Research Profile

John Mark Tangney

Biography

Mark Tangney BSc, PhD, MBA
Principal Investigator at the College of Medicine & Health where I head a product-focussed research team developing microbes as therapies and diagnostics. Interests include Synthetic Biology; development of microbes as therapeutics; associations between bacteria and cancer; and entrepreneurship.
Worked for a number of years at various international institutions (Los Angeles, Boston, Copenhagen) and published extensively in the fields of biological engineering and medicine. Vice Secretary General of the International Society for Cell and Gene Therapy of Cancer (ISCGT); council member of the Irish Association for Cancer Research (IACR);  Vice-President of the Irish Society for Gene and Cell Therapy (ISGCT), and member of the editorial board of several international journals (Scientific Reports; Human Gene Therapy, Current Gene Therapy, Molecular Therapy - Oncolytics, Bioengineered, Biomarkers in Cancer).
My group's work is funded by grants awarded from the EU, Science Foundation Ireland, Health Research Board, Irish Research Council and the Irish Cancer Society. 

Research Interests

'BioEngineering next generation medical products': Primary focus is the development of novel technologies (therapeutic and diagnostic) for use in medicine. Research is translational and commercially focused, and developed by our team of international scientists and clinicians skilled in synthetic biology, microbiology, oncology and business.
See https://marktangney.wixsite.com/website

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Vaccines and Imaging Partnership.European Union01-OCT-1430-SEP-18€787,013.00
Edible Probiotics as Cancer Theranostics.Science Foundation of Ireland01-OCT-1630-SEP-20€605,767.00
LITE: Live Imaging with Targeting Enzymes.Science Foundation of Ireland01-JAN-1730-APR-18€125,458.00
Bacteria in Human Tumours.Health Research Board01-NOV-1631-OCT-19€125,950.00
Development of Novel Bacterial Imaging Probes.Science Foundation of Ireland01-JAN-1331-MAR-14€108,313.00
Market Analysis for Novel Biological Cancer Theraeutic.Enterprise Irl12-AUG-1313-DEC-13€15,041.00
Bactria in Patient Tumours - What, Where and How?Irish Research Council01-OCT-1630-SEP-19€72,000.00
Adeno-Associated Virus as a vector for immune gene therapy of solid tumoursScience Foundation Ireland01-OCT-0630-SEP-09€127,000.00
SFI-Listeria monocytogenes as a vector for cancer gene therapyScience Foundation of Ireland16-JUL-0715-AUG-08€86,650.00
Clinical development of a tumour diagnostic/therapeutic system utilising non-pathogenic bacteria.Health Research Board01-JAN-1131-AUG-14€251,140.00
Combined biotherapeutics for the treatment of metastatic cancer.Irish Funded Research Non Exchequer01-OCT-1130-MAR-15€190,824.00
HRB 'Bifidobacteria Mediated Cancer Gene Therapy'Health Research Board01-OCT-0730-JUN-11€289,944.00
Development of a Novel Vector for Cancer Gene Therapy for Clinical ApplicationEuropean Framework Programme Seven (FP7)01-MAY-1031-OCT-12€283,465.00
CRI "Anti-angiogenic Gene Therapy for Breast Cancer"Miscellaneous Non Exchequer30-APR-0801-MAY-11€195,332.00
SFI"Public Awareness on Genetic Modification" Supplement Teacher Cian O'MahonyScience Foundation of Ireland20-JUN-0815-AUG-08€11,639.00
Anamate: A Web Based Tool For The Easy Creation Of Flash AnimationsEnterprise Ireland01-JAN-0831-DEC-08€90,000.00
Long-term, systemic antitumour immunity via local, non-viral gene therapy of malignant tumoursHealth Research Board01-OCT-0530-SEP-08€275,000.00
Online Software For Generating Scientific Research Multimedia AnimationsEnterprise Ireland01-JAN-0731-DEC-07€82,015.00
Travel Support.Enterprise Irl29-MAY-1223-OCT-12€2,354.00
Bacterial-mediated Therapy of Prostatic Tumours.Irish Funded Research Non Exchequer01-DEC-1230-SEP-16€211,664.00
consumable budget only from R12305Health Research Board01-OCT-1231-DEC-15€51,000.00
Probiotic Bacterial Trafficking to Tumours in Cancer Patients.Health Research Board01-OCT-1230-SEP-15€273,093.00
Commercialisation of Bacterial Imaging Technology.Science Foundation of Ireland01-MAY-1431-AUG-14€31,842.00
Immune Reactivity To Foregut Cancers; Investigation Into Mechanism Of Oral ToleranceIrish Cancer Society01-OCT-0630-SEP-09€176,000.00
Probiotic Bacteria in Cancer MedicineHealth Research Board06-JUN-1627-JUL-16€2,000.00
A software tool for visualisation & co-ordination of research dataEnterprise Irl01-OCT-0830-SEP-09€96,535.00
SFI "Public Awareness on Genetic Modification" Supplement Teacher Dan O'SullivanScience Foundation of Ireland20-JUN-0815-AUG-08€14,744.00
Bacteria, Tumours and Imaging.Science Foundation of Ireland01-JUN-1531-AUG-15€35,195.00

Publications

Peer Reviewed Journals

 YearPublication
(2018)'In situ biomolecule production by bacteria; A synthetic biology approach to medicine'
Flores Bueso, Y.,Lehouritis, P.,Tangney, M. (2018) 'In situ biomolecule production by bacteria; A synthetic biology approach to medicine'. J Control Release, [Details]
(2017)'Designer Bacteria As Intratumoural Enzyme Biofactories'
Lehouritis, Panos; Hogan, Glenn; Tangney, Mark (2017) 'Designer Bacteria As Intratumoural Enzyme Biofactories'. Advanced Drug Delivery Reviews,   [DOI] [CORA Link] [Details]
(2017)'Development of a click beetle luciferase reporter system for enhanced bioluminescence imaging of Listeria monocytogenes: analysis in cell culture and murine infection models'
Ur Rahman S, Stanton M, Casey PG, Spagnuolo A, Bensi G, Hill C, Francis KP, Tangney M, Gahan CGM. (2017) 'Development of a click beetle luciferase reporter system for enhanced bioluminescence imaging of Listeria monocytogenes: analysis in cell culture and murine infection models'. Frontiers In Microbiology, [Details]
(2017)'Intratumoural production of TNFα by bacteria mediates cancer therapy'
Murphy C, Rettedal E, Lehouritis P, Devoy C, Tangney M (2017) 'Intratumoural production of TNFα by bacteria mediates cancer therapy'. Plos One, [DOI] [Details]
(2017)'Synthetic Biology in the Driving Seat of the Bioeconomy'
Flores Bueso, Y.,Tangney, M. (2017) 'Synthetic Biology in the Driving Seat of the Bioeconomy'. Trends Biotechnol, 35 (5):373-378   [DOI] [Details]
(2016)'Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria'
Lehouritis, P. Stanton, M. McCarthy, F. O. Jeavons, M. Tangney, M. (2016) 'Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria'. Journal of controlled release : official journal of the Controlled Release Society, 222 :9-17   [DOI] [Details]
(2016)'The Microbiota of Breast Tissue and Its Association with Breast Cancer'
Urbaniak C;Gloor GB;Brackstone M;Scott L;Tangney M;Reid G; (2016) 'The Microbiota of Breast Tissue and Its Association with Breast Cancer'. Applied and Environmental Microbiology, 82 (16) [DOI] [Details]
(2015)'Local bacteria affect the efficacy of chemotherapeutic drugs'
Panos Lehouritis, Joanne Cummins, Michael Stanton, Carola T. Murphy, Florence O. McCarthy, Gregor Reid, Camilla Urbaniak, William L. Byrne & Mark Tangney (2015) 'Local bacteria affect the efficacy of chemotherapeutic drugs'. Scientific Reports, 5 [DOI] [Details]
(2015)'In vivo bacterial imaging without engineering; A novel probe-based strategy facilitated by endogenous nitroreductase enzymes'
Stanton, M.,Cronin, M.,Lehouritis, P.,Tangney, M. (2015) 'In vivo bacterial imaging without engineering; A novel probe-based strategy facilitated by endogenous nitroreductase enzymes'. Current Gene Therapy, [Details]
(2015)'Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging'
Vorobyeva, A. G., M. Stanton, A. Godinat, K. B. Lund, G. G. Karateev, K. P. Francis, E. Allen, J. G. Gelovani, E. McCormack, M. Tangney and E. A. Dubikovskaya (2015) 'Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging'. Plos One, 10 (6) [Details]
(2014)'Bacterial-Mediated Knockdown of Tumor Resistance to an Oncolytic Virus Enhances Therapy'
Cronin, M;Le Boeuf, F;Murphy, C;Roy, DG;Falls, T;Bell, JC;Tangney, M (2014) 'Bacterial-Mediated Knockdown of Tumor Resistance to an Oncolytic Virus Enhances Therapy'. Molecular Therapy, 22 :1188-1197 [DOI] [Details]
(2014)'Bacterial-mediated DNA delivery to tumour associated phagocytic cells'
Byrne WL, Murphy CT, Cronin M, Wirth T, Tangney M (2014) 'Bacterial-mediated DNA delivery to tumour associated phagocytic cells'. Journal of controlled release : official journal of the Controlled Release Society, [DOI] [Details]
(2014)'Microbiota of Human Breast Tissue'
Urbaniak, C,Cummins, J,Brackstone, M,Macklaim, JM,Gloor, GB,Baban, CK,Scott, L,O'Hanlon, DM,Burton, JP,Francis, KP,Tangney, M,Reid, G (2014) 'Microbiota of Human Breast Tissue'. Applied and Environmental Microbiology, 80 :3007-3014 [DOI] [Details]
(2014)'Bacterial systems for gene delivery to systemic tumors'
Cummins J, Cronin M, van Pijkeren JP, Gahan CG, Tangney M (2014) 'Bacterial systems for gene delivery to systemic tumors'. Methods in molecular biology (Clifton, N.J.), 1141 :201-209 [DOI] [Details]
(2014)'Oral Tolerance to Cancer Can Be Abrogated by T Regulatory Cell Inhibition'
Whelan, MC,Casey, G,Larkin, JO,Guinn, BA,O'Sullivan, GC,Tangney, M (2014) 'Oral Tolerance to Cancer Can Be Abrogated by T Regulatory Cell Inhibition'. Plos One, 9 [DOI] [Details]
(2013)'Use of optical imaging to progress novel therapeutics to the clinic'
Byrne, WL,DeLille, A,Kuo, C,de Jong, JS,van Dam, GM,Francis, KP,Tangney, M (2013) 'Use of optical imaging to progress novel therapeutics to the clinic'. Journal of controlled release : official journal of the Controlled Release Society, 172 :523-534 [DOI] [Details]
(2013)'New targets for the immunotherapy of colon cancer-does reactive disease hold the answer?'
Boncheva, V.,Bonney, S. A.,Brooks, S. E.,Tangney, M.,O'Sullivan, G.,Mirnezami, A.,Guinn, B. A. (2013) 'New targets for the immunotherapy of colon cancer-does reactive disease hold the answer?'. Cancer Gene Ther,   [Details]
(2013)'Bacteria and tumours: causative agents or opportunistic inhabitants?'
Cummins, J.,Tangney, M. (2013) 'Bacteria and tumours: causative agents or opportunistic inhabitants?'. Infectious Agents and Cancer, [Details]
(2013)'Use of optical imaging to progress novel therapeutics to the clinic'
Byrne WL, Delille A, Kuo C, de Jong JS, van Dam GM, Francis KP, Tangney M (2013) 'Use of optical imaging to progress novel therapeutics to the clinic'. Journal of controlled release : official journal of the Controlled Release Society, [DOI] [Details]
(2013)'Bacterial-directed enzyme prodrug therapy'
Lehouritis P, Springer C, Tangney M (2013) 'Bacterial-directed enzyme prodrug therapy'. Journal of controlled release : official journal of the Controlled Release Society, [DOI] [Details]
(2013)'New targets for the immunotherapy of colon cancer-does reactive disease hold the answer?'
Boncheva V, Bonney SA, Brooks SE, Tangney M, O'Sullivan G, Mirnezami A, Guinn BA (2013) 'New targets for the immunotherapy of colon cancer-does reactive disease hold the answer?'. Cancer Gene Therapy, [DOI] [Details]
(2013)'Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells'
Rajendran S, O'Sullivan GC, O'Hanlon D, Tangney M (2013) 'Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells'. Clinical colorectal cancer, [DOI] [Details]
(2012)'Polymer coatings for delivery of nucleic acid therapeutics'
Laga R, Carlisle R, Tangney M, Ulbrich K, Seymour LW (2012) 'Polymer coatings for delivery of nucleic acid therapeutics'. Journal of controlled release : official journal of the Controlled Release Society, [DOI] [Details]
(2012)'In vivo Imaging & Gene Therapy'
Tangney M (2012) 'In vivo Imaging & Gene Therapy'. Current Gene Therapy, [Details]
(2012)'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'
Cronin, M.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J. B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'. Plos One, 7 (11)   [Details]
(2012)'PET Imaging For Gene & Cell Therapy'
Collins, S. A.,Hiraoka, K.,Inagaki, A.,Kasahara, N.,Tangney, M. (2012) 'PET Imaging For Gene & Cell Therapy'. Curr Gene Ther,   [Details]
(2012)'In vivo Optical Imaging in Gene & Cell Therapy'
Tangney, M.,Francis, K. P. (2012) 'In vivo Optical Imaging in Gene & Cell Therapy'. Curr Gene Ther,   [Details]
(2012)'Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity of infection'
Collins, J. W.,Akin, A. R.,Kosta, A.,Zhang, N.,Tangney, M.,Francis, K. P.,Frankel, G. (2012) 'Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity of infection'. Microbiology,   [Details]
(2012)'Bioluminescent bacterial imaging in vivo'
Baban CK, Cronin M, Akin AR, O'Brien A, Gao X, Tabirca S, Francis KP, Tangney M (2012) 'Bioluminescent bacterial imaging in vivo'. Journal of visualized experiments : JoVE, (69) [DOI] [Details]
(2012)'DNA vaccination for prostate cancer, from preclinical to clinical trials - where we stand?'
Ahmad S, Sweeney P, Sullivan GC, Tangney M (2012) 'DNA vaccination for prostate cancer, from preclinical to clinical trials - where we stand?'. Genetic vaccines and therapy, 10 (1) [DOI] [Details]
(2012)'Bacterial Vectors for Imaging and Cancer Gene Therapy: A Review'
Cronin, M.,Stanton, M.,Francis, K. P.,Tangney, M. (2012) 'Bacterial Vectors for Imaging and Cancer Gene Therapy: A Review'. Cancer Gene Ther, [Details]
(2012)'Control and augmentation of long-term plasmid transgene expression in vivo in murine muscle tissue and ex vivo in patient mesenchymal tissue'
Morrissey, D.,van Pijkeren, J.P. ,Rajendran, S.,Collins, S.,Casey, G.,O’Sullivan, G.C. ,Tangney, M. (2012) 'Control and augmentation of long-term plasmid transgene expression in vivo in murine muscle tissue and ex vivo in patient mesenchymal tissue'. J Biomed Biotechnol, [Details]
(2011)'The emerging role of viruses in the treatment of solid tumours'
Bourke, M. G.,Salwa, S.,Harrington, K. J.,Kucharczyk, M. J.,Forde, P. F.,de Kruijf, M.,Soden, D.,Tangney, M.,Collins, J. K.,O'Sullivan, G. C.; (2011) 'The emerging role of viruses in the treatment of solid tumours'. Cancer Treat Rev,   [Details]
(2011)'Targeting of Breast Metastases Using a Viral Gene Vector with Tumour-selective Transcription'
Rajendran, S.,Collins, S.,V. A. N. Pijkeren JP,O'Hanlon, D.,O'Sullivan, G. C.,Tangney, M.; (2011) 'Targeting of Breast Metastases Using a Viral Gene Vector with Tumour-selective Transcription'. Anticancer Res, 31 (55):1627-351627   [Details]
(2011)'Preclinical Evaluation Of Gene Delivery Methods For The Treatment Of Loco-Regional Disease In Breast Cancer'
Rajendran, S.,O'Hanlon, D.,Morrissey, D.,O'Donovan, D.,O'Sullivan, G.C.,Tangney, M.; (2011) 'Preclinical Evaluation Of Gene Delivery Methods For The Treatment Of Loco-Regional Disease In Breast Cancer'. Exp Biol Med, 236 (4):423-434   [Details]
(2011)'Induction of Effective Antitumor Response After Mucosal Bacterial Vector Mediated DNA Vaccination With Endogenous Prostate Cancer Specific Antigen'
Ahmad, S.,Casey, G.,Cronin, M.,Rajendran, S.,Sweeney, P.,Tangney, M.,O'Sullivan, G. C.; (2011) 'Induction of Effective Antitumor Response After Mucosal Bacterial Vector Mediated DNA Vaccination With Endogenous Prostate Cancer Specific Antigen'. J Urol,   [Details]
(2010)'Gene therapy for prostate cancer'
Tangney, M.,Ahmad, S.,Collins, S. A.,O'Sullivan, G. C.; (2010) 'Gene therapy for prostate cancer'. Postgrad Med, 122 (33):166-80166   [Details]
(2010)'Gene therapy for cancer: dairy bacteria as delivery vectors'
Tangney, M.; (2010) 'Gene therapy for cancer: dairy bacteria as delivery vectors'. Discov Med, 10 (5252):195-200195   [Details]
(2010)'Ex Vivo Culture of Patient Tissue & Examination of Gene Delivery'
Rajendran, S.,Salwa, S.,Gao, X.,Tabirca, S.,O'Hanlon, D.,O'Sullivan, G. C.,Tangney, M.; (2010) 'Ex Vivo Culture of Patient Tissue & Examination of Gene Delivery'. J Vis Exp, (46)   [Details]
(2010)'Murine bioluminescent hepatic tumour model'
Rajendran, S.,Salwa, S.,Gao, X.,Tabirca, S.,O'Hanlon, D.,O'Sullivan, G. C.,Tangney, M.; (2010) 'Murine bioluminescent hepatic tumour model'. J Vis Exp, (4141)   [Details]
(2010)'Tumour targeting with systemically administered bacteria'
Morrissey, D.,O'Sullivan, G. C.,Tangney, M.; (2010) 'Tumour targeting with systemically administered bacteria'. Curr Gene Ther, 10 (11):3-143   [Details]
(2010)'International Society for Cell and Gene Therapy of Cancer 2009 Annual Meeting held in Cork, Ireland'
Guinn, B.,Casey, G.,Moller, M. G.,Kasahara, N.,O'Sullivan, G. C.,Peng, K. W.,Tangney, M.; (2010) 'International Society for Cell and Gene Therapy of Cancer 2009 Annual Meeting held in Cork, Ireland'. Hum Gene Ther, 21 (11):9-269   [Details]
(2010)'Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors'
Cronin, M.,Morrissey, D.,Rajendran, S.,El Mashad, S. M.,van Sinderen, D.,O'Sullivan, G. C.,Tangney, M.; (2010) 'Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors'. Mol Ther, 18 (77):1397-4071397   [Details]
(2010)'AAV2-mediated in vivo immune gene therapy of solid tumours'
Collins, S. A.,Buhles, A.,Scallan, M. F.,Harrison, P. T.,O'Hanlon, D. M.,O'Sullivan, G. C.,Tangney, M.; (2010) 'AAV2-mediated in vivo immune gene therapy of solid tumours'. Genetic vaccines and therapy, 8   [Details]
(2010)'Sonoporation mediated immunogene therapy of solid tumors'
Casey, G.,Cashman, J. P.,Morrissey, D.,Whelan, M. C.,Larkin, J. O.,Soden, D. M.,Tangney, M.,O'Sullivan, G. C.; (2010) 'Sonoporation mediated immunogene therapy of solid tumors'. Ultrasound Med Biol, 36 (33):430-40430   [Details]
(2010)'Bacteria as vectors for gene therapy of cancer'
Baban, C.K. ,Cronin, M.C.,Oâ¿¿Hanlon, D.M.,Oâ¿¿Sullivan, G.C.,Tangney, M.; (2010) 'Bacteria as vectors for gene therapy of cancer'. BioEngineered Bugs, 1 (6):385-394   [Details]
(2010)'Optimised electroporation mediated DNA vaccination for treatment of prostate cancer'
Ahmad, S.,Casey, G.,Sweeney, P.,Tangney, M.,O'Sullivan, G. C.; (2010) 'Optimised electroporation mediated DNA vaccination for treatment of prostate cancer'. Genet Vaccines Ther, 8 (11)   [Details]
(2010)'Editorial [Hot Topic: Bacterial Vectors for Gene & Cell Therapy]'
Tangney, M.,Gahan, C. G.; (2010) 'Editorial [Hot Topic: Bacterial Vectors for Gene & Cell Therapy]'. Curr Gene Ther, 10 (11):1-21   [Details]
(2010)'Listeria monocytogenes as a vector for anti-cancer therapies'
Tangney, M.,Gahan, C. G.; (2010) 'Listeria monocytogenes as a vector for anti-cancer therapies'. Curr Gene Ther, 10 (11):46-5546   [Details]
(2010)'A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy'
van Pijkeren, J. P.,Morrissey, D.,Monk, I. R.,Cronin, M.,Rajendran, S.,O'Sullivan, G. C.,Gahan, C. G.,Tangney, M.; (2010) 'A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy'. Hum Gene Ther, 21 (44):405-16405   [Details]
(2010)'Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation'
Whelan, M. C.,Casey, G.,MacConmara, M.,Lederer, J. A.,Soden, D.,Collins, J. K.,Tangney, M.,O'Sullivan, G. C.; (2010) 'Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation'. Cancer Gene Ther, 17 (77):501-11501   [Details]
(2010)'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'
Tangney, M.,van Pijkeren, J. P.,Gahan, C. G.; (2010) 'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'. Bioeng Bugs, 1 (44):284-7284   [Details]
(2009)'Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth'
Ahmad, S.,Casey, G.,Sweeney, P.,Tangney, M.,O'Sullivan, G. C.; (2009) 'Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth'. Mol Ther, 17 (66):1101-81101   [Details]
(2009)'Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours'
Buhles, A.,Collins, S. A.,van Pijkeren, J. P.,Rajendran, S.,Miles, M.,O'Sullivan, G. C.,O'Hanlon, D. M.,Tangney, M.; (2009) 'Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours'. Genet Vaccines Ther, 7   [Details]
(2008)'Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers'
Cashman, J. P.,Larkin, J. O.,Casey, G.,Whelan, M. C.,Collins, C.,Aarons, S.,Tangney, M.,O'Sullivan, G. C.; (2008) 'Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers'. Cancer Lett, 262 (11):94-10294   [Details]
(2008)'Viral vectors in cancer immunotherapy: which vector for which strategy?'
Collins, S. A.,Guinn, B. A.,Harrison, P. T.,Scallan, M. F.,O'Sullivan, G. C.,Tangney, M.; (2008) 'Viral vectors in cancer immunotherapy: which vector for which strategy?'. Curr Gene Ther, 8 (22):66-7866   [Details]
(2008)'Tripartite meeting in gene and cell therapy, 2008: Irish Society for Gene and Cell Therapy, British Society for Gene Therapy, and International Society for Cell and Gene Therapy of Cancer'
Guinn, B.,Casey, G.,Collins, S.,O'Brien, T.,Alexander, M. Y.,Tangney, M.; (2008) 'Tripartite meeting in gene and cell therapy, 2008: Irish Society for Gene and Cell Therapy, British Society for Gene Therapy, and International Society for Cell and Gene Therapy of Cancer'. Hum Gene Ther, 19 (1010):967-78967   [Details]
(2008)'Effective tumor treatment using optimized ultrasound-mediated delivery of bleomycin'
Larkin, J. O.,Casey, G. D.,Tangney, M.,Cashman, J.,Collins, C. G.,Soden, D. M.,O'Sullivan, G. C.; (2008) 'Effective tumor treatment using optimized ultrasound-mediated delivery of bleomycin'. Ultrasound Med Biol, 34 (33):406-13406   [Details]
(2008)'Multimedia visualisation for Breast Cancer'
Chen, YJ,Rajendran, S,Tangney, M,Tabirca, S; (2008) 'Multimedia visualisation for Breast Cancer'. International Journal of Computers Communications & Control, 3 :206-211 [Details]
(2007)'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'
O'Sullivan, G. C.,Tangney, M.,Casey, G.,Ambrose, M.,Houston, A.,Barry, O. P.; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'. Int J Cancer, 121 (99):1930-401930   [Details]
(2007)'Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'
Riedel, C. U.,Monk, I. R.,Casey, P. G.,Morrissey, D.,O'Sullivan, G. C.,Tangney, M.,Hill, C.,Gahan, C. G.; (2007) 'Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'. Applied and Environmental Microbiology, 73 (99):3091-43091   [Details]
(2007)'Electrochemotherapy: aspects of preclinical development and early clinical experience'
Larkin, J. O.,Collins, C. G.,Aarons, S.,Tangney, M.,Whelan, M.,O'Reily, S.,Breathnach, O.,Soden, D. M.,O'Sullivan, G. C.; (2007) 'Electrochemotherapy: aspects of preclinical development and early clinical experience'. Ann Surg, 245 (33):469-79469   [Details]
(2006)'Oral immune tolerance mediated by suppressor T cells may be responsible for the poorer prognosis of foregut cancers'
Larkin, J.,Tangney, M.,Collins, C.,Casey, G.,O'Brien, M. G.,Soden, D.,O'Sullivan, G. C.; (2006) 'Oral immune tolerance mediated by suppressor T cells may be responsible for the poorer prognosis of foregut cancers'. Med Hypotheses, 66 (33):541-4541   [Details]
(2006)'Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours'
Soden, D. M.,Larkin, J. O.,Collins, C. G.,Tangney, M.,Aarons, S.,Piggott, J.,Morrissey, A.,Dunne, C.,O'Sullivan, G. C.; (2006) 'Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours'. Cancer Lett, 232 (22):300-10300   [Details]
(2006)'Non-viral in vivo immune gene therapy of cancer: combined strategies for treatment of systemic disease'
Tangney, M.,Casey, G.,Larkin, J. O.,Collins, C. G.,Soden, D.,Cashman, J.,Whelan, M. C.,O'Sullivan, G. C.; (2006) 'Non-viral in vivo immune gene therapy of cancer: combined strategies for treatment of systemic disease'. Cancer Immunol Immunother, 55 (1111):1443-501443   [Details]
(2006)'Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors'
Tangney, M.*,Collins, C. G.*,Larkin, J. O.,Casey, G.,Whelan, M. C.,Cashman, J.,Murphy, J.,Soden, D.,Vejda, S.,McKenna, S.,Kiely, B.,Collins, J. K.,Barrett, J.,Aarons, S.,O'Sullivan, G. C.; (2006) 'Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors'. Cancer Gene Ther, 13 (1212):1061-711061   [Details]
(2006)'Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy'
Walsh, M.,Tangney, M.,O'Neill, M. J.,Larkin, J. O.,Soden, D. M.,McKenna, S. L.,Darcy, R.,O'Sullivan, G. C.,O'Driscoll, C. M.; (2006) 'Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy'. Mol Pharm, 3 (66):644-53644   [Details]
(2005)'Combined electric field and ultrasound therapy as a novel anti-tumour treatment'
Larkin, J.,Soden, D.,Collins, C.,Tangney, M.,Preston, J. M.,Russell, L. J.,McHale, A. P.,Dunne, C.,O'Sullivan, G. C.; (2005) 'Combined electric field and ultrasound therapy as a novel anti-tumour treatment'. Eur J Cancer, 41 (99):1339-481339   [Details]
(2004)'Salmonella carriage in an Irish pig herd: correlation between serological and bacteriological detection methods'
Casey, P. G.,Butler, D.,Gardiner, G. E.,Tangney, M.,Simpson, P.,Lawlor, P. G.,Stanton, C.,Ross, R. P.,Hill, C.,Fitzgerald, G. F.; (2004) 'Salmonella carriage in an Irish pig herd: correlation between serological and bacteriological detection methods'. Journal of Food Protection, 67 (1212):2797-8002797   [Details]
(2004)'Isolation and characterization of anti-Salmonella lactic acid bacteria from the porcine gastrointestinal tract'
Casey, P. G.,Casey, G. D.,Gardiner, G. E.,Tangney, M.,Stanton, C.,Ross, R. P.,Hill, C.,Fitzgerald, G. F.; (2004) 'Isolation and characterization of anti-Salmonella lactic acid bacteria from the porcine gastrointestinal tract'. Letters of Applied Microbiology, 39 (55):431-8431   [Details]
(2002)'Effectiveness of the lactococcal abortive infection systems AbiA, AbiE, AbiF and AbiG against P335 type phages'
Tangney, M.,Fitzgerald, G. F.; (2002) 'Effectiveness of the lactococcal abortive infection systems AbiA, AbiE, AbiF and AbiG against P335 type phages'. FEMS Microbiol Lett, 210 (11):67-7267   [Details]
(2002)'AbiA, a lactococcal abortive infection mechanism functioning in Streptococcus thermophilus'
Tangney, M.,Fitzgerald, G. F.; (2002) 'AbiA, a lactococcal abortive infection mechanism functioning in Streptococcus thermophilus'. Appl Environ Microbiol, 68 (1212):6388-916388   [Details]
(2000)'Identification of a DNA region from lactococcal phage sk1 protecting phage 712 from the abortive infection mechanism AbiF'
Rince, A.,Tangney, M.,Fitzgerald, G. F.; (2000) 'Identification of a DNA region from lactococcal phage sk1 protecting phage 712 from the abortive infection mechanism AbiF'. FEMS Microbiol Lett, 182 (11):185-91185   [Details]
(1999)'Expression, regulation, and mode of action of the AbiG abortive infection system of lactococcus lactis subsp. cremoris UC653'
O'Connor, L.,Tangney, M.,Fitzgerald, G. F.; (1999) 'Expression, regulation, and mode of action of the AbiG abortive infection system of lactococcus lactis subsp. cremoris UC653'. Appl Environ Microbiol, 65 (11):330-5330   [Details]

Book Chapters

 YearPublication
(2016)'In Vivo Bioluminescence Imaging Of Intra-Tumoural Bacteria'
Michelle Cronin, Ali Akin, Kevin Francis and Mark Tangney (2016) 'In Vivo Bioluminescence Imaging Of Intra-Tumoural Bacteria' In: Bacterial Therapy of Cancer: Methods and Protocols. New York: Springer. [DOI] [Details]
(2015)'Bacteria as Gene Therapy Vectors for Cancer'
Byrne, W. L.,Tangney, M. (2015) 'Bacteria as Gene Therapy Vectors for Cancer' In: Smyth Templeton, N (eds). Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. Florida, USA: CRC Press. [Details]
(2013)'Plasmid Transgene Expression In vivo; Promoter and Tissue Variables'
Morrissey, D.,Collins, S. A.,Rajendran, S.,Casey, G.,O'Sullivan, G. C.,Tangney, M. (2013) 'Plasmid Transgene Expression In vivo; Promoter and Tissue Variables' In: Gene Therapy. Croatia: In Tech. [Details]
(2011)'Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods'
Collins SA, Morrissey D, Rajendran S, Casey G, Scallan MF, Harrison PT, O'Sullivan GC, Tangney M. ; (2011) 'Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods' In: Gene Therapy - developments and future perspectives. Croatia: InTech. [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2012UCC Teaching Fellow UCC
2011Cork Person of the Month Cork Person of the Year Body
2010The Outstanding Young Person award (Junior Chamber International- Europe) Junior Chamber International
2007UCC Quality Promotion Unit Award for Research on Innovative Forms of Teaching and Learning UCC
2007UCC President's Strategic Fund for initiatives in the area of generic training for postgraduate students UCC

Professional Associations

 AssociationFunctionFrom / To
International Society of Cell & Gene Therapy for Cancer (ISCGT) Vice Secretary16-NOV-16 /
Irish Association for Cancer Research (IACR) Council member01-MAR-13 /
Irish Society for Gene & Cell Therapy Vice President10-JUN-09 /
European Society for Gene & Cell Therapy (ESGCT) Scientific Committee member (Non-Viral Vectors committee)01-FEB-12 / 01-FEB-15
Current Gene Therapy Associate Editor06-JAN-11 /

Education

 YearInstitutionQualificationSubject
2001UCC PHDMolecular Biology
2014UCC MBAMBA

Outreach Activities

 Description

Empowering all with scientific literacy:

- Developing Country Initiatives: Erasmus+ funded initiatives with Latin American universities; Equipment donation to Latin American laboratories.

- Schools: Development of 2nd level school modules; BT Young Scientist Competition entries; Hosting of Public Engagement events (Science & Society); Science Foundation Ireland STAR projects from 2007-2009

- General Public: Charity fundraising for research; Frequent TV, Radio and press appearances. Regular guest speaker to community groups.

Journal Activities

 JournalRoleTo / From
Current Gene Therapy Editor01-JAN-11 -
Scientific Reportsscientific Reports Member of Editorial Board01-JAN-17 -
Molecular Therapy Member of Editorial Board01-JUL-15 -
Human Gene Therapy Member of Editorial Board01-JAN-09 -
Bioengineered Member of Editorial Board12-JUN-13 -
Member of Editorial Board06-FEB-10 -

Other Activities

 Description

- Regular journal reviewer for
Nature Medicine; 
Nature Nanotechnology; 
PLoS One;
Molecular Therapy;
Cancer Gene Therapy;
Oncogene;
Cancer Immunology Immunotherapy;
Clinical Medicine & Research;
Journal of Gene Medicine;
Leukemia and Lymphoma;
Gene Therapy;
BioEnginered;
Biomarker Insights;
Cancer Therapy;
J. Medical Hypotheses;
J. Angiogenesis; A
CS Chemical Biology;
Journal of Controlled Release;
Integrative Biology;
Human Gene Therapy;
Technology in Cancer Research & Treatment;
Journal of Healthcare Engineering;
International Journal of Cancer;
Expert Reviews in Molecular Medicine;
Current Microbiology;
Theranostics

- Ad hoc grant reviewer for
Medical Research Council UK;
Association for International Cancer Research;
Breast Cancer Campaign UK;
The French National Research Agency;
Genesis Oncology Trust, New Zealand;
Research Grants Council Hong Kong;
Swiss National Science Foundation;
Genome British Columbia

Teaching Activities

Teaching Interests

- Research-led Teaching; e.g. iGEM http://2017.igem.org/Team:UCC_Ireland#


- Teaching & Learning with Technology

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2016Michael Stanton University College CorkPhDDevelopment of tumour imaging and therapy strategies utilising unengineered bacteria
2010Yin Jen Chi NUI (UCC)PhDVisualisation Frameworks for Tumour Growth
2012Ryan Guo NUI (UCC)PhDCancer 3D Modelling
2013William Byrne NUI (UCC)PhDImmune Gene Therapy for Cancer
2014Chwanrow Baban NUI (UCC)PhDExploring the relationship between bacteria and tumors
2014Simon Rajendran NUI (UCC)PhDEx vivo culture of patient tissue and examination of gene delivery
2009Sarfraz Ahmad NUI (UCC)PhDDNA vaccination for prostate cancer
2010David Morrissey NUI (UCC)PhDBacterial cancer therapy
2011Sara Collins NUI (UCC)PhDAAV-mediated cancer gene therapy

Current Postgraduate Students

 StudentDegree Type
Walker Sidney Peter Doctoral Degree
Flores Bueso Yensi Alejandra Doctoral Degree
Yallapragada Venkata Vamsi Bharadwaj Doctoral Degree
Hogan Glenn Doctoral Degree

Contact details

  • John Mark Tangney
    Principal Investigator
  • m.tangney@ucc.ie
  • Cancer Research at the CoMH
    Western Gateway Building
    University College Cork
    Ireland
  • +353214205709

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Biosciences Institute

BioSciences Institute, University College Cork, Ireland

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