratory research projects for the MSc Molecular Cell Biology with Innovation (ML6001) and MSc in Biotechnology (BT6002).
  • Professor Sullivan acted as the Department of Anatomy and Neuroscience's representative on the College of Science, Engineering and Food Science Committee for Academic Programmes and Curriculum Developmeny from 2002 until 2016. She represented the Department on the Biological Sciences Committee from 2002 until its dissolution in 2009. She was Departmental representative on the CK402 (Biological and Chemical Sciences) Board of Studies until 2016.
  • Professor Aideen Sullivan is invited external examiner for the MSc in Stem Cells and Regeneration in Bristol University, UK (2013-2018).

Current Postgraduate Students

  • Grace Crotty MB BCh BAO.  Doctoral Degree Structured (2013-2016). Biomarkers for Parkinson’s disease. 
  • Erin Dolan MPharm.  Doctoral Degree Structured (2013-2016).  Characterisation of cognitive deficits in the alpha-synuclein rat model of Parkinson’s disease.

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2014Shane Hegarty University College CorkPhD‘Characterisation of the role of canonical BMP-Smad 1/5/8 signalling in the development of ventral midbrain dopaminergic neurons’
2013Aisling Gavin University College CorkPhD‘Expression and function of the neurotrophic factors GDF5 and GDNF in the nigrostriatal system during development and in rat models of Parkinson’s disease’
2012Grace Collins University College CorkPhD‘Generation of a ‘suicide gene’ system for cell replacement therapy’
2012Martin Kelly University College CorkMSc‘Optimisation of GDF5 protein expression from an adeno-associated viral vector in SH-SY5Y cell cultures’
2010Sean Crampton University College CorkMSc‘Stereological quantification of GDF5-treated dopamine neurons in vitro and of the brachypod (GDF5-null) mouse brain’
2010Aoife Keohane University College CorkPhD‘Effects of pro-inflammatory cytokines on the fate of embryonic and adult hippocampal neural precursor cells’
2008Caitriona Long University College CorkPhD‘The role of inflammation and p38 in 6-hydroxydopamine-induced dopaminergic neuronal death-implications for Parkinson’s disease’
2007Robert Barrett University College CorkPhD‘The effects of astroglia on dopaminergic neuronal survival: implications for Parkinson’s disease’
2006Kevin Clayton University College CorkPhD‘The expression and function of growth/differentiation factor 5 in the rat midbrain’
2006Meghan Coakley University College CorkMSc‘Examination of the roles of DJ-1 and PINK-1 and their interaction with the survival signalling pathway controlled by Akt and PTEN in adult brain and in Parkinson’s disease’
2006Suzanne Crotty University College CorkMSc‘Morphological correlates of cell death in a model of Parkinson’s disease’
2006Emma McDonnell University College CorkMSc‘Sub-cloning and expression analysis of the Ki67 promoter’
2006David O'Sullivan University College CorkPhD‘Establishment of growth/differentiation factor 5-expressing cells for transplantation in a model of Parkinson’s disease’
2006Daniel Shanley University College CorkPhD‘Characterisation and manipulation of expanded neural progenitor cells derived from the embryonic rat brain’
2006Katie Spitere University College CorkPhD‘Generation of an enriched population of dopaminergic neurones from neural stem cells’
2004Jennifer Godsell University College CorkMSc‘Optimisation of neural stem cell culture techniques’
2004Margo Harty University College CorkMSc‘Astrocyte diversity in dopaminergic nuclei: implications for selective neuronal degeneration and Parkinson’s disease’
2004Gerard O'Keeffe University College CorkPhD‘The role of the dopaminergic neurotrophin growth/differentiation factor 5 in the developing rat ventral midbrain’
2004Terri Wood University College CorkPhD‘Dopaminergic neurotrophins and astroglial-neuronal interactions in the rat ventral mesencephalon’
2003Daniel Shanley University College CorkMSc‘Quantification of cellular phenotypes arising from embryonic day 14 rat cortical and striatal tissue grown in long-term neurosphere culture’
2002Daniel Costello University College CorkMD‘Use of a cell line expressing the neurotrophin GDF5 to enhance the efficacy of transplanted dopaminergic neurons in a rat model of Parkinson’s disease’
2001Fiona Hurley University College CorkMSc‘Neuroprotective and restorative effects of GDF5 in rat models of Parkinson’s disease’

Current Postgraduate Students

 StudentDegree Type
Mazzocchi Martina Doctoral Degree
Mc Carthy Erin Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2022The Anatomical Basis of Dental Hygiene AN1004The Anatomical Basis of Dental Hygiene
2022Behavioural and Cognitive Neuroscience AN4009Behavioural and Cognitive Neuroscience
2022Structured Literature Project in Medical and Health Sciences MH3010Structured Literature Project in Medical and Health Sciences
2022Human Nervous System AN3012Human Nervous System
2022Advances in Translational Medicine MH3050Advances in Translational Medicine
2022Neurobiology of Regulatory Systems AN3003Neurobiology of Regulatory Systems

Research Information

Internal Collaborators

 NameInstituteCountry
Dr Cora O'Neill University College CorkIRELAND
Dr Sean O'Sullivan Cork University HospitalIRELAND
Dr Andre Toulouse University College CorkIRELAND
Dr Yvonne Nolan University College CorkIRELAND
Dr Gerard O'Keeffe University College CorkIRELAND
Dr Suzanne Timmons St Finbarr's Hospital, CorkIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Dr Eilis Dowd National University of Ireland, GalwayIRELAND
Dr Frank Ploeger Biopharm GmbHGERMANY
Dr Karen Keeshan University of GlasgowSCOTLAND
Prof. Maeve Caldwell Trinity College DublinIRELAND
Prof. Michael Zigmond University of PittsburghU.S.A.
Dr Michele Morari University of FerraraITALY
Dr Sean Wyatt Cardiff UniversityWALES

Contact details


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Department of Anatomy and Neuroscience

Anatamaíocht agus Néareolaíocht

Room 2.33, 2nd Floor, Western Gateway Building, University College, Cork, Ireland

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