Research Profile

Olivia O'Leary

Biography

Dr. Olivia O'Leary is a Senior Lecturer in the Department of Anatomy and Neuroscience, University College Cork.  Olivia graduated with a BSc in Biotechnology, NUI, Galway, followed by an MSc in Neuropharmacology at the same institution.  She was a visiting scholar for over three years at the University of Pennsylvania, Philadelphia, USA, where she conducted her PhD research in behavioural neuropharmacology.  This was followed by postdoctoral research at the Neuroscience Centre at the University of Helsinki where her research was focused on the role of neuronal plasticity in pathophysiology and treatment of psychiatric disorders.  In 2008, Olivia was awarded a prestigious Career Development Award from the Health Research Board to conduct her research at the School of Pharmacy, University College Cork, where she was appointed as lecturer in 2011.  Olivia then joined the Department of Anatomy and Neuroscience as a lecturer in 2012, followed by promotion to Senior Lecturer.        

Olivia's main research interest is in the neurobiology and treatment of stress-related psychiatric disorders with a particular focus on depression.  Her research has been published in high-impact journals including PNAS and Science.  In addition, Olivia has been the recipient of several awards from international professional societies including The Rafaelsen Young Investigator Award from the International College of Neuropsychopharmacology (2011) and the Fellowship Award from the European College of Neuropsychopharmacology (2010), as well the career development award from the Health Research Board Ireland (2008-2011).  Most recently, Olivia was honoured with the 2015 most outstanding Junior Faculty Award from the International Behavioural and Neural Genetics Society (IBANGS).  In addition to her teaching and research activities, Olivia is also an expert reviewer for >60 international journals, is on the Editorial Board for Neuropharmacology and Acta Neuropsychiatrica, acts as an external examiner for PhD thesis and the BSc (Hons) Biology and Biopharmaceutical Science programme in GMIT, is Chair of the Dept. of Anatomy and Neuroscience Postgraduate Student Affairs committee, is a member of several departmental and university committees, and recently completed a Pg Cert in Teaching & Learning in Higher Education. 



Research Interests


My research program is unravelling the neurobiology underlying stress resilience, depression and
antidepressant action, and is seeking novel targets for the treatment of depression.

Current goals of my lab are to:
(1) understand how molecular alterations in discrete areas along the longitudinal axis of the hippocampus play a role in stress resilience and antidepressant action and can thus be harnessed for therapeutic strategies
(2) understand how adult hippocampal neurogenesis, a type of neuronal plasticity,  contributes to stress resilience and antidepressant action and can thus be harnessed for therapeutic strategies
(3) identify how stress differentially affects the female versus male brain making women twice more likely to develop more depression than men;
(4) increase understanding of how brain development during puberty is impacted by stress and how this can impact brain health into adulthood 
(5) To demonstrate that the protein FKBP5 and the gut microbiota are potential therapeutic targets for  antidepressant drug development


To this end, we employ a range of laboratory techniques ranging from molecular neurobiology to cell culture  to behavioural pharmacology and collaborate with Industry and human health investigators.  




Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Sex matters! Identification of novel therapeutic targets to mitigate the increased prevalence of depression in women versus menHealth Research Board01-JAN-1804-OCT-21€357,523.00
Novel antidepressant target validationIndustry Sponsor01-JUL-1701-JUL-19€295,973.00
Gut microbiota and Parkinson’s disease pathophysiology: identification of novel microbial modifiable targets and biomarkers for a major neurodegenerative diseaseOther: Not Listed€39,000.00
xxOther: Not Listed€2,500.00
Novel insights into the roles of the hippocampus and hippocampal neurogenesis in stress and antidepressant action”Other: Not Listed€136,792.00
Stress-Induced Alterations in Hippocampal Neuroplasticity and Behaviour: Effects of Antidepressants and Glycogen Synthase Kinase-3beta InhibitorsHealth Research Board01-OCT-0801-OCT-11€283,000.00
Optogenetics - a platform for shedding light on brain dysfunctio n.Miscellaneous01-OCT-1330-SEP-14€10,000.00

Contract Researchers

 Researcher NameProjectRoleFunding Body
Dr Nirit KaraNovel Antidepressant Target ValidationPostdoctoral ResearcherIndustry Sponsor
Dr Erin HarrisStress ResiliencePostdoctoral Researcher
Dr Martin CodagnoneNovel Antidepressant Target validationPostdoctoral Researcher

Publications

Book Chapters

 YearPublication
(2018)'Revisiting the Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression'
*O'Leary OF, Codagnone MG, *Cryan JF (2018) 'Revisiting the Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression' In: The Handbook of the Behavioral Neurobiology of Serotonin. USA: Academic Press. [Details]
(2018)'Gene by environment interactions in animal models of depression and anxiety'
Felice D., Gururajan A, O’Leary O.F, Cryan J.F (2018) 'Gene by environment interactions in animal models of depression and anxiety' In: Peter Lesch, Judith Homberg (eds). Genes, Brain and Emotions: Resilience and Psychopathology. x: x. [Details]
(2018)'GABAB Receptors and Stress Resilience: A Tale of Two Isoforms'
O’Leary OF, Cryan JF (2018) 'GABAB Receptors and Stress Resilience: A Tale of Two Isoforms' In: Stress Resilience: Molecular and Behavioral Aspects. xx: Elsevier. [Details]
(2016)'Targeting the GABAB Receptor for the Treatment of Depression and Anxiety Disorders'
Daniela Felice, Olivia F. O’Leary, John F. Cryan (2016) 'Targeting the GABAB Receptor for the Treatment of Depression and Anxiety Disorders' In: GABA B Receptor. Swritzerland: Srpinger. [Details]
(2010)'Neurotrophic factors and antidepressant action: Recent advances'
O'Leary OF, Castren E; (2010) 'Neurotrophic factors and antidepressant action: Recent advances' In: Depression: From Psychopathology to Pharmacotherapy; Mod Trends Pharmacopsychiatry. Basel: Karger. [Details]
(2010)'The behavioural Genetics of serotonin: relevance to anxiety and depression'
O'Leary OF, Cryan JF ; (2010) 'The behavioural Genetics of serotonin: relevance to anxiety and depression' In: Handbook of the Behavioral Neurobiology of Serotonin. USA: Academic Press. [Details]
(2009)'The tail suspension test: A model for characterizing antidepressant activity in mice'
O'Leary OF, Cryan JF; (2009) 'The tail suspension test: A model for characterizing antidepressant activity in mice' In: Mood & Anxiety Related Phenotypes in Mice; Neuromethods. USA: Springer. [Details]

Peer Reviewed Journals

 YearPublication
(2019)'Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome'
O'Donovan SM, Crowley EK, Brown JR, O'Sullivan O, O'Leary OF, Timmons S, Nolan YM, Clarke DJ, Hyland NP, Joyce SA, Sullivan AM, O'Neill C. (2019) 'Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome'. Neurogastroenterol & Motility, e13726 [Details]
(2019)'Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome'
Pereira JDC, Rea K, Nolan YM, O'Leary OF, Dinan TG, Cryan JF. (2019) 'Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome'. Annual Review Of Psychology, [Details]
(2018)'Enduring Effects of Muscarinic Receptor Activation on Adult 2 Hippocampal Neurogenesis, MicroRNA expression and Behaviour 3 4'
Ramos Costa AP, Levone BR; Gururajan A, Moloney G, Hoeller A, Lino-de-Oliveira C, Dinan TG, O’Leary OF, Monteiro de Lima TC, Cryan JF* (2018) 'Enduring Effects of Muscarinic Receptor Activation on Adult 2 Hippocampal Neurogenesis, MicroRNA expression and Behaviour 3 4'. Behavioural Brain Research, [Details]
(2018)'Differential Effects of Adolescent and Adult‐initiated Exercise on Cognition and Hippocampal Neurogenesis'
James D. O'Leary Alan E. Hoban Ashley Murphy Olivia F. O'Leary John F. Cryan Yvonne M. Nolan (2018) 'Differential Effects of Adolescent and Adult‐initiated Exercise on Cognition and Hippocampal Neurogenesis'. Hippocampus, [DOI] [Details]
(2018)'Chronic Interleukin-1β in the Dorsal Hippocampus Impairs Behavioural Pattern Separation'
Hueston CM, O'Leary JD, Hoban AE, Kozareva DA, Pawley LC, O'Leary OF, Cryan JF, Nolan YM. (2018) 'Chronic Interleukin-1β in the Dorsal Hippocampus Impairs Behavioural Pattern Separation'. Brain Behav Immun, [Details]
(2018)'Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease'
Codagnone M.G., Spichak S,.O’Mahony SM, O’Leary O.F., Clarke G, Stanton C, Dinan TG., Cryan J.F. F. (2018) 'Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease'. Biological Psychiatry, [Details]
(2018)'Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning'
O'Leary JD;Hoban AE;Cryan JF;O'Leary OF;Nolan YM; (2018) 'Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning'. Neuropharmacology, [DOI] [Details]
(2018)'A low-cost touchscreen operant chamber using a Raspberry Pi™'
O'Leary JD, O'Leary OF, Cryan JF, Nolan YM. (2018) 'A low-cost touchscreen operant chamber using a Raspberry Pi™'. Behavioural Research Methods, [DOI] [Details]
(2018)'The Vagus Nerve Modulates BDNF expression and Neurogenesis in the Hippocampus'
O’Leary OF*, Ogbonnaya ES, Felice D, Levone BR, Conroy L, Fitzgerald P, Bravo JA, Forsythe P, Bienenstock J, Dinan TG Cryan JF (2018) 'The Vagus Nerve Modulates BDNF expression and Neurogenesis in the Hippocampus'. European Neuropsychopharmacology, [Details]
(2017)'Deletion of Tlx and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus'
Kozareva DA, O'Leary OF, Cryan JF, Nolan YM. (2017) 'Deletion of Tlx and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus'. Hippocampus, [Details]
(2017)'Elucidation of the Neural Circuits Activated by a GABAB Receptor Positive Modulator: Relevance to Anxiety'
Pizzo R*, O’Leary OF* and Cryan JF (2017) 'Elucidation of the Neural Circuits Activated by a GABAB Receptor Positive Modulator: Relevance to Anxiety'. Neuropharmacology, [Details]
(2017)'Microbial regulation of hippocampal miRNA expression: Implications for transcription of kynurenine pathway enzymes'
Moloney GM, O'Leary OF, Salvo-Romero E, Desbonnet L, Shanahan F, Dinan TG, Clarke G, Cryan JF. (2017) 'Microbial regulation of hippocampal miRNA expression: Implications for transcription of kynurenine pathway enzymes'. Behavioural Brain Research, 334 :50-54 [Details]
(2017)'The hippocampus and dorsal raphe nucleus are key brain areas associated with the antidepressant effects of lithium augmentation of desipramine'
Cussotto S, Cryan JF, O’Leary OF (2017) 'The hippocampus and dorsal raphe nucleus are key brain areas associated with the antidepressant effects of lithium augmentation of desipramine'. Neuroscience Letters, [DOI] [Details]
(2016)'Regulation of behaviour by the nuclear receptor Tlx'
James D. O’Leary, Olivia F. O'Leary, John F. Cryan and Yvonne M. Nolan (2016) 'Regulation of behaviour by the nuclear receptor Tlx'. Genes Brain And Behavior, [DOI] [Details]
(2016)'Inhibiting Neuroinflammation: The Role and Therapeutic Potential of GABA in Neuro-Immune Interactions'
Crowley T, Cryan JF, Downer EJ, O’Leary OF (2016) 'Inhibiting Neuroinflammation: The Role and Therapeutic Potential of GABA in Neuro-Immune Interactions'. Brain Behav Immun, [DOI] [Details]
(2016)'The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood'
O’LearyJD, Kozareva DA, Hueston CM, O'Leary OF, Cryan JF and NolanYM (2016) 'The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood'. Behav. Brain Res, [DOI] [Details]
(2015)'Differential Roles of GABAB1 Subunit Isoforms on Locomotor Responses to Acute and Repeated Administration of Cocaine'
Jacobson LH, Sweeney F, Kaupmann K, O’Leary OF, Gassmann M, Bettler B, Cryan JF (2015) 'Differential Roles of GABAB1 Subunit Isoforms on Locomotor Responses to Acute and Repeated Administration of Cocaine'. Behavioral Brain Research, [DOI] [Details]
(2015)'Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis'
Crowley T, Fitzpatrick J, Kuijper T, Cryan JF, O’Toole O, O'Leary OF, Downer EJ (2015) 'Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis'. Frontiers in Cellular Neuroscience, [Details]
(2015)'When ageing meets the blues: are current antidepressants effective in depressed aged patients'
Felice D, O’Leary OF, Cryan JF, Dinan TG, Gardier A, Sanchez C, David DJ (2015) 'When ageing meets the blues: are current antidepressants effective in depressed aged patients'. Neuroscience & Biobehavioral Reviews, [Details]
(2015)'Adult hippocampal neurogenesis is regulated by the microbiome'
Ogbonnaya ES, Clarke G, Shanahan F, Dinan TG, Cryan JF, O'Leary OF (2015) 'Adult hippocampal neurogenesis is regulated by the microbiome'. Biological Psychiatry, [Details]
(2015)'Role of adult hippocampal neurogenesis in stress resilience'
Levone BR, Cryan JF, O'Leary OF (2015) 'Role of adult hippocampal neurogenesis in stress resilience'. Neurobiology of Stress, 1 :147-155 [DOI] [Details]
(2014)'Glycogen Synthase Kinase-3 as a Therapeutic Target for Cognitive Dysfunction in Neuropsychiatric Disorders'
O'Leary OF, Nolan YM (2014) 'Glycogen Synthase Kinase-3 as a Therapeutic Target for Cognitive Dysfunction in Neuropsychiatric Disorders'. Cns Drugs, [DOI] [Details]
(2014)'A Ventral View on Antidepressant Action: Roles for Adult Hippocampal Neurogenesis along the Dorso-ventral Axis'
O'Leary OF, Cryan JF (2014) 'A Ventral View on Antidepressant Action: Roles for Adult Hippocampal Neurogenesis along the Dorso-ventral Axis'. Trends In Pharmacological Sciences, 35 :675-687 [DOI] [Details]
(2014)'GABAB(1) receptor subunit isoforms differentially regulate stress resilience'
O'Leary OF, Felice D, Galimberti S, Savignac HM, Bravo JA, Crowley T, El Yacoubi M, Vaugeois JM, Gassmann M, Bettler B, Dinan TG, Cryan JF. (2014) 'GABAB(1) receptor subunit isoforms differentially regulate stress resilience'. Proceedings of The National Academy of Science Usa, 111 (42):15232-15237 [Details]
(2014)'Faster, Better, Stronger: Towards New Antidepressant Therapeutic Strategies'
O'leary O.F, Dinan T.G, Cryan J.F. (2014) 'Faster, Better, Stronger: Towards New Antidepressant Therapeutic Strategies'. European Journal of Pharmacology, 123 :55-76 [DOI] [Details]
(2014)'A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'
Naughton M, Clarke G, O'Leary OF, Cryan JF, Dinan TG (2014) 'A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'. Journal of Affective Disorders, 156 :24-35 [Details]
(2014)'Activation but not Blockade of GABAB Receptors During Early-life Alters Anxiety in Adulthood in BALB/c mice'
Sweeney F., O'Leary O.F., Cryan J.F. (2014) 'Activation but not Blockade of GABAB Receptors During Early-life Alters Anxiety in Adulthood in BALB/c mice'. Neuropharmacology, 81 :303-310 [Details]
(2013)'Drugs, Genes and the Blues: Pharmacogenetics of the Antidepressant Response from Mouse to Man'
O’Leary O.F., O’Brien F.E., O’Connor R.M., Cryan J.F. (2013) 'Drugs, Genes and the Blues: Pharmacogenetics of the Antidepressant Response from Mouse to Man'. Pharmacology Biochemistry and Behavior, (123):55-76 [Details]
(2013)'Towards translational rodent models of depression'
O'Leary OF, Cryan JF (2013) 'Towards translational rodent models of depression'. Cell Tissue Research, 354 (1):141-145 [Details]
(2013)'Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action'
O'Connor RM, Pusceddu M, O'Leary OF, Savignac HM, Bravo JF, El Yacoubi M, Vaugeois JM, Dinan TG, Cryan JF. (2013) 'Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action'. Pharmacology Biochemistry and Behavior, 103 (3):561-567 [DOI] [Details]
(2013)'GABAB receptor ligands do not modify conditioned fear responses in BALB/c mice'
Sweeney F.F., O'Leary O.F., Cryan J.F. (2013) 'GABAB receptor ligands do not modify conditioned fear responses in BALB/c mice'. Behavioural Brain Research, 256 :151-156 [DOI] [Details]
(2013)'Lithium Augmentation of the effects of Desipramine in a Mouse Model of Treatment-Resistant Depression: A Role for Hippocampal Cell Proliferation'
O'Leary OF, Zandy S, Dinan TG, Cryan JF (2013) 'Lithium Augmentation of the effects of Desipramine in a Mouse Model of Treatment-Resistant Depression: A Role for Hippocampal Cell Proliferation'. Neuroscience, 228 :36-46 [DOI] [Details]
(2012)'Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action'
Felice D, O'Leary OF, Pizzo RC, Cryan JF. (2012) 'Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action'. Neuropharmacology, 63 (8):1380-1388 [DOI] [Details]
(2012)'Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice'
O'Leary OF, O'Connor RM, Cryan JF; (2012) 'Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice'. Neuropharmacology, 62 (1):247-255 [DOI] [Details]
(2012)'Early-life stress induces visceral hypersensitivity in mice'
Moloney RD, O'Leary OF, Felice D, Bettler B, Dinan TG, Cryan JF. (2012) 'Early-life stress induces visceral hypersensitivity in mice'. Neuroscience Letters, 512 (2):99-102 [Details]
(2011)'Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain'
Savignac HM, Finger BC, Pizzo RC, O'Leary OF, Dinan TG, Cryan JF; (2011) 'Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain'. Neuroscience, 192 :524-536 [DOI] [Details]
(2010)'Neuroscience. A glutamate pathway to faster-acting antidepressants?'
Cryan JF, O'Leary OF.; (2010) 'Neuroscience. A glutamate pathway to faster-acting antidepressants?'. Science, 329 (5994):913-914 [Details]
(2009)'Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling'
O'Leary OF, Wu X, Castren E; (2009) 'Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling'. Psychoneuroendocrinology, 34 (3):367-381 [DOI] [Details]
(2008)'The antidepressant fluoxetine restores plasticity in the adult visual cortex'
Maya Vetencourt JF, Sale A, Viegi A, Baroncelli L, De Pasquale R, O'Leary OF, Castr�n E, Maffei L; (2008) 'The antidepressant fluoxetine restores plasticity in the adult visual cortex'. Science, 320 (5874):385-388 [DOI] [Details]
(2007)'Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat'
Sairanen M, O'Leary OF, Knuuttila JE, Castr�n E; (2007) 'Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat'. Neuroscience, 144 (1):368-374 [DOI] [Details]
(2007)'The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs'
O'Leary OF, Bechtholt AJ, Crowley JJ, Valentino RJ, Lucki I; (2007) 'The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs'. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 17 (3):215-226 [DOI] [Details]
(2007)'Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test'
O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I; (2007) 'Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test'. Psychopharmacology, 192 (3):357-371 [DOI] [Details]
(2004)'Automated tests for measuring the effects of antidepressants in mice'
Crowley JJ, Jones MD, O'Leary OF, Lucki I; (2004) 'Automated tests for measuring the effects of antidepressants in mice'. Pharmacology Biochemistry and Behavior, 78 (2):269-274 [DOI] [Details]
(2004)'Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors'
Cryan JF, O'Leary OF, Jin SH, Friedland JC, Ouyang M, Hirsch BR, Page ME, Dalvi A, Thomas SA, Lucki I; (2004) 'Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors'. Proceedings of The National Academy of Sciences of The United States of America, 101 (21):8186-8191 [DOI] [Details]
(2004)'Distinguishing roles for norepinephrine and serotonin in the behavioral effects of antidepressant drugs'
Lucki I, O'Leary OF; (2004) 'Distinguishing roles for norepinephrine and serotonin in the behavioral effects of antidepressant drugs'. The Journal of Clinical Psychiatry, 65 Suppl 4 :11-24 [Details]

Conference Publications

 YearPublication
(2017)EBPS (European Behavioural Pharmacology Society) Biennial Meeting
Levone BR., Cryan JF., O’Leary OF. (2017) The anxiolytic and antidepressant effects of fluoxetine are mediated by specific regions of the longitudinal axis of the hippocampus EBPS (European Behavioural Pharmacology Society) Biennial Meeting Heraklion, Crete, Greece, , 31-AUG-17 - 03-SEP-17 [Details]
(2017)European Brain and Behaviour Society (EBBS)
O'Leary JD, Hoban AE, O'Leary OF, Cryan JF, Nolan YM (2017) DIFFERENTIAL EFFECTS OF EXERCISE DURING ADOLESCENCE AND ADULTHOOD ON COGNITION AND PLASTICITY European Brain and Behaviour Society (EBBS) [Details]
(2017)Neuroscience Ireland
Gerard M. Moloney1, Olivia O’ Leary1, Eloisa Salvo-Romero2, Lieve Desbonnet1, Fergus Shanahan3, Timothy G Dinan, Gerard Clarke4, John F Cryan1. (2017) Microbial regulation of hippocampal mirna expression: implications for transcription of kynurenine pathway enzymes Neuroscience Ireland NUI Galway, , 28-AUG-17 - 29-AUG-17 [Details]
(2017)Neuroscience Ireland
Danka A. Kozareva, Olivia F. O'Leary, John F. Cryan, Yvonne M. Nolan. (2017) Deletion of tlx and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus Neuroscience Ireland NUI Galway, , 28-AUG-17 - 29-AUG-17 [Details]
(2017)Neuroscience Ireland
SM O’Donovan, EK Crowley, J Browne, O O’Sullivan, OF O’Leary, S Timmons, YM Nolan, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2017) Investigation of the brain ↔ gut axis in the raav2/6-alpha-synuclein pd model: alterations in enteric nervous system pathology and the gut microbiome Neuroscience Ireland NUI Galway, , 28-AUG-17 - 29-AUG-17 [Details]
(2017)Neuroscience Ireland
Levone BR, Cryan JF, O'Leary OF (2017) The antidepressant effect of fluoxetine is mediated by specific sub-regions of the longitudinal axis of the hippocampus Neuroscience Ireland NUI Galway, , 28-AUG-17 - 29-AUG-17 [Details]
(2017)AD/PDTM 2017, the 13th​ International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders
O’Donovan SM, Crowley E, Browne J, O’Sullivan O, O’Leary OF, Timmons S, Nolan YM, O’Toole PW, Clarke DJ, Hyland NP, Joyce SA, Sullivan AM, O’Neill C (2017) The brain ↔gut axis in Parkinson’s disease: defining gut pathology and the impact of exercise in the rAAV-­α-­synuclein rat model of PD AD/PDTM 2017, the 13th​ International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders , 29-MAR-17 - 02-APR-17 [Details]
(2017)ECNP workshop for Junior Scientists in Europe
Levone BR, Nolan YM, Cryan JF, O'Leary OF (2017) Region-specific effects of corticosterone on neural progenitors along the dorso-ventral axis of the hippocampus ECNP workshop for Junior Scientists in Europe , 09-MAR-17 - 12-MAR-17 [Details]
(2016)New Horizons in Medical Research, December 8th 2016, University College Cork
Brunno R. Levone, John F. Cryan, Olivia F. O’Leary (2016) Regulation of anxiety behaviour by the ventral but not intermediate or dorsal areas of the hippocampus New Horizons in Medical Research, December 8th 2016, University College Cork [Details]
(2016)New Horizons in Medical Research, December 8th 2016, University College Cork
James D. O'Leary, Cynthia Brouwers, Niek Brosens, Olivia F. O'Leary, John F. Cryan, Aideen Sullivan and Yvonne M. Nolan (2016) Impact of voluntary exercise during adolescence on cognitive performance in a touchscreen operant chamber during adulthood New Horizons in Medical Research, December 8th 2016, University College Cork [Details]
(2016)New Horizons in Medical Research, December 8th 2016, University College Cork
SM O’Donovan, E Dolan, OF O’Leary, S Timmons, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2016) The brain ↔ gut axis in Parkinson’s disease (PD): Central nervous system administration of rAAV-α-synuclein altered gut pathophysiology and increased gut inflammation in the rAAV-α-synuclein rat model of PD New Horizons in Medical Research, December 8th 2016, University College Cork [Details]
(2016)Society for Neuroscience
James D. O'Leary, Cynthia Brouwers, Niek Brosens, Olivia F. O'Leary, John F. Cryan, Aideen M. Sullivan and Yvonne M. Nolan (2016) Impact of voluntary exercise during adolescence on cognitive performance in a touchscreen operant chamber during adulthood Society for Neuroscience [Details]
(2016)2016 Biochemical Society Meeting: Inflammatory diseases - mechanisms and clinical perspectives, 3—4 November 2016, Maynooth University, Ireland
SM O’Donovan, E Dolan, OF O’Leary, S Timmons, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2016) The brain ↔ gut axis in Parkinson’s disease (PD): Central nervous system administration of rAAV-α-synuclein altered gut pathophysiology and increased gut inflammation in the rAAV-α-synuclein rat model of PD 2016 Biochemical Society Meeting: Inflammatory diseases - mechanisms and clinical perspectives, 3—4 November 2016, Maynooth University, Ireland [Details]
(2016)APC Microbiome Institute Symposium
SM O’Donovan, E Dolan, OF O’Leary, S Timmons, PW O’Toole, DJ Clarke, NP Hyland, SA Joyce, AM Sullivan, C O’Neill (2016) The brain ↔ gut axis in Parkinson’s disease: defining gut pathophysiology in the rAAV-α-synuclein rat model of PD APC Microbiome Institute Symposium [Details]
(2016)Eurogenesis
Brunno R. Levone1, Yvonne M. Nolan, John F. Cryan, Olivia F. O’Leary (2016) Neural progenitor cells (NPCs) from the ventral hippocampus are more sensitive to long-term exposure to corticosterone than NPCs from the dorsal or intermediate hippocampus Eurogenesis Bordeaux, France, , 11-JUL-16 - 13-JUL-16 [Details]
(2016)Eurogenesis
James D. O'Leary, Danka A. Kozareva, Cara M. Hueston, Olivia F. O'Leary, John F. Cryan and Yvonne M. Nolan (2016) The nuclear receptor TLX regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood Eurogenesis Bordeaux, France, , 11-JUL-16 - 13-JUL-16 [Details]
(2016)Young Neuroscientists Symposium
Brunno R. Levone, John F. Cryan, Olivia F. O’Leary (2016) The hippocampus is functionally segregated along its longitudinal axis: A role for the ventral but not dorsal hippocampus in anxiety behaviour Young Neuroscientists Symposium [Details]
(2016)Young Neuroscientists Symposium
Conroy L, Levone BR, O’Leary OF (2016) ANTIDEPRESSANT-INDUCED REGULATION OF NEUROGENESISIS ALONG THE LONGITUDINAL AXIS OF THE HIPPOCAMPUS Young Neuroscientists Symposium [Details]
(2015)ICVS Neuroconferences workshop, Braga
Brunno Rocha Levone, Ciaran O’Leime, Yvonne M. Nolan, John F. Cryan, Olivia F. O’Leary (2015) THE EFFECTS OF CORTICOSTERONE ON NEUROPROGENITOR CELLS DERVIVED FROM SPECIFIC REGIONS OF THE LONGITUDINAL AXIS OF THE HIPPOCAMPUS ICVS Neuroconferences workshop, Braga [Details]
(2015)New Horizons – Translational Research Conference
Cussotto S, Cryan JF, O’Leary OF (2015) ELUCIDATION OF THE NEURONAL CIRCUITRY UNDERLYING THE ANTIDEPRESSANT EFFECTS OF A MEDICATION USE New Horizons – Translational Research Conference [Details]
(2015)New Horizons – Translational Research Conference
Levone BR, O’Leime C, Nolan YM, Cryan JF, O’Leary, OF (2015) Corticosterone differentially affects neural progenitor cells derived from specific areas of the longitudinal axis of the hippocampus New Horizons – Translational Research Conference [Details]
(2015)New Horizons – Translational Research Conference
James D. O'Leary, Danka A. Kozareva, Cara M. Hueston, Olivia F. O'Leary, John F. Cryan, Yvonne M. Nolan (2015) The nuclear receptor TLX regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood New Horizons – Translational Research Conference [Details]
(2015)European Behavioural Pharmacology Society
James D. O'Leary, Danka A. Kozareva, Cara M. Hueston, Olivia F. O'Leary, John F. Cryan and Yvonne M. Nolan (2015) THE NUCLEAR RECEPTOR TLX REGULATES MOTOR, COGNITIVE AND ANXIETY-RELATED BEHAVIOURS DURING ADOLESCENCE AND ADULTHOOD European Behavioural Pharmacology Society Verona, Italy, , 12-SEP-15 - 15-SEP-15 [Details]
(2015)Society for Neuroscience
Ramos Costa AP, Levone BR, Lino-de-Oliveira C, Dinan TG, O’Leary OF, Monteiro de Lima TC, Cryan JF. (2015) Hippocampal neuronal activation and neurogenesis in a pharmacological model of anxiety Society for Neuroscience [Details]
(2014)Careers in Neuroscience Symposium, Arts Millennium Building, NUI Galway
Crowley T, Cryan JF, Downer EJ, O'Leary OF (2014) Investigation of the GABAB receptor as a modulator of central and peripheral inflammation Careers in Neuroscience Symposium, Arts Millennium Building, NUI Galway [Details]
(2014)Frontiers in Neurology, 4th Annual meeting, Science Gallery, Trinity College Dublin
Crowley T, Fitzpatrick JM, O’Toole O, Cryan JF, O'Leary OF and Downer EJ (2014) An investiagtion into baclofen as a modulator of central TLR3/TLR4 signalling Frontiers in Neurology, 4th Annual meeting, Science Gallery, Trinity College Dublin [Details]
(2014)Society for Neuroscience
G. MOLONEY, O. O' LEARY, L. DESBONNET, F. SHANAHAN, T. G. DINAN, G. CLARKE, J. F. CRYAN (2014) Microbiota regulates microRNA expression in the hippocampus in a sex dependent manner Society for Neuroscience [Details]
(2014)27th ECNP Congress of Applied and Translational Neuroscience, Berlin, Germany
O'Leary OF (Invited Talk) (2014) 'GABAB1 receptor subunit isoforms differentially modulate resilience to stress 27th ECNP Congress of Applied and Translational Neuroscience, Berlin, Germany [Details]
(2014)27th ECNP Congress of Applied and Translational Neuroscience, Berlin, Germany
Ogbonnaya E.S, Lyons M, Clarke G, Shanahan F, Dinan, T.G., Cryan J.F., O’Leary O.F (2014) The microbiota-gut-brain axis regulates adult hippocampal neurogenesis 27th ECNP Congress of Applied and Translational Neuroscience, Berlin, Germany [Details]
(2014)Neuroscience Ireland Young Neuroscientists Symposium 2014
James D. O’Leary, Cara M. Hueston, Danka Kozareva, Olivia F. O’Leary John F. Cryan, and Yvonne M. Nolan (2014) Role of the nuclear receptor TLX in cognition during adolescence and adulthood Neuroscience Ireland Young Neuroscientists Symposium 2014 Trinity Biomedical Sciences Institute, Trinity College Dublin, , 20-SEP-14 [Details]
(2013)Neuroscience Ireland Conference 2013
Bonetti M., O’Connor R.M., Riva M., Cryan J.F., O’Leary O.F. (2013) Do antidepressants affect hippocampal GABAB receptor expression? Neuroscience Ireland Conference 2013 [Details]
(2013)Neuroscience Ireland Conference 2013
Ogbonnaya E.S., Felice D., Cryan J.F., O’Leary O.F. (2013) The vagus nerve tonically regulates the proliferation and survival of newly-born cells in the adult hippocampus Neuroscience Ireland Conference 2013 [Details]
(2013)International Behavioural Neuroscience Society Annual Meeting, Dublin, 25th -30th June 2013
Ogbonnaya S., Clarke G., Shanahan, F., Dinan T.G., Cryan, J. F., O’Leary, O.F. (2013) The microbiome-gut-brain axis regulates the survival of newly-born cells in the adult hippocampus International Behavioural Neuroscience Society Annual Meeting, Dublin, 25th -30th June 2013 [Details]
(2013)International Behavioural Neuroscience Society Annual Meeting, Dublin, 25th -30th June 2
O'Leary OF (Invited Talk) (2013) GABAB1 receptor subunit isoforms modulate susceptibility and resilience to stress-induced changes in behaviour: Implications for gene x environment interactions in depression and anxiety disorders International Behavioural Neuroscience Society Annual Meeting, Dublin, 25th -30th June 2 [Details]
(2013)Royal Academy of Medicine in Ireland, Section of Biomedical Sciences, University College Cork, June 20th
Ogbonnaya S., Clarke G., Shanahan F., Cryan J. F., O’Leary, O.F. (2013) Establishment of the gut microbiome during early-life influences the survival of newly-born cells in the adult hippocampus Royal Academy of Medicine in Ireland, Section of Biomedical Sciences, University College Cork, June 20th [Details]
(2012)25th European Collge of Neuropsychopharmacology congress, Vienna, Austria
Felice D., O'Leary O.F., Bettler B., Cryan J.F. (2012) GABAB(1) receptor subunit isoforms differentially mediate susceptibility to early-life stress-induced depression related behaviour 25th European Collge of Neuropsychopharmacology congress, Vienna, Austria [Details]
(2012)All Ireland Pharmacy Schools Conference, Cork, Ireland
Felice D., O'Leary O.F., Bettler B., Cryan J.F. (2012) GABAB receptor subunit isoforms differentially mediate susceptibility to early-life stress-induced depression related behaviour All Ireland Pharmacy Schools Conference, Cork, Ireland [Details]
(2012)ECNP Workshop on Neuropsychopharmacology, March 15-18 2012, Nice, France
Felice D, O’Leary O.F, Bettler B, Cryan JF (2012) GABAB(1) Receptor Subunit Isoforms Differentially Mediate Susceptibility to Depression-Related Behaviour Following Early-Life Stress ECNP Workshop on Neuropsychopharmacology, March 15-18 2012, Nice, France [Details]
(2011)Wiring the brain: Making connections, Wicklow, Ireland
O'Leary OF, Zandy S, Dinan TG, and Cryan JF; (2011) Increased hippocampal cell proliferation as a molecular mechanism for the therapeutic efficacy of adjunctive lithium therapy in treatment-resistant depression Wiring the brain: Making connections, Wicklow, Ireland [Details]
(2011)Anxiety and Depression, 21st Neuropharmacology Conference, Virginia, USA
Felice D, O'Leary OF, Bettler B, Cryan JF; (2011) The role of GABAB(1) receptor subunits in the modulation of early life stress on anxiety and depression-related behaviour in adulthood Anxiety and Depression, 21st Neuropharmacology Conference, Virginia, USA [Details]
(2011)Neuropharmacology Conference, Virginia, USA, November 10-11
Felice D, O'Leary OF, Pizzo RC, Cryan JF; (2011) Adult hippocampal neurogenesis is increased by a GABAB receptor antagonist : Relevance to antidepressant action Neuropharmacology Conference, Virginia, USA, November 10-11 [Details]
(2011)Anxiety and Depression, 21st Neuropharmacology Conference, Virginia, USA
O'Leary OF, Savignac HM, Felice D., Bettler B., Cryan JF; (2011) GABAB(1) receptor isoforms confer differential susceptibility to the effects of social defeat stress Anxiety and Depression, 21st Neuropharmacology Conference, Virginia, USA [Details]
(2011)European Behavioural Pharmacology society, Amsterdam
O'Leary OF, Zandy S, Dinan TG, and Cryan JF ; (2011) Adjunctive lithium treatment has antidepressant-like behavioural effects and increases hippocampal neurogenesis in a model of treatment-resistant depression European Behavioural Pharmacology society, Amsterdam [Details]
(2011)Health Research Board Watts Medal Competition
O'Mahony E, O'Leary OF, McKernan DP, O¿Malley D, Dinan TG and Cryan JF ; (2011) Investigation of glycogen synthase kinase-3 as a biomarker of schizophrenia and early-life stress Health Research Board Watts Medal Competition [Details]
(2011)Anxiety and Depression, 21st Neuropharmacology Conference, Virginia, USA
O'Leary OF, Zandy S, Dinan TG, Cryan JF; (2011) Adjunctive lithium treatment has antidepressant-like behavioural effects and increases adult hippocampal neurogenesis in a mouse model of treatment resistance Anxiety and Depression, 21st Neuropharmacology Conference, Virginia, USA [Details]
(2011)The International College of Neuropsychopharmacology (CINP) thematic meeting: Polypharmacy: The Good, The Bad and The Ugly, Salzburg, Austria
O'Leary OF, Zandy S, Dinan TG and Cryan JF; (2011) Increased hippocampal cell proliferation as a molecular mechanism for the therapeutic efficacy of adjunctive lithium therapy in treatment-resistant depression The International College of Neuropsychopharmacology (CINP) thematic meeting: Polypharmacy: The Good, The Bad and The Ugly, Salzburg, Austria [Details]
(2011)Neuroscience Ireland
Felice D., O'Leary O.F., Bettler B., Cryan J.F. (2011) The role of GABAB(1) receptor subunits in the modulation of the effects of early life stress on anxiety and depression-related behaviour in adult mice Neuroscience Ireland [Details]
(2011)Neuroscience Ireland
Felice D., O'Leary O.F., Pizzo R.C., Cryan J.F. (2011) Adult hippocampal neurogenesis is increased by a GABAB receptor antagonist in BALB/c mice: Relevance to antidepressant action Neuroscience Ireland [Details]
(2010)European College of Neuropsychopharmacology (ECNP) congress, Amsterdam, The Netherlands
O'Leary OF, O¿Connor RM, and Cryan JF; (2010) Lithium preferentially increases neurogenesis in the ventral but not dorsal hippocampus of stressed BALB/c mice European College of Neuropsychopharmacology (ECNP) congress, Amsterdam, The Netherlands [Details]
(2010)7th World Congress on Stress Leiden, The Netherlands
O'Leary OF, O¿Connor RM and Cryan JF; (2010) Desipramine differentially regulates antidepressant-like behaviour and the HPA axis in stressed BALB/c mice 7th World Congress on Stress Leiden, The Netherlands [Details]
(2010)European Behavioural Pharmacology Society, Workshop on drugs, psychiatric disorders and neurogenesis, Tours, France
O'Leary OF, O¿Connor RM, McGrath B and Cryan JF; (2010) Lithium-induced increases in cell proliferation are restricted to the ventral hippocampus in stressed BALB/c mice: Relationship to cell survival European Behavioural Pharmacology Society, Workshop on drugs, psychiatric disorders and neurogenesis, Tours, France [Details]
(2010)Society for Neuroscience annual meeting, San Diego, CA, USA
O'Leary OF, O¿Connor RM, McGrath B and Cryan JF; (2010) Distinguishing the roles of the ventral versus dorsal hippocampus in stress and lithium-induced changes in cell turnover Society for Neuroscience annual meeting, San Diego, CA, USA [Details]
(2010)6th Euron Workshop Drugs and the Brain: an update in Psychopharmacology, Braga, Portugal
O'Connor RM, O'Leary OF, Dinan A, Gokul A, Grenham S, Dinan TG and Cryan JF; (2010) Stress-induced Alterations in Hippocampal and Amygdalar microRNAs: Effects of Lithium 6th Euron Workshop Drugs and the Brain: an update in Psychopharmacology, Braga, Portugal [Details]
(2010)European Behavioural Pharmacology Society, Workshop on drugs, psychiatric disorders and neurogenesis, Tours, France
Felice D, O'Leary OF, Sweeney F, Pizzo R and Cryan J; (2010) GABAB receptor blockade induces antidepressant-like behavioural effects: Relationship with neurogenesis European Behavioural Pharmacology Society, Workshop on drugs, psychiatric disorders and neurogenesis, Tours, France [Details]
(2010)Neuroscience Ireland Annual Conference, University College Dublin
Pizzo RC, O'Leary OF and Cryan JF; (2010) The medial prefrontal cortex contributes to the anxiolytic effects of the GABAB receptor positive modulator GS39783 Neuroscience Ireland Annual Conference, University College Dublin [Details]
(2010)ECNP workshop on psychopharmacolgy for young scientists, Nice, France
O'Connor RM, O'Leary OF, Dinan A, Gokul A, Grenham S, Dinan TG and Cryan JF; (2010) Stress-induced alterations in hippocampal microRNAs: effects of lithium ECNP workshop on psychopharmacolgy for young scientists, Nice, France [Details]
(2009)Society for Neuroscience, Chicago
Bravo JA, O'Leary OF, Dinan TG and Cryan JF; (2009) Altered stress-related gene expression in the amygdala of a genetic model of anxiety and depression Society for Neuroscience, Chicago [Details]
(2009)European Behavioural Pharmacology Society, Rome, Italy
Sweeney F, O'Leary OF and Cryan J; (2009) GABAB receptor activation during early adolescence affects adult anxiety behaviour European Behavioural Pharmacology Society, Rome, Italy [Details]
(2009)Neuroscience Ireland Annual Conference, Dublin
Sweeney F, O'Leary OF and Cryan JF ; (2009) GABAB receptor activation during early adolescence affects adult anxiety behaviour Neuroscience Ireland Annual Conference, Dublin [Details]
(2009)Neuroscience Ireland Annual Conference, Dublin
O'Leary OF, Wu X and Castren, E; (2009) The antidepressant fluoxetine increases expression of synaptic proteins in the hippocampus of a model of reduced hippocampal synapse density Neuroscience Ireland Annual Conference, Dublin [Details]
(2009)European Behavioural Pharmacology Society, Rome, Italy
O'Leary OF, O'Connor R and Cryan JF; (2009) Lithium increases hippocampal cell proliferation and alters behaviour in a high anxiety mouse strain: Effects of chronic immobilization stress European Behavioural Pharmacology Society, Rome, Italy [Details]
(2009)Neuroscience Ireland Annual Conference, Dublin
O'Leary OF, O'Connor R and Cryan JF; (2009) Lithium increases hippocampal cell proliferation and alters behaviour in a high anxiety mouse strain: Effects of chronic immobilisation stress Neuroscience Ireland Annual Conference, Dublin [Details]
(2008)Society for Neuroscience, Washington D.C., USA
O'Leary OF, Wu X and Castren E; (2008) Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of a model of reduced hippocampal synapse density Society for Neuroscience, Washington D.C., USA [Details]
(2008)Federation of European Neuroscience Societies (FENS)
Maya Vetencourt JF, Sale A, Viegi A, De Pasquale R, Baroncelli L, O'Leary O, Castrén E and Maffei L; (2008) Chronic fluoxetine administration restores plasticity in the adult visual cortex Federation of European Neuroscience Societies (FENS) [Details]
(2006)Federation of European Neuroscience Societies (FENS), Vienna, Austria
O'Leary OF, Sairanen M and Castren E; (2006) Chronic antidepressant treatment increases expression of plasticity-associated proteins in the hippocampus and prefrontal cortex Federation of European Neuroscience Societies (FENS), Vienna, Austria [Details]
(2006)Society for Neuroscience, Atlanta, Georgia, USA
Castren E, Rantamaki TR, Sairanen M and O'Leary OF.; (2006) Antidepressants rapidly activate TrkB neurotrophin signaling and gradually increase the expression of plasticity-associated proteins in the rodent anterior cingulate cortex and hippocampus Society for Neuroscience, Atlanta, Georgia, USA [Details]
(2003)Society for Neuroscience, New Orlean, Louisiana, USA
O'Leary OF and Lucki I.; (2003) The Role of alpha1-adrenoceptors in the mechanism of action of antidepressants Society for Neuroscience, New Orlean, Louisiana, USA [Details]
(2002)Society for Neuroscience, Orlando, Florida, USA
O'Leary OF, Cryan JF, Page ME, Hirsch BR, Thomas SA and Lucki I; (2002) Reduced sensitivity to the behavioral and neurochemical effects of SSRIs in norepinephrine-deficient mice Society for Neuroscience, Orlando, Florida, USA [Details]
(2001)Society for Neuroscience, San Diego, California, USA
O'Leary OF, Page ME, Hirsch BR, Thomas SA, Cryan JF and Lucki I. ; (2001) Role of serotonin in the antidepressant-like effects of SSRIs in the tail suspension test Society for Neuroscience, San Diego, California, USA [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2015Most Outstanding Junior Faculty Travel Award International Behavioural and Neural Genetics Society (IBANGS)
20112011 Rafaelsen Young Investigator Award International College of Neuropsychopharmacology
20102010 ECNP Fellowship Award European College of Neuropsychopharmacology
2008HRB Career development Award Health Research Board Ireland
2009Oral presentation prize Neuroscience ireland
2010Poster prize Euron Workshop
1995University Scholarship Department of Education

Professional Associations

 AssociationFunctionFrom / To
European Behavioural Pharmacology Society (EBPS) member/
Society for Neuroscience (SFN) Member/
Neuroscience Ireland Member/
Biolink USA-Ireland Member/

Conference Contributions

 YearPublication
(2015)Trinity College Dublin, Neuroscience Society,
Olivia F. O'Leary (2015) Role of adult hippocampal neurogenesis and the GABAB receptor in stress resilience. [Invited Seminars/Guest Lectures], Trinity College Dublin, Neuroscience Society, Trinity College Dublin, . [Details]
(2015)Colston Research Symposium New developments in PTSD research and treatment,
O'Leary OF (Invited Talk) (2015) Role of GABA in stress resilience. [Invited Lectures (Conference)], Colston Research Symposium New developments in PTSD research and treatment, Bristol, United Kingdom , 16-NOV-15 - 17-NOV-15. [Details]
(2015)17th Annual Genes, Brain & Behaviour Meeting (IBANGS),
O'Leary OF (2015) GABAB(1) receptor subunit isoforms differentially regulate stress resilience. [Invited Lectures (Conference)], 17th Annual Genes, Brain & Behaviour Meeting (IBANGS), Uppsala, Sweden , 19-MAY-15 - 22-JUL-15. [Details]
(2014)Updates in Psychiatry Meeting,
Olivia F. O'Leary (2014) Towards New Antidepressant Therapeutic Strategies. [Invited Seminars/Guest Lectures], Updates in Psychiatry Meeting, University College Cork, Ireland , 24-APR-14 - 24-APR-14. [Details]
(2014)27th ECNP Congress,
Olivia F. O'Leary (2014) GABAB1 receptor subunit isoforms differentially modulate resilience to stress. [Invited Lectures (Conference)], 27th ECNP Congress, Berlin, Germany , 21-OCT-14. [Details]
(2013)International Behavioural Neuroscience Society Annual Meeting,
O'Leary O.F. (2013) GABAB1 receptor subunit isoforms modulate susceptibility and resilience to stress-induced changes in behaviour: Implications for gene x environment interactions in depression and anxiety disorders. [Invited Lectures (Conference)], International Behavioural Neuroscience Society Annual Meeting, Dublin , 25-JUN-13 - 30-JUL-13. [Details]
(2009)Neuroscience Ireland Annual meeting,
O'Leary OF (2009) The antidepressant fluoxetine increases expression of synaptic proteins in the hippocampus of a model of reduced hippocampal synapse density. [Invited Oral Presentation], Neuroscience Ireland Annual meeting, Science Gallery, Dublin, Ireland . [Details]

Committees

 CommitteeFunctionFrom / To
Interview Panel Member2018 /
University Animal Experimentation Ethics Committee (AEEC). member2015 /
School of Medicine Research & Postgraduate Affairs Committee Member2017 /
School of Medicine - Programme Committee BSc Paramedic Studies Member2014 /
Programme committee for the MSc in Molecular Cell Biology with Innovation Member2016 /
Departmental graduate studies committee Chair2013 /
Chair of Interview Panel Chair2016 /
Member of Interview panel - School of Pharmacy member2015 /
Departmental Representative for Disability Awareness Departmental Representative2013 /
Health & Safety Committee, School of Pharmacy, University College Cork Member2011 / 2012

Employment

 EmployerPositionFrom / To
School of Pharmacy, Dept. of Pharmacology and Therapeutics, University College Cork Lecturer01-AUG-11 /
University College Cork HRB Career development Award/Senior Postdoctoral Fellow01-OCT-08 / 31-AUG-11
Neuroscience Centre, University of Helsinki, Finland Postdoctoral Fellow31-AUG-05 / 31-JUL-08
University of Pennsylvania, USA Visiting Scholar08-JAN-01 / 15-JUL-05

Education

 YearInstitutionQualificationSubject
2015University College Cork Certificate in Teaching and Learning in Higher EduTeaching
2005National University of Ireland, Galway PhDPharmacology
2001National University of Ireland, Galway MScNeuropharmacology
1999National University of Ireland, Galway BSc HonsBiotechnology
1997National University of Ireland, Galway DIPLOMAGaeilge

Consultancy

 ClientDescription
Janssen
invited presentation

Journal Activities

 JournalRoleTo / From
Acta Neuropsychiatrica Editor11-MAR-16 -
Proceedings Of The National Academy Of Sciences Of The United States Of America Referee-
World Journal Of Neurology Referee-
Acs Chemical Neuroscience Referee-
Journal Of Psychopharmacology Referee-
Neuroscience And Biobehavioral Reviews Referee-
Advances In Medical Sciences Referee-
Animal Behaviour Referee-
Behavioural Brain Research Referee-
Behavioural Pharmacology Referee-
Biochemical Pharmacology Referee-
Biologia Referee-
Biological Psychiatry Referee-
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie Referee-
Brain Behav Immun Referee-
Brain Research Referee-
Brain Structure And Function Referee-
British Journal Of Pharmacology Referee-
Cell Reports Referee-
Cns Spectrums Referee-
Current Medicinal Chemistry Referee-
Digestive Diseases And Sciences Referee-
European Journal Of Neurology Referee-
European Journal Of Pharmacology Referee-
European Neuropsychopharmacology Referee-
Evidence-Based Complementary And Alternative Medicine Referee-
Experimental And Clinical Psychopharmacology Referee-
Expert Opinion On Drug Discovery Referee-
Expert Opinion On Drug Metabolism & Toxicology Referee-
Expert Opinion On Therapeutic Patents Referee-
Fundamental & Clinical Pharmacology Referee-
Frontiers In Neurology Referee-
Genes, Brain And Behavior Referee-
Immunology Letters Referee-
International Journal Of Developmental Neuroscience Referee-
International Journal Of Neuropsychopharmacology Referee-
Journal Of Chemical Neuroanatomy Referee-
Journal Of Neurochemistry Referee-
Journal Of Neuroinflammation Referee-
Journal Of Neuroscience Research Referee-
Journal Of Pharmacy And Pharmacology Referee-
Journal Of Visualized Experiments : Jove Referee-
Molecular Neurobiology Referee-
Molecular Psychiatry Referee-
Naunyn-Schmiedeberg'S Archives Of Pharmacology Referee-
Neural Plasticity Referee-
Neural Regeneration Research Referee-
Neurobiology Of Learning And Memory Referee-
Neurochemistry International Referee-
Neurological Research Referee-
Neuronal Signaling Referee-
Neuropharmacology Referee-
Neuropharmacology Editor31-OCT-16 -
Neuropsychopharmacology Referee-
Pharmacology, Biochemistry, And Behavior Referee-
Physiology And Behaviour Referee-
Plos One Referee-
Progress In Neuro-Psychopharmacology & Biological Psychiatry Referee02-APR-13 -
Psychiatry Research Referee-
Psychoneuroendocrinology Referee01-MAR-14 -
Psychopharmacology Referee-
Scientific Reports Referee-
Synapse (New York, N.Y.) Referee-
The International Journal Of Neuroscience Referee-
Translational Psychiatry Referee-

Other Activities

 Description

External examiner - BSc (Hons) Applied Biology & Biopharmaceutical Science, GMIT (2014 - present)

Reviewer for European Research Council - consolidator grants

External examiner PhD thesis TCD June 2018

External examiner PhD thesis, Trinity College Dublin (Jan 2018)


Examiner for PhD thesis, Ciaran O'Leime (Nov 2017)


External Examiner, PhD thesis, King's College London (Oct 2017)

External Examiner, PhD thesis, Aarhus University, (Jan/March 2016)

External Examiner, PhD thesis, Trinity College Dublin (December 2015)

PhD examiner - Matteo Pusceddu, UCC (2015)


External Examiner, PhD Thesis, National University of Ireland Maynooth (Nov 2014)

Examiner for PhD thesis, UCC, Sinead Ryan (August 2013) 

Examiner for PhD thesis, Fionn O'Brien (2013)

Examiner for PhD thesis, UCC, Dr. Caroline Browne (2012)                      

Examiner for MSc thesis, UCC, Jennifer Keyes, Ocotober 2014

Expert Grant Reviewer, Industrial Research Fund KU Leuven (IOF) (Feb 2016; Oct 2017)




Expert Grant Reviewer: Fondation pour la Recherche Médicale, France




Expert grant reviewer: Medical Research Council (MRC), UK

Expert grant reviewer:
L'Agence nationale de la recherche, France

Expert grant reviewer: Netherlands Organisation for Scientific Research

Expert grant reviewer: Binational Science Foundation (BSF)

Expert grant reviewer: Wellbeing of Women, UK

Teaching Activities

Teaching Interests

Programme Director (Interim) BSc Neuroscience

UNDERGRADUATE:
Module Coordinator & Lecturer:
AN4012 Medical imaging and biomedical devices in the neurosciences
AN3004 Human regional neuroanatomy
AN1063 Anatomy of Exercise
MD3012 Principles of Human Structure for Practitioner Paramedics
MD3015 Topographic Anatomy for Practitioner Paramedics   

Co-ordinator & Lecturer of Neuroanatomy component of:
AN2006 Neuroanatomy and embryology for dental students  
AN2060 Developmental neuroanatomy for occupational therapy
AN2061 Neuroanatomy and embryology for speech and language therapy

Lecturer:
AN4014 Cellular and Molecular Neuroscience
AN4013 Advanced Topics in Neuroscience
AN3013 Neurobiololgy of Disease

Supervisor:
AN3011 Library project
AN4010 Research Project 

POSTGRADUATE:
Lecturer: ML6002 Biological and Clinical Perspectives of Human Disease
Supervisor: ML6001 Molecular Cell Biology Research Dissertation
Develop & deliver induction sessions for postgraduate students in Dept. of Anatomy & Neuroscience
Chair of Postgraduate Studies Committee of the Dept. of Anatomy & Neuroscience








Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2019Lauren Pawley UCCThe impact of Chronic Neuroinflammation on Adult and Adolescent Hippocampal Neurogenesis and on the Stressed Brain
2018Brunno R. Levone University College CorkPHDDifferential Roles of Specific Sub-Regions of the Longitudinal Axis of the Hippocampus in the Behavioural and Neurogenesis Responses to Stress and Antidepressant Drugs
2018James O'Leary UCCPHDAdolescence as a Vulnerable Period for the Effects of Intrinsic & Extrinsic Regulators of Neurogenesis on Cognitive Behaviour
2015Tadhg Crowley University College CorkMScTargeting the GABAB receptor in Neuroinflammation
2014Ebere Sunny Ogbonnaya University College CorkDoctor of MedicineAdult hippocampal neurogenesis and the gut-brain axis
2013Daniela Felice University College CorkPhDNovel Insights into the Role of the GABAB Receptor in Depression and Anxiety

Current Postgraduate Students

 StudentDegree Type
Guzzetta Katherine Elizabeth Doctoral Degree
Mc Govern Andrew Joseph Masters Degree by Research

Modules Taught

 Term (ID))TitleLinkSubject
2020Human Regional Neuroanatomy AN3004Human Regional Neuroanatomy
2020Topographical Anatomy for Practitioner Paramedics MD3015Topographical Anatomy for Practitioner Paramedics
2020Developmental Neuro-anatomy for Occupational Therapy AN2060Developmental Neuro-anatomy for Occupational Therapy
2020Principles of Human Structure for Practitioner Paramedics MD3012Principles of Human Structure for Practitioner Paramedics
2020Neuroanatomy and Embryology for Speech and Language Therapy AN2061Neuroanatomy and Embryology for Speech and Language Therapy
2020Medical Imaging and Biomedical Devices in the Neurosciences AN4012Medical Imaging and Biomedical Devices in the Neurosciences
2020Anatomy of Exercise AN1063Anatomy of Exercise

Research Information

Internal Collaborators

 NameInstituteCountry
Prof. John F. Cryan University College CorkIRELAND
Dr. Yvonne Nolan University College CorkIRELAND
Prof. Ted Dinan University College CorkIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Dr. Malika El-Yacoubi University of LyonFRANCE
Prof. Bernhard Bettler University of BaselSWITZERLAND
Prof. Jean-Marie Vaugeois University of RouenFRANCE

Contact details

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Department of Anatomy and Neuroscience

Anatamaíocht agus Néareolaíocht

Room 2.33, 2nd Floor, Western Gateway Building, University College, Cork, Ireland

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